Volume 40, Number 2, February 2018

Editor-in-Chief’s Note
181 A Tribute to Gertrude Belle Elion on the 100th Anniversary of her Birth
Richard I. Shader
WOMEN’S HEALTH AND GENDER MEDICINE UPDATE: THE OPIOID EPIDEMIC
Editorial
188 The Opioid Epidemic: Overcoming Challenges by Using a Sex and Gender Lens
Alyson J. McGregor
Commentary
190 Women and the Experience of Pain and Opioid Use Disorder: A Literature-based Commentary
Andrew L. Koons, Marna Rayl Greenberg, Robert D. Cannon, and Gillian A. Beauchamp
Original Research
197 Sex Differences in Prevalence of Emergency Department Patient Substance Use
Robert D. Cannon, Gillian A. Beauchamp, Paige Roth, Jennifer Stephens, David B. Burmeister,
David M. Richardson, Alanna M. Balbi, Tennessee D. Park, Stephen W. Dusza, and Marna Rayl Greenberg
204 Gender Differences in Pain Experience and Treatment after Motor Vehicle Collisions: A Secondary
Analysis of the CRASH Injury Study
Tracy E. Madsen, Samuel McLean, Wanting Zhai, Sarah Linnstaedt, Michael C. Kurz, Robert Swor, Phyllis Hendry,
David Peak, Christopher Lewandowski, Claire Pearson, Brian O’Neil, Elizabeth Datner, David Lee, and
Francesca Beaudoin
214 Perception and Practice Among Emergency Medicine Health Care Providers Regarding Discharging
Patients After Opioid Administration
Ryan M. Surmaitis, Alexandra Amaducci, Kathryn Henry, Michael Jong, Emily A. Kiernan, Hope Kincaid,
Lindsay J. Houck, Sandra J. Sabbatini, Marna Rayl Greenberg, and Kenneth D. Katz
FEATURED CONTENT
Original Research
226 Express Track: A Phase III, Multicenter, Randomized, Double-blind, Active Comparator Clinical Trial to
Compare the Efficacy and Safety of Combination Therapy With Ezetimibe and Rosuvastatin Versus
Rosuvastatin Monotherapy in Patients With Hypercholesterolemia: I-ROSETTE (Ildong Rosuvastatin &
Ezetimibe for Hypercholesterolemia) Randomized Controlled Trial
Soon Jun Hong, Han Saem Jeong, Jeong Cheon Ahn, Dong-Hun Cha, Kyung Heon Won, Weon Kim,
Sang Kyoon Cho, Seok-Yeon Kim, Byung-Su Yoo, Ki Chul Sung, Seung-Woon Rha, Joon-Han Shin,
Kyoo Rok Han, Wook Sung Chung, Min Su Hyon, Han Cheol Lee, Jang-Ho Bae, Moo-Yong Rhee, Jun Kwan,
Dong Woon Jeon, Ki Dong Yoo, and Hyo-Soo Kim
242 Relationship Between Atrasentan Concentrations and Urinary Albumin to Creatinine Ratio in Western
and Japanese Patients With Diabetic Nephropathy
Chih-Wei Lin, Nael M. Mostafa, Dennis L. Andress, John J. Brennan, Cheri E. Klein, and Walid M. Awni

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Table of Contents – continued

252 Potential Usefulness of Early Potassium Supplementation for Preventing Severe Hypokalemia
Induced by Liposomal Amphotericin B in Hematologic Patients: A Retrospective Study
Naoto Okada, Momoyo Azuma, Masaki Imanishi, Yoshito Zamami, Yasushi Kirino, Toshimi Nakamura,
Kazuhiko Teraoka, Masahiro Abe, and Keisuke Ishizawa
261 Physical Compatibility of Meropenem and Vaborbactam With Select Intravenous Drugs During
Simulated Y-site Administration
James M. Kidd, Lindsay M. Avery, Tomefa E. Asempa, David P. Nicolau, and Joseph L. Kuti
270 Analgesic Use and Risk for Acute Coronary Events in Patients With Osteoarthritis: A Population-based,
Nested Case-control Study
Caridad Pontes, Josep Ramon Marsal, Josep Maria Elorza, Maria Aragón, Daniel Prieto-Alhambra, and
Rosa Morros
284 Identification of Drug Characteristics for Implementing Multiregional Clinical Trials Including Japan
Mitsuhiro Rokuda, Naoki Matsumaru, and Katsura Tsukamoto
296 Hematologists’ Preferences for First-line Therapy Characteristics for Multiple Myeloma in Japan:
Attribute Rating and Discrete Choice Experiment
Timothy Bolt, Jörg Mahlich, Yusuke Nakamura, and Masahiko Nakayama
309 Methotrexate Dose in Patients With Early Rheumatoid Arthritis Impacts Methotrexate Polyglutamate
Pharmacokinetics, Adalimumab Pharmacokinetics, and Efficacy: Pharmacokinetic and
Exposure-response Analysis of the CONCERTO Trial
Sandra L. Goss, Cheri E. Klein, Ziyi Jin, Charles S. Locke, Ramona C. Rodila, Hartmut Kupper,
Gerd-Rudiger Burmester, and Walid M. Awni
Brief Report
322 Short-term Safety, Tolerability, and Pharmacokinetics of MRX-I, an Oxazolidinone Antibacterial Agent,
in Healthy Chinese Subjects
Xiaojie Wu, Yunfei Li, Jing Zhang, Yingyuan Zhang, Jicheng Yu, Guoying Cao, Yuancheng Chen, Beining Guo,
Yaoguo Shi, Jun Huang, Yuran Cao, Xiaofang Liu, Jufang Wu, Mikhail Fedorovich Gordeev, Hong Yuan, and
Wen Wang
Commentaries
334 Challenges Involved in the Development and Delivery of Abuse-deterrent Formulations of Opioid
Analgesics
Joshua P. Cohen, Mario Mendoza, and Carl Roland
345 How Sensors, Devices, and Biomarkers Can Transform Precision Medicine: Perspectives From a
Clinical and Translational Science Institute
Jill L. Maron and Graham B. Jones
Erratum
e1 Erratum to "Patient- and Physician-reported Satisfaction With Systemic Lupus Erythematosus Treatment
in US Clinical Practice" Clin Ther. 2017;39:1811–1826
Katie Pascoe, Steve Lobosco, David Bell, Ben Hoskin, David J. Chang, Bonnie Pobiner, and
Sulabha Ramachandran
349 EACPT News

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