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Aperio System Requirements

This document discusses the recommended hardware and bandwidth requirements for the Aperio
ePathology system.
Because Aperio ePathology eSlides are by design high resolution and information rich, for best results you need sufficiently
powerful processing and viewing hardware as well as adequate network bandwidth capacity.

Server Minimum and Recommended Specifications

The DSR (Digital Slide Repository) is the server on which your images are stored. It often is also the location where eSlide
Manager is installed.

Note on the Service Account

The service account is used by Aperio ePathology applications that run as services on the server and scanner.
Make sure that the service account:
`` Is excluded from all password expiration policies.
`` Is given local administrator permissions on the server running the Aperio ePathology services as well as the
scanner.
`` Is given “Full Control” access to any network location where image data is being stored (the file share).
`` Is given DBO (database owner) permissions to the Aperio eSlide Manager SQL database.

Preparing for Windows Updates

Microsoft occasionally issues critical updates that you may want to install on your servers. It is your responsibility to
perform regular backups of your servers. Before installing an update, be sure you have a full backup of the server that you
could use to restore the server in case the update causes issues.

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Server – DSR Minimum Specifications1

Component Aperio Image Hub eSlide Manager

CPU speed Two dual-core or one Quad-core Intel Two dual-core or one Quad-core Intel
2.4GHz or faster 2.4GHz or faster
Hard disk space 1TB DAS, NAS, or SAN Storage1 1TB DAS, NAS, or SAN Storage1
(recommended) RAID for redundancy (recommended) RAID for redundancy
Available C: or OS drive space 100GB 100GB
Memory 4GB RAM 4GB RAM
Network card 1GB network card 1GB network card
Power supply Redundant power supplies Redundant power supplies
(recommended) (recommended)
Operating system Windows Server 2008 R2 SP1 minimum WIndows Server 2008 R2 SP1 minimum

Server – DSR Recommended Specifications

If you are using a virtual machine (VM) as the server, you will see better performance in a virtual environment if your VM
meets these specifications.

Component Aperio Image Hub eSlide Manager

CPU speed 8-core processors 2.0GHz or faster 8-core processors 2.0GHz or faster
recommended recommended
Hard disk space 5TB DAS, NAS, or SAN Storage1 5TB DAS, NAS, or SAN Storage1
(recommended), RAID for redundancy (recommended), RAID for redundancy
Available C: or OS 100GB 100GB
drive space
Memory 16GB RAM 16GB RAM
Network card Dual 1GB network cards Dual 1GB network cards
Power supply Redundant power supplies Redundant power supplies
Media input DVD (optional) DVD (optional)
Operating system Windows Server 2012 R2 recommended Windows Server 2012 R2

1.  Direct Attached Storage, Network Attached Storage, Storage Area Network

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Supported Server Operating Systems and Language Support

64-bit support refers to using installers built from 32-bit compilers and installed on 64-bit OS.
We do not support the localization of our software.
To ensure proper operation of Aperio ePathology software, the region setting of DSRs, the scanner control workstation, and
client workstations should be English (United States), set in the Windows Regional and Language Options window
available from the Windows control panel. In addition, the English language Windows pack should be installed on the DSR.

Aperio Image Hub

Operating System OS Bit Native Language Support Release

Windows Server 2008 R2 64 US English, Japanese, Spanish, German Rel 1.x
Windows Server 2012 R2 64 US English, Japanese, Spanish, German Rel 1.x

eSlide Manager

Operating System OS Bit Native Language Support Release

Windows Server 2003 32 US English, Spanish Rel 9.x, 10.x, 11.x
Windows Server 2008 R2 64 US English, Japanese, Spanish, German Rel 11.x, 12.x
Windows Server 2008 R2 SP1 64 US English, Japanese, Spanish, German Rel 12.3 and later
Windows Server 2012 R2 64 US English, Japanese, Spanish, German

Supported Database Software

Aperio Image Hub

Database Service Pack Release

MS SQL Server 2014 Rel 1.x

eSlide Manager

Database Service Pack Release

MS SQL Server 2005 SP3 Rel 9.x, 10.x
MS SQL Server 2008 R22 Rel 11.x, 12.x (eSlide Manager)
MS SQL Server 2014 Rel 12.3
2

2.  Microsoft extended support is available through 2019

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Scanner Control Workstation

The Aperio ePathology scanner system consists of the combination of the scanner and the computer attached to that
instrument, the scanner control workstation. Do not use the scanner control workstation for any other purpose—it is lab
equipment. Both the scanner and its control workstation must be functioning for scanning to occur.

Client Workstation Specifications

Viewing Station Requirements – Minimum

Aperio Image Analysis

Component Aperio Image Hub
CPU speed Intel Core 2 Duo (or newer)
processor, running at 2GHz
or faster recommended
Hard disk space 40GB free disk space
Memory 2GB or more recommended
Network card 1 Gigabit network card or
faster
Video card 24-bit color at monitor’s
resolution
Operating Windows Pro 7 64-bit
system
eSlide Manager
Workstation
Intel Core 2 Duo (or newer) Intel Core 2 Duo (or newer)
processor, running at 2GHz or processor, running at 2.7GHz or
faster recommended faster recommended
40GB free disk space 100GB free disk space
4GB or more recommended 4GB or more recommended*
1 Gigabit network card or faster 1 Gigabit network card or faster
24-bit color at monitor’s 24-bit color at monitor’s resolution
resolution
Windows Pro 7 64-bit, Windows Windows Pro 7 64-bit, Windows 8.1
8.1 64-bit 64-bit

*Users working with large whole slide images (>1GB such as multiple FL channels or z-stack layers) are
recommended to use 8GB or more of RAM to minimize performance issues. For best performance, we
recommend that images be opened from the Aperio Image Analysis Workstation eSlide list page instead of
directly from the file system.

Monitor Requirements – Minimum

eSlide Manager and Aperio

Component Aperio Image Hub
Image Analysis Workstation
Display type LCD (flat panel) LCD (flat panel)
Screen resolution 1680(h) x 1050(v) pixels 1680(h) x 1050(v) pixels
Screen size 24-inch 24-inch
Color depth 24-bit 24-bit
Brightness 250 cd/m or greater
2
250 cd/m2 or greater
Contrast ratio 500:1 500:1

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Monitor Requirements – Recommended

eSlide Manager and Aperio

Component Aperio Image Hub
Image Analysis Workstation
Display type LCD (flat panel) LCD (flat panel)
Screen resolution 1920(h) x 1050(v) pixels 1920(h) x 1050(v) pixels
Screen size 24-inch or larger 24-inch or larger
Color depth 24-bit 24-bit
Brightness 250 cd/m2 or greater 250 cd/m2 or greater
Contrast ratio 1000:1 1000:1

Supported Web Browsers

Other browsers and browser versions may work, but they have not been exhaustively tested by Leica Biosystems Imaging.

Aperio Image Hub

Web Browser Versions Release

Internet Explorer 9, 10 1.x
Firefox 28 1.x
Chrome 35 1.x

eSlide Manager and Aperio Image Analysis Workstation

Web Browser Versions Release

Internet Explorer 7.x, 8.x Rel 9.x, Rel 10.x
8.x Rel 11, 11.1
8.x, 9.x 11.2
8.x, 9.x 12.x (IE9 recommended)
11.x Rel 12.3
Firefox 2.x Rel 9.x
3.x Rel 10.x, Rel 11, Rel 11.1
12.x Rel 11.2
28.x Rel 12.x
37.x - 47.x Rel 12.3 and later

Anti-Virus Exclusions for Servers and Workstations

We highly encourage the use of antivirus software on the Aperio ePathology system. We recommend that .SVS, .SCN, .TIF,
JPG file types as well as the file storage be excluded from “on access scanning” as these files can be very large and are

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accessed continually as they are being scanned and users are viewing the eSlides. You should also exclude the database
files (.mdf and .ldf) from virus scans. Virus scans should be configured to run during non peak hours as they are very CPU
intensive and interfere with scanning or analysis.

Possible Third-party Application Conflicts

In rare circumstances, third-party applications such as virus or security software may prevent Aperio software from
connecting to servers or devices. If you are having this problem, contact Leica Biosystems Technical Services for assistance.

eSlide Bandwidth Requirements

The bandwidth required for different applications varies, as discussed below.
eSlide Manager: When using ImageScope, the data for the viewing session is streamed to the end user. First the user is
provided the view that has been requested, and then surrounding views are cached in anticipation that the user will request
them. The ability to stream this data to end users greatly improves their viewing experience and allows multiple users to
easily share even low bandwidth connections while viewing eSlides. These streaming options can be managed and are
described in the Aperio ImageScope User’s Guide.

eSlide Viewing for SVS and Third-Party eSlides

The minimum network bandwidth required for a good user experience when viewing SVS eSlides is 2 Mbps per user. When
it’s available, our software will make use of additional available bandwidth to provide the users a better viewing experience.
Actual bandwidth usage when viewing eSlides varies with the type of slide, viewing habits of the Pathologist, tissue
area, nature of each case, the client application and performance options in the viewer application. However, based on
experience, Aperio has found that a typical viewing session requires about 25MB of data to be transferred to the end user
with a variable rate of 2 Mbps to 4 Mbps.

eSlide Viewing for SCN eSlides

The minimum network bandwidth required for a good user experience when viewing SCN eSlides is 24 Mbps per user.
When it’s available, our software will make use of additional available bandwidth to provide the users a better viewing
experience.
Actual bandwidth usage when viewing eSlides varies with the type of slide, viewing habits of the Pathologist, tissue area,
nature of each case, the client application and performance options in the viewer application.

eSlide Capture on Aperio Scanners

We recommend that the connection between the scanner and DSR be low latency and dedicated to scanning activities. If
the connection is not dedicated, scanning performance may be impacted or may impact other applications on your network. 
The amount of bandwidth required for scanning eSlides to a network is 1Gb/s for optimal scanning time in environments
where the connection cannot be dedicated or is shared. In instances where multiple scanners are writing to the same
network share, these connections may need to be scaled up appropriately.

Scanner Live Viewing

The Aperio scanner TelePath Live feature requires higher network transfer speeds than eSlide viewing. A typical data rate
for live viewing is about 3.2 Mbps, and requires about 250MB of data to be transferred to the user.

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Aperio ePathology System Requirements

MAN-0052, Revision J | 18 October 2016
This document applies to Aperio Image Hub Release 1 and later
eSlide Manager Release 12.3 and later
Copyright Notice
ÌÌCopyright © 2016 Aperio. All rights reserved. LEICA and the Leica logo are registered trademarks of Leica Microsystems IR GmbH. Aperio is a
registered trademark of Leica Biosystems Imaging, Inc. in the USA and other countries.

Customer Resources
ÌÌFor the latest information on Leica Biosystems Aperio ePathology products and services, please visit www.LeicaBiosystems.com/Aperio.

Disclaimers
ÌÌUse normal care in maintaining and using Aperio ePathology servers. Interrupting network connections or turning off the servers while they are
processing data (such as when they are analyzing eSlides or generating an audit report) can result in data loss.

ÌÌThis manual is not a substitute for the detailed operator training provided by Leica Biosystems Imaging or for other advanced instruction. Leica
Biosystems Imaging Field Representatives should be contacted immediately for assistance in the event of any instrument malfunction. Installation
of hardware should only be performed by a certified Leica Biosystems Imaging Service Engineer.

ÌÌImageServer is intended for use with the eSlides created by scanning glass slides with the scanner. Educators will use Aperio ePathology software
to view and modify eSlides in Composite WebSlide (CWS) format.

Patents
ÌÌAperio ePathology products are protected by U.S. Patents: 6,711,283; 6,917,696; 7,035,478; 7,116,440; 7,257,268; 7,428,324; 7,457,446; 7,463,761;
7,502,519; 7,518,652; 7.602.524, 7,646,496; 7,738,688 and licensed under one or more of the following U.S. Patents: 6,101,265; 6,272,235;
6,522,774; 6,775,402; 6,396,941; 6,674,881; 6,226,392; 6,404,906; 6,674,884; and 6,466,690.

Contact Information – Leica Biosystems Imaging, Inc.

Headquarters Customer Support General Information

Leica Biosystems Imaging, Inc.
1360 Park Center Drive
Vista, CA 92081
USA
Tel: +1 (866) 478-4111 (toll free)
Direct International Tel: +1 (760) 539-1100
US/Canada Tel: +1 (866) 478-3999 (toll free) US/Canada Tel: +1 (866) 478-4111 (toll free)
Direct International Tel: +1 (760) 539-1150 Direct International Tel: +1 (760) 539-1100
US/Canada/Worldwide Email: Email: ePathology@LeicaBiosystems.com
TechServices@LeicaBiosystems.com

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