Nishakathakadi kasayam is very effective in type 2 diabetes mellitus...

It is mentioned by acharaya
bhavapraksha.. A study is conducted to test the effectiveness of nishakathakadi kasaym and yasada
bhasma in n type 2 diabetes mellitus. The prticipants are classified into 4 groups.

1 group- nishakathakadi alone is given

2 group- yashada bhasma alone

3 group- both nishakathakadi and yashada bhasma is given

4 group- standard drug metformin is given

Sample size-26 for each group

Duration - 3 months

Outcome variables-FBS,

PPBS

HbA1c

Study setting- opd, govt ayurveda college

Sampling technique - block randomization

Study type-RCT

RESULT

both medicines show effect in DM individually

But more result is obtained when it is given in combination

INTRODUCTION

Madhumeha which has been correlated with DM has

become a global problem in spite of advances in modern

science. DM occurs throughout the world, but is more

common (especially Type 2) in the more developed

countries. The greatest increase in prevalence is, however,

expected to occur in Asia and Africa, where most patients

will probably be found by 2030.1

WHO has anticipated

India as the country with the fastest growing population

of Diabetic patients. According to Wild et al,2 the prevalence of diabetes is predicted to double globally
from 171

million in 2000 to 366 million in 2030 with a maximum

increase up to 79.4 million individuals in India, while 42.3

million in China and 30.3 million in the United States.2,3

The aetiology of diabetes in India is multifactorial and

includes genetic factors coupled with environmental

influences such as obesity associated with rising living

standards, steady urban migration, and lifestyle changes.

DM is a metabolic disorder result due to the malfun

by abnormal carbohydrate, fat, and protein metabolism.

It is clinically diagnosed based on the accumulation of

glucose in the urine and blood of the person. This condition is known as hyperglycemia. The word
diabetes has

been derived from two words, diabetes (Greek) which

means ‘siphon through’ and mellitus(Latin) which means

‘sweetened with honey’.

Ayurveda includes diabetes mellitus under the

Prameha category. Prameha is a list of urinary disorders,

especially characterized by profuse urination with

several abnormal qualities. There are twenty kinds of

Pramehas in Ayurveda. According to the doshic causes,

these Pramehas are classified as four Vataja pramehas, six

Pittaja pramehas and ten Kaphaja pramehas. Out of these,

DM is termed as Madhumeha which comes under Vataja

prameha.

4,5
In Ayurveda, it is also described as a Maharoga

(major disease)6

because of its multifaceted effects in the

body and also every cell of the human physiology. The

disease Madhumeha affects three Doshas (body humor)

and all the Dhatus (tissues) except Asthi. Ayurveda has

explained Avyayama (lack of exercise) as the first and

foremost cause for diabetes. Daytime sleep, lack of exercise, lethargy (sedentary lifestyle), consumption
of food

and drinks which are cold, unctuous and sweet in taste,

utilization of fatty items in excess etc., are main causative

factors.7

It can be said in a way that the Ayurvedic remedies for

DM are the oldest among all the available therapies. There

are so many poly-herbal and herbo-mineral formulations

in Indian system of medicine having hypoglycaemic as

well as anti-diabetic property. DM has gained massive

disgrace in recent times as it is fast becoming the world’s

largest silent killer. The complications of diabetes are

more dreadful than the disease itself. However, a person

sticks to an Ayurvedic preventive strategy right from

the beginning can easily avert this disease or control it,

if already suffering.

In spite of many advances, the allopathic management

of diabetes remains unsatisfactory. Insulin resistance,

hypersensitivity, drug intolerance, and hypoglycemic

episodes make it all the more important to search out

safe, effective and cheaper drugs.

OBJECTIVES

The main objectives were to assess the clinical efficacy

and clinical safety of Nisha Katakadi Kashaya and Yashada

Bhasma (individually as well as in combination) in the

management of Type 2 DM (Madhumeha).

MATERIALS AND METHODS

Study Design

This was an interventional, open randomized multicenter clinical study. The study protocol and related

documents were reviewed and approved by the Institutional Ethics committee of each participating
centre i.e.

Dr. Achanta Lakshmipathi Research Centre for Ayurveda

(ALRCA), Chennai; National Ayurveda Research Institute for Vector Borne Diseases (NARIVBD),
Vijayawada;

Ayurvedic Regional Research Institute (ARRI), Mandi

and National Research Institute for Panchakarma (NRIP),

Cheruthuruthy. The study was conducted in accordance

with Schedule Y of Drugs and Cosmetics Act, India,

amended in 2005 and the Indian Council of Medical

Research (ICMR) ethical guidelines for biomedical

research on human participants, adopted from World

Medical Association (WMA)-Declaration of Helsinki.

Trial was registered in the Clinical Trial Registry of India

(CTRI/2014/05/004613).

Outcome Measures

Primary Outcome Measure of study was to evaluate clini

Referance

TY - JOUR

AU - Pitta, Srinivas

AU - Varanasi, Subhose

AU - deep, Vishav

AU - Sharma, Surendra

AU - Sarada, Ota

AU - Prasad, AJV

AU - Babu, Gajji

AU - Radhakrishnan, P

AU - Sharma, Omraj

AU - Dua, Pradeep

AU - Rana, Rakesh

AU - Singhal, Richa

AU - Srikanth, Narayanam

PY - 2018/06/01

SP - 108

EP - 121

T1 - Clinical Evaluation of Nisha katakadi Kashaya and Yashada Bhasma in the management of Type-2
Diabetes Mellitus (Madhumeha)—A Multicentre, Open label prospective study
VL - 2

DO - 10.5005/jp-journals-10064-0046

JO - Journal of Research in Ayurvedic Sciences

ER -