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  • Donepezil Drug Profile

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    Donepezil hydrochloride tablets are used to treat dementia. The drug has the brand name Aricept and is administered orally or via transdermal patch at doses of 5mg or 10mg daily for mild to moderate dementia or up to 23mg for moderate to severe dementia. Donepezil has 100% bioavailability, a maximum concentration of 8.34ng/hr/ml reached after 3-4 hours, and a half-life of 70 hours.

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    Donepezil hydrochloride tablets are used to treat dementia. The drug has the brand name Aricept and is administered orally or via transdermal patch at doses of 5mg or 10mg daily for mild to moderate dementia or up to 23mg for moderate to severe dementia. Donepezil has 100% bioavailability, a maximum concentration of 8.34ng/hr/ml reached after 3-4 hours, and a half-life of 70 hours.

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    7 views1 page

    Donepezil Drug Profile

    Uploaded by

    KIRAN
    Donepezil hydrochloride tablets are used to treat dementia. The drug has the brand name Aricept and is administered orally or via transdermal patch at doses of 5mg or 10mg daily for mild to moderate dementia or up to 23mg for moderate to severe dementia. Donepezil has 100% bioavailability, a maximum concentration of 8.34ng/hr/ml reached after 3-4 hours, and a half-life of 70 hours.

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    © All Rights Reserved
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    Donepezil Drug Profile :

    1. name : Donepezil hydrochloride tablets


    2. Purpose: Dementia Treatment
    3. IUPAC name: 2,3-Dihydro-5,6-dimethoxy-2-[(1-(phenylmethyl)-4-piperidinyl)methyl]-1H-inden-1-one
    4. Molecular Formula: C24H29NO3
    5. Brand name: Aricept
    6. Pharmacopeial status: IP
    7. Dose: 5mg , 10mg ( mild-moderate= 10mg; moderate-severe= 23mg maximum)
    8. Route of administration: Mouth, Transdermal patch
    9. assay : 90-110%
    10. bioavialability: 100%
    11. Cmax: 8.34ng.hr/ml
    12. Tmax: 3-4hrs
    13. AUC: 221ng.hr/ml
    14. t1/2 : 70 hours
    15. volume of distribution : 11.8 +/- 1.7 L/kg
    16. Dissolution apparatus: type 2 - 50rpm
    17. times for Dissolution: 30min
    18. Storage: 15-30C

    references:
    1. https://go.drugbank.com/drugs/DB00843

    2. https://www.uspnf.com/sites/default/files/usp_pdf/EN/USPNF/revisions/donepezil-hcl-tabs-rb-notice-
    20190301.pdf

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