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  • Collagen Syntesis DR Teguh 05072023

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    Ricky Lapian
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    The document summarizes the process of collagen synthesis, which occurs in both intracelluar and extracellular phases. In the intracellular phase, procollagen chains are synthesized on ribosomes from mRNA. The chains then undergo hydroxylation and glycosylation to form procollagen triple helices. The procollagen helices are transported to the Golgi apparatus and secreted into the extracellular space. In the extracellular phase, procollagen peptidases and lysyl oxidases break down and modify the procollagen into mature collagen fibrils. The entire collagen synthesis process requires various vitamins and minerals as cofactors.

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    Collagen Syntesis Dr Teguh 05072023

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    The document summarizes the process of collagen synthesis, which occurs in both intracelluar and extracellular phases. In the intracellular phase, procollagen chains are synthesized on ribosomes from mRNA. The chains then undergo hydroxylation and glycosylation to form procollagen triple helices. The procollagen helices are transported to the Golgi apparatus and secreted into the extracellular space. In the extracellular phase, procollagen peptidases and lysyl oxidases break down and modify the procollagen into mature collagen fibrils. The entire collagen synthesis process requires various vitamins and minerals as cofactors.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    8 views10 pages

    Collagen Syntesis DR Teguh 05072023

    Uploaded by

    Ricky Lapian
    The document summarizes the process of collagen synthesis, which occurs in both intracelluar and extracellular phases. In the intracellular phase, procollagen chains are synthesized on ribosomes from mRNA. The chains then undergo hydroxylation and glycosylation to form procollagen triple helices. The procollagen helices are transported to the Golgi apparatus and secreted into the extracellular space. In the extracellular phase, procollagen peptidases and lysyl oxidases break down and modify the procollagen into mature collagen fibrils. The entire collagen synthesis process requires various vitamins and minerals as cofactors.

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    © All Rights Reserved
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    of 10

    COLLAGEN SYNTESIS

    A. INTRACELLULAIR
    ANTII. AGING
    Transcription
    MEDICINE

    Pro α 1 Chain

    Gen Transcription
    Pro α 2 Chain

    mRNA Formation
    ANTIII.AGING
    Translation
    MEDICINE

    Migration mRNA From Nucleus to Citoplasm

    mRNA -Ribosom Interaction

    Move to Reticulum
    Pre Pro Polipeptide
    Endoplasmic
    II b.ANTI
    PascaAGING
    Translation Process
    MEDICINE

    Peptide Degradation of N edge

    Lysin & Prolin got OH (Hidroxyl) Hydroxylase


    Process by enzyme Hydroxylase Intervention
    needs Vit C as a Co- Factor

    Glycosylation Gugus Hidroxyl of Lisin with


    Galactose & Glucose Glycosylation Process
    III. Chain of Hydroxylase + Glycosylase
    Process
    Produce Triple Helix Pro - Collagen

    Tri Helix Pro Collagen Driven to Rough Endoplasmic Reticulum


    Divert to Pro Collagen

    Pro-Collagen moved to Appartus Golgi Breakage to Small Molecule


    of Collagen

    This Process is in Vesicel Secretoric


    Send to Extra Cellulair
    B. EXTRACELLULAIR
    Breaking Pro Collagen to TROPOCOLLAGEN
    needs COLLAGEN PEPTIDASE ENZYME

    COLLAGEN FIBRIL Formation needs LYSYL


    OXIDASE ENZYME
    All Process of COLLAGEN SYNTHESIS need :
    Vit C, Vit A, Zinc, Prolin, Lysin.

    Vit C needed for strength Collagen Molecule


    Binding
    : @teguh_tanuwidjaja

    : Teguh Tanuwidjaja

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