3.1 Introduction 3.1.1 General definition of wettability and contact angle Biomaterials come into the contact with a living body, their success requires adequate surface properties [1,2] to avoid undesired host responses such as thrombosis (3-8), inflammatory reactions [1,,10], and infections [1-15]. The fate of polymeric bio- materials under biological conditions mainly depends on several factors among which wettability is a prerequisite property for ensuring desired biological response such as the interaction of the cells and tissues with the substrate [16]. Wettability corresponds to the ease of spreading of liquid on the surface, which is directly related to the inter- molecular forces between the phases and in general, it is estimated by contact angle measurements. Contact angle (8) of biomaterials surface is the angle formed by the intersection of solid-liquid and liquid-vapor interface, and is obtained by drawing a tangent along the liquid-vapor interface. \CamScanner sis tesa