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Br-Vivapur MCG
Br-Vivapur MCG
Dispersible Cellulose
Liquid dosage forms are a common and popular Negligible caloric value Non-laxative
approach to overcoming the many obstacles of Excellent sensory properties: Accurate Dosage:
administering medicines to children, the elderly, and Odorless & tasteless Ideal sprayability
animals. However, instabilities such as sedimentation, Smooth texture Easy pumpability
flocculation, or caking – especially in suspensions – Easy to swallow Drop-by-drop dosing
are major challenges in the development of new formu- Not sticky
lations. VIVAPUR ® MCG addresses those challenges
and allows a custom balance of rheological properties Applications
to guarantee high content uniformity and excellent
long-term stability in suspensions, without the need for VIVAPUR® MCG can be used with a variety of active
an excessive increase in viscosity. pharmaceutical ingredients (APIs), offering the oppor-
tunity for new applications and line extensions for
existing products. VIVAPUR ® MCG is used as a sus-
What is VIVAPUR ® MCG ?
pending agent, emulsifier, opacifier, and thickener for:
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VIVAPUR ® MCG – More than a Thickener
Mechanism of Stabilization
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because this only slows down settlement.
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VIVAPUR ® MCG is more than just a thickener.
ge
After activation in water, VIVAPUR® MCG forms a
three-dimensional elastic gel-network of insoluble Agitation
cellulose fibrils, building a yield point. The yield
point is the minimum shear stress required
to initiate flow. The suspension is stable if the force
of gravity operating on the particle mass does not
exceed the liquid‘s yield point. All particles can be
kept homogeneously within the sustaining network
and are prevented from settling.
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VIVAPUR® MCG – Storage
The Gel that Exhibits Fluid Properties
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VIVAPUR® MCG
Microcrystalline Cellulose (MCC) and
Carboxymethylcellulose Sodium (Na-CMC), NF, Ph.Eur.
Viscosity; η [Pa*s]
The density of the MCG network depends on the concen- MCG 591 P
tration of the applied VIVAPUR ® MCG (Fig. 1). The higher 4.0 MCG 611 P
mainly within the first hour and remains constant after Concentration cMCG [g / 100 g]
Fig. 1 Effect of the Concentration of Different VIVAPUR® MCG Types on the
24 hours. Resulting Viscosity Directly after Activation (30 s) and after 24 h Settling
Time.
100
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VIVAPUR ® MCG – Practical Advice & Exemplary Formulations
2. Apply high shear (Picture 1) (colloidal mill at max. 4. Adjust to final volume and pH and/ or sterilize as
rpm. 3 – 10 min; homogenizer min. 150 bar). required. Avoid air intake, particularly in steps
After activation, the suspension must have a rest 2 and 3.
period of at least 15 minutes.
Butylparaben 0.03
Sodium Saccharin q.s.
Colorant / Flavor ad. lib. q.s.
Water (Deionized) for Volume Adjustment q.s.
Tab. 2
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VIVAPUR® MCG
Microcrystalline Cellulose (MCC) and
Carboxymethylcellulose Sodium (Na-CMC), NF, Ph.Eur.
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VIVAPUR® MCG – The Highly Compatible, Robust, and Versatile Stabilizer
Compatibility 8.0
Viscosity; η [Pa*s]
6.0 Propylenglycol Polyethylenglycol
ingredients commonly used for suspensions, such as Maltitol Sorbitol
sugars, sugar alcohols, artificial sweeteners, wetting 5.0
VIVAPUR® MCG:
2.0
0 5 10 15 20 25 30 35 40
Concentration c [%w/w]
Withstands sterilization and long-term heating Fig. 3 VIVAPUR® MCG is Compatible with a Wide Range of Common
(Figure 4) Ingredients
Packaging
Sensory Advantages
25 kg paper bag with polyethylene liner
Activated MCG builds an opaque-white dispersion which 1 Europallet contains 24 bags 25 kg = 600 kg
masks insoluble particles, giving the suspension a Custom tariff '3912 90 90
homogeneous appearance.
Sample Sizes
The dispersed VIVAPUR ® MCG is characterized by an 400 g Aluminium pouch
odorless and tasteless, smooth but not slimy mouthfeel, 2 kg Aluminium pouch
and handles flavors well, which is essential for pediatric
products.
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