HumaCount 5D

Solution to outperform the competition

Alfons Krug

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 Customer needs

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 The global market reflects the increasing need for
5-Part systems
Seen on the life cycle of CBC systems

Reticulocyte test CBC + 5 Diff CBC alone

"study it!" "surf it!" "leave it!"

Market trend moves from 3 to 5-Part

─ in Europe already fully completed

Market Development Market Maturity Market Decline

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 Physicians are longing for 5 instead of 3-Part Diff
diagnosis
EOS, MON, BAS, NEU results by analyzer – reduces blood smears
Stress,
Parasites bacteria 3-Part Parameters
(TB) MID = MON + EOS
GRA = NEU + EOS + BAS
EOS
NEU
Viruses Immune Fungi
LYM
system

Each cell type may provide information about

MON BAS
• An immune response
e.g. Tuberculosis Leukemia • A disease type

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 5-Part Diff reports provide crucial clinical
information
Never possible by 3-Part Diff systems
3-Part is
sufficient

CBC
tests in
clinic 5-Part provides a differentiation of all 5
parameters

5-Part Example fever (5-Part)

is a  NEU = bacterial infection = antibiotics
5-Part provides must  LYM = viral infection (flu) = rest/repose
helpful information

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 It is important to separate between EOS and NEU
parameters to provide the correct treatment
Never possible by 3-Part Diff systems
“I would like to get a 5-Part
system, particularly get the
EOS/NEU parameters separated”

 EOS  NEU
(parasitic infection) (bacterial infection)

Eosinophile (EOS) determination

5-Part Differentiation is a MUST

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 Hematology labs ask for analyzers reducing
need of blood smears & time to report results

Key requirements from 5-Part Diff customers “If an analyser does it,
• reduce number of manual blood smears why should I do it?!”
• report faster
Myeloid Lymphoid

LIC ALY
Immature cells

5-Part
BAS EOS NEU MON LYM Diff

ALY, LIC – blasts (2-5% of the samples); very experienced

personal is required, not available in small labs

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 Physicians and patients ask for a least invasive
method to collect blood
Small volumes by skin puncture are highly preferable

At a health post where For children – make up

only a nurse is available approx. 30% of samples
Demand for
capillary blood Patients asking for a
private check-up

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 Our solution

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 HumaCount 5D
A 5-Part system to ensure high growth rates in our hematology
business

• Stand alone system, small foot print

• Closed system to secure our reagent business
• Low sample volume 20 µl
• Up to 60 samples/h, 29 parameters

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 HumaCount 5D
Fulfilling the needs of physicians – a good differentiation

EOS MON

NEU BAS
LYM

HumaCount 5D
• Reliable 5-Part Diff
• With 3D laser scatter technology
• BAS, MON, EOS, NEU, LYM excellent Differentiation

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 Extended parameter portfolio - to speed up
reporting time by reduced number of blood smears
Saves costs

A-typical LYmphocytes
ALY Large Immature Cells
LIC

Reduced number of blood smears

Report in minutes instead of hours

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 Unique, intuitive software
Easy operation, like HumaCount 80TS

Known software architecture 2D barcode Data storage of 50.000

(Measure, QC, Review, …), Icons target value upload samples

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 Attractive price/test offered by the possibility to
select between 3 and 5 Part mode
Patients will pay only what they really need
5 part only 3 reagents
Savings of HumaCount 5D in % on price/test
3 part (CBC) only 2 reagents

3 Part test HC5D vs

HumaCount 80
5 Part test HC5D vs
HumaCount 5L
3 Part test HC5D vs
HumaCount 5L
-5 15 35 55 75 %

Ideal system to replace installed 3 Part systems

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 CBP Technology – a unique capillary blood process
Reduces stress in collection of samples and increases rate of
successful blood collections
Competitors` capillary pre-dilution mode HumaCount 5D capillary blood process

• Automated process with pre-

• Manual preparation defined volumes
of NaCl, blood, dilution ratios
HUMAN patent application

Unique CBP technology

Low accuracy, error-prone preparation
High accuracy in capillary blood mode

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 Competitors pre-dilution mode
Low accuracy, error-prone preparation

Incorrect dilution
Manual preparation Manual suspension Dilution inside
ratios, insufficient
of NaCl solution of blood sample analyzer
volumes

High dilution: Count

of ~200 cells only

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 HumaCount 5D capillary blood process
No manual steps and higher accuracy

Exact diluent auto- Blood collection by Defined dilution ratio

Mix
dispense into capillary tube of (process) auto-aspiration
sample
tube by analyzer exact 20µl volume of partially diluted sample

High accuracy: Count of ~3.000 cells, >10 x more cells than competition (patent app.)

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 Low volume capillary samples processed by
CBP technology
ZERO dead volume (10 times less sample volume needed)
Competitors` capillary whole blood mode HumaCount 5D capillary blood process

• Sample aspiration (e.g. 20µl)

• Dead volume 200-500µl
• Blood collection by capillary
tube (20µl)

Difficult to collect,
high risk of dilution by cell
water Dead volume 0µl
Needed sample volume Needed blood volume to
to collect: 200-500µl collect: 20µl

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 Easy, least invasive blood collection by one drop
of blood with a HUMAN capillary tube!

No physician is
needed for blood
collection

No dead volume
(low sample volume!)

High
accuracy

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 Proof and evidence
Extensive evaluations to assure to meet your expectations
• HUMAN R&D department
• German University Hospital

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 Extensive evaluations to meet market
expectations
• Evaluation by our R&D department • Evaluation by German University
Magdeburg (>1500 samples) Laboratory (>600 samples)

Dr. Grundt, Head R & D Dr. Borucki, Head Laboratory

“All specification could be verified, a “The method comparison with
very robust system.” (Sysmex) XN-3000 was excellent.”

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 Proof and evidence
Extensive evaluations to meet the expectations of the market
• Field testing in Kenya

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 Evaluation in Kericho, Kenya
Lab of Mr. Sang, lab manager Mr. Samson
Presented by Mr. Collins Mase, Chem-Labs

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 Feedback of service engineers
Johannes Ongola, Arthur Oduya, Chem-Labs

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 High quality components
Building the base for excellent analyzer reliability

 Pump: KNF (Germany)

 Connector: Value (USA)
 Valve: SMC (Japan), ASCO (USA)
 Needle: Unimed (Switzerland)
 Tubing: SAINT-GOBAIN (France)

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 Answers to your concerns!
Engineers and lab managers appreciate the HumaCount 5D

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 Outperform your competitors in the market
HumaCount 5D with unique features – use them!

 5-Part Diff by 3D laser scatter

BAS EOS NEU MON LYM

 ALY and LIC important parameters added

Immature cells LIC ALY
 3 to 5-Part mode switch for cost savings

 Capillary blood process

Robust system with excellent references from labs from Europe and Africa

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