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Reysioie ridee@heurgkusc.co kr Sector Report Alt /Bfo| 2 7|AA|AA4: NASH NASH(Non-alcoholic steatohepatitis, IBY AIYAE 2 AOI Als SD} MY YS 2 VAS SS] SYS YEE NAFLD! aI YY MeO, Mz ArioIn| THY MBA, B71 ge Ia! IBS Q oy z Bele! WA BH 7IBL2 BY e179) 20-30% NAFLD, ©] & 1020367 NASHE AIoHHS 222 ujSHElCy, ¥IRI, et MPH| NASH ASSOZ 99! WS AANPt ei YeOw 20301 300% Sein| Aly AOA VV ALE richelo wket AOI SoHAA SUSE BROMO NEIL SIC. NASHALRNIZE BEI 1S Ol S FA QU YHA slolol Betowy vloinlal QA71 aoc Oleh SoH AVM AISR/HHO]S ALANA NASHO] Bela} BOIS of2s 57] Sieh HWSID Qi ALRAHES cielo] ADAP etc ie Heungkuk #354 AITO, a > Heungkuk ea 718 N24: NASH Contents 5 |. Executive Summary Ih Key Charts MW, APSE 1. NASH AV BS! A88t INAFLO8 NASH? NASH ALR ARS. 2, NAFLD} NASH wetiejer - NASH 82h EEE ol HA 221, 894 221, A 29! 3, NASH Pipetnes = _NASHY molsajciet =g7/Al ~ NASH Alstall iW FDA 7I9I=2I2) 2 NBM BR = 5p 9, e1OleH C2940): HH8I71 BeIRIO| BelRIC, 362 2, O}OLAK| (170300): NASH MoIsTA}e! ers 1 Heungkuk a |. Executive Summary . NALD(Nonalcohol ic Fatty Liver Disease, wi@haia) AME aelet, este wheel] his 7 gu, EHSY das HAE AAG SHS Mole ABs ae apPheGR oe] Vg a Be, wlataad AWD, sleds) A] PzHANASH, Nonalcoholic steatohepatitis), 7 Als, 7 AMER EBB: Agel}. ashe] Yelea| ose HAV AoA ayo] 5 ol4b 34} So] 71491 AZ U EelzelAle| (triglycerides) $e WSS Heeb We WF Ge A) BS, OU AEA TS BY, NAA Yah, NAG} Soe Dae, SRM ot HELA NSH Aa] HES Saat AS vs ofeeh. olf NASH aah) a £4487] Bate), W944 Wyse US PF Q ever Va Fee da as 7 BS Gola] Aaol AMS BH} OM ARAe|7] Bol. acy} NILE 7h Bohs oF SAL FSAO|7] OH NASHE Aaa SA] LPS el] ogc. olo| BY ALP, CT, Bal 4 dolar] § Hales A vel ot yt Deel ayy gle WANGIS 3SSeR Seve Aude ge Heee, Few se} ge lee Hate & Aa Be Ae] AES S icfelat Neh. 20208 SLE HallsleHH (off-label) F412 2.400% FRO} ABS YAS glen}, Alf SAL} eo NAH Alea) ALD} OVS Wd ee AasD lh. Aa MS UAE 7 Wo] ASSIS CHES ve, wee yee} NAFLDS) WE Aa} eo] NASA eG AS che}, Misia] Bele Valsad weal] esky, FAA, BBA Ael, Mole] AY 44 Plea Ay, Abs} asa, abs} ARalAs} vEeEelst eae F le Wale] BMAow Bese MUR Wess Ree eel gy SMS dese] ee shee He SAE Beteleh MSHA 24 sol GFE Velo] Asi] HE, FR AeMe) PE aa Seley, 53] 14 449] dy) az, late as ws aut az, @ desl aes vlale as SAAS AY Sole. PR AHA, ACC Asal, GLP 4-8 Aa, PGPI/21 HA}, OcRe/CCRS Fal HHePeL 7/419] CHES] 7PWS|st gle, acto} ofa] epgo) aesHs Dual SE Triple @¥io] Eelsz *el alate. FDA: NASH AlEAl NES Selsp7] Saf 201d NASH AKA PL Ab 7ho|Sebels Wah. ole Waaon Baa Lou}, oS HI POMONA] ASH NAS ATs AE BE Ae Soria te Fy NASH Als ge 71YLS ALES EAS} Buy, SHA 360,000 Ave) 7A] S|, AM OM USWA ugha aloes use Sobol AE}S Aolasheh ™@® Heungkuk mev/siels 3364 71d nie: NASH ll. Key charts ely AC! Zoln| NAFLO/NASH 2 aH NASH/NAFLD Spectrum Nomallner tense) wroteon stress flroemvemnoss “camera” O00 7-w BOY, son om asm sam 3am 2m | 1am 70-200 tmocesson aca ‘wmaorenmaa ‘a ce Bay ie Snes avr, BASH AHA vaya NASH Alaa AIRE eB ete 5,000 NASH ALS AIS AS 2.886, 4,000 3,000 2,000 1,900 ° ee ee ee TE hakate Prova, FRED SAUL 2u3 R91 Agziel Al Wer ae cr] oe uielae ae Becta ngrg Sat Tell BE leet ABs ue ao ot 28 ol 28 ol apari® ele Av 72 aval a 28 oS BIS Avo ABS o1Sz=e wo ot Buse aa 2 07 ae ot aBteoict BB eAwote ele ape EBteolet BABENe, dae Sa asad 2B, 7a 20 BS 2 eit ay ot aca 288 eaas vise, awe WE Sania Veal Coronel 918, TAG AW, SSSA TAT 1. ger sto12. Bq Heunakak ee AITO, 2124: NASH T.NASH AIS G3 YAY NAFLDS} NASH #1? NAFLXNonalcoholic Fatty Liver Discase, We) ANB! alaolet, Bats Heefo) ge 7H, ALAA Wb HARI BABA FAS Mole AMOS Pe AH ols] 2) ‘OE HE, MLS APD, lela APHIS, Nonalcoholic steatohepatitis), AS, WaWSs Rests added. Mss] Wel Sxose Dae aoa ap 9] ok Olt aslo} 7A14e Ale Ul Belted Ae|= (triglycerides) S2 AVSS Heh 2s AF ee AMS, ESAS BE lel, NE Sash, AG} Gow al adh. abel GALS] NLD SAEe: HE APSO Weis], NAHE Wals|ane Oech. ee 2) WANES WAKA aoe) Ae) Feber False wale ie aeSe] eve MAE] A]ze}] SS IF NALDS} 4IZHE eel NasH= ZANS]T}, NASH 2b] ef 208g Abs] lod ehh Zravios: Aas + ge}. wee Aedes Sete) oF 12 ee} A AESHHO)S ABTS gles waved. NALDe| He Fe] Maps] TSH, Ce Aho] ok oar SxIsfo} 7pala|el ALE YF Eel ‘Hee (triglycerides) Fe AVSS HIT, Aes] Et He] ae ww ot ey & UA Boe Bole}, we atsre zsleo] olde] 44 BHF 2g, vale} B+ she 30g *IRtolojor se), ayvHeel Zhalah, wlolelAg wel, ey S che Wales whalsley abate. SEM LF FES MSI AMS) AMES Sass Ae MS fei. ols MoT Aaah 7] S194 4A] Mate, aes Woe eat WS CEST Wg Faz elo eee ANS eal] aado] Alas 247) whe aleeiol7] sze]ch. alley} NARLDS 71 al Babs OPE Stolz] AES NASHS: Aeks|at gles] eb el] fee. lof AHF AGS, CT, ARS Yelialel Weish= Walepa vio] eel] S ulalgea alt wel aie 7h ete) Aes eH, nas NAFLD 29) 2s 2& me aa css! Smpk soatoss Cass 2 ‘Stealoss and lobular itanmation Css 3 ‘Steatosis and ballooning degeneration Css Sleatosis and balloring degeneration and ether Maly hyaine body a boss AMO, FRET AMIRI 6 Heungkuk IQ} /4}012. 1. daca 2154: NASH 2a? eet OHM NAFLO/NASH BISH as NASH/NAFLD Spectrum net Nasi Nast Nase opatccetaar NormalLver —Glesoss) vofross —fixoslsfrossrchrhoss carcinoma O00 -" teomeiGth spay om asm oom aaa zm | 1M 70-2004 ‘ocatsson 9 cant vwivour cess AB nea Sec aves, BER STRATLET Ses NAFLD 8 Gal irhosis AB Fretior iy Parasleey, B38 OWE] AITO, > Heungkuk 71 NIA: NASE 3368 NASH AIRAL APE 2 HR GA MSHS ASSOB SWE Ale yHo8, Hee 4} aUgel olzE Ba} TRE Ache BFLAle) AES S 7] Be}. 2a 7]EOE Halle 2H off-label) SMOR 2.40028 FV] ADS BAleha gov], lo BA, gow NA aTzA AAR 7h OHS YQ OZ as|D seh. WAL MSI clazz 7PF Wo) ASST HES MEE, SLoteleleole}. POA MASiel AGS TER SEES OAeEES Asia ge. BEB Pegs} ease She ASI RLSo}A AW yEebO}, MAINE Gael Pest Walale] BY rhssha. nko] 2%, sbi eeu Abe rHssiehat elses we Sa] MSI] 7H FS AMS ASAI}. lovely AS Pe] AWS ade 908, Ase] BAS asec setae Meh Aalst Ach, Ket apaete] gis Abel, Al MEDS Bol Tose] Ae NASW wet + seks BS Fekeea whe ales] a4) & ASTILS V+ 3d. uo NASH ALBA APE 2 Rh coats 5,000 NASH ALS Ala AS 4.885 pole «onze «=~«taE:*SC*«éME:*C*«iCS*«é ‘a auate Pree, BRE SAAT B® Heungkuk series aaea 71d nie: NASH a0 ABBR NASH 24 BS 90%) 80%. 50% 70% 0% 50% 40%, 30% 20% oe 15%, oe 10%. ox + 10% out PPAR” VisminE FR Slhmarn ABUB — agonist, agonist agonist ‘eas ISS ER, BSSN ARI ag ABMS UZ eet A AS 35% 20% 25% 20% 15% 10% 5%. ox 4 10%. ot PPAR VlamnE —FAR—‘Symarm MBue — agonst_ gon agonist I oan 4 R91 Aga Ala Wer ae a cc seeie ae ae clatigais Sat ee pcs ay oie a set sigaelele glee Med ig alee ale BB OSL ANS 7RS Aiea ASRS nleze9) Be ole aa BSE ay ot 201s we oe -Palasalt PE AAlvoIe! Acta saalasotch -Balasale ‘Palgolc, Ziel 3a asaael 88, 284) aks aa let wy ot smteiBele v3 ae eas iso, aztlet IB Sumiza Veal | Castroenorl 018, GAGA PAS, EFST AML 1. Heungkuk _ Mey Hels 338m 218 nel: NASH 9 MIERIE + OBRIES Et SEAINASH with T2DM, n=105) Te BIERIE 7h NIEIEN2SelEHS enc conn MO) vow sexo genoa aco ewan OO x soxiorees ‘ast 10 v0 to Ayaincoon) anal awsio0i8 eeinn018) ‘BAluteslpH0.022) vue sue ‘oun ne ord soy te 20 eau ta ‘Baca ates Coe OW, BAST ATA 234 MEV ASN THE NASH 7AM AS Sa WE wae a eon teri ne ma 96 2660-00 sASsegereet eT} 90-0001 CCnarinNASSm bine —-1S8037 9994013 4942036 3442029 410202 2001 Sete mone W249 7G m6) GH — 2940) Heungkuk er/HLoLe aaea 71d nie: NASH eUSeE Phil uvlal ASS Falls} Veg aAlalee ele MASH oleh. aPE 34 AWS FHAES BSA BS Abe) Eze, IL-6) Abe Salslzi, oF a] ASILES MAES), MAE, BSP -S GO Aa WARS Beh Cul MSS ASAI, ER TAAL, AY SAM Bde ole] Ao) ERSe WCE Bah) AD, HCH SA, BES S71. ACh Ae GALA Fe Tha, IL-6 S Ao] SAMS UAE UH AS 443} lea AAS feeaeh, ole 29] ARS, AS, ASol chal SHAS} ae WAAR Fa AEA, AR Palo] lai Geos eel HC BLT AT, AE Seas Shalala Ast 2 FS pelo) sels] Aes GI. Fz R/O Maa, 1008 BPS lala, ahete-3 lala) S2] eee] e424 vealed] alas}at gic}. Che BARS HSCe] NASH Bel ALSolAle| Hetoleh. LR Fah ACHE, DAP, AZS| AE BS} THAR AR HABA WSS AolEAKI, ABIRISS Ball HSC Sga}-lle}, ols yale! WSC Bebb ches ths wel, AN Fel de] dy BASS Gee, ole Ses Hat AES) 712 Guile) ahs ebalsiziy, Wsce] Myss Talal WESS ose] ABST Me. Fel eS Sess BAe) LOL”) AlaaVh wes NASH @AHSo} le] LOZ as] Heol chet ehate] alae]at ge. 1a) NAS (NAFLD activity score definition Ten Definition _, ‘Slesioss Low to medium power evalition of parenchymaliwoverren steatosis Grade SE Tobilernilammaiion Overall assessment of alliniammatory foot ll Wotecl o “ie ber B00 xed 7 ~eatecpa aborted ———SOC~“‘~—;:S*«~ a 0 i 34 Tes par B00 xo Ballooning None Fon baloon cals alefporineni balbaring 2 nas: NatNAS ee Bordering 8 NSE m8 {HB Molecubr The apy Nuk Ais 2015) 6 252, BREA ARNEL a ig Heungkuk (feels 3368 2124: NASH 3. NASH Pipelines NASH Bto|Hetohs 2187/4 MaSHAleAlS lel S>go4) cee Belo] zee] Gol], PRS alee] At aed So) . $8) Ja So] ob ae, aalel SS ws Het BB, 7 tsb aS Pale Dae: SUNOS AY Sele. FRR 2}GA: FIRFarnesoid X receptor) 2: ts} 24o| Seal Washes +8aolch, Bee FuRSo9] 4iel eles alls} Gysre Qe aeishat, elevel Wade Saleio}, dal oe US) AAS 2a}. ARAOS SIEVE Bore} Ae] OCAobet cholic acid)7t SUC. OCA Zolotd ella STAstolAl Zt AAS 7A oles VEsES}>] FDAS} wel 4) HUAS ABM, MAS VF FAAS AFI] Sele Asa, al a EVE ROGENERATE $7] abs alagshSt gE}. AC Alaa: AOCCacetylCof carboxylase) 212) 4'21 Uh 2212] AA] BA acetyl-Carsh SHINS malonyl-Cors Sula] ALE Ay AIS HSH, AE AHS ehalall ApS & Haeeh. Selaks 2020kdel MSH FRE Accalsal SelAbseAebe (Pel6221304)s eet CAO PERE, >t FY 26 DGATZ Aaalel lyr Lee Pr-OHRSTTL) 2 Qo} WAFS] Mic NS AGSOZ VOR MM MACEM OL zg eal aad 28 Sel, 20244 gee! alyo]eh PPAR 4}: PPAR(peroxisone proliferator-activated receptor) GE a} 3g: 2a ahs es Bash elabel 48h HEalelch. PPG Ze RA HAAS) Wel SUSU], PPRaS] BIS Ad PES VFM, AMAL MISH, 2d HS, RoR eS ees Haze) WS fetch, Pry GA sea) Wsiead, aed asiel at ott Zu HES AIS ely lee Was dole. Ae) HAS wa Salo] els ASHE Fisch wht Fae Vee] seh. ARGNIT)S| Bef] Bebe 27} USEC PPR Atel, AAHREMLIE IDA] 2s} Fle ws ols USP A Kain Ve Suse. GLP-1 484) AHA: GLPL(glucagor like peptide 1} 24] 434) 4] chee! BHIDS Sale} 2, PE HS ahs Ho] Helse SBS. GPE He) HH EUS a wel] H8He|7] HEH DPPtol| S}a HaHE|2] GH GLP-1 4-84] AMS eleiow He) Ale Ae. GPL Pa) BAG BS Be, AS a4 F UMS HSS Bolted, 58] Nsiel shal he] ayy 42s} es we ASKS welts Ree dealt, ig Heungkuk 3368 AITO, 2124: NASH LONL2 atl: LOX(Lysyl Oxidase) Al@2] Ht Hel Alt SRS Salehe] 7 AAS Be, Bl Hales alec. DelolsAbola Ae LL HACE Aalshe Yale % Simtuameb (4H ABOU, IE eo Al) we YHOU YESS Wy sate PGPLO/2L APA: POLO eee Ab ASS Ste, ANAL Md SS Fpal4y7] 2B, 1 Pea Hy R RES aS cali, ee dae} Sed wll she] Bs FFI9+=A)7} al Habgch> APaeyt seh. PaZL A) EES} alalcAbl Helsh> a) ghee aD de wl ele WS Yo} sp] zieleled. He WESHL als Sol7] shal sof ASS uu THEE Atel det See Moly alas Ah, Ocea/OcRS atl: COR(CC-ctmokine receptor) 2] ABaks VHF vlawewals a YS aoe Beis DAA) Wake Feel ze] {Maks feted. Nass} viet ARS coRaY} CcRS7} APE ATO WH-7t Beh. Welz} Cenicriviroce] NASHS] AES AWE dss Mie, Ws wey IS das ade] Sess. ASKL Aisha: ALE hol} ISH PISS shel AIK AP, aS, ANSE Salah ch A Mae, AGASS AMIS Sabet BS, Sel AY, ES] 78 alas Geel F Aas] Skee Ze TG Ba ab) alee}. Delle 7h ietebel ARAL 4) MASH ASSS] aS AlefoR Selwe Roe 7hmou was HAA WPS Sab] Rein) Ie] Oana. AIS/BtO|S "@ Heungkuk 71k Nel4: NASE 3368 2517 QF 2/324 BA BA NASH Pipeline 87140 Be ‘I Naure Raves [Casvoariaraby & Hestgy, S352 ANTE, vas NASH Maal 27181 cae wa ual Hepnaby 278 vel 8, SSH ANANE = @® Heungkuk aex/tiols. e368 71 2124: NASH 28.13 Pharmacological agents under developmen or eaten of NAFLDINASH (1) ‘Highest developmental stage/ ase Tents tn cons Ee nde van soon rian rcstPramamiiat —yergey pus ineen Pha Grid mete rian srerxPhamsece 28 crn TwofocrUNS) rer BAPRar — stom ann vrs ee — vo NARS coma we sa Ran craraPramndiie Ph 2aNETBNE EH oser Piao Gla coe Pos NTRS wen PITS a a od sr rte Shofiomscecee —__PassaNSTETETN Flafbranor PPARa/d activator Gent Phase 3/NCTO2704403 oreo sens real 2yrDeraey Ps nero visi Pon ate ira tame Pr heres oto bate en Pr here coeare sec evi Gi eres Pham cons esr Acoenbrw Pie Pr 2a NTozne ee fan S00 Gates Paracas an ozce Pct shone reo 9A te Note ram aeroierere esr Set Pir Pi eos — en Vises Pam aNCTOT eon Te tr ri Vina remnden ha aT 1a SLT be Nos Pr ANTONE 0 rer “ a Erte Phe = cons ti Contant via NTRS Scr 196 Gi Sere Ps TORN SSC nfoTnedoro char Pg Pre NCTE nie Annan al (azD4076) _microRNA~ 103/107 Requirfaskazenenion (giscontinued)/NCT02612662 "AB: frontersisEndochokgy2018), BEM BARINEL IQ} /4}012. a Heungkuk 714 N14: NASH 53120 Phamacolbgical agonts undor dovlopmant for toament of NAFLD/NASH (2) ‘Highest developmental stage/ Ones Tastt ion compary reper —————E——— va supe Plo oe ancrioe Cees atone Ain Pr aNoxoe70 avers ae socom Sesh oetomPhamats Pas ZaNCTONETSS coat Helier oti Gale Ph acronis Tipelukast (MN *t i ie LTPEL-40 rnb Wadena ase 2aNCTERES5 Nair FS “Ranacost Twat Pamaconca Pas 2NCTOMGERT cree ‘sat at a-fteBoptoma Phase ANCTorora14 Dee r=) eee D8 Bopwmaltmrne Phase aNETOZOASA oNO-2 Car be Gath Tesoetes tae ONCT2ACIET Pra 2 Smaniraies- Lowaentr GikedSserems (corinne, _ SST croer279 BS DINO = aa 7a te rkrous Preheat —— ete 2 inmaen Pra 2ancronter? setrenyen taco arte conga he Pr 2NToRO59 Fosos1 HI bir FotnarraRoe Pras N20 s0700 Laveen ‘si Bram Pras INTIS? vow Fors rao vow a0 Pras 2aNCTEPNSYE aus-286%8 Pras NCTA, (PEG-FGF21) FOF2T analog ews NCTO3¢B6912, Lilie Lr want Now Norse Prac 2nerorzri9 Sensis Lt eran Now Norse Pras NcrIeTIO? Pras CTOs Stagipin Dep s rnibeor sD ‘Not apolicale /NCTO1260246 esin ao tr os Nevalese heigl? apa sanaesee nl Serums Pras 2NCTIOTI9 ucaonie-t ecpe oe el Med Preelncalenaie ussoonCPIL ep il Phas Ch laa vansen am a Paracas aa aes, Neuse corer vow a0 Preelncalenaie wasree cara i anonst Yates Csraon Prelacalenaie "RB: FrontersnEndochokgy 2018), BEM GAANEL a. Heungkuk 3382 38121 Pharmacobaical agents under development for veetment of NAFLDINASH (3) ngs Target of Aton Company Tropiexor {JNAS2) AISE/ HOLS Jie nie124: NASH oonenos (ove) PR A9enst + CCRZIS cual antagoist, Novas + Aegan Phase 26/NCTORSI7S40 Selorsaris (G5 deormeg ggve+ ASKCT nhbtersACC inbter+ PAR Goad Scunces Phase 2INCTORTEISHA, 5-9674 eacrist NeTaseaa446 "RB: frontersnEndochongy2018), BBM @ANNEL 282 BOI NASH ALBA R718 RE Poe, F358 SAAT 20 ig Heungkuk (feels 3368 2124: NASH NASH A12AI 7% FDA 2ro|E24e1 ASHE NAFLD] SMES MAbs) alalsl= Seb Sle Sako] Salslz) 7] aheel, 27 At R Rt felch. Weaglel ea] A zy Jajah Aaaiel AS wSoll shal Be Ae] Qelel Sa Wee = NASH Aza MARES Biol eat cabele Aalsheel oe Al Sey, elo FONE 201B%! NASH ARAL 7NE QE lol seals WHET. lt Cade. QAR AAS WOU, ols cls eo} VWatsh= MAS Alea I MhYS shehah Bata eich, FDA NASH2)RA 14} Awol glo} eletel StelAHKGeneral Consideration), 271 242 4, £7] WA, Wastes] Mew 71S, eb del, ws AVP, eee ate} 29S tat NASHs] SHI Aehe OYA HES] LAVeIe] Aho} ele reset] ole AGA A AS WAG AS AHS AF Ase slo] Paes Hl ae4 sel eos 188} AAS AAD +H UES MbolomlS AMAL ale eleetat slo}. Se) zeae] w E S49 Melgevls BSE AST aspartate aminotransferase)9} ALT(alanine aminotransferase), 7 AME B24 AEs Ye Vt GAs Poca} aes B4e AS UM. Le 27) dolls Mais] ABA} Baolal= eat, Bap w WAYS, AOU, ASS USE + Me Vd, Bale att SS BH + leh. 7) Wasa BS BAU AS A Ae Bale Bee] S7HE IS RIES al) AE AE AR Ich. MIR We] Saeaow Avis] eps BS deta VF ABA Ae 12-1871] }°F ah, 8, VSS MAb SH] BS, MASH AHSAN ALTY AST 4s ZA] A eleie] ol} Sv 24 et Uae ate se + one, hg eee wale, MebE 4 SS EES Mss] AWSHS BEE OES, ole] aMPe BASS 67h ©] FSS Soaleh gepst glatehat sly. 4 CALE double blind, $19F US eboz Aaeho} sie, WS PLL] AP. NAS GN ARS AF sol 7} AHS Halt AM] Vat, Aaleow ayes] 240] all ASIEA) OPE B7telok Beh. AI] AIL aye Belo] gov, MS A+ O- 19) BS 84, URE Sasls] oWoe Bole eAR-SO] HANS NISL ORY ALES} ES eee o}4) MRs|7ie, ABS] esKNIS a 2 Baa, BS, WS ate] Sv} Mart tigee ae. 21 @ Heungkuk mev/siels aaea "225. Endpoints in clinical trials on NAFLD and NASH onsen | td iron, —— hee ete EE OURWAL OF HEPATOLOGY, Ag Heungkuk 3368 HAIet/ toe Jie nie124: NASH 23 AIS /BtO| 2 1@ Heungkuk 3368 2124: NASH NV. 24 SS 1, GUIS (128940): feH7] SaNeto] Bzigich. 2, SOOHAE] (170900): NASH MFolse}e! Bo 3368 Aist/wHole OMe 79250-2836 rhlee@heunghuksec.coke > Heungkuk BUY aa aaiF 7106/14) 38cm apie ase S204 aa pea eames 203218 cord oso (4) Buea (12) 383 (220) aa) ow aE a5 AaRRIBORI a5 a a ag 76 eon ® rar 10 KARE 2 BS on one ae PR as a Se ESI 63 Hess ot OE i Ww RH i 292,0008 23.2% Ss a0 70308 238.008 oun 18 a8 100% ak vo Toe 85 8D isa 552 8 8,8, Wel awe aE an 12681300 "3 ie eats a7 @ 7 Su 5726 S08 55 alt ur a me 12484 we mow 02 02 02 at 83 S18 Sui ar 6774 Gr nose, 2 KOSPSHRI. AITO, 71d nie: NASH (128940) OFS gro] OFS oh] Bao] Sagi SAE sloletagol lal A212! Buy, SEF} 360,000R22 HsielA| € PAIBICL Holes Valiaionol: Gxt QI) Sel DUAL agonist (HM12525A), TRIPLE agonist (HM1S211), Belarafenib(HM95573) 2+4i9} 127181 FWD O14} EBITDA 2,128%48I0H Targel EWEBITOA 164 SE! 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DhstIch EX|SEMLE HERZ Exon20 Wo] W|-eALEH| ef Xt CHa At ‘SAMS WASH, SA] AMERAIol 2015 2Bol BlolMActRS| sich. 2EE29| HER2 NSCLC 2ka|aM2 THE Qaed Was ez FOAO NOAS AI, Sal 118 2 Mole BE Atelzpssich FA RED Holme}! oe ‘SALE NASH, NRASHO| THe S chest Ho|Zelels SrskR Ach S| Dual agonisti= GLP-12} GCG 0|S4t8M2] NASHA|ZAIZ 202014 88 MSDol 22a 7H/ Bol Werks elolirotse wc. 20210 7M Se fH Yaewel] Soiztt, Bet Y SEA ooloi, 2 Mol Br WE 7) HEICH Thole agonisti= NASHS HSS°Z ste GLP-1/GCG/GIP AS ASMZ, Za YOe SRY Bars SAA sew} TIME SME pan-RAF Mala] BvIEMES 2016 MESO] & Moka 9941 AB} Siejol Bol of-BAHCL 202114 SH ASCOOIA MH BANAL S 2} BE BEAEG, NRAS Hol SHB aA} 1398S GNOZ ORR 8.5%, mPFS 73H] BI} SBS} MLSS NRAS Ho] SAS BAIN Se BAe aS OOl|S WIESE YPD-1/PD-LIAE 2 BE NAAS Hol SHA RAS MIE COS Bele cle, ES SUM W/EIMESNO| IBY INAS wasn Uh 25 x Heungkuk 8358 1, OHH] FDA Sel Ot 2 Rolontis & Poziotinib: ‘SAKE ae) SHEA, MAloe}y 27 Bolstedelol) Hal MO Sel ot Aaa alae] oh. 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