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Physiology MCQ - Renal
Physiology MCQ - Renal
18. calculate the free water clearance based on the following values. Urine flow
200mL/h, plasma osmolality 300mOsm/kg and urine osmolality 450 mOsm/kg
a. 100 mL/h
b. 77 mL/h
c. 300mL/h
d. -77 mL/h
e. -100mL/h
19. Regarding H+ excretion
a. H+ is secreted in the PCT via an ATPase
b. P cells in the collecting duct actively excrete acid
c. The limiting urine pH is approximately 5.5
d. For each H+ secreted in the PCT, one Na and one HCO3 enters the
interstitium
e. Carbonic anhydrase in the DCT luminal membrane facilitates H+ buffering
and the formation of H2CO3
45. What is the GFR (ml/min) if the urinary concentration of inulin is 40mg/mL, the
urinary flow rate is 60mL/h and the plasma concentration is 0.4mg/ml
a. 0.6
b. 2.6
c. 100
d. 160
e. 1000
49. With respect to the following ABG taken on 24% O2 – pH - 7.56, pO2 – 135,
pCO2 – 28, HCO3 – 26
a. The person would b expected to have a lower pO2
b. The person has an acute metabolic alkalosis
c. The person is demonstrating respiratory compensation
d. The person has a chronic respiratory alkalosis
e. In a few days time they would compensate by lowering HCO3
concentrations
51. In micturition
a. Contraction of the trigone is mainly responsible for emptying of the
bladder
b. The relationship between bladder volume and intravesical pressure has a
linear relationship
c. The first urge to urinate is produced at 250mL
d. Urine in the female urethra empties by contraction of the periurethral
smooth muscle
e. Sympathetic nerves play no role in micturition
52. With regard to tubuloglomerular feedback
a. The GFR increases when flow through the distal tubule increases
b. The macula densa on the affertent arteriole is the sensor
c. The afferent arteriole is constricted by TXA2
d. It is designed to maintain Na re-absorption
e. It does not operate in individual nephrons
56. What is the clearance of a substance when its concentration in plasma is 1mg/mL,
its concentration in urine is 10mg/mL and urine flow is 2mL/min
a. 2mL/min
b. 10mL/min
c. 20mL/min
d. 200mL/min
e. clearance cannot be determined from the information given
57. regarding the PCT which is false
a. Na is co-transported out with glucose
b. Na is actively transported into the intracellular spaces by Na/K ATPase
c. The cells are characterized by a brush border and tight junctions
d. ADH increases the permeability of water by causing the rapid insertion of
water channels into the luminal membrane
e. Water moves out passively along osmotic gradients
58. With regard to the effects of hormones on the renal tubules, which is correct
a. Aldosterone increases K reabsorption from the distal tubule
b. Angiotensin II increases H secretion from the proximal tubule
c. ADH increases water reabsorption in the PCT
d. ANP decreases Na reabsorption from the PCT
e. PTH increases PO4 reabsorption
73. All of the following represents an acid load to the body except
a. DKA
b. CRF
c. Fruit
d. Ingestion of acid salts
74. What is the osmolality of the interstitium of the tip of the papilla
a. 200
b. 800
c. 1200
d. 2000
e. 3000
75. What is the H ion concentration at a pH of 7.4
a. 0.0001meq/L
b. 0.00004meq/L
c. 0.0004meq/L
d. 0.0002meq/L
e. 0.00002meq/L
77. Which of the following would be best used for measuring GFR
a. Radiolabelled albumin
b. Inulin
c. Deuterium oxide
d. Tritium oxide
e. Mannitol
78. given the following values, calculate the GFR: urine PAH 90, plasma PAH 0.3,
urine inulin 35, plasma inulin 0.25, urine flow 1mL/min, Hct 40%
a. 120
b. 150
c. 180
d. 240
e. 400
ANSWERS
1. D 28. E 55. D
2. C 29. B 56. C
3. E 30. E 57. D
4. D 31. E 58. D
5. C 32. D 59. D
6. E 33. A 60. A
7. C 34. A 61. E
8. ?C 35. B 62. D
9. B 36. A 63. A
10. C 37. D 64. A
11. A 38. B 65. E
12. A 39. C 66. B
13. B 40. C 67. E
14. D 41. E 68. D
15. E 42. A 69. B
16. D 43. E 70. ?
17. A 44. E 71. B
18. E 45. C 72. A
19. D 46. C 73. C
20. C 47. C 74. C
21. B 48. B 75. B
22. B 49. E 76. B
23. D 50. C 77. B
24. D 51. E 78. B
25. D 52. C
26. B 53. B
27. ?C 54. B