Ovxzll areti dtabeticg SULFONyL _UREAS «Reduce. blood glucose levelsiotn ) normal Subjects anal “BIS, ype 2 dtabetis melts . ~dassipeadian, Weo-A —— sulfonyl aveas Binds 4s specifte sulfonyl used Seceptor Gus) Locededl on pancreas. P Call membsans : i ‘ Blocks ATP Sensitive ke channels | : poles ie vepolavization anal influx of Catt Inds p - thod odser'$U) ation, dueuognD 4) = eaueet metabolism + phar) . : altahelism Phenom, ebasbitone Bifainpre 2 Ny, chaonte ) eppesite axtion| suppeess tnsuhn gal ease cp, {wsosemide,_sthagic Conticost 7 eroial sADR. Cineisenea af {8 low). ge Hypo qlycaernl a. mam tommon in elelerly . paslenct Hh wer and kidneys dls. + -qolbutamide Carvier7s IDwesk BISK duets lop poteney 4 short duration... acon Q__Non— specifle Side _ eatects >We gain Cl-seq) ae «Nuatusea, Vornttting \o7 parsuesthasias \ ALonstipaction 9 heal cLiawshseo. - Aeorulenee. aie 3 — _ ltypessenstttui ty A * Rashay, photosensitivity ce : 7 7 a nex 2puspusa branstent tentopenia |) reevel ulacutos) S i + Alushing anol clisulfrramy Nee. cate Taking alesnol re Some —tneltaluads tating SUs - - Tlbutamidle reduce) “Jegiele uptake: * sU5 seesetedl tn vou , Ahoy should be quven ts hursing inomeg liunide / phenyl alarima’ “anétlougier: Repaglinide . + meglitinide . analoug e : : : ‘ sthatk binds (Hh sulphary| uxeq Reaaptos —> clasuse af: Arp sense Ktchannel —> depdlansafion *—7 trsuby Ralease . qusosred host * ig quetly and sapielly absesber -motabeli zed + Administved bq each , Major mea\ , to. Corea! post peand tal bypengy cecrmnta, use! selected type 2. clighetl “suffer from J psancal hyperqweama oxde supplement nat Fearn, ADR sup ' emitd hea ache, dyspepsia ardircllgia , WE GAIN *CI! Inhwerw clisedse_ Nateglinide. Pi # De phenylalanine. clewvatiVe - “+ stimulage insulin Release by. closing ATP sensies: em, b+ channels b : ~ Gwen 4d min bg. ereails to Condso| postprancitad byper Bipcerorn'g ow) est on Fasting blosel —_glucese level Apr. Naused, dizziness, flu- lke symptoms , Joint pam suselin ype PM ath then anatd abot).HYPERSENSITIVITY REACTIONS + AY AMA's ote Copabl f Regiglan 2 Supeonf ection SS This wefessto the appearance sea news [ntetion 05 eesuit of arti micaobial thesap, Cause Some. aheta’ in the Nosmal Plowa 4 mz ee the N/ floso— tondribyten — tx hast dae gy Substan&) feed bactenocins § wyhieh «use g most AMAs muerohig) Clabosadin Inbibit path ogenic Seqanism 5- combihed USe * gnctimPvobtals Rodiondlo prinetplen f- arettbyotic _cOSing Mic Cminimum — thhibitosy contend scHt on > 15 tha. Lowest — qrefibfotfe. § Concarctrrectton thet prevents the owt of inlerearqanisins abler 24 by tnecabatley eg » With.a Sthd. ovqaniam Toeuitoel (gy ;superinfection P + Apparante of howd chsenise. infection asa al aretimerobial ~the apy _pahagenes!s Novmal flovt —» pactesjocing =» (bible pathae, Miersoatganisins Nosma) flova — _ tsentta) ee pathogen Tiley nulmends ongantars. changerin Novel lack of ethadenic. oxen, => lael 2 pelnagen % cues competition Invade, Tut y Produce Supesintadion, * Supevinfections dye. moe. = Common thon host sleler, \s Compromise] osteo Sterol © Thorsey peg eee Ley keaimnta?s and hey maliona ny Alps Agrenettaceyt 0519 Diw oll age - Ster involved 5 4 haya instestine Genito wainaey oat “Respreettooy tau: fae 4 Hh use bode] eaten) Slee seein ied Vite eo fetedeylry, amprelly Mow th — fombinatHon a deug s+organism, aysease, Bud} cfov Aveedding = Supen ing Dy tandhalar ae 3 housh, Tier ea VY 2 Treatm-» 7 wetatn cle Q) Resistant Haphy tococtt — erdentuy, tile a — Voncoryein , clexacthn \¢ proteus —> UTL, tterity = wo oe => Gertarmen [tephaleson . Ae el. dfFale 2 pseuclemembranasys erderacitty WL melrondagol , Vancomyd 5) poendemonals —> utd) endevity > teto gon | qenstamety to minimize. super infeedion s | 4. use syeasic AawA Cravrow - 2 De nok - use andimuacbial for Sel untenable mfpecst on > un necessarly poolong arelimieso bal They sum’) himiting o¥ 3~ Do notchlosoguine action —Pnythwaxgtic Schvontoddasf- ay Rapid plasmodt um specter tértvol elevicaly cracks. a moA ip Saas glen unigedl by * «eae, matarsal. parasite .. wiiganis: Pou" ialadie. ““pavasite ) fre ¢ Heme Chighy Chisroguine Quins met lequire(-) (4) hee. poymacase. Hemagdn CNdttoxic 0 pla smodtum) ebloay vin kena inside the, acidic Vacoule, F pavuste nd — Rasen PR af cule. and-thier mbibtt Conveesion of heme. her heme. polymerase a irra by ee m hovey ume heme. fomplex feoms — ane d aang)° chloroquine i Resistante : pavasiter + efflux mechemsms 4 phawmatologica) elioh 4. Arctimalqoial tection re txtraendestinal umoebasts, . 3. Gtasdiasis 4 ~ Amnintlammad o, — RA otha s se total anaesthetic oe Bf Any avgéthmic, — histostifiic Pk Goal oval absooptions jjovs > 209" es atntntrated in tives, Spleen, Jeidney, Lungs , skin leacocgter oe 2 Solechive. accumyledton in Rotina. on prolnged We. ois . mera bolgced In lwex, oxereted. tn Uitte oth = Gato days , duertoy) ¥isie» binol ing ;s¥nall amsunts peostse Sn. : body woth . teamna! Yoo 1-2. a morelh, Abe - ML “Thooupeestic. dose. — Nausedly p Nérivtting , anoyenta, ae qastrte pafn : oealas somatye uneasiness , Hehing , head ache- Wigs hi phen doseq_ » boss 4 \asto h Cosnoa) deposks locs of hearing Gaaying of hare + rental elistva banter, Rasher + photo allosgy Thapepentc uso} « malaviq * Greatdig "Atmel £ Histolytic - piscoief Lupus eayih ei coais “RA ae we : + Lepsa Raaechon : T mohonucleosis 7 Photogente Reavedieis CX, gosiontLwverie’ disease { en ‘seyent “OI! neusd fogtea) , ‘ina “aa tan be given in PaegnainyxANTIMALARIAL. —_—— 4. Causative pe ne Kn maladie. ‘9 plasmodium The. Vectos /defnrwe ost 5 the female ainaphele, ‘e the. Weteamodliale rast (5. man \ raosqurhag. and + date tyele — Oltels partly in, mosquitce atl sexuc) may Cascruad. haxpny spoacgayy ) and in nn Casexe oy « When mmosquttoe brtds, man it transmit Spriegate to bloods - + sporogottes travel torhe Lyex ,Whese t& Reprodutey ond the merogette) infects—the. soducy MeroZaHe : Hi yo asexudl — muHidicetion "9 new RBC and Antticdes RBC * Rec buss and stavisthe infective cycle. + Some mevagottey alevelops tirto male. ond female matey, whore as Some merogote} vemains cbyment Cioyprogoriey) heh Can | Ceune — Relapse af infection 6 Neder + plasma ovele 9 Vitar. & then — mosgurtses binds Infected pews" ae Geman ore Aatenip — Vatih esd meals The mote — merlve Inde gut & mosqultoe ahd fuse to form —_ doletmade — fghich devel sps into we| s VL 5 porogeaite, Ceruabigorogaiy) AMY Pui Sporogortey sae do. leap, qlond “5, goin and infect )'New |-pesson, ie \ * Reativene ot mala het Bata 20544 eam se {rude sense, {89h oronl. yoyt silo bk aan Beds pHisint “fowxtorn affTherepecttic _classiftcection 4)* — obrectveh of. aartimalatia)l di C sheaf jog ca fee toro preverct linea) ota of CPiaete prophybic Cause) poophylakien- Messe + adttack the $9) pre — erytrronse exc phase — lres tuhich 4s Cause of matasiel infection Ctssue Schi2 om Foctde) qe Primacime proquan!| ‘Suppuessive frophyAacteay: Suppress whe 2 mplboog dl ¢ phase and fprevends odtae le 4 — malarial fevey ee chloroq tina , Pooquaril 2 metloquins, psophytanis — advieadl fn so Nov-immune travellesis do —-endlemic areas - » N6n—?mmune pessons tung Cndemic avea for fined awms( uamy ° indants, childsens, peegnard Ronon 31h Sndemic Aven, ._Schizordoade Chlowoguine, quinine eo Completely + evaclveahe pawaste Son lhe body CRadteal Curse’) The hugs Kats hypomagentey tn Care of ~~ plasmodium vivax and ovale . i . primecqaline gamers lal chugs Caste tha, gametes) they hepsin preveratthg sransiffssibn of malasier From she. fensons-to other:Loh dose of cblewog dine + 6 ; Aci clad tn p: feletparum ADM on ¢ Single ee pith chlowaqutne..) $ Cok down — A malaria Asvtemisinin ae Agemisinn \s the achye potncipla at. plang oa misiag, AAnua_ ; ° Seaquttlespéprine. Lactone. dlevivcdive. | most potent cad POPE eng —Schi2onatetdey 4 p> faletpacun —veststant to gil Gtherdougs + puede Shot P OAL hugh chante: A. wrecsuclexense WhoA These. Compounds have - hane fnalepevomde: dougs toon ie Choaver=»./ his Endoperoside. bridge to Fecm- highly deaclve, bree SNE al damage. posasite, inembsans- by : to rank, proteins :Arfesunate co. ‘dy oo Soluble Bley + (aa be, ye ai , nt, iW paola fp Ad nretios E Lips d polubla ata - One and If Ake cthos - Chey wile - Raab p= tbasss Ataretans e Vad? in “conaban ye Ds mG - Drob use . mid APR , Nausea: iwomHlirgy , ibd omina) pa Harseyy Pere pa tise Uncomplicated plasmadtum Pabeiparai m igo fo’ fos both ehlowcyuma = SensHwe = mala aA sto seve malaria > parasecte vell7! ts Con peu ae Hat ld f tor binds begat ie Relanced age ‘| Connbin Lous pound cans rake » Abrure of ° savisdane Good aah. poof AcT rans (nN use cS Byese feaw> e ewe x Arte sunate — sulfadoxine, — pyatmettarnine Se rote sunate — metloquina cE Kepemetho 3 =~ \uma.> | JB. : Treel WwpRr __—TB- Sand RNTCP -veqiman foo MPR ~TB- —tntense phase _ cendinuadiion ‘phase 6-4, moreths) Ce morcths)) Lev fe evafloxactn ofloxacin Gahinrcmnmnte ethoun lout +. L i Eshambuto) Ethonamid<- Ye, € kaneimyey YZ Ceqlosemthe Ethtonamtde + pyrsidoxine, 100 mg\day - e., defined a8 Resistanes, ina] Rifompm wh on vothout —Resistanw. to aay othes an -TB chugs _mpe canbe —-treacledl “eather specificaly ‘desrainad Stancerdig eal vA inchyicuraligen| eqimans. 2 + Genova ppeineipler of. Avead ait Wipe. 2 the ‘weqimon shand | have ‘aHleast 4 aug s cavtain “to tbe effective - 5 Aveld Combing (es Resstunte elougs ie ab Fag eh em youh emptetin amikacin , ts wth teaizidone. —> Include dvug -foom Gxoup IC — w mn Ordes @P = Lae) tanbe & maluded add one trged Cap), one Faqs Cqrop al) and 2 qrcup Wd | | Pyvazinamide Cyelosotha hrerarehto$PEMens — Heomaldgy 5 gen 4a. paenss 4 (ourse f “the acy ie s du Ore 78) doug WA Prevent Neusrortety sf ve “ highly Sus ccoyf-y | Regimen : Aifampin-Restlont+ TB C pp TB) ’Teeatec| as Wbp —1 * — Baeih ~ Sensitive to A 2 This addeled te moe Degimen ai as Sider RR —TB 1p er Ce-4 meaneths) Cig morths) j rscr2imamide(Z) c onan ce ° clasewine C ENenanide- 5 \ Levofloxacin... ol y Edhamlato| ¢* _—-# —lsomarde=———. ‘ Monod Resistand-TB oT flast line “doug othosthen R hich — bacillr sens ( 4S! ine doug fo, WI Ra 62) 4 the We ond |ine doug + one FQ a ees phase ot 3-4rrenhs, q tl —> Wen ally ee Re ee= ‘thems prophylaxis 2 the — purpose te poevens rsoge aston Infcello 4 ae cm a Ihe n to We chisease. cubpeds @ high tek g Tubes Lula a + indicatcel monly IN developing aetve TR - tnetections — for chemo poophylaxis- +) Neonates of. TB mojhes re ) chitasen = HH = Sputum AVE pod! ent tr. the fay »D tontact of pen tase, = Whe show = vetart tray, (onveosion . 4) patients + Dw, silieosls 5 conluostessid “Thesapy leuleeamia AID standesed — dmud—> . INH 200mg Gongleg In chee) datly for 6 moneihs. 7 Another Teqimen: Pafapenstica, Grigg) INGE ig dase (ong) quel, “for BS honths , on 2 week — ely f tetas ft Cs ove CL in TB. o “They may be usaf —undles adlequate chomo Thamaperl ¢. coven ; >in wrously ill peerds C pulmonary /radl ace TED . > whan enna Real cxtuy due to Ant tala drougs « rane meningeal // wena J penicarsdia TB ov pleural effusion wes fo): Reduce Crduadten, ’ provers - IN AlDe pation tout fe er ; sma Sewtous — yranifestlions a tntestingl 7p,” > beer.” silens fertonaPlen i . Gan ours. | MACs thfecctisn /, ateease. develops when cmx ister low MORE 2 oe GIRL, HIV RNatan + MAC 19'0n OPPuetunistic. pathogen — Catisay ” chess inihated § murifocal — cliseaise: 1h \amunocompsomised CHly—Albs) patel ost nlauoedlace ; f * Toeadtnant 7 regime) — consist ofa 4 dmugs:tn Intensive phage, «. followed, bYook B dawg.) nainsergnes Bevis sdliontanee cokes Hy TE te ) for readme 3 eqran’ er wae infection Ineensive. phase oe oe ee 2, elaathsomycn Secwng ‘tise daliy/_ FS Chaetives myn j AzHhromyun,.SOOmMy ontedally bs “os odgls lecomyetn 22 Gthambutal =!eo021g peetay” 2 2 ihambutol) Rebar} ro ¢ dsingleg Neate aah. ona’ Fis Bo e-Rifabutin oom peaday : + CU. Jeiprorlexaciy— ‘soemg tute chaprpow is Leyoflexaein — Bost ohte-dally moxiflexacn - Hoong ontedaly* Al patents — miuadTecelve ArT fow HIy "el, e thavraenz. uted ART. Tegan tnalucen i medeibolism 3 go she close — tnereased Soom Iday +0 450 / ngs, _ pr vlaris of- Ac lnfectton fim —To protect Alps pallens trom. deuelopingaty, | wac disease duang te Perted, bg dest: telat Cc. Single doug = — AzHheomyemn Ako mal Wek “oly clasithasmyen Seomg BD : se Rifabutn 300mg day ts weed | “epher af Tee deougs cannov be given. : Go 1. labora" of. p— Lactamaser which a specitie _ cephalosporins Ceephalosp oairiaser 2 mpermmeablyy ab! 4p the Anabiotu oF iflux so thet | deer not weaich 1e)s.site acHon . 5. Akewivattons In’. Taaget psoteins pap > wad aspiaty, tow the . ardibiolieSULFoN_a mines Bee ee | = Clagsifrcation » Araibacteaial spectoum a Bactesio sat Static aqanist Gram sve. | and Q@r0m -ve bactenta Staph. ctumen, oronccoce ith Feoh, Shigelta ¢ feared. INGOCOCL , prournotacy, avg) MOA = holes dann, ‘tet Mo-dp : Pe => E =e Rapely anal completely absosbeo Prom GT T- * Widely — clistatbuted — tn the body ~‘endes Sevous Cavite eastly aa sete; slatanta «eal 2 Excwetec Th h ktdnes : + less soluble in tod uit: Sey precipitate crystallin, Tepeaily used Sulfohamdey > sulfaaetamide . sex] aa rasteasche . \_Saltascila 2ine use —9 PA iy G Levee lO i ie ee salfadlter2t-ADR $ 4 « Nausea, Yomdtin epiqasinc m o caystallyvia. ( Plerdy of flutes; entalinteation Fn «Fevers, UoHeervia ; Rasher, “uw Hepatity hemalysts in &-6-Pb deficient: Indwduad ducto | high.dése. > a sulfonantid er . ® Neutsopeniay . - kemictems in NIB —» Wheose BBB fs, mene permeated displacement gt biroubr n Peon Bosmapretany binding site, . 2 : | use Bote i Lo Necardtosis ie sulfamethoxazole + Tsmethopairn) pO ei wit 7% p+ Tisvyeaci Infection M-_pakierct woHh AIDS. sulfa digg ine + proimehamina > “Toxoplasmosis - + sulfereloxone 4 pyrimethamine > hice wine Resislang. ae bAaei 5 lg felerpacum malaria | UM Sod: Satt of Sulphaatamde —> ophthalmic, infeetons> Topical silves Sulfadlagine,/ mafende —> Pseverct infection ...on buen suvface. iYON Bactesciaay , Sarna yy, et Se \rcteota Cail Wold srrdlnany FemeMna svn \ a / ephalos pons _ Retlassifteastions Abr ed 2 2.Classifteaction 3 ahh gene vention | ¢ephalasposinis ©. * They de. Ss | Coferena CH vw) ey Non— Suxeptible +o thducibly | ‘ ae " ond P— lactamase, precdutedy | erpirome (im V7 Some. Recioleint , bacleria.» \ f Asis ate potency clganist entenobactena SE Pme Sy Amasseh, BBB + Highly Ressiant 46 p--Laatamases * Active aganist —— Ps. auewginosa , Steep »phewrmania, Staph. oureus, Heinfleunya. | SUS eH Apncumens ~Hactewearnig , septeamy4 fevole ' Newetwo penta i 1 ANe = houss higher Contant ration.) Ce ottamod in CSF Ex txeted by letcinew ' Cefpreome * Move. potent — dganist | Gram ve. f Gum —ve bactenta than gal genavad| o Compounds + Resistantdo — p—Laelumases’ ahi -ppe P— Lactaindse poducing Gntemoberete oriedeas . Use : ; © Lowes RTF (nfect , « septiceamiay «game as “thie generation Resesved) re fox hosprtat ceqursed Regitant —-nFeaell ony - User —9 a) CeRaaxone, | + has Lag POA, peomting ones,/ a ‘daly | + penetration Indo (SE. Is good : sthmmnection -thasugh — Ucinand bike. use) ; *Bacteniap — Moningttty. - UT? - mutisesistuncd Tepheld fever - Septiceamiay. + single. close dq im > aprorrhsea p ofc ad & + Allemative doug doy inne 1g im fo F494 Abe! “Hypo Prothronahoamig Bleeching j | hemolysis. | APR | of Cepha) o sparing | —— Bul ° wel toleratee) move oxic. than pentetliy | A ‘pan. aes tm Infection Qe Thoombephlebttis Of. Iyected veipo- 3- Pvrrshoogs ( tephalexin, Cefapero3 one, cop aumne)g ‘byperesensHivrly Redhs | noid . | %) 5 “Imp Abe ef (ephalosporsing | Rashen » Anaphylaxis Angisedemg } » Achma « UAL Ces 14 sNephactoatetty, in posierst- Hh peeensting Ronal dise Contussend — aalmintstaa 4. amineglyconde/lsop dur Bleedding « f Neussopenia one Thaombouyopemia — Cefaaiciine . ) el | pisutrsam te. tedewa wrth alcohol — Cefepesagone > mest Common|yused| Ardiblot) use Of: Cephalospovins ive. ko rally = — For. ENT Attesnad pen eer the. 46bgenevadion Cubanaous infecdion ol Gompouna] ROY be used 2 > Respreatony jumnay, soft sue Infesiions Cefuroxime, caused b Gran v2 on efinis”) ee Cofotanirarnc Hebstella, proteus CePaa Xone. nt cap ade pen a CoFAcrrolina- fosami] { a4 Copto biprole. med. cal HAP hee eT P : a= ofa yoline fosami) —> . Csinpleatéd| | shina ) Infeedions due to Mig om « femeillinase UCING Soft, Staphylocacal atlas (6) Sepliceamias Cause) b @nam ve ovqanisry Cephalospowin + arnnagly casid e . () Suagial paophylaais C ishqeneaun tephalosporns az Nav > cefazolin re 0 5) Prophylonis ftoeatment — of ingestion sin, het vopentepia eg Ceftazidime / > Sther 3°4¢ genoa —ailone oh tombinetion —4tth_=—aminog lyceside : > f a) med aerobie and angenoble Infections th _tantiryaben. | pedtends undergoing’ Cola vecdal seeeay | - eqs — cefuroxima. , cofadler Ge onat- the Thie| qenaca’.» Coimpound 18 used . 8 the ection —achelv> low levels in ese fi 5 peng tee iC = Pht useful (7) meningitw >) G Emprsico) ‘The-wapy ' : Cepemaxens. / eto taxime oop Armplcalling va ncoaye" [, ox both. « toplazidime + genta Hen TP Mosh eppenttve. then fr poeucl omonas maningyttS Gonorrhea. CRenieitinase, preducing ouganisms +) ~9 Fost chaice 9 febtraxone: > syphills Caluyoxima S Cofetaxims -ee jo) hespital acqursed — infectlony Cirtectiosin icy oo. Respracctony ) @ > cefotaxime Cottizoxime . gh geneva cephalospootn 7 + vanesiayciny Thyphoid — FeveCendonte even ) e Cefdxiaxone ing Cefapena gona V ~> fastest desing € mest —-ellable. aleug fox enteme Fevey a . squck deferve scence usually e-3 days eavly abetmant xf gumpkoms, 2 Used to -toeat typhoid Casoers Low wis ot >) Relapse-and. ..tempheatians: i poevenct Corsnes, atte due do etdal actlon onthe bacilteAE att ioe eee LORE CE / Pep ceils dis ‘ WHO Approved = Ebe ot = tem} x REE cwotio, dt 1 hopin + Sulfametho xara), DY. chance declan MoA a& bactenal Is eth ee pABA Folate syrethetase © Sulfamethoxaz le - pds! bE Folate Reductase . Vv @ Tormethop om THEA? © tombination procluten A supadl addave eftech +) B® optimum Synesqy @ Cnaandsan Soe A Feinethe prim = more lipid soluble . jendess many . dssuey , Larges Volume distmbution -than $ -low plasma (nants. Uses BRB. and plaunia. g > poowentyy — -@& « Rapully absosbed Seen Sao Additional —s Salmenelr -Yyphy, Elebsiello._ enters bast ey - Reswtand — Stoains ef SHaph-aus, Strep -Pyogenr, €- coh ygReststanae J « plasmid — mediated) Prolection ADR * Nausea, Vomiting, Stomatib , head ache * Bhod elyseaasia, . Folate deiaeny Cmegalch > eT +> Pregnancy stemethopsm © being Gh aniifolate > Terdogente ise Neonatal hemolysis § Mmethaemog|lobinaam iq ocue te le ls given heas teom * patiends wth Renal disease pase Should be Redued G Upeamla dlevelopy Eldesly people <—, Bone. mavsow Cotamoxazole- ies iy 2ku 4+ toksmoxazole 7 Theombou : DiuT. gptope! toxiety fxom Asen uncer} recrficc| 4 ae 2 most. effect We fos. 9 ee : LUTE Leblet’s-o+ eakarmpya | sige cute Q m2 : ‘a ve Tomethopem get conensraied - Cpsot due tO Relatively aeidte pi ot nm prostatic uteCINH and Ro ve the 6 S0 0 thot BRITT Tl chyasore * . + Begonch ys - mU and t- RTL - facio 7 manillagy tnfeetions s) Bacteata) _ dtarssbhseas : and _ dyserct y. 3» eis used fox seveve veinal tavasive !Mfeotiy Comsed » Ecol, shigetta ») chanersota} 3) Typhord y neUMoLYstls ».-plroved neumonia..tn_ neLebropeny 2 saat AlD5,.pectlents- p Hig Tereatmont f& TB Ll Goals ot Arcitubestulas “hanapy » kiting 4 dlviding boeitlr : yp ~ Rall Pewsistlang badith® 3) prevent Relapse Prevent emargenea of Resisdan 5) To = Roduw a oh tote) clyrwa” of “Therapy most VL of . clecraly Synargist ic bo Therapy Reducal, {2 —4 months Addition of 2 $0 total @& a months fusthar Rede! ucaN ef treatmant to 4 mondhs combina] on Is2 single dally lose 1 Pest | sp \s be dvedat coors) In Ge are tB | Shot moutee ochamet hewapy <= Cpo3 3) + theve ave Severna] 6-$ months duog” eich ae | less toxfe, convenPanit ) bighly effective . S hot Course. Tegmons ot eAll Tegimens have 2 phasey : {reensive phase . : a ~ fordinuation phase hs Peeae 46 mo6redhs - tontain 4 ovédoug ( ersain 3/4 dougs. ee Aim-y Kil bored Rapiolly ; - bent | * Bring abot spulu ee, ile eahversion call pas o Affosd faust symptomale ; rreliep RNTCP has classi fea Te “SSCTRFO 1. Doug Sensitwe TB | o| pastents baci ave susceptible +7 all seat | ans] TB drugs cabs \ line o ; o : | alt new “patients whe fgve. never taken any? ATD op ¢tdken akém 2. -Yimoneth —> doug gorsttive. TB oe Mor IB : ‘ » 8 Rosigtont , Rove wh / | Js betcllt Oe peaistan @ 4 0... 0NY 15% line FB ey’ 8) _Re-7B a patients bacih ‘Resixtart R bat hot Hah) touhout —sResistanwa{o thor ATDS ~ fame. Treatmarss = for MPR —TH - DOS a Sac Resistant +6 5) __ PPr—TB patiend2s aly Resistans +6 one or move FeAl, ATDs except Rand H Reststana: 4) ‘tolerlerl — GB XDe.- TB one 74 line = ATDs shubtr, = An MipR -TB case Whose_ bacilh has acl ditions Reactane eto a Faq and one = serond Sine empet ATD Soy Susie TE . A “fe phase. 7 ‘es phase Tote | due Newpatient = Q HREE 4 ure Lg as par Q HRZES 5 Hee ge TL uRZE or New _pattend?s inHlal Teeactmant- vou 4 dougs 2) bactencidal CHRZ) ee bactests static Ce) : es basitasy loael fi : ae RUE @ selecting Resistant bal |Afler aw mort zis clisconetinua ef I Remaining — HR for 4 months —> Elimnale “alt beeilftaa%, bod ly fox previously treated pallens of 1B All | Poet line ATR owe. admmnisdvecl daity for 2 moreths > ngected 5 {a Slopped 5 Pst for J month 5 in. conned lon phase Re (eat ad mintstr | daily foo 5 months i dose . ft Host line ATDs body HpZe 14 Condtiny pall weight basis Boab Td aes R —lomgltg : > Js mg} eg ev E romalkg ' S bo hdiore lomglkq- , Sok eee ci hi_ fee. Lemania ( P-Aactomase hibttor, % Csheethe Eagyna * produced by mary : hestints ) dea f (staphylececei, gonacocai im He and ye beeserrta. : a B-subths, 2-H 54. meluan z « macteater Pela lactam eetibiotign by 3 ro “ang Pening. Peta Lactar » IE «Pr Lactamase produced sby q mam sve bade Clavalanie act of sulbactam Tazobactam clavulante ace} , od eee Sour .. sheplomycey . Cleyuligesus 5 Was B Lackam ing but % and bacterial cetmity os own . Naa = Binds votth ial Lactamase orevensibly intel, [ater becomen torcalent © progressive mnbibuios. Get Inactivated otter” binding “to ~tha engene Csurerde Inhibieow)—PiKe 1, © Ropielabsoupa toh A a tissue distriburtjon_. machen WHR ef amoataillin elmnated kidne ale medabolism ' Cehmnation ts nok alttent2d Yy prabencid ) * Route san/iy = Addition of Clavulonic cicid —-xe-establishey the aetivity op famoxteillin aganist- bela Lacdamase — Producing. haeteaiq Lives (o—amoxiclay used for 3. sein and Soft tssue _ Infection 7 Intra. ~ abdomiag and gyneta legteal Sepsis 2 Weinayy, billaoy | eT Infection esp. for hospriai Acquised infections’) d— Gonowrhsea. Rationale «gf amoxiedin + Clavalanre aero Ss APR ; ae ~Qxr Intolerance cord Candithal vaqinitl 9, * Rasher, StomakitisSULBACTAY som Sptthette bela lactamase Jahibites simlae to Clavuline acid — but less potens. _ Route Vert! C preffesed) ; Combined §— OH) ampicillin ! Ape . pain @ im Site ‘ Theombophlelt’s of tjected vein, : Rashey + Plavshooa - Tazs baclam > similaz to. Sulbaectenm - combined wh Pipewactilif Aen vy. MONOBACTAM S MONS BACTAM Sancta Azzeonam Atypca| peta. Lactam —aniibiot¢ Coma xing ™Mising MoA: binds +0 peneallin binding poten ave endeole Laeillins, ro Spectoum: haesow Canhibtt qram ae is pea it OUTIT? QI le user: hespial crcquised infections fran “gle, Gem oS: Shave trac Route WimADR= Ratsher, vke In Se7UmN Avansaminase No (toss senstiVity huh = other beta lactam Andthoy exept Cettazichime. tent penem “perivehie — af thenanycin Spectoum: Geam+ve , tyvcim Ve. , anexob &) enorme lmpenam — undeaqses “rapid yerrolysis by engyme cle hycraspeptid ase. l lecated on the baush boudey F — wena) tubular tells. hen combined wih CILASIANTIN, C xeverdible thhibitog af ‘le hydra pep tidy Use TT sewleys hospital Geqhired Intecsfongey Lian RG pele, — Sin, SoP-Hissue. inPecaPa, ce App. = , Davrhoeg , Vem ting , Route 11 *Se13yren - Cmose_ Way’) Deperrensit ivity__ Mer@penem _ nok bydwosed — by debydeaope priclasy . eno — COmbined Hh CILASTATIN . Reversible rou For tre ab ing serious tn Fecticn Mines Mealy to Cause SelQd0a.ECTRUM ANTIB lon cg = i MAO: — |hbibit Pactevial protei, BROAD §P Telracyeliien CI lassificaction 3 Based oh souae Seinigerethaae \ Tet tegen etn oo leleaeychna minocycline Qe Based on pd oA. Shoot aeding | Irelex mediate bong acting | Mechanism ef. Resistang “ plaserid mecerted Paotection + Less Q tong machanisn Speetoum of. action > Gram + and ve (cel, baci 4 spreechaten, chamydia, Rickettsiag iw plasmod ia, Actin mycas ~~» mycoplasma and thaAdv & © semayethetic tetracyclines , At fe: Epigastoie par, Nausea, ‘Vornttting os Esophageal ullevad lon gu supeanfectlay $ —Theombo phlebiti s poe Releted sBona anel teeth : phototonicity » Lear and Kidney. damage CF Ls) tetas 2 a poecorrllon pf ssenioe - No use. cut dalle Fare ps hot «omx Hh penicillin Ctnactwale anc thet) j fo L Emprovel tharapy a. Feop > Freche oa sor) u elSe MAG: Inbibs extension ef Proyy Machansm — of- * Resistemta- ditinny pewmeability a ~ plasmid mediated ase Agans-evase , 3 compugadion FR fa ; Loney affinity for 2 oi a, —spectoum faciwnty (sane yon fen diffecenvef) Less active euganist: — Geam +¥e (occ, opens Addnicnal > salmonel Mote. uetive aqanist — Huntley js. typhr Not 9 detive. aganst — Eredvemba 2 chlarsydig Pk ° CWS Bep ALR * lor tatve + Supes lnfectlon - fone rarzow le psessich o 3 laby gyndecne ( exqugeded © Gaogy Ts 7 & ac den owe? gata otegees No If Welt aternalive . Nod tO Rapeartedl dose Ro IN MoS lakes tH Ysen, “pphoid Pyogente mengl tig Indrcoullae feat, |AMINOGIYCOSID ES smamstay Ww dvealtimon4 Gee aewoht Cy, Gram Ve. bac; «Stable ab — adeous solut fen “3M: cardiibioticn C4 Atmkeiem, — SF vamnyein, steptom yi ctn Gertamenn 4 kanamycin cB’) MAo! tee ge bye. tha cugh pom channek (o Usarsport acwoss Active ok — reduecel pi Ac} by Wrdlewfere bath — bae- Protein «syathe € OK Crude ‘eae i apr (\ Cas) iting ae la"arctbiotic_ eect corinuies WIS deity — even ater the Conen? tats batay reine inhibiiooy (chtorevctticn . egr — Flere quinclonen ¢ gumuns ately os! i; = . oe + Gream ve) baciltt Cea, eleberila,, proteus. Gram 4ve tocer” eq’ Haph auaeus ‘ Sep feacalts steeptomycin CTR 9 Fiest chelen of-deug’) => myobacter ium Tubeace lo95 Pe Brucella Q vers ina 3 + celeetivaly accumulator re innewear and kfdne PH ototoheity ane] Nephrotoxtetty Resistance Steeptonye fh» Pog, Bouratlicnis Gertamfer > synewise veh p—Laclam use: UTI, S4Be ‘pseclomonal (nfecions aretibtaelen.Amikaei apt fine’ Te doug. App. —=—=——. i *Nephactoxic , ss _ dtotoxich ty Ctestige &” paralysis Avoid 4a Poegnany Cirveversble loss A-heaing )i MAcR ol(pes © matevocycle lactone af eis 2 8 Roe Ings attatched 46 Suqats. empthvomyctn Newer semisyrthetle moyrolieley et Rox Hhromyein + Clavthae mycin + Aaelhso my cy * Sprramycly..., MAL - (np tageam ee =D. en © pactesiosratic @ ke low Conentvajion — Var con? + Geis — accumulated] frctele. the.,;, beielesia ane! tobi bt 5 $ Bacteoial — psdtein syrethesig > sep f pin syrcthesis, '8 Inhibited Vind P + Apter tha, . pepude bond. , foornal,., hewy Poomed 44 ond —nastens peptide chain@ — aaptow Site the. elengal feptide Is eanclecated back to “the — peptady Ste malng A fie she. Nallable forthe. New AA envied b £-RNA. “this step Ils anhibited! b, mav2oliden "here tha. Riboserne. fells te. mave! Qiong Ahan mRNA Wt expose tho next (odlone -ee lide em to mace! bactenial f aioe en. owl peameability af ; “ bydoolyge : nog estedse to =} i * opel, mechanisms — I bactevia 45 fury . ve. mateoltcley : Ateonatlon tn tha retbosomail binding sites foy macrolide 7 Dot. penttliy/” A2vhvomytin + Any micvobrel spectoun an APP PY is * Nave Spectoum 7 st Fe - P p Tahe : ie mamly Quam -+¥e ~ S “fram 'Sbecteum C pericilin ‘4 spectoum) Additional « speetsumy «B. catavrhall&, chlamydia trachemadls 4 1 Compe bactor, Legfoneila, mytaplasma + Be peotudis Nemenigiditis 4 - ‘influenge nan” o Ricketstaa ; *, Gaydne ta vaginalis Ceapeemyeih oP Ri . Bbsorbed From OPReS past: OF intestine o Acid labtle. Co enteve — ‘tealed ablets) * Koel interfere, = Hh aa + widely disteibuted C Abscess", senousmembyana, plank ee) :+ poos!nt (oss BBB pally metabolised th Liwes , excreted in bile, by = 1>-N has toe = 250 ~ Soomq Chey C30 60 rglitgldyy) ADR. *@ @1T Epiqast rte pawn gy NaqUseo 9 Anerex te: Diavshsea : = Rowesible hearing imeeeman Cae nar dose e wHpersendinitty — oct Ctinfrequent}—o C bsahey, pet DI = Astamiole/ retecln /197" : ma lewer « Inhtet hapade Sn many frien ay leaks do zise tn plas 4 olae Casbamazep\ne, wordaainy exgotumin ag MHewnadive to pent ely d. cae ca ed constlitts) Community atquired sopra (nPeations caused by preamo tocet ein Hetinal 2~ Telanus ' a sxho _Lepreshsons | egermneet Asa. fost cheiea, pug for » AYpical | pneurmonta. C myeplasmna. presmente’) + Wheo i . hacked “ ughahd thoie — ahugin ~ campylobertle a enderiats CEQ sp rele — Legtonavse 2s pneumonia C&Qs/ cs i chtamydia. Avachomalls Coos ramen ornylin Swe macho tines (4:5 y ) 7 the — have been cle veloped do ovesrome Limnos of eaythromycin Q Nawsow specs oy : gestae Wtolesante. S) poor owl BA Acid Labile Y 4) showt- +Y>- RoxiHthaomyen pRetlew aval absorption vv Add Stable “ty = lohes > tute etlew gestae 4olerabitty “Similars Speetoum and ay “Seyler Atleonodtive te exyhvomym Sox ski ENT, AL tissue» genital teack lesions. Clasithyo mycin sip. hag simlar adv like © paler owl absonption —@F_Roxtth-vornycin strc Loleaabillty lepsak. e jy ye Additonal] Spectru BAM Eph e Acted Stable - ; aie a 50. dele Fiest pass ‘9 Me away : Food delays but doer not decrease aksorpt{ oy compl H pyleoy - ) crush; off Via media ‘ubooping coh er anal ; Oy tac Infection th “AID?S peclions ye : Ae. Sahni typ B44 J soudlemembrancous enderocolels : J 4 Read myOlysis. » hepatic dysfunction AZITHROMYCIN | . Azalicle congenes eaphrsomyeln + Aighip actwy aganist my(oplasma , peunglyeng a, chlamyd, Campylebaétox, movaxella, WAC ca wa wv o Aad stable <3 Repiel evel) absovplion toon empty Stomach os long t¥e_ 75 has vNo signtleant Ot Not much ADR « Larges Issue distatoytion anding vatollula D penstean «ill extvellom mainly C_ bette x oblend-temphané 5eomg = ona. daly dosfrs : TF betod- igh , convener one daly dosage Flee chore doug Jn better qaseme olewante- spac a m Ladiennasers preumoniq + chlamydia. ah Sie ny trachomatis, chlamydia pneu menig + benoveinosisChanevoid anol ppnae Uretha» Single ty dos thos Indtamions atttts media “tansifftv, acquive al preamon 4 “MDR Typhed eves Phoy oyngtisy Comm uitey ADR Abdominal path ead ache. P12 airesa@enre. OTHER ANTIBAC TERME. d- Lintosampe — ANTIBIOTS chadamyery, Lincomyemn As Glucopepticee —_ antibiotics Vanconye my Telcoplanin is uw OXAZoll dinona Une2olid 4 — Pobpeptide — aratbiot Icy. poayan-B, Murrecin | Fyscidic acid Bateitraen, clindainy én © potent : 2 Binds 16 50s aibasoma] subunit — Peeve 4 net d Syethes}s C “ ey ighby oe Tor anuevober — tuctesatls Fragile a aqanist most Pie D recn : seas AM Ve cece! ( steophouce', “Set « Good ora) absoaption penetrate Steletal and Soft-Assuey do Not ertep bean and CSE » Aaymulat - umulate, in Necsbophils an of macoophagel a % w2 houss . ts el tats 1Ave sasha, utticariq, Abdominal pein + Mejor problem wediarsrhoea and, Cause. pscuiale mambrsancous ergesocoltls = due t* — alrdittide Supersingestion te doy should be Hopped and Stovk WH “al mnecteontda2o| IM tngeetten — Theombophlebitisaf- injected Vein . USES ue ts Restricled 40 ansersbic and med tofectons- — Abdominal, pelvic, lung abs(ess , Sepere abo lon ated 3— Skin ana — Soft tissue infeelions 1n —petierds —alllengic 40 | penicillin 4— prophylaxis of Endocondliets in penieillin’> wllengic peclensts 7 = AIDS patents . Combines} 4h fyoumethamine fox» Toxoplasmosis’ 1 Topealy fox ac vul als ; 8 fombinedl; oth» Prima quinine. btiioioapheumeogas an _ Atemsdive to coxycychne, insupHimenting Juinineih mM pR fal. malang aN COMyCIN i et = ° Giplopeptide Aratbioy) ¢ In 1956. 0 EfPtaeays Gqantst- mesa, ele clirtiale Steep wadow ow :Me OA ——_ . At by tohibiting — Cell wall» Sprethes ts. > Binds 40 4. tesminal dipeptide sequenca ‘of Peptidedy units ' Pk = @ Noe — absssbea! ove . widely distoibuied ates IV injectkn~ entess Senuy Cavitlen and Inflammed meningitis 6 TASTY BL bhors AbR © systemic toxictly Is high +, Cause, plasina bon can dependens. heave. deathoas — peomanens . Krelngy ~ dose rolated| damage > dtotonte and . Ne brsotex og Carsesully © aclministred| t ed rehatiae "Cause histamine Release chills, Teves, — Uaticarsig " — Rapid 4 geese Intense flushing — Red — mon spral-some &= 3h fue > 9h ‘ USER rene Sync | Teo | sal | an chae tO Metsonidarcle for antbiotic assaciatedt voy, | pseuile membvanaous enjerotolitis staphylotocea | enderd colts ShiRsA Angeckion fenous Stn Sorttisou » Skeletal intectloh ‘ Empraical Aho tapy of Saeleoal mange vy Vancomycin + Cebltiaxond /eefekaxime « > penicillm gesistand pneumotaceal infecd ons Teicoplanin + Active only To +e Organism . ‘ ; mote. aclive than vancomyen agaist ertero@cd + canbe. Fngecdeol 1M esreokr™ wh i. iV = a4 ay woo 2 t de AS M46> Similaxrto Vencomyc'n tot yee eee Is. less sthoin Vancomycin y lS : Ape = Rasher tbehing oe f fever. ” Enderovscea| ° Be endo lasdttls oe oe ot! 1 O. Osteg myeliiy Grranuloegtope * Suagical — prophylaxis: inpeeliong fenteatin pesistank arseplecoual pertan) nerd Crt ee febaile. Reuhopentars Wa Wound infeclions ¥ Od i Restate} —diug for sndabmant dig tend doug Rasnjyare Cxoe) Te. it fox extensivelyAve. ———— 4 } + Abdaminal pain ~ Rquseq. ~ Didvoh - Fase istuab ahe 74 wks of Therapy sy opte neuropathy Gnd pennphers indeyacHons tes MAO thbibiboy — Indewetedtinn) athe adeeneng c/ Soxotononergle. daugs - Tysumne, ete. é * serotonin Syndrome When gwen Hh ssel” 3emmon Pes TE uM 442 Aminelycaside Arcibloticy pagers, Systemie_ammeglycosiclen Topleal amingg Vyeastden Streptomycin Neomyéin Amikacin Framy eth Kaneimy Cth, tobsamy cin ‘ Sisomicin Gertamt cath M.o-A == Amino gbycesicl & dee bactencidla) agents — “Inbib = Peotein — Syrethests Atninog bwesicle enters Tntp bacterfar “thsough pooin channels 1 Transport — weross cm “thes h_@ 0 ted ated delve Lranspoot, a L bh Binds to 30s ribosomal) “thay . (nist Whelan op S Pin swiss ol peace ated Ge a oF pln synthesis Wrong eee i « oS pepticlechat ne formosion F dogectwe Pansv Incowportlon of. clefeasive Peetetns Into bacterial cm Alte rwee| pemmacbilirr, ahd dliscuptfon of cw C. bactericidal eect ) | chtowamphenteo| -~ aL oe i pg comyeyry! Ardibiotin — tnbibit proiy syrah is —> _Teteaty clingy eds | a | More: d) Inactivotion of doug yo boctenial engymey : ret 2 buctestal Cell g decoeased erty ty. ee wtboso 5 pecweatsec| atinity et the, dO forrhe sibesomey. Exhibit ~~ sConexneta® dlepenalenet kedlhing > Higher fhe plasma. Coneanstoa more f tha bacleriq Elled —Tapiely sagen Tne jeRM ete) ‘tones dees ke Ing 7 post—> arcibiolre! ebfecd ‘tordinuen 5 aehvany everobles The mittnum —— tnhibttosy “aoncentou? : ffoctVe. - = OD. regimen 8 SRE tencen falls below Pages eeeAbe SS 4 _olvioxicty & cochlear ‘and — vestibular dysfunchions ¢an ouus due to i" Newe. damage. sNestbvlas and —eochleaw hates Sensooy (eis ancl hee Unclengoe?s Conundralion depenalent desteuctive changen 2 AGs eertclops 48 Cause ototoxicity When tnstilleof im patlends — WHh peofo vated eardoum. 27 obotonicity is. greater — when plasma. Conunt sn 4 doug Is pessstently heh os ; » “these drugs ave Loneanstratecl ay Leb ayatrethine. flute] and slowly wemoyec) Lsomit~ Whan plasm (onan falls ps Wilt lied day e ~PTanitus ( PF deathess pesmdnans ?) os 4 leanamy cin ane amikacin — paochuce greartes Chehleors —olorioge than thar Ams. > No~vegenera"-of —Sehsety—tEIS Otte 55. vestibulae demarge > eHeal ache, Nausea, Vomiting , digginess |; Vers akania , Nysteg mus - Streptomycin and qeretamicn produce more Vestiby law damage. = PRik tacos 7 (Q) Clelers| patiens mp we cated] Counsef Amings | Pessistenet| n acne St dotg in P “ > allends volth pre-enist! ocho Pagan. g) _Nepeot eee Saab Lames Get tontendected thyoy wehal,, tower, oxehemteity Nephsotexteity es on 1 ond sfpedaee. sph PNOTe golly } : + Resuting Into “Urrinorey tontanctoding ponds, Low GF 'R, Ny welendion, albuminers a. a : Rsk Facloos + Elder patients i preeaisting ., Redney > elisease jwwbd- Apiresvo" A? + streptomycin 19 least nephsote Are. andl, highest votth neomycin ; dD Neusomasanere’ | (’Blaceddle ee slesa cal eReduta , Ach Release fyom, the PESO ID rit io) eto2i2 motor aasve end tr el — or yoo lB ons are}! > due to ask 4 fetal ofotoxiely 4) cEin pregnanty J. Avo! corert use f- Ohew repinotonte doug Nsalps , Araphotericin B cydlespool D-~ cautious wee in patients 7 66Y ws ) pedlensts with kedngy damage . | $ = do nok mx — aminezlycoside worth any Sane gyainge/ — mntusi oh, bottle: | doug tn dheRie ae —— il + Get © actunulated 1h Penal (Come ano} endlalymph huhich ave Responsible Fox ololox tally and Nephvotoxic ty eg cres plaansta —afound in foeteth blood / arnnto t. — use. clung pregraty Can ~2 hoaaing Ins © extvedec! > unchanged| lh ueing > tow Absowption fom tnpesstton alte. 14 at) Is Rapid - tbo «ty = a4 hous 5osin imon Ar avereige Odut wth ClLew> Farin —> usuas” dosey ' oleae : meee sortiayen | oa single ghee a sisom (ein / netilmieth stseptomycin /hanamyetn ) So to smal kq lay, arn baci) /- datl dosing vegnman — total deatty dose 13 ove ‘ at is Ma smgle — inyecsHon oo i prefte sed} > Becr tk 18 prefered ag muHple dose regimen BS Highes peak plasma conte" to achewed follavang single dose. > & saler ~han muttiple dose ‘weaimnan - > KI conventen} muttiple daly dosing seaman — toll dlastly dose Is adminstyed In 2/2 equally dwided dose.y pentetllns _ pentcun sane: 71 tna ponelin ~06 gat stone peprecton MOA Joe ap lactam arctibictien produce baclesjeidal 2ppeat cel wall yMthests M sysceplble bactesia - mod —okefer Tara. Arctbactevial _spectourn Goam Ee Pacll >? Bacillus arshwacw a Cox. cliphthasia . by Inhibttlre + Acinomyer tsvealé” + Aerobie grain’ “negate: bec > niga ee) protozog , chu dat, oe ee ss Mechanism of Resista +2) produciges P= lagemase ¢ pemertlaie?) oes she p- Laetam ag and =, jnaciteaten,,. PhO iz og aw Indleung,, tol 9 Staphylococet : prodilca penteillinese D due to. atteseel BPs Which have less attiony ton p— Laviams %) 4° ages pheumanieota D Ble te —detweased ability ef the. drugo, pennteadedo Ws site of action.BB wks spenieilly Go 18 aer labile». « Absorption of sod. penicillin @ I Prom IH Ses Rapid aire} Complete . Radtonale af! probehetel cpenteiliny probenecid] cletseasey Volume 2f., distibution a penteitllins - 3 Tubulas seevelton of pa ts blacked b penteslline — higher ane long last plasma Contant sod ONS (vr ixarweisacherved>. Abe : a nsodooan aint pny pan @& (nyeetion sites iia ~ Nausea ‘on oval ligestioy aS wo theombophlebitis of ingested vein 8. Torey 0). %2 boain 35, rmendal,.tenfuston.y convulsions, muscular -twHiehing |, coma. : ~~ gleed! — Ibtevfese oth pir fancklon we micwoemboltsiy — anne SIV cingeciiay “f= paocamnd® penta” 3 nis’ sey Stimula", halldemnia,”''Covuisiores'® fal toi RtOCAlM “osgyotedge : typemsenstivity Rea? * Most tmp . Rashey + Mehr «fever * > Sos + ills + Umbieaeia »spires ing + Angianeuratic. edema fSeoum sick negy _ ‘Anaphylaxts - | Co supers Pinbectons + [Fenccilin alllewqy ts commanty ' een | atka po aoe whan _ oval adminstvatioh _, Incidento’ is highest th poocain penteillins © gasisch— herx hemes req"! + tues When penailin injected th a. syphyltie papas 7: predue shwveseg, fee, myalgia, exexerboslonf lesions, even aswlag Collapse 3? he ts due to Suelolon —Ralease of —spraochater) Wyte. Products. . : fl sic: . 2 kt don not tetas, aind| _oloen not reed irelesouply sai A ee UuSen (li - -@ pPAISy = Streprotoceal ‘tnfédhions © Base Sees %» otitia malia.. ..., 4 Rheumasic Fea: Q- Gono woh ears... 3- paeu moroceal Infection DP pneurnonfa, > meningit 1, 4— meningococcal mfection S- — sy philis - Pra & the. doug of — choicas = ©pe \Lep tesprrosis Sate biphthesia . . Tetanus and gasqvene.. 4a, Aetinomyten. and Arcthasax le ame la (4) Rheumalie eves: (2) Bacterial enalocaodit. classifitctiby of Sem gyrethetlc penterfins TS Papgplo Gxetériledd Anim penal joum penicillins eee Sensitive . eine! ‘agama all eaqanisis 1 Reststerrct tO. Pn@ | + hon— B- Lactemase pooducing Gram —ve baelllt Nee E-cely proteus, a infleung 1, H-pyloet te. inhibited - : + mere. active than Pr& fov strep vie fais entevococt!’ : Sem * Equally aetwe fov premcti_ quota 5 meningococe! (to sh fesse oval absooption Is incormpleke. bur adie not degraded by qastaie acng 1 Kod — tnteafewt wth ab 500 Pt) op + plasmoe ty, = thesUser *s) UIT: DP Respiratory \ Aewered Infection > beonchitis “2D Sinusity 4 otitis media . 5) TyPhod fever o~ BH) menmapts. : dmcrydiine %s.. she, inst the doug, 3) Gonosshsea': rest na. elug for oval. tseaSment of hon —pentei thnase. Prodicing gonococeal infect ons. 4 Baclllagy “)dysenel ay, Cdyents *! chigetla) D cholecystitis! 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