Webinar Solusi Farma, 9 May 2023

OUTLINE

1. Sensitive skin & Dehidrated Skin

2. Cetaphil OH Concept
3. Hydrosensitive Complex Clinical Result
4. Cetaphil OH Clinical result

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Multidimensional hydration

Sensitive, dry and dehydrated skin requires special care1,2

• Sensitive skin can be both dry and dehydrated Dry skin

Lacks lipids
Sensitive skin
• It is fundamental to address skin inflammation in Weaker barrier function and
higher inflammation reaction
order to achieve optimal hydration3 Dehydrated skin
than non-sensitive skin4

Lacks water

• Sensitive skin that is dry and dehydrated reacts to stimuli normally well tolerated1
– Stinging, burning, pain, itchiness and tingling
– Rough, flaky texture and feels taut and uncomfortable

• Proper hydration is critical to healthy skin

– Maintains enzyme activity, pH and moisture5
– Prevents sensitized skin6

References: 1. Misery L, et al. Sensitive Skin Review Article. JEADV 2016; 3(Suppl. 1) 2–8. 2. Siddappa K. Indian J Dermatol Venereol Leprol 2003;69:69–75 3. Jieun Han, et al. EADV 2015
4. Reinke J.M, et al. Eur Surg Res 2012;49:35–43. doi: 10.1159/000339613 5. Guzman-Alonso et al. Household and Personal Care Today. 2016; 11(1): 35-40 6. [Howard 2019 – need paper]

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HydroSensitiv Complex

3 active ingredients that soothe and hydrate sensitive skin

3 key active ingredients

Work synergistically to hydrate the skin

Glycerol Aquaxyl Blue Daisy

Alcohol sugars derived from Globularia Alypum leaf extract rich

a polyol present in the skin in soothing glycosyl-iridoids & anti-
wood and divers plants. With
with hygroscopic nature redness phenolic compounds
ability to form hydrocolloids in
order to retain water.

Work synergistically to soothe skin neuroinflammation

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HydroSensitiv Complex

A complete approach with HydroSensitiv Complex

• HydroSensitiv Complex plus additional moisturizing ingredients provide a complete approach to skin
moisturization including both humectant and barrier modulation activities to increase and maintain skin
hydration

Ingredient category Activity Optimal Hydration

Healthy Glow Daily
Cream Ingredient
Occlusive Helps hold water in the skin by slowing down evaporation and creating a thin film on the Squalene
skin that helps block water loss
Emollients Remain on the skin’s surface, lubricating, reducing flakiness and improving its overall Dicaprylyl carbonate
appearance Butyrospermum parkii

Humectants Bind water to the stratum corneum (to draw moisture from the environment and from Glycerin
the deeper layers of the skin to the surface) Hyaluronic acid

Lipid/barrier modulating Lipid organization is crucial for barrier organization1. Some ingredients can change Capriliy/capric triglycerides
lamellar organization of the intercellular lipid matrix in the stratum corneum to make
them less permeable to water1-3
Humectant + barrier modulator Increases and maintains skin hydration HydroSensitv Complex:
(glycerol + saccharides +
globularia alypum )

References:1, Verdier-Sévrain & Bonté 2006 ; 2, J. Caussin, G.S. Gooris, J.A. Bouwstra, FTIR studies show lipophilic moisturizers to interact with stratum corneum lipids, rendering the more densely packed, Biochimica et Biophysica Acta (BBA) -
Biomembranes, 1778 (2008) 1517-1524. 3, J. Caussin, E. Rozema, G.S. Gooris, J.W. Wiechers, S. Pavel, J.A. Bouwstra, Hydrophilic and lipophilic moisturizers have similar penetration profiles but different effects on SC water distribution in vivo,
Exp Dermatol, 18 (2009) 954-961.
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 HydroSensitiv Complex

In-vitro testing of Hydrosensitive Complex – efficacy on hydration

and skin inflammation
1.Decreases Skin
neuroinflammation

5.Keeps skin
2.Optimizes lipid
hydrated 3 times
organization in
longer in over
skin barrier
drying conditions

In vitro testing was completed on the

Hydrosenitiv complex to test it’s efficacy 4.Boosts skin 3.Optimizes
on hydration and skin inflammation: water content by partially bound
INFLAMMATION STUDY 50% water
RD.53.SPR.118777
RAMAN STUDY RD.53.SPR.118777

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 HydroSensitiv Complex

Hydrosensitiv Complex: Decreases skin neuroinflammation (IL8 release)

20

Irritated level
18 (stimulated with Hydrosensitiv Complex
capsaicin)
16 Basal level • Reduces baseline inflammation (-70%)
(unstimulated)
-35%
*
14
• Is significantly better than capsazepin (gold
12
standard) to reduce inflammation
Il-8
10
(pg/ml) Anti-inflammatory -70%
effect of *∞
8
capsazepin

4 Anti-inflammatory
effect of
2 Hydrosensitiv
• “*” = significant differences versus irritated level (p-value<0.05)
Complex
• ∞= significantly better than capsazepin (p<0.05) and baseline (p<0.001)
0 • All Pairwise Multiple Comparison Procedures (SNK method)
Normal condition capsaicin capsazepin Blue Daisy 0.015% +
Hydrosensitv
Glycerin 0.5% +Complex
Aquaxyl
keratinocyte-neuron co-culture 0.2% 7
 HydroSensitiv Complex

Hydrosensitiv Complex: Decreases skin neuroinflammation (CGRP release)

12.0
Irritated neuron • Hydrosensitv Complex
(stimulated with has a significant soothing
capsaicin) effect by reducing the
11.0 release of CGRP after
-61% irritation

10.0 *
CGRP
9.0
(pg/ml)

8.0 Basal level

(unstimulated)

Note: CGRP is a pain mediator in sensitive

7.0 skin. CGRP release is a marker of neurogenic
inflammation

6.0
Control condition Capsaicin 10µM Hydrosensitiv Complex

• “NS” means non significant

keratinocyte-neuron co-culture • “*” = significant differences (p-value<0.05)
• All Pairwise Multiple Comparison Procedures (SNK method)
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HydroSensitiv Complex

HydroSensitiv Complex preserves the skin barrier

Preserves skin lipids organization* and barrier function Improves stratum corneum organization

Lipid lateral packing of the stratum corneum (at

the surface) Hydrosensitiv Complex
Optimal Structure
2.15
• Preserves a maximal lipid organization
and the barrier function* under high
Band ratio: vasymCH2 (2882cm-1)/vasymCH2 (2852cm-1)

2.10
relative humidity (blue circle).
2.05 • Effect is maintained and slightly
2.00
enhanced throughout the dehydration
process.
1.95

1.90

1.85 Hydrosensitiv Complex preserves

Water alone
1.80
skin lipid organization and skin barrier
Hydosensitiv Complex
1.75
whatever the environmental humidity
1.70
0 1 2 3 4 5 6
Weaker Structure Time (h)

*In vitro study on the epidermis on the complex under dehydration/overdrying conditions versus
control
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HydroSensitiv Complex

Hydrosensitiv Complex: Boosts all states of water in the skin (i.e. global water
content)
Increases skin hydration

Water content (All 3 types) of the stratum corneum

Stratum corneum with Hydrosensitiv
Complex has a long-lasting (at the end of the
Band Ratio: vOH(3100-3700 cm-1)/vCH

(at the surface)

drying process) surface water content 50%
0.6

Water alone
superior compared to water alone
0.5
Hydrosensitiv Complex

0.4

0.3

0.2
Hydrosensitiv Complex
0.1 +50% boosts skin’s water content
0
0 1 2 3
Time (h)
4 5 6
by 50%*

*In vitro study on the epidermis on the complex under dehydration/overdrying conditions versus control
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HydroSensitiv Complex

Hydrosensitiv Complex: Keeps the skin hydrated for 3 times longer

Increases skin hydration
Water content (all 3 waters) of the stratum
BAND RATIO: VOH(3100-3700 CM-1)/VCH

corneum (at the surface) Stratum corneum treated with Hydrosensitiv

0.5
Complex reaches the plateau (minimum of
moisture in low relative humidity) 3 hours after
0.45
the start of the dehydration process (blue
0.4 rectangle), compared to 1 hour for water alone
(green rectangle)
0.35
x3
0.3
Hydrosensitiv Complex keeps the
0.25
skin optimally hydrated for 3*
0.2
0 1 2 3 4 5 6
TIME (H) times longer in over-drying
Water alone Optimal Hydration Complex
condition
*In vitro study on the epidermis on the complex under dehydration/overdrying conditions versus control
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48H Activation Serum

Refines & smooths sensitive skin to improve appearance, after just one month 1

9-very intense

5.00
4.50 4.17
4.56
At 28 Days
4.00
3.54 3.54 98% reported the product helps to
3.50
3.00
improve the appearance of
2.50 sensitive skin over the long term
2.00
1.50
1.00
98% reported the product improves the
0.50 quality of the skin overtime
0.00
Skin grain fineness Skin radiance
0-absent

D0 D28
N= 41, 4 weeks in use test - Clinical grading by an expert on a 10-point scale p<0,001
(Significant at 5% - Wilcoxon test)

Refines and smooths Improves appearance

After one month, refines and smooths sensitive After one month, improves appearance
skin to improve appearance

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Refreshing Eye Serum

Reduces the appearance of dark circles, eye bags and puffiness1

9-very intense
7
-8%*
6
-22%* Reduces the appearance of dark
5 -14%* circles, eye bags and wrinkles
4
Clinical scoring reported significant
3
decrease in dark circles (-8%), eye bags
2 (-22%) and wrinkles (-14%), after one
month of twice-daily use.
1

0
0-absent Visibility of Dark Circles Visibility of Eye bags Visibility of Wrinkles

D0 D28
N= 42 or 22 (eye bags only), 4 weeks in use test - Clinical grading by an expert on a 10-point scale
p<0,001 (Significant at 5% - Wilcoxon test)

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Healthy Glow Daily Cream

Respects skin barrier & soothes skin sensitivity1,2

95%
The product soothes my sensitive skin 95%
100%

98%
The product has a soothing effect 98%
100%

98%
The product is suitable for my sensitive skin 100%
100%

The product helps to decrease my skin

100%
sensitivity 100%

98%
The product leaves my skin more comfortable 98%
100%

Immmediately after the 1st application D7 D28

Respects skin barrier Soothes skin sensitivity

There was a significant difference for TEWL* at Patients using Healthy Glow Daily Cream
30mins and 4 hours, after application1 reported that the product helped to decrease skin
sensitivity

* transepidermal water loss

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Body Spray Moisturizer

Decreases skin roughness & improves skin quality1

9-very intense
Roughness (tactile evaluation)
Overall liking (satisfaction) of the product. 85%
2.5
-49%*
2

The product helps to improve my skin quality. 97%

1.5
Mean

The product improves the quality of the skin

0.5 92%
overtime.

0
D0 D28
0-absent
N=41, 4 weeks in use test - Clinical grading by an expert on a 10-point scale
*p<0,001 (Significant at 5% - Student test)
Improves skin quality
Decreases skin roughness After applying the product once daily for one
Clinical scoring reported significant decrease in skin month, patients agreed that the product helped
roughness after 1 month of daily use (-49%) improve skin quality

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