The naproxen test can be performed to differentiate infectious and neoplastic etiologies of FUO. The test is conducted over 3 to 4 days, during which patient temperatures are trended while a patient is given naproxen. If temperatures decrease substantially, malignant/neoplastic etiology is likely. However, if temperatures remain the same or only minimally decrease, the FUO is likely of infectious origin. The utility of the naproxen test is not well studied, and at this time, experts believe the test is not specific enough to be useful for the individual patient, tis important to remember that up to 51% of cases remain undiagnosed. However, the prognosis for these patients is generally good, and it is highly probable that FUO will spontaneously resolve in weeks to months. In stable patients without a diagnosis, non- steroidal anti-inflammatory drugs could be used for symptomatic management.|6] Goto: Differential Diagnosis ‘The differential diagnosis for FUO is broad but can be grouped into the following four categories based on etiology: infections, neoplasms, connective tissue disease, and miscellaneous. Infection accounts for about a third of cases of FUO. The most common infections causing FUO are: + Miliary tuberculosis (TB) + Brucellosis © Q fever + Intraabdominal, pelvic, intranephric, and perinephrie abscesses + Typhoid/enteric fever + Actinomycosis + Amebiasis + Atypical mycobacterial infection + Blastomycosis + Brain abscess + Campylobacter infections © Cholangitis + Cholelithiasis, © Chagas disease + Candidiasis + Dengue fever + Diabetic ulcers + Empyema thoracis