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They
Supplement
The Pharmacokinetic Profile of Tamsulosin Oral
Controlled Absorption System (OCAS")
Martin C. Michel , Coes Korstanj' Walter Krank Mirjam Kuipers
‘arat
Fotis hyperlnin(LUTSBP hs oon doch. Tis forlaon ws he Popitay rlconaled
"eat sat (OCAS coco ch ha he ptr con he ee dag fsa
‘fee ihe aaa OOS rao wisps ng ad li aa Pa
Meh Tsing do Pdi tamvsbinOCASO4 mma (5, Sand 4) in soon th
{tose ay al scoff rhc dso
“src wisn cunt nna ne Ge tmaon CAS
‘Coay ernest
peta Cay era cn) an sae ncaa
{icc ne he MI ape ’
‘och ton sca wel as theese of the dally ose wl que susxquent contr cline
(6204 eke Al ihe mene
Keywode: Tamsin: Cnt css formation; Or contolo ston som: Been pron
1. ntroduction AR stg in indication de 0 fo
‘etapa ao wih send by
Taplin isan a-xoncsplor (AR) atagait the entonaon of a mae sh eh
tiny wat sito ugzstie of boiz psa po ic tm lease MR fr
IpepisaLUTSBPE. Seis medion mts te
mapa en tone ‘Fat mpl serpin aa fe he
Scat thcniste (04 maps sfonde stakefain ste, maximum plas concern (Cau)
‘thc aes unr thee (AUC) ce a
‘pe and Ps, oy, compre whe i
(ae ate heat There, the aeling
Fated adhe vets (AP) the dine, hace
‘sateen a rae
Inge epson cio tme cane ad
2. Modified release formations in the
‘eatmont of LUTSIBPH
‘The denopne of new parma foal
‘neil eis perth dcp
‘oly fran dus hat have to be
‘Companewiphemscurapy. Ingen ey
‘alr tse) can especy esters y Be
Wert hese sarin 9 Gag in th
ssl GD vat an ec hecolen
{a comin 2 har pharmacologic
Inthe a of LTS RPA, vara MR forme
Si uo to ead
fekase (XC) feelin ef lftusin
atte for dasa tra the
Ibe wap cre and he Mcrae
(roid y he ger aroun te pl I he
CG the pallets ae ara a the rg
Fekased. Doki GTS us the ase pump
‘Simi FOROS") det by Ala he
‘water ap hss pele mba he
Select pated tom boro ree aa
[roids aw, setae and ema lee a
‘csi dco by Skye Phar. A inte
‘Sead an mtn ce pra br ye
‘thethc bp ero hears
She asin pant the pace a the
nents vice os
the pron of nar the lt lee he
{ive ion ‘Cosy eke (and
‘cs abarin ste din the page ot
‘he foelaor bought clo were he wut ot
‘Shit eich new ar smote planSctnt 24 Br past cements
‘tat fo lc» svelte sory
Toe yc (OCAS®) wa eco eee
tow pin ra tee The OCAS fre
tins oni se spc te
that compo fe ming gets 8
fafa gc is air components. Ths
Ptindpeoskt ug rhase al Ctaglae
Fest et formaan The die concep
(Pith conmnt dp su, toupou he
‘in Ti acta
spies aly mpeiptaien tt ra ck
at compte aon sus peo rl
Aaa tr the ol the he gal as
‘alr gel swt a an aces re
iStkcolon nae mater ply sale Thi
fone ted due ee nde upper Laan
Fesko‘ragh fcaton (PT) han the Mp
‘Smad oe dcr. Tamonn OCAS®
‘ny roves ufeon day wsameor of LOTS
rel a hi he gc i ne
‘n comparion vith asain MR epaks nd
costs te
eS
‘So Neo icin Al jes ee wo
ekcote
SSS
‘Senay pop mo ag ae ma
Ein Otte einer me
= aeeasroe
pie one organ Us i Meese Pa
2 i OAS we ln a
ro
in Se a ae
RS
‘Benge coor tnd ters at eee
‘intact accu
preehoterrid
lpi in
ssh cen gn ey
‘mi my hp we te rah a et
Teves a nce emanetcy in,
Site ts
15 Ite end ab prin
ay no sb sre map a
tl ot AE i et a)
{Sie mest gc no nese
SUE cores oe aaa
ss yy peta at dp Se
govsimiiiamioi sett
‘urge by ar ab ey se
Shen orem
eee eras
pier
ee
a
CATE anemet a acorn
shesua yim a
Seiursiswurcpaa eres
SS
SS
coments gas
Ben a
iy ium contin od re
Sate ie Spee Oey Tea
ESS Ss
{ir ns mew A 9 nn Sata
ee ee
Se ee Soest eee
Soe tewataeos wee
SS
SrasSan trian oan tone a
lass
wees vate te! sus Ae
Sank
LQTS ees
coon Sckamdioke
(aceasta emlige
oe Se scemcrs
masioeenssas
Resse ees
SSvocconasSag tae aren Ae neers Mamie
‘ct aera w el 8 wt
Seca akan Coa} Teg watcha
= Ser rean 9 ge haley wegen?
SESE en ay at Ry cents
2, Set aa Thee oajch sae wit Seng Ay plo
een etn ae
Sisco antares ‘ty Sn be cnn bj wo cad
Seika teietemedie eds ae sacy nae. Tacks wes oe
SENG Seeman pa er enh no tod
Setgvan teckel sacs Sie wr send wc 2 ab fr
ct ore Ga Fe Gace tm ly I AF ace cd th
EM Gittnc acc crs cca Stag DOE dy, Ts ee rng fom 19 4 ar
cb MlortyciitetacktS nase cacy Giean 2 jean ty ‘ight wa ween 0 ad
ROLDAN Spay cme Pll, 100g (mean Mg) a Say mae nn ated
a ‘Stwcen 194 ap 39pn can 2442 ie dove pharmacies
singh de asa MR toes ad)
‘kf compre wih ce lee asiin OAS
(Sig omulain S3 53 ad 0) gen aed
‘rund 14 ng anand Yo The PR pote
lhc OCAS Oe oral was cary ere
tren una hemp Ec
tine ath mln Mpa, he ean Coe
caps ets inl ny
Fa Hwa fre OCA oo 3 and 84
‘Grainne Accomm
Sette cod peak eet he ta a=
Serene for OCAS 88 and od deen oF
‘OCAS 1 Ths tal un pls omc
trom hay ats he arate eo
Ice carry o the tice tmeaban OCAS
{enwe. The terminal elimination hal-ife vauos were
te presen pie of & Scrased Cau, 2 WW
“re tect OCA rains 2,3
come, 0 mg meant ee
‘Somer The cof ne decane
inte er S208” nn a
Smet pote te Ay
itoqe mad Ce wate of eps de FR
wats and APCs AUC
‘Sine dso afer Zh (7 =0999F and 09991,
‘especie Whe Cn sme te cht cel
Sgro nesta
4 sei ne amas
‘mle vores Tie Soto umantnOCAS Ge
comftion: ae ese (Omg) was aso teed ue ed
ste the mae tough comsaon
hrsgut he dosing pd. The Eh onc