Vaccine-naive

Vaccine-naive is a lack of immunit y, or immunologic memory, t o a disease because t he person

has not been vaccinat ed. There are a variet y of reasons why a person may not have received a
vaccinat ion, including cont raindicat ions due t o preexist ing medical condit ions, lack of resources,
previous vaccinat ion failure, religious beliefs, personal beliefs, fear of side-effect s, phobias t o
needles, lack of informat ion, vaccine short ages, physician knowledge and beliefs, social pressure,
and nat ural resist ance.[1][2][3][4]

The time-course of an immune response begins with the initial pathogen encounter, (or initial vaccination) and leads to the
formation and maintenance of active immunological memory.

Effect on herd immunity

Communicable diseases, such as measles and influenza, are more readily spread in vaccine-naive
populat ions, causing frequent out breaks. Vaccine-naive persons t hreat en what epidemiologist s
call herd immunit y.[5][6][7] This is because vaccinat ions provide not just prot ect ion t o t hose who
receive t hem, but also provide indirect prot ect ion t o t hose who remain suscept ible because of
t he reduced prevalence of infect ious diseases. Fewer individuals available t o t ransmit t he
disease reduce t he incidence of it , creat ing herd immunit y.[8]

See also

Immune syst em

Out break

Pulse vaccinat ion st rat egy

Vaccine

References

1. Menson, E. N.; Mellado, M. J.; Bamford, A.; Castelli, G.; Duiculescu, D.; Marczyńska, M.; Navarro, M. L.;
Scherpbier, H. J.; Heath, P. T.; Paediatric European Network for Treatment of AIDS (PENTA) Vaccines
Group; Penta Steering, C.; Children's HIV Association (CHIVA) (2012). "Guidance on vaccination of HIV-
infected children in Europe" (https://doi.org/10.1111%2Fj.1468-1293.2011.00982.x) . HIV Medicine. 13
(6): 333–336, e1–336. doi:10.1111/j.1468-1293.2011.00982.x (https://doi.org/10.1111%2Fj.1468-129
3.2011.00982.x) . PMID 22296225 (https://pubmed.ncbi.nlm.nih.gov/22296225) .

2. "CDC Smallpox | Smallpox (Vaccinia) Vaccine Contraindications (Info for Clinicians)" (https://www.bt.cd
c.gov/agent/smallpox/vaccination/contraindications-clinic.asp) . Bt.cdc.gov. Retrieved 2013-07-15.

3. Wallace, H. Shortages require practices to take extra measures to keep patients up-to-date on vaccines:
Calling the shots. AAP News 2003; 23:54–56

4. Turner, N.; Grant, C.; Goodyear-Smith, F.; Petousis-Harris, H. (2009). "Seize the moments: missed
opportunities to immunize at the family practice level" (https://doi.org/10.1093%2Ffampra%2Fcmp02
8) . Family Practice. 26 (4): 275–8. doi:10.1093/fampra/cmp028 (https://doi.org/10.1093%2Ffampr
a%2Fcmp028) . PMID 19477931 (https://pubmed.ncbi.nlm.nih.gov/19477931) .

5. Kiera Butler (2013-05-27). "The Real Reason Kids Aren't Getting Vaccines" (https://www.motherjones.co
m/environment/2013/05/vaccines-whooping-cough) . Mother Jones. Retrieved 2013-07-15.

6. "Prevention and Control of Influenza with Vaccines: Recommendations of the Advisory Committee on
Immunization Practices (ACIP), 2011" (https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6033a3.h
tm) . Cdc.gov. Retrieved 2013-07-15.
 7. West, D. J.; Calandra, G. B. (1996). "Vaccine induced immunologic memory for hepatitis B surface
antigen: implications for policy on booster vaccination". Vaccine. 14 (11): 1019–27. doi:10.1016/0264-
410X(96)00062-X (https://doi.org/10.1016%2F0264-410X%2896%2900062-X) . PMID 8879096 (http
s://pubmed.ncbi.nlm.nih.gov/8879096) .

8. Garnett, G. P. (2005). "Role of Herd Immunity in Determining the Effect of Vaccines against Sexually
Transmitted Disease" (https://doi.org/10.1086%2F425271) . The Journal of Infectious Diseases. 191:
S97–106. doi:10.1086/425271 (https://doi.org/10.1086%2F425271) . PMID 15627236 (https://pubme
d.ncbi.nlm.nih.gov/15627236) .

External links

Cent ers for Disease Cont rol and Prevent ion (CDC) immunizat ion schedules (ht t ps://www.cdc.g
ov/vaccines/schedules/)

CDC Vaccine cont raindicat ions (ht t ps://www.cdc.gov/vaccines/schedules/hcp/imz/adult -cont

raindicat ions-shell.ht ml)

Portals:  Biology  Medicine

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