1. The most possible issue you are experiencing - immediate start-up crash.

For this issue, "Problem details" section inside the crash dialog shows this:

Problem Event Name:

APPCRASH

Application Name:

DevilMayCry4SpecialEdition.exe

Application Version:

1.0.0.0

Application Timestamp:

556d7520

Fault Module Name:

DevilMayCry4SpecialEdition.exe

Fault Module Version:

1.0.0.0

Fault Module Timestamp:

556d7520

Exception Code:

c0000005

Exception Offset:

006970eb

Note the Exception Offset value. If it's same for you, this is your problem. Here is how you can fix it.

 a) Launch your hex editor. Drag-and-drop the DevilMayCry4SpecialEdition.exe file from the

game folder to hex editor window. Or press Ctrl+O and use that to open the file.
To find this file on your PC, right-click Devil May Cry 4 Special Edition in your library
- Properties - Local files - Browse local files.

 b) Go to offset (Ctrl+G): 6790E7 (or 6787303 in decimal mode).

Older version (pre-2018.03.28) offsets:
WW: 6964ac (or 6907052 in decimal mode)
Japanese: 69686c (or 6908012 in decimal mode)
You'll see the following hex values at cursor position:

80 02 00 00
Change them to this:

00 05 00 00

 c) Save the file (Ctrl+S). All done.

You can try running the game now. This should work for absolute most people having this exact
crash.

Still having the same crash happening? Are you from the future? See below.

 a) Repeat the above editing process, but this time write different values to the same offset.
Depending on screen resolution you want to use in game, try these:

1280xAny and above: 00 05 00 00 <- this is the value suggested above

1360xAny and above: 50 05 00 00

1440xAny and above: A0 05 00 00

1600xAny and above: 40 06 00 00

1920xAny and above: 80 07 00 00

2560xAny and above: 00 0A 00 00

3840xAny and above: 00 0F 00 00

 b) After this change, even if the game will run, it will not allow you to change th