hasic Liquid Dosage Form, Monop Pe n pharmacy are either mong sed ii a $ comonly a form refers to liquid prepa, ie eo Ss It is represented by true Solution ly one phase. . at is prepared by qi... in which there 18 Of homogenous mixture that : ; Spare y disso. true solution is a clear The componen: s n Presen, i i ag in a liquid. ‘ dey et as ‘solvent’ and the component presen i nt S in large amount 18 E ‘solute’. small amount is known as ‘solu Liquid dosage form: or biphasic. Monop! Classification ceca: ; Monophasic liquid dosage forms are classified into two groups:— (i) Liquids meant for internal administration, for example, mixtures, syrups and elixirs, (ii) Liquids meant for external administration, for example, Sargles, mouthwashes, throat paints, douches, nasal drops, eye drops, ear drops, liniments and lotions. MONOPHASIC LIQUID DOSAGE FORM —T EXTERNAL INTERNAL MIXTURE SYRUP ELIXIR LINCTUS Aeeucatoy — USED IN none INSTILLED SKIN THE MOUTH io Bopy CAVITIES UNIMENT — Lotion GARGLES MoutH THRo, WASH Panny DOUCHE NASAL DRop SPRay 148 ae a @ scanned with OKEN ScannerpNOPHASIC LIQUID DOSAGE Fors s MON os 149 © qs MEANT FOR INTERNA, ADMINISTRATION woe preparations for internal administration includes following Lia of preparations:— ae" (1) Mixtures (2) Syrups (3) Elixirs (4) Linctuses (5) Aromatic Waters MIXTURES A mixture is a liquid preparation Meant for oral administration in ich medicament or medicaments W re dissolved or suspended in a ssiuble vehicle. Generally, several qo es ate dispensed in a bottle, In case, a bottle contain one dose, it is called draught, Mixtures are not Prepared to keep them for they are mainly prescribed for acute condition: tion, diarrhoea, Constipation ete, extemporaneously prey a long period because S such as cough, indiges- ‘0 the mixtures should be Pared and supplied nly for small number of doses which can be used up Within a short Period. then a fresh mixture j @ Simple mixtuy tures contains only mixture and expect res containing soh Soluble ingredien torant mixture, Method of dispensing (1) Dissolve the sotia 2) Examine the soluti foreign particles uble substances : Simple mix. ts e.g, carminative mixture, diarrhoea Substances in 3/4th of th on critically by holding it against the light, If are visible, strain it through a Cotton wool, Add any liquid ingredients, Add more of Vehicle t Transfer the mix: Polish the bott the bottle and le vehicle, @ 4) (s ‘© produce the final ture into the bottle, Ci le to remove finger prints. Attach the label, dispense volume, @ scanned with OKEN Scanneraining sOgIUr savy” i due (0 atmospheric oxidation. ing agents + No special colouring agents are ntain coloured medicaments. The following flavouring agents are com- reson. ion yates cont added but url mixtures co rin agents : used in mixtures:— ic water such as anise water. ning children’s preparation. sk the saline taste of certain i) Aromat! (ii) syrup and glycerol for sweete (ii) Liquid extract of liquorice to ma mixtures. over the taste of alkaline citrates. jrit to mask the me- alts in paediatric’ (iv) Spirit Jemon to c (v) Orange syrup and compound orange Sp tallic and astringent tastes of iron s mixtures. @ preservatives : Diluted vegetable extract and are the source of growth of bacteria and fungi in mixture. chloroform (0.25% v/v) and benzoic acid (0.1% w/v) is used to preserve such mixtures. flavouring agents Hence storage of Mixtures Mixtures are dispensed in plain glass bottles with uniform internal diameter. These bottles are available in three different sizes to supply mixtures of 60 ml, 120 ml, and 240 ml. The mixture should be dispensed and supplied to the patient for not more than three days to prevent deterioration. The bottle should be fitted with a suitable cork which will ensure its easy removal and to prevent spilling of mixture. The mixture should be placed in a cool and dry place. SYRUPS A syrup is a concentrated or nearly saturated solution of sucrose in purified water. The concentration of sugar is 66.7% w/w. The syrups are sweet viscous preparations. The syrups containing medicinal sub- stances are called ‘medicated syrup’ and those containing aromatic flavoured substances are known as ‘flavoured syrups’. ” @ scanned with OKEN ScannerPENG Pap ty ‘ups we Advantages of *" me oxidation because it i party Miho, (1) Syrup Paieam such as, laevulose and de: s * hy reducing § decomposition of many vegetable sy stances Sy (2) It a aeeate Pressure which prevents growth, of acta hae ei moulds which are the chief causes of “mos fun 156 i tter, tions of vegetable mat a ey are palatable. Due to sweetness of a isa ah, 3) vehicle for the administration of nauseous and bitter Subse Methods of Preparation (1) By simple solution method e.g., syrup, SYTUP ginger, ty orange and syrup lemon, Example 8,6 Prepare and dispense 100 g of simple syrup Lp, R Sucrose 66.7 'g Purified water, Sufficient to produce 100 g Method : Add Sucrose to purified water and heat it to dissolve sucrose with occasional stirring. Cool it and add more of purified Water | to make the required weight, Example 8,7 Prepare and dispense 100 ml of “Ginger Syrup” rp, B Strong ginger tincture 5.0 ml Syrup, Sufficient to Produce 100 mi Method : The Syrup is prepared by mixing strong ginger tincture in small Quantity at a time With syrup, Tolu balsam 1.25 g Sucrose Putitied wa Method : Add boit the tolu bals tared vessel, ¢, el Tightly and boit ty oa ents aif "an hour, sting Frequently. Add pure’ water tg. SeMlly for Specified weighe Cool, filter the sotutign and add sucrose. “4iUSt the Water bath to ; dissolve the sucrose, Finally add surr, : ‘© produce the Tequired volume. " 66.4 9 "eh Sufficient 10 produce M8 purified water to ™ conti... ‘ont, ‘Over the vess, ‘dined in a u feat on cient Purifieg Wate @ scanned with OKEN Scanner|S E FORM § MONOPHASIC LIQUID DOSAG! che ae (3) Syrups made by chemical int gpense Il Example 8.9 Prepare and re food). ferrous phosphate 1p. '55 (Parrish’s of ction y nd sy f compoul 00 ml 0 438 ® on wire 48 ml Phosphoric acid 13.6 8 Calcium carbonate 1.08 Potassium bicarbonate 108 Sodium phosphate 3.5% Cochineal 700 g Sucrose 50 ml Orange, flower water 1000 ml Purified water, sufficient to produce Make a syrup t. Direction : Two teaspoonful to be taken afier the oi 25 ml Method : Mix in a small flask 20 ml of Phos E ao and heat Very of purified water, add the iron Wire, cut into small pieces carbonate, gently on a water bath until dissolved. Triturate the a portion potassium bicarbonate and Sodium phosphate with the sare ie it the ng with water in a capacious vessel. Ai an solution of iron phosphate, Boil the cochineal with water for al ai 15 minutes. Add the Sucrose, again boil for 15 minutes, cool , strain anc add sufficient purified water to Produce required volume. Filter into this syrup, the solution Containing phosphates of iron, calcium potassium and sodium. Add the orange flower water and then sufficient purified water to make final volume, Filter, transfer into a bottle, label and dispense. € place during the Preparation of syrup, Fe +2 HPO, — Fe (HpPO4)) + Hy The following reaction tak CaCO; + 2 H3PO, —5 Ca(HyPO,4)) + CO) + H,0 KHCO; + H3PO0, —> KHpPO, + H20 + CO, NajHPO, + H3PO, —s 2Na HPO, Formulation of Syrups 1. Vehicles ; Syrups are Prepared b Potable water should n Contains both volatile a 2. Adjunct the formulati Y using the Purified water, ot be used for Preparing the Sytup because it S well as non-volatile impurities ts : The following adjuncts are Senerally added to improve ion of syrup:— @ scanned with OKEN ScannerDISPENSING by \ Al itol a My 5: erin, sorbitol and PrOPY Leng 4 "eo, jiners * eve, chemical stabilize ity to the syrup lo Peveent the ep sta @) Olit small qu Nurfactants Tike tweens can pe llsy adda” ain S 158 A Comp. a ae ients in the s nb of SUOFOSP: solve certain ingredients in the syrup ma to alss with syrup a clear syrup: ts: Many syrups are attractively Coloure ; artrazi Wig (b) Colouring ar as amaranth, compound tartrazine ANd grog eh coal tar dyes sue / 8 and tartrazine. + The following flavouring agents are gg (¢) Flavouring agents * are the flavoured syrups:— to preps . F in simple syrups ne tingture lemon, and tincture ginger ures : SU i) Tinctu a ae ‘ Fruit juices : such as raspberry juice, wi y, (iii) Essence : such as vanilla, orange. ew Gili)” Bssene : The syrups containing 66.7% w/w of Sucrose (@) Preservatives otic pressure which prevents growth of bacteria have high ost pest preservative is needed. Genera fungi and moulds. ate, methylparaben are common benzoic acid, sodium benzoate, methyl pat te al used in appropriate concentration. Use of fe container and closures is also effective way of preserving syrups, Storage of Syrups ; The syrup should be stored in well dried, completely filled and well Stoppered bottles in a cool dark place. The syrups should be stored at a temperature not exceeding 25°C, ‘The glass bottles fitted with white polypropylene moulded or black thermosetting plastic screw closures are commonly used for the storage of bottles. These bottles may be colourless or amber coloured (light Tesistance container). ELIXIRS Elixirs are clear, Sweetened, aromatic, hy i ids it ; a ned, * hydroalcoholic i juids in- tended for\ oral use, The main ingredients of elixirs are ety! alcohol (5-40%), water, glycerin or Propylene glycol, Mavouring agent, col in Seent and some suitable preservatives ee Medicated elixirs ueualhe ne 4 potent drug such aS, antibiotics, antihistamines Rae a " flavoured elixirs are non-medicated ses. ee fed and are used as flavours and Exam, le 8.10 Prepare and dig i elixir Lp, Pare and dispense 100 mi op Pipe Tazine citrate @ scanned with OKEN ScannerF «¢_ MONOPHASIC LIQUID DOSAGE Fors 159 cs Piperazine citrate 18 Chloroform spirit OSI Glycerin ; 10 ml Orange oil 0.025 mi Syrup 50 ml Purified water, sufficient to Produce 100 ml Method : Dissolve the piperazine citrate in part of purified water, Add the orange oil, glycerin, syrup, Chloroform spirit and sufficient purified water to produce the Tequired volume. Example 8.11 Prepare and dispense 100 ml of phenobarbitone clixit LP. % Phenobarbitone 400 mg Alcokol 90% 40 ml Compound orange spirit 2.5 ml Glycerol 40.0 ml Amaranth solution 1.0 ml Purified water, sufficient to produce 100 ml Make an elixir, Direction : Two teaspoonful to be taken at night. Method : Dissolve the Phenobarbitone in alcohol 90%. Add the compound orange spirit before adding the glycerol and amaranth solu- tion. Add sufficient quantity of water to make the required volume. Transfer into amber coloured bottle, label and dispense. Formulation of Elixirs 1. ‘Vehicles : The elixirs are usually prepared by using water, steohol, syrup, glycerin, sorbitol, propylene glycol. ‘The water is used to dissolve the majority of ingredients of clixit. ‘The flavouring agents containing essential oils are easily soluble in aleohol. Certain medicinal ingredients of elixirs are easily soluble in alcohol. $0 alcohol in the Concentration of 5 to 40% viv is used to make a clear solution, Glyc- «rin, sorbitol and propylene glycol are also used as vehicle many a times 10 dissolve certain drugs which are not easily soluble in water and cohol. For example, paracetamol is slightly soluble in water. So it is dissolved in a mixture of alcohol, propylene glycol and glycerin to make & clear elixit. Syrup or flavoured syrup is commonly used in the Preparation of paediatric elixirs @ scanned with OKEN ScannerSENG Py ‘Ac nets are generally Addeg t % Hh jxits— chemicals or Speciay So «The various le elixirs. For ex, Mey the form sizer ¢ ake stab! . Mle cen ay ln ded (0 ast he PHL by ey are used in ANY acid elixir on storage. Similarty iso, 4 ing of eli eze heavy metals that Cag ONLY Use « dyes are commonly 4, ; ing agents : The coal eaten tartrazine, Bree, 4 (b) Colouring ag ple, amaranth, me ing agents us, d and tartrazine. ence fei - : . ; : . (©) Havowring ie raspberry syrup, lemor rage black current , tation in elixj ne ld growth and ferment ing ee at fe 20% or more, pa alyeo), me cee asa vehicle. The high — Pressure alycol , ti elixirs which are prepared by using syrup, pt @ Stowth, f microorganism. Chloroform water in double Strength, Pexzie acid and methylparaben is also used as Preservative jn many elixirs, Containers Elixirs are. dispensed in well filled, well closed, ip “et glass bottles having screw caps, Storage Elixirs are Tequired to be Stored in a coo] Place, Protected from light, LINCTUsEs Linetuses are Viscous, liquid ang oral i ous, Preparations ¢ at are &eneral} prncrbed a the relief Cough. Ty tain ledicaments which tag, Cmuleent, sedati OPectorant action, inetuses. gp | en in 'mall doses, Sipped and Swallowed slo) ; re be th Water in order Ne the ating it ‘medicament Need effect of @ scanned with OKEN Scannersoso Ast LIQUID DOSAGE FORMS 161 $ ; & Chloroform spirit 2m Compound tartrazine solution I ml syrup to make 100 ml pethod * Weigh codeine Phosphate and dissolve it in water, heat iy. if required. Add benzoic acid solution, compound tartrazine een and chloroform spirit, Add the lemon syrup and adjust the out py adding more of syrup, v0 mulation of Linctuses a 4, Vehicles Simple syrup is generally used as a vehicle for most of the jinctuses. Syrup tolu is preferred in certain cases because of its matic odour and flavour. Moreover, it is believed to have a mild expectorant action. Invert syrup, glycerol and sorbitol solution are also ysed as a vehicle in certain elixirs, 2, Adjuncts (a) Chemical stabilizers : The majority of linctuses are stable because simple syrup is used as vehicle. Colouring agents : Coal tar dyes are commonly used as colour- ing agent in elixirs. Among them, compound tartrazine solution is most popular colouring agent. Flavouring agents : Lemon syrup and black current syrup are commonly used as flavouring agent. Oxymel and benzaldehyde spirit (almond like flavour) are also used as flavouring agent in certain elixirs. 0) ( @ Preservatives : When syrup is used as vehicle, no preservative is needed for the preservation of linctuses. due to high osmotic pressure of syrup. Syrup tolu has a mild antibacterial action due to benzoic acid and cinnamic acid present in it. The linctuses which are made in sorbitol solution or diluted with water are preserved by adding spirit chloroform and benzoic acid. Storage Linctuses are supplied in well filled, well closed airtight glass bottles having screw caps. Linctuses are stored in a cool place, protected from light. AROMATIC WATERS Aromatic waters are the clear saturated solution of volatile oil or Volatile substances in purified water. They are also known as medicated water. @ scanned with OKEN ScannerOM, Ng, flavouring agent e.g, “AMPho, 162 used as vase ters are aromatic va water IL 7 ie 68 chloroform water, Pepe. inati tet, pePP? od as cart in st «le e.g. chloroform Water, 2, They a ing vehicle &-8 water. ed as sweeten re ae US alti 3, They reused 8 preset’ 4, They ic Waters ¢ Aromatic Woe two types ar mai waters are © 0 waters 1, Simple aromatic 1S ion of volatile 9; 2, Concentrated wal a saturated solution I * Is r centrated water jg rn ic water re as CON simple somatic purified watet an water can be Prepare - ces ater. volatile substan we . ith 39 Volum, aromatic atic water wil les fines Ss ia of concentrated arom: ae rc by diluting one of purified water. enstruum €.2. chloroform, Mat fe me ic Waters Methods of Preparation of Aromatic W: ile oil or volatile Substance 7 : The volatile oil or Stane imple solution method : The vo rae is hisiel oral water by shaking in order to cor is diss into small oil globules, Example 8.13 Prepare and dispense 100 ml of chloroform water LP. & Chloroform 0.25 mi Purified water 100 mi Method : Measure chloroform and transfer into a bottle. Add Puri- fied water. Dissolve the chlor roform in Purified Water by 'Y shaking the bottle. Filter tray ® nsfer to a bottle, label and dispense Example 814 Prepare and dispense 1 & 00 mt Camphor Alcohol 99% pis Purified water, Sufficien og Meth t to produce 100 ml an tod : Dissolve camphor in, alcoho] «Add al i ada ‘or in smaly ortions to the Purified Water py fa au ee aditon More of purified ater 10 rode, req each ter, transfor the camphor Water to a bot rang! n tired le, label ang dispense “lume, @ scanned with OKEN ScannerptssIC LIQUID DOSAGE Fora i ‘Alcohol 90% a purified water, sufficient to Produc: od: Dissolve dill oil in alc, we umes with vigorous shakin, : gl oduce required volume, dd 5g of ya 4 keep aside for a few hours wi ic vl mio bottle, label and dispense, Os the precipitated non aromatic Portion of a solution. f lati 2, Distillation method : In this method, crude dru ini voile oil is subjected to distillation. The distillate is Sear iver, ‘The distillate collected have two layers; the upper layer is of jie oil and lower layer is. separ: ° toile ; ‘ated and on clarification, clear somatic water is produced. The aromati Ry ic wate i ethod is called distilled aromatic water, = Beene PY is 60 mi © 100 mi ‘ohol 90%, 0 ater each Add purified water in A addition, Add purified Powdered tale, shake it ‘ith occasional shaking. Filter, the oil and thus helps to make Example 8.16 Prepare and dispense 100 ml of Aqua Menthae Piperitae USP. 3 parts of dry pudina leaves for 10 parts of distillate 1 part of fresh pudina leaves for 2 parts of distillate Method : Place the drug in a distillation flask, Add sufficient purified water and distillate carefully so as to avoid the burning of drug, The distillate is collected in the receiver. The excess of peppermint oil is removed with the help of separating funnel. The aqueous layer on clarification produce peppermint water. Transfer into bottle, label and dispense. 3. Dilution method : In this method, concentrated water is diluted with purified water, The concentrated waters are alcoholic solution of volatile oil and volatile substances. These are 40 times stronger than simple aromatic waters. ‘The aromatic waters are prepared by diluting one volume of concen- {tated water with thirty nine volume of purified water. Many volatile oils consists of aromatic part and non-aromatic parts. The aromatic part is much more soluble in water or in weak alcohol than the non aromatic Part. When alcoholic solution of volatile oil is diluted with water the @ scanned with OKEN ScannerAR | i ' i « fine precipitate Whig) ing y ccparated a nce tale is added to abson th, a sett . Her jltration, per ac on on filtr tn, non ajnevert¥¢ sO ict golutto sty of . ah cant ot aon or -pwaL USE aro EXTERNAL ‘: pOR PATE types:— meant FOR see are of three {yPe le LIQUIDS 4 for external ¥ he skin, for example, inimen, rn an 9 the . 7 Liguids me applied to be app (i) Liguids ith, for example, gargles, rou lotions. in the mout, “a ee vaints. ds to Be Use and throat Pi (ii) Liq throat sprays and cavities, for example, ouch, ae tilled into boey eye lotions, etc, (iii) Liquids to be i rays, ey! 1 S| eye drops, nasal drops. nasal Sp) FE SKIN LIQUIDS TO BE APPLIED TO THI LINIMENTS ; i-liquid preparations meant for appli. The liniments are liquid or semi lp to the’ aL m cation 19 the shin,” The Se ae may be alcoholic of oily SeaaeTe eae alcoholic liniments, alcohol helps in the penetration of medicament into the skin and also increases, is Counter umitant and rubefacient action. In oily liniments, arachis oi is com. monly used which spreads more easily on the skin. Soap iS also included as one of the ingredient in some of the liniments which help in easy application of liniment on the skin. Generally, liniments contain medicaments Possessing analgesic, Tube- facient, soothing and counter irritant or stimulating Properties, A liniment should not be applied to the broken skin because it may Cause excessive irritation, , Containers The Jiniment should be dispensed in coloured fluted ottles in order to distinguish jt from Preparations Meant for internal use. Labelling The label MUSt state, + the bottle well before Use”, Th take stout he wer Sbake arr applied to pen Wound of broken skin”, Ythe “aing, “Noto - Storage Liniment Should be sto, tainers ing Cool place, red in “ightly Closed airtight con- @ scanned with OKEN Scannere g.i7 Prepare ane’ aispense 100 ml of {urpentine liniment lent fo & sft. on 9g pent oil (freshly rectified) & A purified water, sufficient to produce 100 mi «Mix the soft soap with small quantity fi tio otution of the camphor in the freshly rated orto al s nting 1 add the carephor Solution to the soap mixture with ituation 5 cgeamty emulsion is formed. Add sufficient purified water to i the required volume. Mix it thoroughly. Transfer me pottle, label and dispense, er; Tamer the prepare ‘ot prample 8.18 Prepare and dispense 100 ml of soap liniment 1.?, ‘ Soft soap 8.0 g Camphor 40 g Oil of lemon grass 15 ml Purified water 17.0 ml Alcohol 90%, , sufficient to make 100 ml Make a liniment Direction : To be applied on the affected part three or four times a ay. Method : Dissolve the soft soap, camphor and oil of lemon grass in deohol 90%. Add the purified water and sufficient alcohol 90% to produce the required volume. Set aside and then filter. Transfer the liniment to a bottle, label and dispense. LOTIONS Lotions are liquid preparations meant for external application without fiction. They are applied direct to-the skin with the help of some absorbent material, such as, cotton wool or gauze soaked in it. Lotions may be used for local action as cooling, soothing or protective purposes. They are generally applied for antiseptic action e.g., calamine lotion. Alcohol is sometimes included in aqueous lotions for its cooling and soothing effect. e.g., salicylic acid lotion. Containers Lotions should be dispensed in coloured fluted bottles in order to distinguish them from preparations meant for internal use. a @ scanned with OKEN ScannerFENSING py >, Fe » i cl id be labelled “For oi i y ing mind ut ca ses in sg be lal bd well filled, wel) a “ the store’ Therefore, should be “ny Storage sivas a cool place: ta air tight 0 re and dispense 100 ml of calamine loi lp 19 Prepa Example 8. 15.0 g % Calamine 5.0 g Zine oxide 3.0 g Bentonite 0.5 g Sodium citrate 0.5 ml Liquefied phenol 5.0 ml es duce 100 mi to pro water sufficient a sodium citrate in rose water. ae the ay ae ide and bentonite with a solution of sodium citrate, the refed pheno, Add the glycerin. Add purified water in Sufficien, the lig tity to produce the required volume. Transfer the lotion toa bottle, quanti cork, label and dispense, Example 8.20 Prepare and dispense 100 ml of salicylic acid lotion B.P. 1988. R Salicylic acid 20g Castor oil 1.0 ml Alcohol 95% Sufficient to Produce 100 mJ Make a lotion Drcton Tobe ‘plied on the sap (Wo or th ie acid in 30h of a Guantty of alcohol 95% a make fro! 95%. Add castor ito a bottle ang label make fina) Volume, Transfer ree times g day, Sl 7 Colaions ate liquid PPaton extn ti reel "2 mixture of ethyy er er ane ee ning py ans ei as aot They 2 When ether and alcoho) Sel evaporat a cs 2 gpultabl itor the surface of the skin Collodions are pave’ * film oj Pyroxy “olatle solvents are usea rts preparation 8 lam, ible because uss in @ scanned with OKEN Scannerw oPHASIC LIQUID DOSAGE FoRyas 5 . o sare available as meg 167 jodions ese Ieated and Cr alions are USed TOF protecting smal cae MMe form, Mea 0 ped collodions provide py all Cuts and ree H rolonged ¢ Cratches, i A ed contac les, Whereas ne’ 1. Collodions act bet a icamen Me Water repellent, m ” “anainets ColOTIONS shoul he W capped, coloured, fluted glass “i in the cap of supplied Separately, wil , ‘i The containers sh abelling tne S should be labelled «5, yt a0 indicate caution, “Highly ines For external use only", ipensed in sm, Vials with g Tals with a brush OF applicator Med aes” imable keep away from storage Collodions are stored ins . . containers in a cool place, Small Tight resistant, wel closed Example 8.21 Preapre and dispense 100 mi f pyroxyl . Pyroxylin collodion & Pyroxylin i Ether 15 Alcohol Be A Method : Add the alcohol and ether to the pyroxylin cont suitable container and stopper the container, Well occasionally until the pyroxylin is dissolved fained in a Well shake the mixture Pyroxylin is a nitrocellulose. It is prepared from absorbent cotton wool by reacting with sulphuric acid and nitric acid at 15°C. The following reaction ke place Cy) gOKOH)g + AHNOS 2H) gO NOV) (OH)>+ 4H,0 cellulose nitrocellulose Sulphuric acid facilitates this re formed during the 2 would lead to defective nitration of the cotton tion and also absorbs the wa action, preventing dilution of the nitric acid wivich Example 8.22 Prepare and dispense 100 ml of flexible collodion LP. R Pyroxylin 16 Colophony 3.0 Castor oil 20 8 Alcohol 90% 24.0 ml Solvent ether, sufficient to produce 100 ml Method : Immerse the pyroxylin in the alcohol, Add the colophony and the castor oil, and finally sufficient solvent ether to produce the - Ge. @ scanned with OKEN ScanneroN ANA) , 1 until dissolved set ide fy y ‘onally occasi li ty 8 ke at ali . 16 ume. shal the cle se 100 ml of salicylic acig ci required ve, Dect nd disper n settle. al deposit 1° prepa Example 5+ 10g dion USP. ity to 100ml 5 siylic acd ricient quantity Salicylic dion suffi . dion. Ady i ible Colloc , Flexible coll mr is 18 fe ; isso euired volume id : Diss! a st on to mé * a UE, MOUTH 5-70 BE USED IN THE GARGLES vent or treat throat infep, sons used to prev Jutions ust alee. form with direction k Gargls ae ‘ay avaiable in crimes brought into intimge tions, They are ae before use. They dilution with warm of the throat and are alloweq to e 5 cous membrant e they are thrown oy comet wi a ‘ith it for a few seconds, a rild coat infection remain in con lieve sorene: u on, used to rel of the mouth, Leet present in small concentration fa its enol fox tiymol is ane chlorate is also included in Bargles for antibacterial activity. laxed throat. It also stimulaey its weak astringent effect to tone up a rel secretion of saliva which relieves dryness e.g., phenol gargles, Potassium chloride and phenol gargles. Containers Gar, tles closed with a LIQUDDS sles should be dispensed in clear, fluted glass bot. Plastic screw cap. Coloured bottles are Tequired to be used ifthe gargles need protection from, light, Labelling The containers should be labelled “For external use only”, The direction for Proper dilution, should be stated on the label. Example 8.24 Prepare and dispense 100 mt of Potassium chlorate and phenol Sargles BPC, & Potassium chlorate Patent blue y 3.0 g Liquefied pheno} 9.0009 g Water Suffic cient to make Ls mi Method : Dis, ti 100 mi © potass nes dd liquetied pheno) ‘Add SUM chlorate in wi Volume, Water, Cool and the dye Solutic Iter rar . on, filter and nse 0 a con “ Cork, label ang dispense me up the @ scanned with OKEN Scannerl “opts LIQUID DOSAGE FORMS wo! a MOUTHWASHES aqueous solutions with a pres? and deodorise the buccal wot fe agents, alcohol, glycerin, 5 ring 0801S: 169 Pleasant taste and odour used to cavity. Generally, they contain ‘Weetening agents, flavouring agents ainers Mouthwashes are dispensed in white fluted bottles, ying The label should clearly indie: gjuting the mouthwash before use. Also Oe exteral use only”. gsample 8.25 Prepare and dispense 50,0 mouth wash B.P.c, cost ‘ate the proper directions apply the secondary label, ml of compound sodium oid ko . Sodium chloride 1Sg Sodium bicarbonate 10g Peppermint water to produce 100 ml Method : Dissolve the weighed quantity of sodium chloride and sodium bicarbonate in 3/4th of the peppermint water. Add more of -ppermint water to produce the required volume. Transfer to a bottle, abel and dispense, Example 8.26 Prepare and dispense 100 ml of zinc sulphate and zine chloride, mouth wash B.P.c, * ine sulphate 200 g Zine chloride 1.0 g Dilute hydrochloric acid 1.0 ml Compound tartrazine solution 1.0 ml Chloroform water to produce 100 ml Direction : Two teaspoonful to be diluted in a glass of water before use Method : Dissolve the zinc sulphate and zine chloride in water. Add dilute hydrochloric acid 10 make a clear solution, Add compound tartrazinc solution. Add chloroform water to make the required volume. THROAT PAINTS Throat paints are viscous liquid preparations used for mouth and throat infections. Glycerin is commonly use viscous, it adheres t0 mucous membrane Provides a sweet taste to the preparation, asa base because being for a long period. It also The commonly used throat @ scanned with OKEN Scannernol glyceriny fans ZC Blycey; hy, | "son, 170 og in, P ”) poroe paint) 7 i pats nit nares os ints should be dispensed in airy \ ies ing from Preparation, contailet> jer (0 OP generally used in Such bog, "ea, 3, oy ers labelled “For Ih «or should be external y jmvernal US sontai i Theo id be stored in airtign, 9 abelling ints shou! auttighe 43s at pal 7 pe tho mt, storage in coo! ol ye and dispense 100 ml of iodine Pai le repal mM vont id s paint) BPC. " A , 25 g Potassium iodide 1.25 g Iodine 4.0 ml Alcohol 90% 2.5 ml Water i 0.4 ml eppermint Ol oe to produce 100 mi ide in water. Add the ioding tassium 10% .d, Dissolve peppermint oil in alcoho} 90 fer it into iodine solution. Mix wel), A aint into a measure, 44 Method : Dissolve the pol stir until completely dissolves in a small container and trans! lycerin and mix thoroughly. Transfer the pi more of glycerin to make the required volume. Transfer the prepara ion into a well closed container, label and dispense. LIQUIDS TO BE INSTILLED INTO BODY CAVITIES 7 DOUCHES louche i it rel solution meant for rinsing a body cavi aa el Bs often used for vaginal solutions aa s ally called ittigations. Douches. ar too wat . 'S are also used { lo to dilute it in a speci toa specific quant wu me ity of oa I eas with direction Douches ar cS se. Vagina Benerally used for the fo, “4 lowing Purposes: (1) Cleansing agents 1 ™ chloride sing i ol Bents €.8., isotonic sodiny lorid Solution, @ scanned with OKEN Scannerr asic LIQUID DOSAGE FORMS rf optics &8» MetCuric chloride 001 m stiseP 995%), lactic acid 0, %), Dotasg: iy ‘ga (0.025%) 05 to 2%), Chlorohexice Perman. ingest CB alum (1%), idine (0.02%) o a aa . . @ is administered by SfaVitation Ww a is a igid polyvinyl chlorigg eam “sing douche can, ee care long, along with a nozzle ; iS wy 2 a yitre of solution is used ag dou fe S attache With j che, hit 4 pole. ti ling ‘The label should state “For exte; storage Douche should be stored in coo mmple 828 Prepare and disp douche solution. mal use only”, I place, nse 100 ml of potassium permanga- Potassium permanganate Water add upto Make a vaginal douche, Direction : To be used as a vaginal douche ater for preparing 1 litre of 1:4000 sotution, Method : Weigh and transfer pou portat. Grind the crystal with water potassium permanganate in water, sintered glass filter and mal water through the filter. tote, label and dispense. Ol g 100 mt after diluting it with assium permanganate to a glass and add more water to dissolve Filter the solution through a clean Up the required volume by adding more Transfer the solution into a narrow mouth AS Enemas are aqueous or oily solutions or suspensions that are intro- duced into the rectum for cleansing, therapeutic or diagnos ic purposes. Enemas meant for cleansing purpose are used to evacuate faeces in constipation or before an operation. ‘They act by any one of the following method:— (@) By stimulating peristalsis : Enemas stimulate the peristaltic movement of intestine and thus help to © This occurs by any one of the following mec (a) Enemas cause osmotic retention of water in the bowel eg sodium phosphate enema and magnesium sulphate enema @ scanned with OKEN Scanner© PPENSING, } » Nay Ry + large volume (0.5 to 1 lt ven st urpentine enemas. & soap an 5 8 olive and arachig ri = In (b) Enemas aes soll SOS " va acted face i) By purpose are used as; ( paraldehyde, expulsion of threag _ corticosteroids useg for “ey yeutic for therap' oral hydrates 5 Quassia for Enemas (a) Sedatives eg. ¢ (b) Anthelmintics (c) Anti-in! ory agent ©. (c) Anti-i flammatory agent i 5 is impai: tive colitis. en absorption by mouth is impaired, Nutrient—Whe! va be warmed (0 body temperature i ef e administered by Using douch, ey ar hiloride container. A rubber tthe in, Dauehe can is it Ce nocre is attached with it, of ‘ith a nt 2 meter long, along wil | Nowadays 4 eae ume enemas should not exceed 100 Oe ‘ i iso y aan ji enemas are commercially av’ ane tsp able Oa led to a rect . These ay inyl chloride bags sealed These ag eS el administration becaee the patient jy ver sinply to insert the nozzle and then squeeze the bag. Enemas should be freshly prepared diluted the strong solution With warm water before use. ‘ hou! Large volume enemas sl oe i er administration. These en Containers Enemas are supplied in narrow mouthed, plain screw capped bottle, Taabelling The label should state ‘Not to be taken’ or “For recta use only’, Storage Enemas should be freshh ly prepared and used, storage of enemas are rarely done, Hence, Example 8,29 Prepare and dispense 1000 ml of Soft soap enema, B Soft soap 50 Water to make g 1000 mi make a cl Method : Soap is dissolved in water to Example 8.30 Prepare and dispense 100 R ear solution. ml of paraldehyde enema, Paraldehyde Sodium chloride Solution to role @ scanned with OKEN Scanneronttasie LIQUID DOSAGE FORMS 173 . pissolve paraldehyde in Normal sali ; saline solution s to make ‘ ution 08" g.31 Prepare and dispens “ Pense 100 ml of prednisolone enema & prednisolone potfered solution 20 mg ‘vilvas io 100 ml ; Prednisolone is issolved in br i i i wc in dpostbe bape uffered solution, It is avail- ole EAR DROPS are solutions of drops th; instilled i it hese se goltion is a lat are instilled into the ear with a on h 'y Prepared in water, glycerin, propylene M1 or dilute alcohol. However, vehicle like glycerin and propylene g ol are preferred. These are generally used for cleaning the ear, Senin the wax and for treating the mild infection. Containers Ear drops are dispensed in coloured, fluted glass bottles sath 2 dropper in the cap. Ear drops are also dispensed in a suitable plastio containers. Labelling The label should state, “For external use only” and sgyore in cool place”. | Example 8.32 Prepare and dispense 25.0 ml of soda glycerin. Sodium bicarbonate Sg Glycerin 30 ml Purified water, to produce 100 ml Prepare ear drops. Direction : Place 2-3 drops in each ear as directed. Method ; Dissolve required quantity of sodium bicarbonate in puri- fied water, Add glycerin and more quantity of purified water to produce required volume. Transfer into a bottle, label and dispense. Uses : It is used to relieve itching in the ear and soften the wax. Example 8.33 Prepare and dispense 5.0 ml of phenol ear drops BP.C. Phenol glycerin 40 ml Glycerin to produce 100 ml Method : Mix phenol glycerin with sufficient glycerin to make up the required volume. Transfer in a dropper bottle and label. @ scanned with OKEN ScannerMay ays be diluted with Blycerin i, My 4 j alwa ys caustic, to, mea swt spenol car-dFOP / i phenol : wwaner renee! jspense 100 ml of borie acig te pitution #1 4 Prepare and ¢ hy -gample 8-4 2.0 ml Eexamp! 4 20.0 ml Mic acid 7 Boric 100 ml ‘Alcohol 95% Purified water (0 id in purified water. Add ajo ic ac red yoy, a « pssolve the bon {o produce the req Volume Mathod : Ds f purified water e more incorporal NASAL DROPS er ‘ons of drops that are instilled into ip oy a te is not used nowadays because oi The oily vehicle in nasal MUCOSA and if ys iy with a dropper. movement of cilia in the Tipoid pneumonia, drops inhibit the ach the lungs and cause lipotd j ‘ior Toe perio aye onic with 09% sodium chloride having Nasal drops should be iso ilar to nasal secretions bY using 45 neutral pH and viscosity simil capacity of nasal mucosa is quite low, my eel: The el ae considerable damage to cilia, yy, ' : ution vehicle. Nasal preparation must not interfere with the cleansin, of epithelial cilia of nasal mucosa, ‘These are aqueous $0 as Action Containers Nasal drops are dispensed in coloured fluted bottles fied with a dropper or in a suitable plastic container. Labelling The container should be labelled “For external use only”, Storage Nasal drops should be stored ina cool place, Example 8,35, Prepare and dispense 100 ml of ephedrine nasal drops BPC. R Ephedrine hydrochloride 0.05 g Chlorobutol 0.05 g Sodium chloride 0.05 Water to produce 100 ml Method : Dissolve the i Sodium chloride in warm wae “metre * chlorobutol, and WalEr. Coo, filter if iyi Volume through the fl 5 1 rye at make to ee in ‘er. Transfer the nasal drops to the Container, mE @ scanned with OKEN Scanner, ase LIQUID DOSAGR FORMS, on . : NASAL SPRAYS 175 ’ ¢ used to red s are USCC 10 reduce jag, ie ays Sal Congest; of nasal spray jg eesti wii it al st ren the na teat inf Min HE nasal RE, Ror his yy MS Souon no fy pe for™ of coarse droplets by usi bes the nas solution i Ho sit squeeze bottle. The n; sory a Spray type of atone ot 6.2. They may contain antibiotics ant be isotonic ang ‘ee int Nasal sprays are Stored in small Antihistamines, Co asic Squeeze bottles, atomisors or a ate for administration, Pres loured, fluted ured, glass SSutised aerosols. are rs Nasal sprays should be stor, red i stor These should be protected from Teht on Vi on le 8.36 Prepare and di som 'spense 100 ml of nasal Spray, & Menthol 20 ‘ g Camphor 20g Taymol aon Eucalyptus oil 5.0 ml Liquid paraffin to 100 mi Method = Triturate menthol, camphor and thymol in a dry mort aaiie eucalyptus oil, Transfer to a dry measure, Rinse he ee sah guid paraffin and add more of liquid par affin to make requi woiume, Transfer to the container, label and dispense. a INHALATIONS ‘These are liquid preparations containing volatile substances and are used to relieve congestion and inflammation of the respiratory tract. The inhalations containing the volatile substances which are volatile at room temperature may be placed on an absorbent pad or handkerchief to inhale therefrom. In other cases inhalations are added to hot, but not boiling water (about 65°C) and vapours are inhaled for about 10 minutes, Nowadays inhalations are available in aerosol packing. Aerosol inhalations are solutions, suspensions or emulsions of drugs in a mixture of inert propellants held under pressure in an aerosol dispenser. ‘The dose of the medicament in the form of droplets of 50 um diameter or less is released from the container by using the metering valve. The patient then inhales the released drug through a mouthpiece. Containers Inhalations are packed in small fluted glass bottles. @ scanned with OKEN Scannerky | col packing: . My acros id be labelled For externa) Us shol stored in an air tight Cony t er s are als ota mw me should be iy in . Label tts f benzoin ; re 4 aispense 100 ml of benzo "hal cool place: 937 Prepare a” i, le 8. ian 10.0 g pe a 508 * erin ee 100 ml Prat’ s6 make d prepared storax with aleohy ‘Alcohol the bei ae alcohol through the jp! sufficiel n T b Transfer to a bottle, label and dispeng.' pense 100 ml of menthol ang ey, +: Macerate Method : poms Filter, an mn i e. ie the required volume ae an Example 8.38 Prepare yptus inhalation. 10g Light magnesium carbonate a Menthol tel Eucalyptus oil ie Water to produce ; | / oy solve the menthol in eucalyptus oil and add lig a eatbonti Add sufficient water to produce the Tequired magnesit y a volume Transfer into a bottle, label and dispense. MARKETED MONOPHASIC LIQUID DOSAGE FORMS (A) Mixtures 1. Carminative mixture (Zandu Pharmaceutical Works) ; Contains Sodium bicarbonate, Spirit ammonia aromatic, Tr, Gentian comp., Tr, Card co., Spirit chloroform, Tr. Zingiberis, 2 Kaolin mixture (Arora Pharmaceuticals) : Each tablespoonful contains Light Kaolin 2 mg, Light Magnesium carbonate, 00,6 &, Sodium bicarbonate 0.6 & and Peppermint Water 15 ml, 3. Gelusil (Warner-Hindustan) : Each Wisilicate 625 mg, dried Aluminiu ®) Syrups 'S ml containg Magnesium m hydroxide get 31 mg. Croc d Lrocin syrup (DapherIaterfr Paracetamol, ipl ‘erftan) : Each 5 ml Contains 125 mg of @ scanned with OKEN ScannerFR oNOPHASIC LIQUID DOSAGE FORMS 7 2, Uliragin syrup (Geoffrey Manners . | agi” 15.62 mg, Paracetamol 15.62 me & Co.) : Each 5 ml contains : Benadryl syrup [Parke-Davis (India)] : piphenhydramine hydrochloride 12.5 me a) = Bach 5 mil contains 4, Corex ae syrup (Pfizer) : Each 5 ml contains Chlor- eniramine ma leate 4 mg, Codeine phosphate 10 mg, Ephedrine prpcniorde 5 mg, sodium citrate 150 mg and mentho 0.1 mg 5, Polybion syrup [E. Merck (India)] : Multivitamin syrup. cr (©) Elixirs 1 Cadiphylate elixir (Cadila Pharmaceuticals) : Each 5 ml contains theophylline ethanoate or Piperazine 80 mg, Ephedrine hydrochloride 12 ag, Glyceryl guiacolate ether 50 mg, Phenobarbitone 4 mg, Alcohol 0.55 ml. , 2. Ephedrine compound elixir (Parke-Davis (India)] : Each 5 ml contains Ephedrine sulphate 22.80 mg, Caffeine 91.2 mg, Sodium sali- cylate 114.0 mg, Sodium iodide 60.8 mg, Extract Belladonna 14.52 mg, Alcohol 0.787 ml. 3. Piperazine elixir [Burroughs Wellcome ()] : Each 5 ml contains Piperazine citrate 750 mg. 4. Phosfomin elixir (Sarabhai Chemicals) Vitamin B complex elixir. 5. Phosfomin iron elixir (Sarabhai Chemicals) = ammonia citrate 46.5 mg with vitamin B complex. contains Ferric (D) Linctuses 1. Coscopin linctus (Biological Evens) : Each 5 ml contains Noscapine 7 mg, Citric acid 28.75 mg, Sodium citrate 3.25 mg, Ammo- nium chloride 28 mg, Chlorpheniramine maleate 2 mg. [Rhone Poulenc (D] : Each 5 ml con- Chlorpheniramine maleate 4 mg. (Astra-IDL) : Each 5 ml contains 4 mg. 2. Phensedyl cough linctus tains Codeine phosphate 10 mg, 3. M.LT's linctus codeinae Codeine phosphate 10 mg, Chlorpheniramine maleate L) : Each 5 ml contains 4. M.LT's linctus D (Astra-ID Phenyl propanolamine hydro- Dextromethorphan hydrobromide 5 mg, chloride 25 mg. @ scanned with OKEN Scannerworks Co.) : Bach 3% ical <, chemice » Guaiphenes: 6 FP clears M mg iphenes:, 3 y 1 inc oy ide ; : 5. nt hy’ aid Pharmaceuticals) ; p, | ; iis Ppa cts (Bor te 125 mes Ephedrine ina 5 1 pe fT ym cit ! pa cous soli rol Sol. 0.133 ml. “oy! rose ng, as N cae 3 anti ,, Bellad® gma, : ide pla) * Bach 10 ml contains Salbu, hy Each 5 ml co, chloride Tog Me in i : 5 1, Asthal a jphenesif ° ‘Allenburys) . mg, Ammonium . rector" 2, Dies" OP ride Methdilazine ia) c] sum ctate 50 MB est India) : Bach © mi con ee mt (Hoeehest TT toride 125 me, Meng! 3, Avil peor yg, Ammonium © a a lleate ” Pheniramine ma say als 5 ml conta), 1.14 mg. India): Bach a 4, Piriton expectorant (Gran moni chloride 125 mg, s,. Chlorpheniramine, maleate 5 MBs dium citrate 55 mg. 5, Zeet expectorant contains Diphenhydramine 100 mg, Guaiphenesin 50 mgs img. 6. Cadistin expectorant (Cadila Phi tains Chlorpheniramine maleate 2 mg, Sodium citrate 44 mg, Guaiphenesin 80 mg, Laevomenthol 0.8 mg, TTerpin hydrate 4 mg, Tolu balsam 6 mg, Vasaka syrup 0.133 ml. 1. Glycodin expectorant (Alembic Chemical Works Co.) : Each 5 ml contains Ammonium chloride 62.5 mg, Sodium citrate 50 mg Terpenehydrate 10 mg, Menthol 2.5 mg, Vasaka : ‘l hieiaaiaenl ig, Vasaka liquor Ext. 0.235 ml, emical Works Co.) : Each 5 py 8 mg, Ammonium chloride hydrochloride 4 mg, Mentho, (Alembic Ch hydrochloride Bromhexine armaceuticals) : Each 5 ml con. Ammonium chloride 100 mg, (F) Linments 1. Turpentine liniment (Alpi st Ss ap pine Industries) : ¢ fi i conta E 90 g, Camphor 50 g, Turpentine oil 650 ml, Purified rae ncaa ml mi. 2. Turpentine ti 2. Turpentine liniment (Arora Pharmaceutical: waceuticals; 90 g, Camphoi urpentine oil 650 mi ied water 8, Camphor 50 g, tine oil 650 ml, Purified wate to 1000 ml. 0 1000 mi 3. Methyl salicylate lini M ¢ liniment (Alpine Industri salicylate 250 mg, Arachis oil to 100 rt aoe ) : Contains Soft soap Contains Methyl @ scanned with OKEN ScanneriopHasic LIQUID DOSAGE FORMS, Int Ml Ojon ‘ ot ‘gary lotion [Parke-Davis cd mine hydrochloride 9% ony tir a if lotion (Nulife Pharmaceutical ) Ba G oheraie 2 eae i ) = contains Cettimide we Clotrin lotion (Nulife Pharmaceuticals 179 (ndiay} + conta: Camphor O19 amine 8% > Denatured spirit . ) Contains. Clotrimazole wi . ie ine lotion (Stadmed Pyt) . scabine lotion Vt.) = conta side 2%, Cvrmide 05%, Snians Gamma benzene hex- Hi Calderm skin lotion Dermocate Lap . ir oS NGA Lab.) : contains Calamine 15%, 6, Calamine lotion (Arora Pr, : armaceuticals) + js Zine oxide 5%, Bentonite 36, Heals) : contains Calamine (g Collodions 1. Salactin paint (Nulife Pharm: p wceuticals) : 16.1%, Lactic acid 16.7%, Flexible ee ains Salicylic acid collodion q.s, () Mouth Washes and Gargles 1, Listerine mouth wash (Warner Hindustan Division) : contains Thymol 0.06%, Eucalyptol 0.09%, Methyl alicylate 0.06%, Menthol 04%, Benzoic acid 0.15%, Alc hol 25.27% viv. 2. Povidine mouth wash (Stadmed Pvt. Ltd.) : contains Povidone iodine 1%. 3. Alphadine mouth wash (Nickolas Piramal India) : contains Povi- done-iodine 1% w/v. 4. Betadine gargle (Win-Medicare) : contains Povidone-iodine 1% wiv. 5. Wokadine gargle (Wackhardt) : contains Povidone-iodine 1% wiv. 6. Dettolin mouth wash & gargle (Reckitt & Colman of India} : contains Chloroxylenol 1.02% w/v, Menthol 0.12% w/v, Absolute alco- hol 60.80% w/v, Amaranth as colour. (J) Throat Paints i i i armceuticals) : Each ml contains 1. Paintex paint (Mendine Pharmceuticals) ; Each ml : Clove oil 3% Camphor 0.1%, Menthol 1%, Glycerin 5%, Tr. Iodine 7%, Sol. ether 10%, Cone. peppermint water 15%, Alcohol 56% —_— a @ scanned with OKEN Scanner—NSING ‘ hy , in iceuticals) . , (Glenmark Pharma “IS Bay My 180 aid mouth paint “oy aoe ies) \ cyeuinazle aint (Alpine ey ita P tries) 3, Mager! pine Indus "5 paint) (Alp; int (Alpi Mandle's paint) (Alping Ing 4, Gum pam’ pound ( jodine CO" ty . are Labs.) : Each cont 5, Paint of int (Dermocare 5%, Thymol 0.29% Tay. 6, Dentex gum wa os rain 0 si . i ium | jd 3%, Potasst | ' tse, Camphor 0.2% int (Glaxo Allenburys, Mumbai) 2 in paul 1 Dequadin Dequalinium chloride 0. , Sensoform pain! G ticals) : contains ¢ Pharmaceut r (Warren i Ye , Todine 0.03% wa ‘iy +e 66.27%, Potassium iodide op ‘ Thing si i 058, cet 72% APP 0.033%, “ (K) Douches 1. Tantum vag douche (Elder Ph armaceuticals) : Each Sache " ide 500 mg. tains Benzydamine hydrochloride 5 Enemas . ; “ 1. Laxicon enema (Stadmed) : contains Dioctyl sodium SUlpho, . Laxicon e1 succinate 0.25% solution. 2. Exit enema (Stadmed) : conta jodium phosphorous 6% Wh, Sodium acid phosphorous 16% w/v 3. Neotomic evema (Neo Pharma) : contains Glycerin 15%, Sodiun chloride 15%, Purified water Qs. 4, Mesacol enema (Sun Pharmaceuticals) : contains Mesalazing 4 2/60 ml 5. Procalyss enema (Mount Mettur. Pharma) contains: Sodium drogen phosphate 16%, Sodium phosphate 6° (M) Ear Drops 1. Chloromye vetin Famphenicol 5% w/y, 2 Bactig. why iy Ear-Drops |p, ‘arke-Davis, ( India)} Benzocaine 19 i WIv, Propy en E/E Drops (FDC) contains Chlo- ycol qs i “enlins Gentamycin sulphate & Gentieyn EE Drops (Nickolas. p; Gentamycin sulphate 0.30 ‘iramal India) © Benzalkonium eh contains loride solution 0,0, 4% wiv A ~~ M @ scanned with OKEN Scannerot ast LIQUID DOSAGE Porms a 8 E/E Drops (Conce 181) or conflox PS (Concept phy con 0 Pt Pharmacemti 4, at 03% Bervalkonim cho ag teal : ci” sofracor! (Roussel India) ; contains Dp : 5 pena 0.116%, Framyeetn sulphur rametasone sodium a8 a contains nasal Dros pecon nasal drops (Cadila Hep " rpreclride 1%, Benzalkonin| hoe ot one 3, Dristan nasal drops (Wyeth, Lederle) : ctl de 2.5 mg, Pheniraming maleate 2 m Me alkonium chloride 0.2 mg, Menthot 0125 pot 0.004 ml. 3, Fidrine nasal drops (Wyeth lederle soma : contains By i iol 0.55, Camphor 0.5%, Eucalypiol 05% Canoe heen om . Nasivion nasal drops (B. Merck (Indi one oe ‘ops [E. Merck (India)] : contains Oxymetazoline 0 Contains Phenylephrine 18, Thiomersal 0.02 mg, mg, Eucalyptol 0.2 mg, en 5, Otrivin nasal drops (Novartis) : contains Xylometazoline. (0) Nasal Sprays 1, Beclate nasal sprays (Cipla) : - contains Bi as sirpionate 50 mogtios ntains Beclomethasone 2. Econase nasal sprays (Glaxo Allenburys) : contains Beclometha- sone 50 meg/dose. 3. Betnesol-N-nasal sprays (Glaxo India) : contains Betamethasone sodium phosphate 0.05%, Naphazolin nitrate 0.05%, Neomycin sulphate 0.5% 4. Rhinocort nasal sprays (Astra-IDL) : contains Budesonide 50 megidose. 5. Efcorlin nasal sprays (Glaxo Allenburys) : contains Hydro-corti- sone 0.02%, Naphazoline nitrate 0.025%. (P) Inhalations 1. Asthalin inhaler (Cipla) : contains Salbutamol 100 meg/metered dose. 2. Salbutamol inhaler (Glaxo Allenburys) : contains Salbutamol 100 meg/metered dose. 3. Venorlin inhaler (Glaxo Allenburys) : contains Salbutamol 100 meg/metered dose @ scanned with OKEN Scanner