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DOI 10.1007/s11999.0000000000000014
Abstract
Background In 2012, a new Knee satisfaction, and physical involvement was 18% and loss to followup in
Society Knee Scoring System (KSS) of a younger, more active population the intervention group was 13%.
was developed and validated to address of patients undergoing TKA. Revali- We quantified cross-sectional (pre-
the needs for a scoring system that dating this tool in a separate population operative scores) and longitudinal
better encompasses the expectations, by individuals other than the devel- validity (pre- to postoperative change
opers of the scoring system seems scores) by evaluating associations be-
Financial support provided by a Cana- important, because such replication tween the KSS and KOOS subscales
dian Orthopaedic Research Legacy would tend to confirm the generaliz- using Spearman’s correlation co-
Grant (SEC) and Surgery Internal Re- efficient. Preoperative known-group
ability of this tool.
search Fund, Schulich School of Medi- validity of the KSS symptoms and
cine and Dentistry, UWO (SEC). Questions/purposes The purposes of
Each author certifies that his or her in- this study were (1) to validate the KSS functional activity score was evaluated
stitution approved the human protocol using a separate sample of patients un- with a one-way analysis of variance
for this investigation and that all inves- dergoing primary TKA; and (2) to eval- across three levels of physical health
tigations were conducted in conformity status using the SF-12 Physical Com-
with ethical principles of research. uate the internal consistency of the KSS.
Methods Intervention and control ponent Score. Known-group validity
This work was performed at Western
University, London, Ontario, Canada. groups from a randomized controlled of the KSS expectation score was
trial with no between-group differ- evaluated with an unpaired t-test by
S. E. Culliton, K. M. Hibbert Western ences were pooled. Preoperative and comparing means across known ex-
University, London, Ontario, Canada pectation groups. Known-group val-
postoperative (6 weeks and 1 year) data
D. M. Bryant, B. M. Chesworth Elborn were used. Patients with osteoarthritis idity of the KSS satisfaction score was
College, Western University, London, undergoing primary TKA completed evaluated with an unpaired t-test by
Ontario, Canada the patient-reported component of the comparing means across yes/no re-
KSS, Knee Injury and Osteoarthritis sponse groupings of the PASS single-
S. J. MacDonald London Health Sciences
Outcome Score (KOOS), SF-12, two question outcome. Internal consistency
Centre, University Hospital, London,
Ontario, Canada independent questions about expect- for each KSS subscale was evaluated
ations of surgery, and the Patient Ac- with Cronbach’s a.
S. E. Culliton (✉) Western University 1201 ceptable Symptom State (PASS) Results Cross-sectional validity (ie,
Western Road London, Ontario N6G 1H1 single-question outcome. This study associations at a single point in time) was
Canada email: scullit2@uwo.ca
included 345 patients with 221 (64%) supported because correlation coef-
All ICMJE Conflict of Interest Forms for women, an average (SD) age of 64 ficients between KSS symptoms, func-
authors and Clinical Orthopaedics and (8.6) years, a mean (SD) body mass tional activities, and satisfaction scores
Related Research® editors and board index of 32.9 (7.5) kg/m2, and 225 and scores on the KOOS pain subscale
members are on file with the publication (68%) having their first primary TKA. ranged from 0.60 to 0.73 (all correlations
and can be viewed on request.
Loss to followup in the control group p < 0.01). Values were similar for
Copyright Ó 2017 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.
78 Culliton et al. Clinical Orthopaedics and Related Research®
2017 Knee Society Proceedings
associations with the KOOS function in reporting both total and partial knee Patients and Methods
the activities of daily living (ADL) sub- arthroplasties globally [14]. Over
scale (0.66-0.69) and less (0.41-0.58) for time, uncertainties and insufficien- The data are from a randomized con-
correlations with the other three KOOS cies with the original tool have trolled trial (RCT) designed to de-
subscales. Longitudinal validity (ie, emerged questioning its utility and termine if exposure to an e-learning
associations of change scores between validity with current patients un- tool affected postoperative patient
two time points) was also supported be- dergoing TKA [14] and revision expectations and satisfaction after
cause correlation coefficients between TKA [5]. In 2012, a new Knee Soci- TKA. The patient population for this
KSS symptoms, functional activities, ety Knee Scoring System (KSS) was study came from a doctoral dissertation
and satisfaction change scores and the introduced to meet the need for that has not been published. Details of
KOOS pain and ADL change scores a scoring system that better charac- the RCT were registered and approved
varied from 0.63 to 0.73. Correlation terizes the expectations, satisfaction, at ClinicalTrials.gov (NCT01732562).
coefficients were lower for the other and physical activities of a current, We screened 835 patients; 416
three KOOS subscale change scores, younger, and more varied population (50%) of the patients were randomized
suggesting a weaker relationship with of patients undergoing TKA [8]. The to the control group (n = 207) or the
KOOS symptoms (0.48-0.53), sports long form [8, 14] is recommended for intervention group (n = 209) (Fig. 1).
(0.47-0.51), and quality of life (0.60- research and the short form is Within the control group, two patients
0.65) (all correlations p < 0.01). Known- expected to increase the rate of did not undergo TKA, 19 did not
group validity (ie, differences between completion in clinical use [15]. complete their preoperative question-
groups that are known to differ on Validity and internal consistency naire, and eight did not complete any of
a given characteristic) was confirmed are two essential components in the the postoperative questionnaires at 6
by between-group differences for the evaluation of a measurement tool. weeks, 3 months, and 1 year. Loss to
symptoms and functional activities score Validity is the extent to which an in- followup in the control group was
comparisons as well as the comparisons strument measures what it was inten- 18%. Within the intervention group,
with the expectations and satisfaction ded to measure. Internal consistency two patients did not undergo TKA, two
scores of the KSS (all p < 0.01). Cron- describes the relationship among items patients were ineligible, they did not
bach’s a (ie, association among subscale in a given questionnaire. Validity and provide an email, 25 did not complete
items) varied from 0.68 (discretionary internal consistency are not all-or- their preoperative questionnaire, and
activities) to 0.94 (postoperative nothing phenomena. When similar 13 did not complete any of the post-
expectations) across four KSS subscales. findings are gathered on two in- operative questionnaires at 6 weeks, 3
Conclusions Moderate-sized correla- dividually collected samples of a target months, and 1 year. Loss to followup in
tion coefficients and consistent differ- population, it enhances the generaliz- the intervention group was 13%.
ences between known groups support ability of the tool and provides greater Data were collected on patients
the validity of the KSS. Internal con- certainty about the results through undergoing primary TKA under the
sistency values were also acceptable. consistency. In 2012 the KSS was care of one of seven orthopaedic sur-
The patient-reported subscales of the a new tool [8] at the time our study was geons (JH, BL, SM, JM, RM, DN, EV
KSS are a valid and internally consis- undertaken. Revalidating this tool and at the Joint Replacement Institute,
tent outcome assessment for TKA. confirming the internal consistency of London Health Sciences Centre, Uni-
this tool in a separate population by versity Hospital, London, Canada).
individuals other than the developers Patients diagnosed with osteoarthritis
of the scoring system seem important, scheduled to undergo primary TKA
because such replication would tend to were recruited at the preadmission
Introduction confirm the generalizability of this clinic from April 2013 to April 2014.
tool. To be considered for participation,
T
he Knee Society Clinical Rating We therefore sought (1) to validate patients had to be > 20 years of age,
System was developed in 1989 the KSS in a sample of patients un- booked for an elective primary TKA,
to rate patients’ functional dergoing primary TKA; and (2) to and of sound cognitive capacity to give
abilities before and after TKA [6]. It evaluate the internal consistency of informed consent. We excluded
has been useful for tracking and the KSS. patients who were undergoing revision
Copyright Ó 2017 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.
Volume 476, Number 1 Validity and Internal Consistency of New KSS 79
2017 Knee Society Proceedings
Fig. 1 This flow diagram illustrates patient enrollment, randomization, and pooled analysis. PAC = preadmission clinic.
TKA, patellar resurfacing, hemi- or was similar to the sample for the pro- (PROMs). Overall, patients expected
unicompartmental (unicondylar) knee totype instrument used in Noble et al. that their TKA would substantially re-
arthroplasty, high tibial osteotomy, or [8]. We believed it was reasonable to duce their pain (83% intervention, 84%
knee surgery to address a tumor. We pool the patients together for this control), allow them to return to ac-
randomized patients using a web-based study; although there were 10% more tivities of daily living (78% in-
system stratified by surgeon and by females in the control group, the other tervention, 76% control), and
first or second TKA. The study was characteristics were well balanced be- recreational activities (74% in-
approved by the Health Sciences Re- tween groups. Of the 345 patients in- tervention, 65% control). Preoperative
search Ethics Board at Western Uni- cluded in this study, the majority were patient satisfaction was low with few
versity, London, Canada. female (59% intervention; 69% con- patients satisfied with their present
There were 345 patients in this trol), had a mean age of 63 years, state before surgery (14% intervention,
study. Control (n = 178) and in- a mean body mass index of 33 kg/m2, 11% control).
tervention (n = 167) groups were and were undergoing their first primary Baseline demographic character-
pooled (Fig. 1). This was a suitable TKA (66% intervention, 69% control). istics (Table 1) and preoperative
group for the purposes of the current Additionally, both groups were similar PROMs (Table 2) were collected at
study because the baseline de- with respect to their preoperative the preadmission clinic visit, Time 1.
mographic profile of our study sample patient-reported outcome measures Postoperative PROMs were
Copyright Ó 2017 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.
80 Culliton et al. Clinical Orthopaedics and Related Research®
2017 Knee Society Proceedings
Table 1. Preoperative demographics collected at Time 1 (n = 345) [12, 13], the SF-12 Health Survey [17],
Demographic Frequency (%) of patients* two independent questions (pre-
operative and postoperative) about
Women 221 (64)
their expectations of surgery [3, 10],
Age (years)† 64 (8.56)
and the Patient Acceptable Symptom
BMI (kg/m2)† 33 (7.47) State (PASS) satisfaction single-
First primary TKA, yes 225 (68) question outcome [16]. The KSS
Working, yes 110 (33) (long form) was designed to be a com-
Live alone, yes 53 (16) prehensive patient- and surgeon-
Dependent on others, yes 61 (18) reported scoring system for TKA
Caregiver, yes 80 (24) recipients [14]. The patient-reported
subscales evaluate pain relief, func-
*Except where noted.
tional abilities (ie, walking and
†Mean (SD).
BMI = Body mass index.
standing, standard, advanced and
discretionary activities), satisfaction,
and fulfillment of expectations [8, 14].
completed at the scheduled consul- Patients completed all patient- The KOOS is a PROM composed of
tation time periods of 6 weeks (Time reported components of the KSS five subscales; pain, other symptoms,
2) and 1 year (Time 3) after surgery (long form) [8], the Knee Injury and function in activities of daily living
(Table 2). Osteoarthritis Outcome Score (KOOS) (ADL), function in sport and
Table 2. The new Knee Society Score (KSS) and the Knee Injury and Osteoarthritis Outcome Score (KOOS) PROMs are reported for
each consultation time period
Testing time period: mean (SD)
Time 1 PAC Time 2 6 weeks Time 3 1 year Change score Effect size*
PROMs preoperatively postoperatively postoperatively (n = 345) (95% CI)
KSS
Symptoms† 7 (5) 15 (6) 19 (5) 12 (6) 2.0 (1.8-2.2)
Satisfaction† 13 (7) 25 (8) 32 (8) 19 (10) 1.9 (1.7-2.1)
Expectations preoperatively‡ 13 (2)
Expectations postoperatively§ 8 (3) 9 (3) 1 (3) 0.3 (0.2-0.4)
Functional† 33 (15) 40 (20) 67 (20) 34 (21) 1.6 (1.5-1.8)
Walking† 12 (7) 13 (7) 22 (8) 10 (8) 1.2 (1.1-1.4)
Standard† 12 (5) 18 (5) 23 (5) 12 (6) 1.9 (1.7-2.1)
Advanced† 4 (4) 6 (5) 11 (6) 7 (6) 1.2 (1.1-1.4)
Discretionary† 5 (3) 6 (5) 11 (3) 6 (4) 1.5 (1.3-1.7)
KOOS†
Symptoms 42 (17) 59 (17) 76 (16) 34 (20) 1.7 (1.6-1.9)
Pain 41 (17) 61 (18) 81 (17) 41 (21) 2.0 (1.8-2.2)
Daily living 46 (18) 68 (18) 83 (16) 37 (20) 1.8 (1.6-2.0)
Sports and recreation 18 (25) 32 (31) 55 (29) 36 (33) 1.1 (1.0-1.3)
Quality of life 19 (15) 45 (20) 65 (22) 45 (24) 1.9 (1.7-2.0)
Copyright Ó 2017 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.
Volume 476, Number 1 Validity and Internal Consistency of New KSS 81
2017 Knee Society Proceedings
recreation (Sport/Rec), and knee- impairment, do you consider that your displays a converging or predictive
related quality of life [12, 13]. The current state is satisfactory?” (Re- relationship at a single point in time)
SF-12 Health Survey asks patients sponse options were “yes” or was determined at Time 1 (pre-
questions on their views about their “no.”) [16] operative). Longitudinal convergent
health. Physical and Mental Health Mean KSS and KOOS values over validity (that is, determining whether
Component scores are calculated us- the testing time period showed im- a measure displays a converging or
ing selected values from the 12 ques- provement in both the KSS subscales predictive relationship over several
tions [17]. Expectation questionnaires and the KOOS subscale scores from points in time) was determined be-
were completed both pre- and post- the preoperative time period to 1 year tween Time 1 (preoperative) or Time 2
operatively. The preoperative expec- postoperatively (Table 2). (6 weeks postoperatively) and Time 3
tation questionnaire addressed four (1 year postoperatively). These two
expectation constructs asking about forms of validity were evaluated with
patient expectations for pain relief, Statistical Analysis Spearman’s rank order correlation co-
ability to perform ADL, ability to efficient as a measure of the strength of
participate in sports, and expectations Our sample size exceeded the minimum the relationship among the different
for global recovery from surgery [10]. required sample size of 189 for identi- scales and subscales in the KSS and the
Our postoperative expectation ques- fying correlation coefficients of 0.60 KOOS [12, 13].
tionnaire provided patients with the with a confidence interval width of 0.20 We also determined known-group
response options that their expect- (a = 0.05) [2]. Descriptive statistics validity (ie, the ability to discriminate
ations were “met” or “not met/had no were expressed as means or frequen- between two or more groups that dif-
expectations” [3]. The PASS was cies, as appropriate. All change scores fer on a given characteristic). At Time
a single-question outcome that asked, were calculated so positive values rep- 1 (preoperative), we compared the
“Considering all of the activities you resented improvement for patients. KSS scores for symptoms and func-
do during your daily life, your level of Cross-sectional convergent validity tional activities across three tertiles
pain, and also your functional (that is, determining whether a measure (low, medium, high) of the SF-12
Table 3. Measures of KSS components and KOOS subscales: Spearman correlation coefficient (95% CI)
KSS components
Symptoms Functional Satisfaction
Cross-sectional validity (PAC visit)
KOOS subscales
Pain 0.67 (0.61-0.73) 0.60 (0.52-0.66) 0.73 (0.68-0.78)
ADL 0.67 (0.60-0.72) 0.69 (0.63-0.74) 0.66 (0.60-0.72)
Symptoms 0.43 (0.35-0.52) 0.41 (0.32-0.50) 0.49 (0.41-0.57)
Sports 0.51 (0.42-0.58) 0.53 (0.45-0.60) 0.43 (0.34-0.51)
QoL 0.58 (0.50-0.65) 0.57 (0.50-0.64) 0.53 (0.45-0.60)
Longitudinal validity (PAC visit to 1 year)
KOOS subscales
Pain 0.71 (0.65-0.76) 0.63 (0.56-0.69) 0.73 (0.67-0.78)
ADL 0.68 (0.61-0.73) 0.69 (0.60-0.73) 0.70 (0.64-0.75)
Symptoms 0.48 (0.39-0.56) 0.47 (0.38-0.55) 0.53 (0.44-0.61)
Sports 0.51 (0.42-0.59) 0.50 (0.40-0.58) 0.47 (0.38-0.55)
QoL 0.60 (0.52-0.66) 0.65 (0.58-0.71) 0.61 (0.53-0.67)
*Unless otherwise indicated, all p < 0.001; correlation between PAC values.
KSS = Knee Scoring System; KOOS = Knee Injury and Osteoarthritis Outcome Score; CI = Confidence Interval; PAC = Preadmission
Clinic; ADL = Activities of Daily Living; QoL = Quality of Life.
Copyright Ó 2017 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.
82 Culliton et al. Clinical Orthopaedics and Related Research®
2017 Knee Society Proceedings
Copyright Ó 2017 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.
Volume 476, Number 1 Validity and Internal Consistency of New KSS 83
2017 Knee Society Proceedings
Table 6. Known groups for postoperative expectations Table 8. Cronbach’s a values for the new
Postoperative expectation question Not met, mean (SD) Met, mean (SD) p value Knee Society Knee Scoring System (KSS)
Copyright Ó 2017 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.
84 Culliton et al. Clinical Orthopaedics and Related Research®
2017 Knee Society Proceedings
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Acknowledgments We thank Dr James
of Clinical Research: Applications to outcomes in knee and hip osteoarthritis:
Howard, Dr Brent Lanting, Dr Steven
Practice. Upper Saddle River, NJ, USA: the minimal clinically important im-
MacDonald, Dr James McAuley, Dr Richard
Pearson Prentice Hall; 2009. provement. Ann Rheum Dis. 2005;64:
McCalden, Dr Douglas Naudie, and Dr Edward
10. Razmjou H, Finkelstein JA, Yee A, 29–33.
Vasarhelyi, who together with their staff, were
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a foundational part of this study.
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Copyright Ó 2017 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.