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    Viral genomes come in different forms and require different mechanisms for replication and protein production. The summary discusses: 1) Viruses have genomes of either positive or negative stranded RNA or double stranded DNA, and each type requires specific enzymes and processes for replication and expression. 2) Negative stranded RNA viruses replicate their genomes into positive stranded mRNA for translation. Retroviruses use reverse transcriptase to produce DNA from RNA and then integrate into the host genome. 3) Poxviruses replicate their double stranded DNA genomes in the cytoplasm using their own viral DNA-dependent RNA polymerase, rather than host polymerases.

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    Consequences of viral infection

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    Viral genomes come in different forms and require different mechanisms for replication and protein production. The summary discusses: 1) Viruses have genomes of either positive or negative stranded RNA or double stranded DNA, and each type requires specific enzymes and processes for replication and expression. 2) Negative stranded RNA viruses replicate their genomes into positive stranded mRNA for translation. Retroviruses use reverse transcriptase to produce DNA from RNA and then integrate into the host genome. 3) Poxviruses replicate their double stranded DNA genomes in the cytoplasm using their own viral DNA-dependent RNA polymerase, rather than host polymerases.

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    Consequences of Viral Infection

    Uploaded by

    name
    Viral genomes come in different forms and require different mechanisms for replication and protein production. The summary discusses: 1) Viruses have genomes of either positive or negative stranded RNA or double stranded DNA, and each type requires specific enzymes and processes for replication and expression. 2) Negative stranded RNA viruses replicate their genomes into positive stranded mRNA for translation. Retroviruses use reverse transcriptase to produce DNA from RNA and then integrate into the host genome. 3) Poxviruses replicate their double stranded DNA genomes in the cytoplasm using their own viral DNA-dependent RNA polymerase, rather than host polymerases.

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    Lecture 14 - Consequences of viral infection

    Virus replication - think: what is the GENOME? how is the GENOME


    replicated?? And how are proteins formed from the genome? Anything
    else needed? (e.g enzymes, reverse transcriptase
    -ve ssRNA +ve Retrovirus dsDNA Poxviruse
    virus ssRNA virus s
    virus
    Genome -ve ssRNA mRNA +ve dsDNA dsDNA
    ssRNA
    Fates Transcript Translatio Reverse Transcript Replicates
    ion by n or transcripti ion in in
    RNA-dep transcripti on by nucleus cytoplasm
    RNA pol on by reverse using host tho
    originally RNA-dep transcript DNA-dep
    present in RNA pol ase to RNA Pol II
    virus into -ve produce >
    ssRNA, dsDNA -> translatio
    then dsDNA n in
    replicated integrated cytoplasm
    into more into host > some
    +ve genome proteins
    ssRNA (the transporte
    provirus) d back to
    > nucleus
    translated for
    packaging
    Enzyme(s RNA- Reverse No nucleic The viral
    ) required dependen transcript acid DNA-
    t RNA ase polymeras dependen
    polymeras originally e!!! Only t RNA
    e, present in uses host polymeras
    originally the virus RNA Pol II e that its
    packaged genome
    into virus encodes
    Infectious No Yes ? No since Yes No
    ness of they are because
    the not they also
    purified translated need the
    genome directly? viral DNA-
    dependen
    t RNA
    polymeras
    originally the virus RNA Pol II e that its
    packaged genome
    into virus encodes
    Infectious No Yes ? No since Yes No
    ness of they are because
    the not they also
    purified translated need the
    genome directly? viral DNA-
    dependen
    t RNA
    polymeras
    e for
    transcripti
    on from
    promoters
    Remarks Full-
    length
    transcript
    s may
    need to
    be spliced
    to express
    viral
    proteins

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