Che th bo vA che thinh phn ECM due ding g6t v8s hau abt ‘ch nga shién. D0 dc didn agiu nhign nay, rit bhé ab ad va cde iu dong chay chi ti8t tx8n thang do chibu dai té bae hose aust td bho. Tuy nin, €& thé nd ta va dnb Iukng thinh phin md néu st ‘yng phusng phap thing ke, trong 46 e4¢ ving mi 1én hen chia hid 16 bao age xen xét. Tong trutna hep nay, tée 9 dng chy truna biioh qua Ké c6 thé 13én quan dé thinh phin ke tung binh bing ‘ach si! dyng IY thupee mos truseg adp, Vi nb thulng 18 dng chdy tung Binh qua mot ving ad duge quan tie thye té, nén phuong phip nay 1a ho&n toan phi hop. ira 8 hn mehr ny tan tony ang ke tha et ng tb ng 52M c8 mang 28 eng ss hae aan en. 5.1.1. inh ude Darcy Tai thoi din nay, edn phd c6 age sy chuyén hung hd ab m6 14 hing did ca bin cio 1Y thuyét MBL teutng xbp. MBE vat 118u 6p bao gn wot ma tron rin ite thin AL ABT mang Lut ac 26 xing, thing €6 clu truc Lien Abt zt phic tap. Ly thuyét 6k sung dp thing due st dung a mb td dog chy qua vat Ligu Kini qué phe tap hodc hd md td ding chiy qua ting 18 xEng trén co 8 ritng 1e. Dinh luge ea bin ad t8 ding chiy tzung bleh qua mb 28 do Darcy, Trong mGt oat thi nghiéa, Darcy ép enit 1éng 61 qua cde vat thé bp co dién tich mat cit ngang A va chibu dai ding chiy L. chénh Ich dp subt thic ay déng chiy 14 chét 2éng 2am vie cé 1 nhot . vo két qué 1a tée 40 dong chiy @ Cua do (Hinh 5.1.) ‘theo kink nghiéa, arcy phat hign xa xing df Liu cia anh dy twong quan vA ohau BOL adi quan he 5.2. oth se 0, ae KE ay — a 1 Tango, 128 ae em ee we teu ae F sis tthe (te 6 tbe ty Me) co f lente bh ang the he Fs Tone tour tne at tm et ce be enw alt ap: ge 8m 9 oh ‘habe wo Kich thie tdng thé cba ms ie sen xt. be tring cho ey 38 dng nt hdt Hog c6 th aque v8t Lu ap. inn 1uat Darcy chi co nieu lye 464 wai dong chiy mgt ph chan (sb Reynolds chip) cin chit Iéng Newton qua not ma tro xép. Tuy nhién, 6 chinh wdc 13 tinh hubng xdy ra ki chée ng chy ava) 4a, vb do a6 ching 185 Ly phuong tein (5.1) lin didn bit diy cia Sth dish kg ding chly tong Lj xing Q/A 1a van tBe trung bin (hoBe bb mgt) cia chit ‘ng trong vat 136u xp, va 46 19 gradien apPLubk theo hung dong fehly (e), hiking tinh (5.1) 8 thé die vide 2 ‘tang 46 u 1A vin te bb mbt theo ng 2Sells Din lust Daey Pong trinh (5.2) c6 thé dude thai quit Na than dong be ‘hidu Bing cdch thay thé (v8 hung) w vi dix bing vects an tée bi bE u vA gzadien bp suit, evong the, AB thu diye K len oa) Phung txinh (5.3) phat bidy x8n9 te ab vin chaydn chét 1éoq tzung Binh (u) 9B th va th dng in ag WAL ng 5B 18K / Soh tam sae ph ab Ching £6 58 dp dung aint luge Oazey Bf use tinh thal gin 18 ping m® phi nb (sung), ching han nha vét bm tin. Moi rgul ‘abu quen thie vi Kn nigm bb tm: cou Unt bj. chin thing be, sung eve B6 va Abs miu se née sau vi nay Va nat sinh 1, chin thong g8y ra mgt lost cic a kgm cin ‘kn abt in todn ven ele mbt nS mao mpch. Didu nly cho phép chit ng, protein huyét tuong vd céc yéu t6 hinh thanh di vio Ke. (nk Lng a a 9620 ng eve HO ph abd ns Lap nf m8 mao mach Linh 29s, ede mB sung quanh sé trang théi qué dn. 803 v1 mbt 2ukng Bing Ké protein huyét tUong hin 6160 trong #6 phu nd, nén dp suit tao keo trong Khong Ke gin bina vat dp suse trong mao mach. do ab St dich those v8o mae mech. 5-22, Lae spe pond Thay vio 46, chit Ling z2% Khti md phd ab blng cAch chiy vio ‘cae a0 mach bach huyét. Ching £61 tim cich Use tinh thot gfan ob me ‘host x9 ngodi nhu Ta mt chUe nang cia ede 6c tinh cia ne ke Ro ng 18 nGt ving mb nit dish se cdo mhibu neo mach beeh huyée, va cde cd ahong eh kde atu Lom ding, chit Iéng se chdy v0 feo mach bach huyét gin mhét, Gid sil ring tit cd cae mao mach déu ing shou, do 4S, di a xen 26t ne moo mach bech huyEE day ahée, Im ching 104 che zing chiu trach ohigm hit chit 2éng tu mgt ving (hede min) Minh tru co bin kan & ras Soh2 tam saen ph ab Ve mgt hai nig, todn bp mo c6 thE dtc chia thinh cBe ving shu vay. abi ving dn Iuu a0 ma0 wach trung tan cia nb. Bn inh ee 5s ving € 14 aft hin cla 56 Lugng nao quda tztn mgt don vi thé ‘ich: hidu mao dn han <6 nghta 1a mt nao quan phil dn Luv wpe una nhd hon (R nnd han) 8 nhang thay abi edn thiét DE pin téch vin dd niy. cn phi hidu diag aye Kaidn chit ng ro nds wb, Tat ch cde mh Abu nde B hydeat ha can bing ode can bina m6 moi. Ms bi hue muse, khtdn ee thirh phn EOH (abe Bige 18 proteoglycan) phing len vigt qué gi tri cén bing cia ching. VE mat rnigt ding Ive Rec, cae proteoglycan co Tai va tx8 ve cu hinh can ng cia ching 18 thug ot : Kai lin ahd vy, cSt dng pdt duge Gy a bd,6.2.2. Sy thodt thly dich & adt binh thuing va mét bi tang ‘ohio fp Ding thiy dich thie su Eh: nb chi dite tao ra é de 30)2p4E/@;SMMNBRERH( tung Binh + 66 1gen chuln; ehep do ban ngay 8 nguoi 16m vis 20s89/RUBS). Oieu nay cueNg ng WAI te dd Tush chuyén kodng 1% thé ich Khoang pia ‘rude mi phat. Tuy nhién, dong chay chén nay ai a@ gia cho cée md v6 mach é phia truée alt cén séng va UVR ‘TOP: duang-tanh Knodng aSumEHOS ka ek eso me sen ety eh rd vy ee nk tg ze mb pe an vn? cht gi Kile cose 4p cube trang abt ade ide mga ab nb & rong ne Dhan Kb Hep? “vs quan trong ant, albu oi ly 24 tang bin tang nhin to od ap subt tang cao? 6.2.2. Din Iu thiy dich @ mit binh thuéng va alt ting ahin p babu née thoy deh endy qua con eng théng thug. bao od cle wo chuyén biBe nin 8 gée cto hoare pha trudc, nin 8 sy KEE top eda ming ad, ide ap v8 ing mae (Hirh 6.8). i 6.2.2. Din Luk thiy dich @ mit binh thuing ve mit ting nhin Sp "rong phn 1 cde nh ng abn So, 4 coo trong IP 18 bt aut cis a chide 8 bing din 2 thiy dich, thing 1A de oig thay i trong lc 8 hs the thug. Bo, ching ta Bay sem AF ae ch sk te en thy ach chdy 20 i ne. Ty ich co hd thle sth then hal con gs con ng ie (4 18 con rg thing thts vd can long cing mae ning 88 Ao (habe Ang hee iy 8). Bone chy ens He lg BO io ekg eA ma a Rd eng tre me chy ev Ar eevee cba Aue cna ‘tuivemengpemexanamnansae, 226 6b me co UE moa obng wer We “van a tOR0™ ‘org cée tu Kien hich ep 16.2.2. Din uu thiy dich mit binh thultog va mit ting nhin Sp6.2.2. Din lub thiy dich é mit binh thuthg vi nt ting shin dp ap ake te dp ng nay gt ky hes hg de 20 ng ey eng mang ah tebe oe poo Gg tem. De HEN gH |S hn he re hig ng po Do ge @ eh ag “eb age at te tg eh may (ae an Hang ae ee ot te am vb vie tay AOE baer tegen tg rn se nan sere ce tn sip a, am he men cg ny 28 mat ang rey a8 ae see oA Rs onsen Kam, 8 p08 A og by Sem a bg yay ha, 16.2.2. Dn luu thiy dich @ mit binh thutng va mit tng chin dp a vi kan rhe ats trang mit eft aging, ching cal Kéoh 12 hai chiéu, nghta 1a aloe hints thank be hai tin cong cong (inh 5.9) mo yes I | iS oN en) ecm omer 5.2.2. pn lua thiy dien é mit hinh thuing v2 mét vang shan ap ln, dal dién cho eit cl Kénh Schlem ge 988% har BAS ming cing tong abs cing, habe Ble taeng bin nga, 28 be ayag. the us, dat ign he mat eds Sones seat KE N8L mang Lui tzebeculer, hogs bic tang bin teary, 2B thin va co thé bsdn dong ins mang Ides trabecular ‘osdu nay 66 nga 12 “enibu cao" 612 phiong cia Kenh 18 mot che rang ca tek, xb 10r 6.2.2. fm luu thu etch 4 mB binn thudng va nit tang ohan ap. (Cau hdl Gat xa 18 Lieu éng Schlenn co thé sup xulng aii dé t20 1 ue cin dang hay ing ké hay thing. cau tr8 as cho cB hes nay phy thude vao sy cin bing gids had higu ung. 69 cing (20 din és) cia uss be co vu hung gal cho éng tu md, ‘ong thi dp suit gidm tzén Ludi be v8 thénh trong cls dng ly Schlam cé xu huting bube dng tay phsh ding Leh Oe by phn efch nfo vt au trek ry lu phks tinh dn hte ng my fh abs tin tnrg phn ch 2b be tin a. ibs 05 cB roa 18 St A) ct dna AE io Bag Bn ech 4 qua tin tron ott 128 tang te 48 ng cha cae ExONG Bow Ly, CO Luong end ng a 20 rg tiy hu thee a0 TOP. 29 sift cur 9 Ben tren fing ype), v2 De can ng en cn HBB va Ra frog. cy Ee 10 pao = 66.2.2. SY thoat thiy dich 4 mt binh thuéng va mat ‘tang nhan ap Vé phi ca Cong thuc (6.4) bidu tht téc 46. thuy dich oi vbe éng Schienm tr8n mgt don vi chabu dai cig éng tly. Dé thuan tign, ching toi Léy x ‘lan aién qiva cia haz ken thu'va x= £3 lan vi tri cia ostia kenn thu gan nhat. ude tiép theo 18 1itn he Sp suit trong kénh Schlenn vei dding chy trong Kérh. Vi 8 Reynoles cla ding chiy trong éng Schlenm nén ching raves hb gid <2 dong chdy @ ni nal 12 at centdu, 60 49 gradien ap suit tzong éng ty co thé thu auge to rnghign cho dng chéy ting gids cic tin song song: Qe oo 2 ay 66 WB thiy dich €d abet, w 18 48 stu cla fog tly vio mat pining cla trang trong Minh 6.8, v® h(x) 18 “chiéu cao" cue BO cia bing tty 5) 6.2.2. Thoat thiy dich d mat binh thudng va mat tang nhin p @uéc cubi cing 1a tinh dén tinh dan hdi cha be Lu. Jannson v8 Kane gid din zing chy te IusL exobecular oat ding gtdng nm not 16 x0 tuyén tinh, trong 06 bién dang cue BO 13 1 vei a tin ap cuit edn eh trae Lunt trabecular, 10P - pix) oh a ben Lo? Wax h e Taong a6 € 18 26 cing cls 15 x0 v8 Ad 24 caida eas kmh ling bi bidn dang, tueng dng vai truéng hp 10P bing dp sult trong che oh tha. 6.2.2. Din Iuu thiy dich @ nt binh thuthg vi mit ting hin ap Che pong telah (6.4), (6.5) va (6.6) bidu dia ba phudng teteh eho c&e bn 56 had. BCE) v9 O139. ching C6 thé duoc ket hap ab (hua ra mgt phdong t3in vt phn phs cayln tinh ep mal (hing ta pdt chi inh hai pin dd 1igu bide 62 gidi quyét vin &b. Cruing 14 Q(3) = @ tal x = @ ¥ pla) = pee taL X= #5, trong 4 pce 18 ap subt trong ker hu i tndng kt qué 28 pnt tuyén tinh vi agt git phép dong ding letng daze bit alin; do a8, Janeen va Kann di gis ns bag £5. Ke qb Th ai wal che Ld txt gp 1) cia Abu vao. ting 36, agit te dy dain xing st co sc cin ding chy HhOog déng kb tzong chin erg thy, goat tr @ ap sub cue Ten (50 ang) Kh Bg thy DL sap 6.2.2. That thiy dich @ ade Binh thiéng ve nit ting ahBn Sp Hon nda, mB inh dy doin zing néu éng Schlenn gin shu bi sup 48, {We cén cla he thing chéy xa sé 14 mt che nang x8t phi tuyén inh ca TOP, khang duge quan <ét bing thie nghiga. Kat Iugn 18 sup 45 cla Kian Schlenm dling oh Khtng quan trong trong at bbinn thong. Nay c4 kh Schlem'zzcanal bi xep phin len ¢ auc ‘50 mnbig, eve can cong chiy za ngoai vin thip han zo ves dt bi ‘tng nin ap, cho thiy bérh tang ahgn dp Khéng thé gid thich doc bing su sup G& cle 6x9 Schlenn. Lie thé nto 48 kdeh cia Schlenm “bide” én abu thé abe? Ching ta 45 hee tzene Phin 2.9.1 xing ede dng mgch Lém di chinh ich thie cia ching d& dép dng véi Iuong abu chay trong ching habe cu thé hon 1a thy suit eft ee tng Ten cac té bdo nf md Tot cla ching. €6 LE mot co hb ni vy cg dang hat dng trong Ken Schlam. Hh Khdn vit gid thuybt nly 14 the 9 dng chdy cia thy ‘seh wap ab mue £4 ve au ong sult ee Len ese t6 bao ngs ns ag Schema 38 ht abt6.2.2. p&p 1uu thiy dich & mit binh thidng va at tang ohin 4p Ching taco tl mghitn cin thn Aimy tng cdc sta ab imo hrinh dng ty déng mi Schlenm dugc trinh bay @ trn. Vi ching ta bidt rang sy sup ob cla dng tay chi x4y ra é 10P rit cao, ching ta iy cot ng ty 18 cang (hing th tu 99m) shang cng cp ae tila tne th non od bleh he band cath Ue tion Ong sub he tren che th tb at 16 Bge con i, Oe gt, thay vt 4p oh tic dng iy Schlem bae hat the song song, hing taco tht ot bg ty eb aed go Bush flip, vei bn ave oh avd bln txye 1098 (em flo bin trong, Ho 6:30). Tong tng hap my. png tein (65) Ge they ON bs tap atin ° ox ab” on (6.2.2. ofa lus thy dich d ndt bin thing va ait tang han 4p (4 phaong eran cor bay glo 18 (6.4) vB (67), mb chang ta co tnd dt op a cs anc phuong ti ae Hat cho O13) VE vin 0 nay hang 201 then cac bu ken ten G = @ tat x = 0 v8 (x) = QeoEIm Cat x = 25, trang a9 grat 12 tng tée op otng muse enay ra va La oh tig am ha GLbs dp Us 41 rare cei 20h ab R, 2Nsksh wai We «a ax ‘ilinghan vd cng af 45 do ich tac wi sign tfc ade edt ngang ie bag Schlenn, vb if fd Liu ela Fo, ching t6i cd thé tink tod clog oang cach alos tnam trong v8 goad trung Linh 22 khesng 8 OE na ‘EHUD v2 SUEDROTINSEMGEMMAN-eD. Sau co. Aét lun dng 999 M120 12 ng suit cit nin rang knoing 2-5 anerem2 . ng Ue Hse DIET So vor long cade mnem tndy 8 ete sng mpcn Ion 6.2.2. Dan 1uu thiy dich 8 mat binh thitng va mat tang nhan Ap idu nay cho thly xing dhe subt cit e& tht e& the dng sinh noc 18n cae t# bdo mdi HO, diy ndy ause NB tre BBL céc phi hien ‘tye nghién cho thy ring cde 1 bdo nL x0 énp clin Schienn cho thiy SW Ltn Het us tHén, 09 66, CO ve phat dng sude cit cla tutng otup iba chin kich thiée cla dng Schlenn 4 c6 kind ning Anh hung an cin 1y t6 bio ng nd. Tht Rip ale Knit nght rng 56 may th bho fin teuydn ca hoe vd chm onén ca nee host ang rit tt trong Me thing mich ms eB ise cae To bas ngs md Sng euy cla Sehlanm du chon age chen dan gidn od kibn east thn cB &ng thy cia Schlem. Didy gh sau db c6 thé gldi thich Iue cn ding chiy tung abi 40 Lien quan Gen vi8e din Iu thy dich wi abt? 6 hal gia thay 6.2.2. Din luv they dich 6 mat bin thudng v8 mt tang aban 4p 0 hal gid thay + dige bide, mang IUBL txabecular thay ey thé han, ha we tide gldp val kdnh Sehlem) chia ohidu ring 60 gel gidu proteoglycan. MO hinh hia €8 cho thy sing bang gel rly cb thE tg0 za bd ning ehdng chiy dang kb vb (Ar 1444 gi aay cho thy doann thu cin che thank prin get niy 14 41s didu bién bd hoot ding netal2icoproteinase ma tibn hbo di trong mgng 10s trabecular. Tinh thin thoy 1ye cia rhidu no 1idn Ket ndn kde vol co thé dige diy Knidn bol ining 4 cia che gel protecclycan6.2.2. Din luu thiy dich @ mit binh thing vi mit tng nin dp 6 hak gid thay + Lp nb mo cba Brg schtew co tnb wang Tat hiew gud dng be 80 edn ding chiy. Lap td 6 iy 1 Be hig: oh dy, nd es ‘train eo ane cia eft by Lap opt nt rd trong ea nb, vs ei L820 g 7 1, sung no tery 6 cia 35. cae td bdo 19 ens 4uge WEL hau Bing che afd nbs ehgt ChE tad pin AE tbe hn hs TOP sang len vs age eke us e4e 15 188 ming (1B chan 20mg"). Be a cu ase BU 10, wha 9m hu che cin hae ofa win chap thy ach Luts thong thiy dich @ tién phing ruse RAL tty dich thede xa bhés at, nd AL gus ing tw, at {UF dn phing dé tidn phng, 28 Iau thing trang tide phdng. SU Tu thing ndde trong Khoang pha true Lb KEL qud cla agt sé kich thich, bao atm chap abt, didu chinh (they abi Rink dog thbu kink ab thay 451 tieu cy) v8 dBi Tew tv rin do nniet g8y 2 SL Luu ey hdd cSt tha vi vi ed thd ed ¥ nghte Lim sing. Ws ly x2 do glée mac thudng fp sie v8i thing hit xung quenh; de 86, fhidt db 4 DE mat olde mec sau thip ha mit chit so vl mhige 6 eo ‘hd. Bidu ndy ta0 ra not gradient ahi8t 6 crn Hoang pha true, do 46 thay dich abt hon glo bé mbt gide mac 121 mung va thy dich han gin nag adt tang en. (Hin 6.11) 16.2.3. Luu thong thiy dich d ctén prong tu thong thiy den @ tién phing compe ab dang str tng anan dp trong 46 tang 1 shag pbb 16 Abt oud ede attr they as trang He eg a Lay cla wn 422 Ohing nade gn les 248u a Bin ting chin Sp 9Se ding, nb ‘inh trang dy ra Kh még at xcay ve pinta trude va chan quydn tray cap hn che edu trie din Idi & gfe tide pking. u6ng nu c® np lenymh tng GES phSu cho tanh hung ny ing nat cue Kj nbn clo vd md hh hoa a cho thiy sy thi vi ‘ating the 0a bids dang nina ndtv dng mule chiy ae (hag 00 va gi ty tSan thi wag alt, ae bape Hed ade i ohtdy BOL chap ast0.2.8, 69a teh foe a day che hart ea abe tang bam tang nbn 39, chong ta enuyén sy em y sang cy this oh ent on ay 0nd tat Beg cae Sol true ca 18 bdo hah wong aC, chou tach ten sang thing tin Mi dah 2 vSng ge dine, bés ey 4 Hhlp nes dn wing nae nay trang Eésh tng akin 5 Ching 265 thing Sit du ted 265 cho chu iby, ag C6 Wg cng apr weg whan gt Ae 12 0.2.8, 65 steht a ay de tt aac Tal sao ching ta nght xing Tenina cribrosa 18 quan trong trong bh tang shan 4p? ob teh Ia chu hat my, ching ta cA Bide at eit vb sinh 1y td bdo cia td bio thn ido. Che t blo chuyén BABE ny cf tht ause chia ahd thinh che ving Hale Bist vé hich *AbL va hdl ig, bao gia thin 8 bio v2 ndt hode ahidu qué trinh kéo dA dude got 12 sai tru. Co thb té bio chia shan vi 2a neh tng hap protein v8 ng, trong kni ede egh tye Khing tao ra protein Protein v8 ce vat gu nde diye vin chuydn doe theo so true trong cdc ti gin vOi protein van ding “be" doc theo ch vi brg chy trong s¢l true. Qué crinh vin chuyén sol taye nay Ta diéy clr enidt 24, eb son me a cay On ei Oy lee Che nghidn cit ben du ¢8 ching winh ring sv the nahn cla sud tear ue ehuyin may ("av pheng ta sol trye") ay ea Kh IOP ting cao mgt Ach nén tinh, vb hon nda, sv phong the nay xdy rad Tanina iz Mn eda, equal to bidt ring hin théi Lanine cribrosa bi bib ang trong bénh tang han ap A nhang thay As nna vay c6 thi xe jem exvse sy phat sha ala cng ne ths Ie. Call cng, mb et rake eg tive thtong quan vat ait oj wd 266m kde trong Lamina cribrose rung auan <3 nhu vay a8 edn ain nnibu eu eh y cap rung vio co sinh hoe eGo Lanine exibress, vil me tiku hidu 10P 18g coo An Sin 1a ehdang td bho hech veg mye nhu thé nb16.24. 6 ek seh foe hy iy thn eam em ac Vi mat co im toe, lamina cribrosa ud Sng cing mge 14 ning chu true ade eho vt. Lasina crizzosa ehugng be gbe icing 16 thn cexsbsform, hoje Janellae, chia collagen lopi IV, Landnin vb elastin. WA thn duge dyc 16 1150 din 600 15, que ab cdc b6 set txve chay (qa. ti ching ta col nBt niu a0 1dp v6 hn cd chiu dp ue, hb rn cing mac. King Khic 9 mot cat 18 trén mach miu nay. 18 na tap ‘rung ang suit cuc bd, Lamina cross, DOL vi no Th mt a8 Hh in Mtoe fag nay, tid sa triton tng Bb dang va Bib ang La tat surg tng sung part Bt ang. mung pan ct nay ch ain in 1 Cuyée co need ban 17 in Kin ehh gas tog mn ap, gtd on ng cle Ong aude eo Mee ting coo the Sing Bin tewrg lenin criorese din tin ede hang aah te 6-24, nk sn Mee ay eminem em ae 0.2. od toh ty ay nln ww em ge enor ray aves ces ere cea tng te, ang hay ve 05 ce wd ae ten lon tng ut eat nbs HREM Sm ee 8 ong tre cites, 1h ih ene 18 nth ne tle lm ff ce ng AB 0g ng ie che tb Ate nbn Kh AB che tke Rn Kh he ge Kh Nyt, ey Ah 6 yd, age then i i 2g ak eth ae es he eh a yay 38, ee Me Ren Bde Lich Mage degen cg lp eg ok lg (gh doh eg Mh EGh AMch yp) ch ede th be th lon ang qu ching, by 40 cht hdtatfbtethn Ke Ch ne 9 aye ea en cheb a mg eg ge te ng A tg tte op, AYE 99187 edt Mf mg, A ag ae og ng hy a el ln fe tl ch ig ep cn Dade 24, eo eb son ec ay enn net em ae coe nang ty olds oa ehtng dy od t20N9 ca rnseh cba ong sgch mi ngin pia eau cang chp whi cho ving tg vi cde bide ening SE naybe ng hee cla mgeh abu ang quan c6 hb sing age val txt tong aul telah iy (55-54. C6 Bing ching te ng Ung MO ch 2 ‘thuydt hoc vd 17 Uyée mech abu vé thn thug gldcba, vb cb 18 ‘tring hap bin 19 thn kin th} ge 28 Kt qu cha sy Kd hap ea cd tak ca ehh. Cong cd thb 18 obhing hie ng nt way £6 thd Tang te vat sau; vt a, Bidn dang ea Rye cia lamina cxibroa c6 thd sin io thiK nu CGc 6 thing aun sy bide dang cia cdc m00 mech ‘rong abl tring hep. 10 rang ts cube thie Ludn @ ttn rang chung ta cin nidu x5 hen vb ec ehh sinh hoe cia ede mb ahi dty thin anh tht gle, vi je bi8t 1 cd chd sinh he cin lanina exibrees Gk Nid 23 han ve clch BEnh ting Adin dp din dln abt che mdng thi iseee es Lunn thé nko ching ta cé thd déoh gi mii tng co sinh hoe bn trong lamina eribresa? Tagt Uhng may, Lamina exibroea ahd, ‘ting afi kno tHdp cn, min vd auife Bao quanh DAL at WB cung hon rhidu (adng cing). Di2U my c& nghta 18 st nhbt pli néi xing vise Go luting dng subt vb ste cing trong mb by 12 aft théch thde! Do dé, Indu hit cdc Ual nghide chi do bién dang cia Janina tzong cde abu vit sau kek chit, bing cfch kids tra m8 hoc hoBe bing cdc KY thudt gid tik Hose 1d uae inn ese Bike ang co hoc, trong tanh bog nis v8), vide chuyda sang Lip m6 inh 1a du ding chien. Oi8u by cng ing dan idm, vi Lenina 1A vgt Liu xbp, di hung, phi tuyén tinh ‘i Aish hoe phe tep. Tuy ahién, ban phil bit hy tW da 66, vd ‘that hep Ty Hed bie au bing cach cot Tanina 14 wOt tin t1én ding ikt, ding hung, ain hii tiydn tinh, €& dp dy aL han chu ne 4p ude ing ont 5:24. Conk ston Mac eu ay enn Bh eM HE Xvong otdeg out dn suit oye tetnh bay trong Phin 2.8.2 4B at mgt ming din mbt méng cfu sp ye, ee ang aut ubn ban trong danina exibroce zt quan txeng trong vise AE te UAS ap aude va pst ‘auge tinh dn. DE dot dive me dich nay, He vA Ren db xen x€t taung hep a gen nha eda age che tren chfu ge cang #0 ming cing «ang quan dards va Goce thea not cen thi c4n tung ty, cho php 46 Lech ‘én nung Bb que se cing cin cing mac ngogs vi. € ly ching t84 28 phe thio agin gon céch eidp cin ee Edwards vi Geed, de tx8n bp Aub vd nag Wong phét sinh tex ee cb didn cla vi. rong suét qué tray din sade nay, ching 081 5E had the thie té 24 0 dy ca Lavina cribrosa (126 din 450 ym, ty thude vao nit) 12 th co vA tng Kirt cin lamina (thing 1A 3,9). 62.4, Cr enk coh ea ay ste tm em ge Dida bét abu 12 vie mfe bide thie cho nig 2ugna bide dong 6ldc Las ted trong dia tbo dei digs cho Lavina cxibrosa, trong 6 8 hal ing gf: mang Tuam én dang do ub cong. Vbending ¥2 nang 1igeg tide dyng do Ata bi Kho cing Khi né cong vb pia eau , tbo (aL. C6 thé chi ra ring dL voi mbt dta aie TAL OL ang CO bin Jann a, 68 day vA WB un Young & 6) vieoey Or g tare dung Gr_18-49 1éch ban cba Ata so vot dp sube tbe (@tiak 6.15), 14 ty <6 Polsson va 0 1a ap cong ulin cia ata, cho et Eh —_ 629) ni 5.2.4, Cab tah Me ay enn tnh om ge a ele aren bra6.2.4. CG ehé sinh hoe cia au diy ‘thin kin thi gide Phltng txinh (6.9) khdog JB suy x0: tem 19i, 6 wide phat vige wen wet mgt prin tend cla dia 6 ich thse dr nhin voh &, va las y ang ring Lusng ain dng dn ela pin tl rho ny 27 26 wes 6 cong eye Bp cla pain td hin vei mé men use Bén trong tc ding én phin td « ‘bs ve ue gu dan i, md wen bn an trong tf 18 vot 48 cong cue Bb, do 8 ning Iusng bide dang ty 1e v8i cde 58 hang be hai 1ién quan dn db corg cue b® ela chin tl Pdi vei mbt dia tron chiu tai @bi ang, co hat ban kinh cong chinh cho bei dz # VA dear Nang aueng bién dang do kéo dan eis cing n@t phin ty rhs nay ti 1€ vai tich cia céc Ive tac dung doc theo mét phing ida cua ofa va eae bidn dang trong dia. 6.24. ced teh ie a dy hd teem ge WL én nda, 664 vil abt dia din hii, che We the dung Lin aBt pig gia cf 1¢ thutn ve cc bién dang, do 66 dal lueng vgtan za 13 be hat rong cde bid cary 22 2 = woo DFE 3 (5.21) ‘ong 99 nat thao phn bids dang ex va «® awe emo adn du aOR Ge (6.12) % = (6.23) zomg 6 uls) 1B 6 dich cay di i 6.3) not phd A ee ie (Hin eh eto Ne ah by ede he 2 gle ching to bike wie) va win) cing ta c6 tb cin cing wie ie phony inh (6.9) vb (620) tin ning Lug ibn deg, shine ching ta Sng as Ae. Tuy niién, cé abt cich gin ding sing tao dé gidi quyét vin dé nay, 46 18 due za cic phing doin cé co sB cho w(x) v8 uz) Timoshenko B xuit céc bidy thie c6 dang: : we (6.4) urrar CC ry 2 (6.35) trong a6 C1, C2 vi wo 18 cc hing $3, véi n@ bidu thi 49 2éch eve pn cia eta tei tan cle nd. Lu y zing cac bidu thve ny théa nan you chu Khtng c6 ap Ich @ dp Ta va a 1fch ung te ing Khtng Stn die, 6.20. cad teh ge ha diy hd tae gue Ln thé ne a xbe inh Ch vb C2? Ching ta cb thd if rg thet 13-4 ergy 58 cn Beg, ning Luong bid org cds is phss 18 mle 86 end a vie EN nae 2 ee me ee SW oot © 6m cna chp che Sid the che CL vi C2 vb che the ich w@ v2 dia ute cut cing 18 2 dng nguySn 1) céeg deb tinh 08 hidu ngsyn 1y myo tng deh 248 mt at an Ew chung te cho 24 chi tac ra la wt Go rep Gee WE AL =6.24. a a eh ge hy Eb Usa ene ang ta git i thin vdng nat 2 trang thas cn ng, ua stu a gid 0 xing hot t2hi qua agt chuydn Sing nhs (2 dich chuyde 42), 8 ing do dude the high trong qué tinh dich chuyde 0 nby 24 bee (o.2) rong 6 chuyée vi do due gid inh 1b ab ohé ab e&e Lue Hhéng bE deh ng. sy 190 ely ng cog wee Bo tr Ye me 45 S86 tay j Bu 28 Bg © KML vb eh He FO cat ma 1a aid kien a8 hat & trong thli cén bing. es cach inde, you elu edng vide So alge ehye Mign txan gt bing king mang Lo 4:84 Kin cba bing cho hot 63.4, eb seh ge a diy ahd Kio Om ge 1 vo mot tap hap cBe hae Ct dy, mot chi én dn md). cing do duge the hign c& thi auge chia thinh e&ng do neat We vd cing do 1g Ye. Cong do nL Wye thye Min age chuyln aL don gin hun ang lug din M&S dy E20, vb do de S94 lugmg sou cht 18 gi 114 fn ela ning lung bin dong; do 85, trong tring hap Khoa We cd thd, did kign cB bing c thE age bid thi hd VE ud + texong 6 tich phn duge Ly tetn bd wBt Qik hon cia vBt xin ain ‘bt tnayed bidu thd céc Ic bin ngodl téc dung én vat én va OV 28 1681 ning Iddng bién dang do chuyén vi de Su. o (6.29) 0.2.8, ce a sn noc lu ay en seh a ota Ching ta cd thé if dang dibs ny inh tod cu Rink cin bing cla fe ata xn chau t2c dung cba mot ap subt ba bing cach ght V sso 16.20) (ae chi tHdt cén Tom xb, dng dt gui cubi cing 23 thu de oft pong ‘rinh cho nl aves dong spt non cus p subs tSe ang. Eavarde va Good a ibs chish ob 2éch cin Lanine cribroza aise Ay dain bing eich tidp cin ry ‘ai AT Ligu thie eghign cla Yan et a2. =i dng m8 cin cia Young Lan thon 28 a ep. o-26, ob sok tec au aay np eam en ee ‘Sau db, c6 th8 tian tain ede thinh phin én dng tzong aude Lamina cribrese, vi dy bing céch a0 dire Cong thie (6.12) wd (6.13) 484 vd de [de song binn thiong eaaree va Good use tian ee Ban gang Bémh tng aing 206 v8 cbc is dng cbt Hhcéng OC kh IOP dot ade coo Sl 14 sir dung mot wo ish gin CLch cho ca hE sHoh hoc cba Lanna crahrosa 12 abs tho vi hung tnt fobng way, chong TOL phat ala ra WOE sé (1d dink end non 8, cha tan mh cot Lanna 22 mot az2 ping Keg co ue cing ngena ti cing mee surg quan hing 12 co thd nt éng abt <6 gid dink iy Bing céch <0 dng nd hich phdn td Rly hon rghién cd Ranh vi cd he eis Bu dy thin Kain th ‘ang ehsnh 26s 45 8 12 Stemig nim trong tining ts ain st, thép non mE rut mmung co thb co inn wes gi8 125 alse af dan nes Eawaree va GadJa co hd to ge a ay eka am en gid fe eit c6 thd mbt xing git phlu aia hé ehéog tun bode trong st rit phe tap. TE ch miu duse cung ep cho ahén elu, mi alt vd ee ed ngobi ahin elu bal eg nach ndt, Lb mB hich cue ding msch Bin thin qub chu mit cb hai hE thing mach alu chih: véng spc vb ming 8 dio. Tube habm ving tac 18 WE vane Kid kin (Soe rach, tify 60g nach, nao mech, rida tinh mach va tinh mach) nn tz ingt true cla ving mae. Tubn hon ming bd dbo 6 thé ge chia thanh + tuln habn ming BB ste crue cung ebp cho adng mit, thE al (rot giip hn thinh thiy dich) ve gide mac ngoed Bin. + tudn hotn mang bb oo sau ud mang IW6l mach mu chuyén bieC vd ew 4c bit gol 1A ming mach, nin txén bb mBt én ngoAd ch ong 24. coe ah el dy thle oh ite ‘otdy thu vi 18 tzong ede ths nghie in vitro, c4e ching Sie ay 19 ait Lopt cde higu dng sinh hoe trong cde 18 bio thin Kink, de thing trong Lanine ertbroas ti 10P tng a9 cb the aby hel cho che t& ing en Lis ¥ sing chu trie ie Janina ertbzosa, nal ede ys th nb 1ién kee tueng abi eng duGe bao quash Lai a thde Kin og rarh, co the heat dag ab “khuéch dai higu aud cc ching tren cic ching doe tinh oan 8 dy VE dy, Sellezze bing cdch xen xét at ad hie één gid ha cla lanira cribrosa boo gle nt mang Lu6i thing wuyen cia cée “chu nb nb itn bét bic qua mbt Sng cing npc hin elip. cho thly sv gia tang dng sudt ding Md trong che edu Lamina eribrosa, trong not <6 trike hop, ofp hen 12e Tin 12° age 4p cng,10.1. nhay. 10.2. MO ta ve di bO va chay 10.4. Géc vin ad 10.1.1. hay dling ude ohby pn CSch wnt. NOE Bue why ng c& thE Alte chia think has at Soon, une aie ha oh sou (Ma 38.1) (balay: Se au tu tu thé cUt mgUEL, Yon cng Vien ding hat chin ching suing aft cho dén khi hai chin x85 Khoi bt be etwanetndagy th thes didn hd 201 Knds nt Ae cho bn kn dat a0 td de ba taong tan Vie phin tien cu nhy ang due thic hibn dB dang anit nu ching t2 68 qua ching thay abi vé tu thé va hung co thé trong Kh thy va chi xen ndt ) cao eh 909 the. nr sais cut ce Dag FF m ev ! =< 7 Ve oe 10.1.1. hay ding De ching 84 nde ih = khaing chch trong thn dige he xulng, fe do ting Ong vei cao ela tzong thn tai thél dide chin i Kho at at aie 40 bina tn aaa an cing it a eu thn ea = 69 a0 t6i 60 cis trong ti B= vf ted thing ing cde trong thn, aife do dtr {il ste ahd tx i, = vba tde thing ang cia trong the, mye do. dong ted laa,10.1.1. nhay ing Trong glat doen ching dly, ching ta niin xa zing aft Iie F(t) do hat chin tbe ding a mit at, vl mt phir ye tueng ng eo mst be the dung Len hai chin (inh 10.2). Ap ding dinh ut tha hat eta Newton cho sin Iuang jumper vee oe) pew WO tay ae "ch ph gg tsi (48.2) theo tO gan 88h vt Drea gt me 18.3) Brewer oo) Bie pray 10] 3 foam j1co Joo. as P° E40 att =] 2 ee i4 wee Jp Bo : : i we xa 10.1.1. hay ding Ta chgn t= @ 1h that Aide bit dhs pho dy, Wav = 8 ting 8 tzong phidng txinh (10.3) kins 36 hing ©, do do ve & ? a9.) Fede gt fob tidp tye phan tich, ching ta cn bide va éidu ve ich st We, F(E). Woe 6 oO 1360 vt du ve VE tet Hadi tan cin vei ony ah rot han cia thet gian trong cle aiat dan eit mqueh v8 oy nave cia ae dy ding dase the ign tzong Minh 430.2, TU ohang do Lieu nay, ching ta cb thé si! dung phung txinh (20.2) 48 suy za phn ue nbn, 146 nay cong duge thé high trong Hanh 10.2. Hanh dang cia ong cong Ive nay c6 ¥ maha tric quan: trong ini cOi mou, phir Ive hd hon trong Iukma c@ the, rhung sau 4 ‘ang Ldn 2én sn tzong lulgng ca thi ht rout abby tng tbe Ln xan, 10.1.1. nhdy dang Do 45, trong gisi dogn dy, 1fch sif phn lye mén c6 hin dong chung duge phéc thdo trong Minh 10.3, trong dé Khedng thoi 38 ian cla giai dogn dy. 08 én gin héa vige phan tich, ching t0i thay thé Lich sif phan Ive thye té bing wot Ich si don ain nea, fauge th high bing Alang a nét trong Hinh 10.3. 89 an ela 14e tae ding trong Lich st gon gin hea, Fequiv, duge chon s30 cho sang lye ti ye thye t& va lye dan gidn nba bing mhau: nghta 18 520 0, Fag dk dts cba ME trang Bit doa chin the ing trang as oan lng ayFoe Fee Bear i Fp pn wa Tal 10.1.1. nhay ding Tage Me pp eam gn dang ad 68) bg Fag trong png tet (20.3), ching ta tm Be ao “A 1 3.8) ida thie niy <6 thé alge teh pa mang Des mz, a or) ‘rong a 20 14 4) cao cin trong en Ki ht abu glat dogn dy. 10.1.4. Nhdy dng Logi bd thei gian gia cde phuang trinh (10.6) vd (10.7) cf ag = (0.8) w ini kit thie uh trinh dy (tai thai did t= ), aft} 20 Blog © vk WLU) bing vpushot. They thé ede gid tx} nly vio phusng tinh (0 (20.9) ‘rong giat doan bay txén bong, co thé thye sv 12 abe vin dan chia ia téc trong tzuing Kong abs. De 6, 40 ca0 dat avec boi trong tan (m1 28, (pushor Bae 10.1.1. nhay dung ke hop dda iy wk png ith (28.9) mong a8 (a0.8) W dong trinh (19.10) cho thy cé thé dgt auge d® cao 10m thin bing cdc tag 49 shu cds ¢ hobe bing chch ting Ie dy tig bin Fequiv. Gia tri din hinh cia Fequiv 2 2M, vi wy hc (Ob sh hoe cho phn Leh tr, hy sen wt ry ng Hue tHE OE Hp ye ehé gL Agee gO bas Johan Chetan Evade (Me Wy, 1962) nhs vat us nt chan deh mit S Feet 9¥5 sch (1.76 mt10.1.4. nly ang Le iy crung binn ma Feguly 6 ce dng trong 2 oy ny 12 ba rnsou? 98 t2a 2o1 cau nba nay, cle phat ava za 90t 56 gid inh. Ching ta # 28y enséu cao ca vin ing Vien aly 12 6 Feet, 530 cho txoNg tan chia ‘anh ta céch mgt Be 36 Arch ht AE tho ng ay. Ching ta cng 5 9:8 inh sing trong kt nay, anh by 43 6irh hug eo end cla minh a0 ho trong tm ea anh Sy ws gt qua thar, vi vy tg cao the ela h 69,5 36inch 33,5 inch (8.1) icing eich eit gibi didn hish cho mot nau cao 6 foot 18 28 finch. St dung cae gia €7h nay, ching £64 tu ise FeaulVin = 2,7, c20 han hodng 358 50 ¥OL mguel Binh thuon. 10.1.2. Chay nhay he 0 (ci ohy chay bu tidn ad ching ta 58 phén tich 18 nhdy sio. Bude nhdy ry va cé bln 2p quan an sy chuydn Bi ming 2ughg cla ral ody - dng nana nodeg ding bana) sang thé nang (3) a0 so v6i thank). rong qué trinh chuydn ai xen bd, mbt king ding Kb nding bing age fuser trong bie dang din SE cla eve, ah xem xt Minh 18.4 cho thy Gla ring qué tzinn chuyén a8 nang duong 13 200% rat ga, erage evion ona tzong dS #14 thBi ugeg ela nq8t nhdy so, v 14 te d9 cia nglst hay 20 Kh cay xufng ong bing va h 18 ab cao thuc sé cbt a2 cle ‘rong tm cla nau ahdy so. 10.1.2. Chay hay in sto Wi vby, hung £64 hy vong 7/2 gan, O9t v = 10 m/s cho aid tri 18 sing hs v= 5.2m. nu trong tam bat du cich age ode 2m kt Bde iu nin, thi 69 cao thi da cla trong tam phai bp x1 6,1. Con sé iy kd abn voi kj ue thé 16h trong nha cl naw 18 6,150. dc do phan ich teén aus x2 cou Crd 101 gin dng v8 do 69 nin bbe auge bin chit cis vin hung 58 xing md qua don gid v8 BO que not sb ydu 08: Ching ta 8 qua HhBS kg ela e&t, bp a & kg. Oidu ny cb ‘thé Lt dh hung din chibu cao na nguel ably a cd thé dat due. 10.1.2. Chay nhay in sto (hing ta 63 bo guD Ive t3e dung bes coh tay cba ng ody AD Len cot is tran bg, cu thé 12 thin ghia thing dina i Iue ray. ety ndy 8 cu hing tng chit cao hin Ching ta dB bé qua Iue the dung bt chin dy tzén ding bing. Lue rnby thd awe st dung db tng ding Luong hing 1én, ching hom bing cich hi txq chuyén ding quay 1én cia chin ty Jo. NO sé ting chibu exe bie. Gt ing Is #2 ning gg hid gu 1804. ny 1am gin atu gud se 108 gin ehidu C20 tho tb Tuong tas ela mgwot andy Jo eves co Wb AL qua di mann nu ngs hay ab thve ion tHe cd cde dng te wB0y rah hep (HAM 10.5). ‘i nay Lan tang chi cao cia than co thé bi x10.1.2. Chay ody Chay hky ea SY ke Diet chinh gia nhiy cae ding vd choy 18 8 ChB chay ahiy 90 c6 9 N8s chuyén 4B dng ning thinh thé ning, Oxéu ny c6 fnghta 18 4} cao dat duge Khi chay ahdy cao Iubn 2on hon 66 ca0 dat use Kt by ng Tuy sido, 36 rang 1a chin try, chu trdeh ahem chuydo abt fog ning hin thé ning, Ken niga gud hom nhilu so w3E try ahly a0, nbs nang tht ky Ive thé giot ve choy ohay coo 5 18 kong 20 feet (6 m) 6 had chin uke chy aby exo chung. Vin ing vién nhiy the 6 aing chuydn cing shibu fag ming vd phia toute think thi ning cing bt, oh dB thdo lun @ txén. Pover jumper phy theic ahiby v8o deg téc hing by chi ding i chin ng wb kin hifu gud hon trong viée chun 4: nang oma ti coi con nguéi di b@ véi téc 86 khdng dBi trén mt bin ls Noh 08 vk sh 3.4, cing SL ls ce Ao ghia Gin don pring: Oy 18 pn coach 4 ab i dt hd oh eh tilp ae wat mitt. Chin thse ee eh! than gia we git Son ng de ot 8 cin Gin dean eu: by 28 pn ca chu WB HL NE can ot ion Ge ang ado, chan thn a v0 lat eon ney Ee got 8 chan Ci coh gt: TH db Kn cin sony tip wc vo nt at 8 ch Toe off: noay Ki chin voay x64 Kadi mgt GB 13 ngbn chin TOL ra,[5.2 te on pd Di sue than 38 ont e38t Oing ‘9p chinh vio dp subt thin thiu proteogtycan dn tt Be thin pin ‘lycoraninoglycan cba chong. Johnson twyén bi ng 4p suit thin thu fa glycerominoglycon phb bib nkke, hyeluronan, qe: cho bi nae 6.20) ais 7 rong 9 A2 age bidu bing wer (9/200 2). hing £01 938 si trong ung phn td M12 508 Ha v8 4 wg sinh IY 20 4500/ dyn em 2 vin 6b 2 hi pin tich ede vat gu xdp, thst én gt ML cb age cdc ube ‘inh 9 thdm cla v3t 1igu ma khéng thie sv shit ep chit 1éng dt ‘qua né. Wot méi quan he don oid cho phép ching ta ube tinh tinh ‘him tu e4e bide my 1a phuong trinh Caran~ Kozeny . yee] 138 ie HSL con heh nt a a eid os nn chy Le thin a 1B, BLAS cb ch Dd in ha 8 2d xig mn last roseuLle an tes rang a8 2B, My tt aang tag he eg hy At gun WML AN, A co EL P aa ap gin ap sudt tw true xa sou Vin ab 2. Kn phin eich cde vot 11gu xp, thie {8a 16h Hh C6 mbt ech Use ‘inh d@ thin cia vB 11¢u md krdng thye sy phéi p ehbt 2éng 6: ue né. Mae mdi quan be don gin cho phép ching ta ule tinh tinh thin che bin mby 1A pling trkoh Cauman~ Koren. 2 Soe Abe oa dy 2 aah sey 4 chy i ng 8 ef ct ‘ * 238 vat 1 518.8 cum coy 6 np wh BE nit vita, ‘eng ima. enh ih bt ee: -€6og_thé vich 16 x5og —tBng ign eich Ud tnt dong ns 59 YB ing tng KobL ung