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Home / Search / "Side e!ects of Vero cell vaccination against Covid-19 among medical students of Nepalgun

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"Side e!ects of Vero cell vaccination against Covid-19
among medical students of Nepalgunj Medical College"-A
Post Vaccination survey (preprint) Full text: Available
Rupak K.C.; Sibika Malla; Merina Shrestha; Saharoj Siddiqui; Aashish Collection: Preprints
Jung Pandey; Niranjan KC; Suraj Adhikari; Rumi KC. Database: medRxiv

medrxiv; 2022. Main subject: Pain /

Paresthesia /
Preprint in English | medRxiv | ID: ppzbmed-
Respiratory Insu!iciency
10.1101.2022.12.22.22283763 / Communicable
Diseases / Coronavirus
Infections / Cough /
Diarrhea / Dyspnea /
Fatigue / Fever
Language: English
ABSTRACT
Year: 2022
Document Type:

Background: Preprint

Severe Acute Respiratory Syndrome Corona Virus 2 

(SARS-CoV-2) is a highly transmissible virus causing

Coronavirus disease (COVID-19). Its key symptoms
include fever, dry cough, and shortness of breath. 
Vaccine plays a significant role in controlling infectious
disease, and reduction of the use of health service
leaving more resources for the treatment of other
diseases.2 Vero Cell is an inactivated vaccine against
COVID-19 manufactured by Sinopharm Company of
China and recommended for people above 18 years by
the World Health Organization. It is administered in two
doses of 0.5 ml, 14-28 days apart. Methods and
findings:
A prospective cross-sectional study was conducted
among undergraduate medical students and intern
doctors of Nepalgunj Medical College a"er receiving
ethical approval from the institutional review
committee of this college. Demographic features of the
study population and the frequency and percentages of
side e!ects among the population who received the
vaccines were calculated along with the duration of
symptoms. All undergraduate medical students and
intern doctors of Nepalgunj Medical College who
received two doses of the Vero Cell vaccine against
COVID-19 were involved in the study. Those who failed
to give written consent and those who were not willing
to receive both doses of vaccine were excluded. Data
were collected using a self-administered structured
questionnaire. The eligible participants were provided
with the questionnaire twice, a"er administration of
each dose of vaccine. Collected data were entered in
structured Pro-forma and analyzed statistically in
Microso" Excel 2019 MSO (Version 2021). About 75% of
the participants had one or more symptoms a"er the
first dose of the vaccine, which reduced to 62% a"er the
second dose. Symptoms were more in males a"er the
first dose (76% vs. 72%), but the reverse was seen a"er
the second dose (54% vs. 77%). Pain at the injection
site was the most commonly reported side e!ect (27%)
followed by myalgia (20%). No individuals receiving
both doses of vaccine had diarrhea, di!iculty in
breathing, tingling sensation, or anaphylactic reaction.
A higher percentage of females experienced pain at the
injection site a"er the second dose over the first than
males. However, males experienced fatigue more than
females a"er every dose. Pain at the injection site and
Myalgia were common symptoms to start early, within
12 hours post-vaccination. However, fatigue was seen
maximally 24 hrs post-vaccination. Fever was seen in
7% of participants within 12 hours of vaccination.
Cough and sore throat as side e!ects persisted up to 2
weeks a"er vaccination. The main limitation of the
study is the low sample size.
Conclusions:
Pain at the injection site was the most common AEFI
followed by Myalgia with other insignificant e!ects.
There were no life-threatening side e!ects. A larger
study on the general population including all age
groups is highly recommended to detect all spectrum
of side e!ects.

Subject(s)
COVID-19; Dyspnea; Cough; Fatigue; Communicable Diseases; Myalgia;
Pain; Respiratory Insu!iciency; Diarrhea; Paresthesia; Coronavirus
Infections; Fever

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