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AnalgesicsAnti Inflammatory Drugs
AnalgesicsAnti Inflammatory Drugs
ANTIINFLAMMATORY DRUGS
Dr. B. Rambabu
M.Pharm,PhD
Professor &HOD
Department of Pharmacology
Phospholipase
----- Steroids
Arachidonic acid
Cyclooxygenase Lipoxygenases
NSAIDs ----- Lipoxygenase inhititors
-----
Prostaglandins PMNs
selection
Non-selective COX inhibitor
Selective COX inhibitor
Salicylates
chemcial Acetaminophen
constitution Indomethacin
et al
Non-steroidal anti-inflammatory
drugs (NSAIDs)
• Some important examples are aspirin,
ibuprofen, naproxen, indomethacin,
paracetamol. (The last agent has analgesic
and antipyretic effects but little anti-
inflammatory action).
The Salicylates: Aspirin
• Aspirin (acetylsalicylic acid) was first isolated in
1829 by Leroux from willow bark.