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  • TIRZEPATIDE

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    Tirzepatide is a new once-weekly injectable diabetes medication that acts as both a GLP-1 and GIP receptor agonist. It works by stimulating insulin secretion, suppressing glucagon levels, slowing stomach emptying, and reducing appetite. Common side effects are gastrointestinal and include nausea, diarrhea, vomiting and constipation. These side effects are usually mild and decrease over time. Managing side effects may involve eating smaller, lower fat meals and listening to hunger/fullness cues.

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    TIRZEPATIDE (2)

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    Tirzepatide is a new once-weekly injectable diabetes medication that acts as both a GLP-1 and GIP receptor agonist. It works by stimulating insulin secretion, suppressing glucagon levels, slowing stomach emptying, and reducing appetite. Common side effects are gastrointestinal and include nausea, diarrhea, vomiting and constipation. These side effects are usually mild and decrease over time. Managing side effects may involve eating smaller, lower fat meals and listening to hunger/fullness cues.

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    10 views2 pages

    TIRZEPATIDE

    Uploaded by

    Chris
    Tirzepatide is a new once-weekly injectable diabetes medication that acts as both a GLP-1 and GIP receptor agonist. It works by stimulating insulin secretion, suppressing glucagon levels, slowing stomach emptying, and reducing appetite. Common side effects are gastrointestinal and include nausea, diarrhea, vomiting and constipation. These side effects are usually mild and decrease over time. Managing side effects may involve eating smaller, lower fat meals and listening to hunger/fullness cues.

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    of 2

    By: Black Cloud

    What is Tirzepatide? Mechanism of action Tirzepatide Side Effects




    Tirzepatide is a once-weekly injectable Glucagon-like peptide-1 (GLP-1) receptors Tirzepatide’s most common side effects are
    medication that will be available as an auto- (GLP-1R) are expressed throughout the body, gastrointestinal. The side effects are more
    injector pen. This new glucose-lowering therapy including pancreatic beta-cells and the pronounced when the doctors increased the
    is called a "dual agonist" or a “dual GIP and GLP-1 gastrointestinal tract. They have been dose. Your doctor will increase the dose to
    receptor agonist.” It’s similar to GLP-1 receptor implicated in the pathophysiology of type II achieve your blood glucose target.
    agonists – which have been shown to lower diabetes mellitus as GLP-1R signalling is
    glucose levels, lead to weight loss, and lower the involved in glucose control by enhancing Here are some common side effects:
    risk of heart disease – but Tirzepatide adds a GIP glucose-stimulated insulin secretion, delaying Nausea
    receptor agonist. gastric transit, decreasing plasma glucagon Diarrhea
    levels, and reducing body weight by activating Loss of appetite
    GIP and GLP-1 are two hormones that the body anorexigenic pathways in the brain. Both Vomiting
    makes which are normally released with meals. glucose-dependent insulinotropic polypeptide Constipation
    (GIP) and GLP-1 are peptide hormones Indigestion
    The function of GIP involved in glucose homeostasis: they Stomach pain
    Induce insulin secretion in the small intestine promote glucose-stimulated insulin secretion
    in response to a meal from the pancreatic beta-cells. However, GIP is
    Bone formation the main incretin hormone that exerts
    How To Manage Tirzepatide Side
    Gastric secretion insulinotropic effects in response to food Effects
    The function of GLP-1 intake.dual agonism at GIP and GLP-1R may

    Slows down how fast food leaves your contribute to the glycemic and weight control Most side effects disappear over time, but here
    stomach effects of the drug. are some strategies you can use to lessen these
    Doesn’t make you feel as hungry gastrointestinal side effects:
    Keeps you feeling fuller Studies demonstrated that co-administration Listen to your fullness signal. Stop eating
    Increases the delivery of insulin into your of GIP and a GLP-1R agonist more significantly when you are no longer hungry. Eating just
    cells increased insulin response and suppressed one or two more bites may induce nausea.
    Decreases the delivery of glucagon into your glucagon secretion compared to separate Eat smaller portions. It is best to serve
    cells administration of either hormone alone. smaller and frequent portions than 3 larger
    meals. Again, pay attention to your hunger
    The co-infusion of these two incretins exerts a Example: and fullness cues.
    synergist effect that helps you lower your blood Check the fat content in your meals.
    glucose level and help with weight loss. Choose lower fat foods and meals.
    Salty, sour, or bland flavors will help when

    feeling nauseated (saltine crackers,

    lemon/lime water, toast)

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