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Neutrophil‐to‐lymphocyte
VIEW
and hypopharyngeal
cancer prognosis: System
review and meta‐analysis

( '

Head & Neck / Early View

CLINICAL REVIEW

Neutrophil-to-lymphocyte and
hypopharyngeal cancer prognosis:
System review and meta-analysis

Xianyang Hu MBBS, Tengfei Tian PhD,

Xueyan Zhang PhD, Qin Sun MD, Yanyang Chen PhD,
Wenxiu Jiang PhD "

First published: 11 November 2022

https://doi.org/10.1002/hed.27246

Xianyang Hu, Tengfei Tian, and Xueyan Zhang

contributed equally to this study and should be
considered co-!rst authors.

Funding information: National Natural Science

Foundation of China, Grant/Award Number: 81725004;
Qingfeng Scholars Program, Fudan University,
Grant/Award Number: QF2224

Read the full text ## $ About % &

Abstract
Several studies have reported the value of
neutrophil-to-lymphocyte ratio (NLR) for the
prognosis of hypopharyngeal cancer.
However, contradictory !ndings have also
been published. We aimed to clarify the
e"ect of NLR on the prognosis of
hypopharyngeal cancer through meta-
analysis. Systematic search of PubMed and
other database with study selection and data
extraction. The combined hazard ratio (HR)
and 95% con!dence intervals (CI) were
calculated using STATA, applying either a
!xed-e"ects or random-e"ects model. Meta-
regression, subgroup analysis, and
sensitivity analysis were used to analyze
sources of heterogeneity. Publication bias
were also assessed. This meta-analysis
included 2232 patients with hypopharyngeal
cancer from seven studies. The combined
HR (OS, HR = 1.80, 95CI%, 1.14–2.82; PFS,
HR = 1.88, 95CI%, 1.26–2.79) suggested that
high NLR was associated with poor overall
survival (OS) and progression-free survival
(PFS). Pretreatment NLR can be used as an
e"ective serological indicator to assess the
prognosis of patients with hypopharyngeal
cancer.

CONFLICT OF INTEREST
The authors declare that there is no con$ict of
interest that could be perceived as prejudicing
the impartiality of the research reported.

Open Research !
!

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