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  • 化妆品抗敏安全性评价模型的研究进展 蔡义文

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    化妆品抗敏安全性评价模型的研究进展_蔡义文

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    26 views7 pages

    化妆品抗敏安全性评价模型的研究进展 蔡义文

    Uploaded by

    adam fu

    Copyright:

    © All Rights Reserved
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    BH | Technique express (min WAS Ei MSA BLL ER, SNR CPi a Rane eTSC RATA, PAR PHL 510000) SR, MET RARE, WAT AY PRET ORSINI SIN LARRbS, Bi INRA. RODS: oR; ies MERA PROS, TOSS — WALRE: A DOI; 10.3969) issn.1006-7264.2021.03.012 SRSA ATP RRBRIS I RANI, SHRI RRL RT BITC T MAPA ATURE MELT, SPOS TTT AOR SCES, 1006-7264 ( 2021 ) 03-0048-07 CABALLERO, TRF SE LE BARMATRLR MN, (LAAT RAR RL AGIA IN, A eS RR MS, ABRADRDAMTMEASAS (ALAM) SAAR RMR, Mike METAR ABSA RIT HR RR ARAHOONOLLE", ART REREHLAL AUER ARORSRU, PREM, SRI AMPERA PR MAMRM HSH TATE, CEMINRER. Bite, HL ARAPTME TASMAN INKED, RSM a Ses ERMA TRAM AA AB RA EI 2, (RHI, “Met “RIAA “RATA SALAH AERAAT, SRARKAHAREEES ESAT LATER, MARSA. 2020598 AGN CARDED ERE) HAT “Se A LR LAR (OLA) ". “ALRIRAN FEAR)” ATH, REP, SEES TARP Be ‘Hei BABS RTL BL LTR PEI B 29 AA SE Ae. STN A, MAR, OS, EE AARNE, IULKRUBION, 2A sats: ALU-11-28 Us A FL AL TE DOTA AMMALSEA, HEPAT IRIEL, RRS RUE RIAA, DSA. IV TARE S RRA, SRI ARAM GATE EOE. DAT AM, FRAT, DRIVER, HME SOONER MATEO CORR, SRAHRALTAL RATER". am en Tt exmn-> [AR SEAEIO, ME > ae aman aE) cameaa I ' 4 Dem eis. Fara, mi eSeIN 1 mA Figt Process ciagram of Type alargic reaction PREGA: SORES"), HHA, RITE, Wet, MU: 15018651271, Emel: 371260235@aacon. zee Technique expr ar eae. a a aa Roe 2 Ivete mist Fig2 Process dagram of Type! allrgicroaction AM, HHRMA MAMMA, GIRASNRES, aH HNURSE. SMAONERE OL Ait, AS TRAE GAME TALL MRT AR AE, MALATE AME AML, Alt, AATRINER, ARETE RASH, DURAN ARE IOLA TRIER THOT ITA 1 BRABANT EE BRAMAN, HLM AMES FER, BAMRAML-AESS RAN, BBX Am, SAMAhKReRS. ASMA EME EAR, MR SAMIAT LM GEE IER PAR i, ROSE EN EMER, TREAT KD HM, FANELURAAAES, RLS Fem, RM, HEALER, ERT ARAN RE Ak, SRAM. ARO SHETPAG ARIANA TS fi, BOHTSE ¢& (HIR). H23E HE (HR), H33E 4 (HBR) FAHAgoe (HR) (3). SRE SMHIRA HARSEth. HIRMGESTS 7 i SUD we AAR, AA K MHADKH, RRL, MRARMEAF RARER ORAS SAAT. MARS SHALE ME RK. Gisn, ‘SHIRAMMARTARE STAT MULTE ER RAVI SMRNRENAS, THeRAM RD oh, SHEMINI, MARSA RADAR, Se eeSLAL AURAL Fe he RTH AR TEA AE SRACLCEHARRIG LDR ATE, ‘a 4 NH Hr asumene RaeEen wenn sssunnesten toh tor mRReRASe epsisioee ke RSeteneai Ee EBR Ce eet) Fig. Diagram ofthe biological effet ofhistamine BHERAMH AMA RM ATOR RAL Wh, S068 EISVMRISEAA)ASymcalminksatas. 4358 BjULAV HREM PL IRINISEQENS (SELB) AE Sens’ flower SD-SCHALTERPRAF. HALIM OAR ZSARZPCHANt allergy 7ASHR RUS SEAR AN, HEIL ARATE SLAM AARMOR IER. Blk, HH) ARPA MURR ER, TLRS WARARS, BRAERM, MOTH. SRL BARRERA, HMLUANHAR ATA MRA DLHIRAMHGR A BUEN, 14 BOR HORIRL ‘BARD, WA MBAR ONEROUS ‘SAE, AROMAS, MRSA, HLM ArHaRALSER” ke, ERS RRS OLA REARARMOMREMAA RIA, BRE ABA SMORIAMA MEM. JER, Beata ARMRMAURDT TARR, Seva, SR TR ARR, ABT, MLR, URGAAT) MERLE POCA ATER ARTE. REET TRH, EN ARMANI LAAN T A ASTOR, BMUAS, Hee, aM PEMSRATAARIMAENM: the RT HAL FRERTOTARAMER, AMAR GMSMA, RAR TRINA 1, SEAR AMM ARES TRITON sana 12 Lambe sninamasae LAREN SA LAR A A PASS nese roiensm 49 BH | Technique express HIRATA AR — AAR NFA ELBO RSTO, ATI SBIR ILRO A RARE, A A ARERR RARE AHR, SAS a Ze ROE TR SASLRE RRA MOAT REARS HOULRLUNL. ASHWINE ‘ap Fe A A BresolD];JRE-A#RHGAVEL ANID AURA UA RAR RLMORIMER, FRAT Bresolliat fe 8 4048/8015 5 ANREA SA RURLRLANER RA, AURA RUE RLARER HIE ER, AMA BHA HMBresol NAHE AM AMAL A MN aE TARR HE ATT I HL 48 COR SHE MRE. = RAG SBA INR BAAR ARLE BEL SA eh, ARRAS Lem y arnt MAIR INIMa, 31 AILS IEM Acie, SkaSAT SER PRB SOMA T SARS AAR ARE STS Hi BRBKAORZIG, AASOASTARIATI IGG Se STARR TR AMM MARR EK, Ait, swe SERMOMGONAIT AAR, MRiTapiNTAa VHA MAR, ARMOIRE RAT LRRTE, AILS FRA ite A HAL A, 1.3 BRAC RIM SHA LSA RL AR NF AP 2, RMSE. Job, Seem, Monette WS}, RRL, ARMAS, SYMRISEA ALR AA SEAOMETI A EMSA MOAB LA MARFRLEIE(10 mg/mL), FF RRA IER, RERTTEEFA(2 mglem’), ZEKE S7= RR HN30. 60, 90, 120. 150minMSENtSRAnLiN ES, ATU AE MAD, SALES RL aymCalminBl iS ‘PPTL MRE ASL ARERR MAN, SOAR. STAR Ok8, FRAN MIME. REMAIOMERS SER BAERS, GREVMARMMORETM, HAR RHF RM RATA MLSE, Hb VRAD A tbs a OTHE, 2 EDR RAR AMHR EMS (AA) ERATE HMMA, HAF sens, EEA RAHN a0, ZENS AH iA70%, THMRAATE AEF RRTP. AAR IM SLSR ATED TURES, KAMER, A 50 Vass Nos ABN EWR AR ARDY A TSE RR, AE RLAA, ORS Hy EE R WIRRPGE, ARLE A, TR F. RAPT, SRAM RERH(LTAGH) BAA RUSE RATING, Keak RPE REET RS BA(LTBA), LIAS SARS SMRMINA, HUM AA HOALTRAS EM DLTBAM Srna Ae SHR NRFR, RAR OMAR, oO Ho a ecepuNen ss Festa Fig Molecular structure of arachidonic ace 24 UVB BBR UVBRRMI ATS] i2 ike meee, eee ME RRS BUVEEIRAME, SAMARIA, oe sane 3K, BURAK MIRAE, AeLMMIB, COX-INF IE HAERAREGM, CRRA —OUN, BOR AMERSHAM A TIARR (PGE2) WTA IGEIRE B, RTNRSAMTRLAT MARR (PCED At WR, WEE AINA. EBL, COXITE DWAR RN TARE IMEMOHEAR, UVBStE ASE TRE A LIOM, ARAVA A ARORA, AG RTIUVBRIAND aS B, RSL R UVES, AMRIT METUVEAG AM CRO ASAE, Inet {RTp53. caspase-3, baxmRNAMRE, WAITILG, IL18 SAEROMRA, MCE TEAS AR ARMMP-1 ORR1A, RBA) ARGE FBTR MSR GPG Ae A824 h, SV AHABOERS-FUVB (25 mi/em'}eORRHT, BE, WHRERPGRIN SKE, SGP RAMI Me SGRIh UVES A MMAR RPGES ID, MATERA, TOR AST SRA HO K-3-H A MF LUV BH HaCaT ROS/COX-2i8i88, A AUVBHHMIE ROSH FEI, st JREFGR, ATHORIRERK, p38, INKAUAKIADEERE, a5 COX2H028i5, ALDINE EFATIARA (PGED) MEAL. iA BEL, Technique expr ar 2.2 AAS MAE EPRHEA ATLA T MRR ZEA, BERMASHE ULHRA SULA, MHA SNe RUHR TSU FR (PGE2) SARAH, MO AAS AE ARREST A ROCHA, ROTA LETRA AT RKREMARR ASHER, I Fete Ra seEAsth = mBaty trem, BHATS™ REL ARATE ARABIA WLMAICOX-1AHRLPGEZA HD, Sy RARER AROSE, mse tse Tae SSEG A ERD, BE TTHCASAIC A ITA TAOSETGMARATHH, SRAMTREMMI ARES AERO TOP, 2.3 AA WESABE AAR SMM NKIE LF (PAF) —FMMm TE SOE, AMRUMINR, HAREM, PARA EAM RAL ALEP APS PRU RSROER, LS sae TE MI TE THE RAR PEROAUPARMAMARS, AOMPARS SRS hk REA, MALMRI PARRA UREN 3 IgEA rae Lig PARE EB = 5b AH 100 LNA ERE A, STURM ERSSH, MA SMARMEAR, SORE RMS™. QE: cBMMMLL AIK MRAM ASAMRAIGERBAK (Feo, CD23) AH AMAIQERH (FoeRI). Fee REAR AARRG ANNE RATA EbLOUSEH (apy2) SOREStaeik. Ecc eR BROS (oy2) ATER. A RLHERLEMIE eR IRIAN AE SUPIQEK FARK, SIQIRARET ARE Hh, FcRMRRA CAM, MBEAN RNA HS, CRA RITIM, IQEREX SURO PANE HISAR AIO BEREAN ROARED, MEMEO RAMIPREMIGERMIAT, RARE bik FRAIL AREDIGERVE LAA HE IGEN AAT BEN ERD, tk, VGH SH AMATE, MBIQES ARAN Sh FOMASRTHESRBSR MASAO SEA 5 SIRE (lgE) 8m Fig Schematic clagram of mmuroclebul E (gE) Kelly2e "FARE FceR IAEA RET NEES AMM, GRAMEEN, TIDE ARAMA PIOUS IR GEMMA. SEP FAHITACHI 717002 eaahce (LSPA LRAT TOOL BL RRGLAMA IGE, MASSON TATE AT ARS AMARIGEAS, APURSMRMIERARANE, FRMIMIGEek Sita Rem He RATAN MSMR. EAM VUGE NER T SERIE PMG SWAERMN, SRA SOREL ARUMAIQERILTAD am, OANBRt-> Sn hey OSS, WNBA ERE AR, MATA BER MOH EURA MARE TNA REAM, BetA IGE, AMHR mg/MLRE PMSA LAT 83.4%, SER FRR. 4 PAF AC AAT MPS MAF SHR ema MHS MMe. Se NEXDESHRIN, ESS HMRI STRAT RRA, SOAEIVEUEL LR Ae SARE (BQ) . SEAMAMMERE EF: TNF-a. TNE-B, AMR: Ila, IL-6 IL-8, SRAPMIREIFG-CSF. GM-CSF, 4.1 TNF cc Rui RF ARORA ARERR SOF, Ce Sa AFAHRRE, ARRRERAPHRERN, RR SG E ATO ng/mLANTN- cA ARISE, AE 820 nmol/L BRAD, AV AEABTNE- co RRL BRR AE PTT RO AEDT, BASRA DRISREE (ELISA) SDL KIRRITNE- cA AEE Pe hanls nae moose mom 51 BH | Technique express a EF ROP eT. 4.2 Isom (LSP) WS RAW264.7 Eimemete ASM (LSP) SEARASHAAM— AHA F, ARAMOW RMS RBA LL SR ORAL FTAA, HN UREA RAIA, BERRA ARRTRAE Ht, SLSPRNM HERE NATAL. LSP HER FRAW2647i5 BAER MALO, TEARLSP-LEP- SCDI4S St6 (EB FTLRS, SFRC5NF-KBAIMAPKs {ES 38, TSERIRAW264,7 EeBsslNaPINOSHICOX-2A7MRNAZ iA, (RUEAEEAEDINOS, COX-2N¢E5R, sMan(e se teen AFHOTNF- a1, IL-GAIL-1 BANE, saa TLPS HSHORAWIE ECARD, RAPS ARYETNE-c, IL-GAIL- PHAM, kD (ER. EMS OVEN SALMAN MAI, a PRBS, MBE AM NEMDRLR SBE RAW264.75}iU 800 ENF INF- ct ORR, 4.3 GhisiPe (TPA) Sav) ER TROBE ‘TRASL/IsE MPBK EU EEA ABA SA ELSES IN AUR TNF-a, IL-1 BSAESGAF, TNF-a ROAR ERM Ee, RA Rei STK, MTA AANR SAAR, (Rit APGEDAT 17Ra, (esteRReFOS- BRNO, nme. ruben PATRAS AH BHM AONE BS PTO ATES FRNO, PGE2. TNF-a Asti, SHEREIRTPARS AV) RR FAK, EMMI MAMAS, we SERTTPA-SA0//RLNAALE, TRON Ti AOR AE LTR, wR, Fete Me MAE SNOT AR LISI TP ASE 5s IRIN PN EE COX-2AAABNEKBIERAIEIL, SMBIEIASE 46%, 5 BREESE (TRPV1) RS RE BMS BURR BOR (TRPVI) iE SAF OTL RN A A SH, BWIA EO me, TRPVIERS AY, fEBIABCa*. Mg? #8Na' SIRF AIL, {8x1Ca"4aMg™ FANREGR, TRVIESROAMAE RES, JMB ANRBRH (Bo), TRPVIT LEAR ATEN MAN RIESE TRIAL, POR TIA SH, VEE AF ANP AE UA AK CGRP) EAL 62 vas Nos RAUF, CGRPRK—TMUERRAM ss OS Sik, 8377 SaSMesM, TRV CORA AM OSH, capsaicin tics ca Nar ot SRR EOD Ise Eek pa RR SEA IS LB A FEL AE SEMEN, EMSA IEA, PIN, Mae AMOI CEG RR EHR AS PALCEBNIR, SARAIVA” FLAIR SAI EA BMALTE AR RENO AO ABH JER, GUAT AERA ARK 5.2 BRR A PIR Sea AMEACMRALEL AAR A MF UE RORM, MARR, MAR NIBH. SYMRISEA F142 4931.6 mg/kqiRhR AI 196i HEN A ELA APAETRESR MOE, SRAMMRMERTIE, ARI 96i A HEAD SE MARS ALL AMT. 6 Hii (Het) (201TH) ATRARET ACRE ARERR, AGRI SHRINE, DLR WIRAMRRTR ROAR HE, Bob, ATL RSLSRA PRATT, MRR AT EI TEWL. @7ki. pHia. Labia, MFIRHHMIREMIR RAMEE AMORMMR ARES, 7 BRB Hee, APLAR, SRLS ADL, ESA RAR FORMAT, AMA RTH HA F, BRAS OACE AROMAT AA 50, RA RUE SRERE, tb IMITATE, REMCHARS, REL bI ARE Technique express | BIH ALANS EY, Mth A RR SII CARTAN AA ASAER, Bl, RAMU, SHANE ea Le EU AL A AS A RL te RTAARRAEREN, HRT, eax: LU) Miah, fees RAM ALAR. WAAR A, 2006, 3514): 260-262 2] WER 2a, BALI, S, RURAL AAA a AI Aes h ha MID) BHF AAs, 200064 41-44 (3), Hea, HIRE, ala, se ak akan LEA ATL A Atl, 2000(4: 87. (6) Ae aes At A Rk Rt AUMSFSEID] Aa: AEP BB KA, 204, [5] BORRIELLO F, IANNONE R, GIANNI. Histamine release from mast cll and besophils{M/isamine and histamine receptors im heath and disease. Cham: Springer International Publishing AG 2017,2017: 121-13. (6) JAMES C, BERNSTEIN J A. Curent and future therapies forthe reament of histamine induced angioedema), Exper Opinion on Pharmacotherapy, 2017, 13): 253-262. [7] HAMANN J, AUST G, ARAC D, etl. Intemational union of asc and clinical pharmacology. XCIV. adhesion G protein-coupled scecpor}. Phamacological Reviews 2015, 612): 338507. [8] MAHONY LO, AKIDS P MU. Regulation of the immune response and inflammation by histamine and histamine recepers{) Journal of Alergy and Clinical Immunology, 201, 1286) 153-1162 [9] ROSSBACH K, SCHAPER K, KLOTILC, el Histamine 1H receptor knockout mice display reused ination in a ehronic ‘model of topic dermatitis, Allegy 2016, 712): 189-197. (10) Fk, RP IR AAO A RID). es Se A se, 2006 (U1) AK, Se, SEO, te SOE eo, ih, GRIESE), LAPIRAS, 2019, 410): 354359 [12] DEESCH 1, THURMOND RL, JONGEJAN A, etal. The histamine Hs receptors anew therpeti age for nlammaton) Trends in Pharmacological Seienes, 2005, 249): 462-469, [13] FABINYI M, SZEBEHELY! J. Effet of histamine on hyaluronidase activi]. Nature, 1989, 163838, [14] MURATA T, MIYASE T, YOSHIZAKIF. Hyaluronidase inhibitors fom Keiskea japonica]. Chemical and Pharmaceutical Bulletin, 2012, 60(1): 121-128, [15] MOHAMED E M, HETTA MH, RATED ME, etl Bicasey-auted isclaion, mabolie profiting, and docking sues of hyaluronidase inhibitors from ravenala madagascariensis) Molecules, 2020, 25(7): 1714-1726 (16]ZABUSKI D, OLECH M, GALANTY A, et al Prytochemical content and pharms-nutiton study on eleutheroooceus senticosus fruits inractum[3]. Oxidative Medicine and Cellular Longevity, 2016(10): 2, (7) 20, BALA ROLE, sha MBAR IDL AR: aL KA, 2015 (08) A148, RAPA AR A Me AE MR ID} Xs sesh KA, 2012, [19] ASHWINI Y, RAFIQ M, VISWANATHA G L, et al Polyherbal formulation Bresol®® protects the mast cells against compound 48/80-induced disruption and histamine release: & non= immunological mechanism of mast cell sabilizaton{J). Zhong Xi Vi Jie He Xue Bao, 2012, 10(6): 690-694, (Ro) ae, HAAS, A, RA MNRAS AAP, eh APRA ASAL), ATP EAR, 201, 28151 4-6, (ny Sea, Sk, Hem, 4, A A AA ALR et SE ALIGHLIP APA, AMEE La, 2015, 45(7) 409-414, [22] whack, aL Ae tne = Mae Ota MBI ALR, So thiRsb thai SAI PID) babs aT A, 201, (23) HR. MARKS = HeAaR a A Ae HA TE, [D] aR: Kae HR, 2015, [24] 200 Z, OUYANG W, LI etal. Cyclooxygenase-2 (COX- 2) Mediates Arsenite Inhibition of UVBInduced Cellular Apoptosis in Mouse Epidermal Cl41 Cells], Curr Cancer Drug Targets, 2012, 126) 607-616. [25] DUBOIS R N, ABRAMSON S B, CROFFORD L, et al, Cyclooxygenase in biology and disease(J]. The FASEB Joural, 199842): 1063-1073. (26) BL. ARE oe UV Ak bd a LH SUID) eles LARS 4, 2011 [27] fk, det HAS. ARF RUVBANHACaT INT ROSICOX-2188 940 -5F EID]. PMs SiH, 2016, 28) Bt, Roh, 4, F, Reba ME ALT. PO AR A A, 2005(2): 34.35, [9] atm, $s, THF, A Mobo st Ap Sahl PEM) AAA CHEEK) ,2017,34(1): 46.50. [30] BHAT K P L, PEZZUTO J M. Caneer chemopreventive activity of resveratrol[J]. Annale of the New Vork Academy of Sciences, 2002, 957(5297): 210-229, aAe$e4$ nae scmaom 83 BH | Technique express Di] RE. Sar RA Ahk Rah Ad PRD) ak Ag 2018, 2] A, 98, Seth, Ne NER STEM ODOT] SPRL He, 20040): 105-107, (33) AAR, Fema a dade Ao Manto RD atts ata PIR APRA, 2006. [4] SUTTON B J, DAVIES A M, BAX HJ, etal. IgE antibodies: from structure to funetion and clinical translation(J} Antibodies, 2019, 81:19. [35] GOULD H J, SUTTON B J. IE in allergy and asthma today[J}. Nature Reviews Immunology, 2008, (3): 205217 6] GALLI J, TSAIM. IgE and mast cells in allergic isease{. Nature Medicine, 2012, 185) 693-704 [7] KELLY D. STONE M, PhD CP M, DEAN D. METCALFE M B M. IgE, mast cll, basophils, and eosinophils.) Journal of Allergy and Clinical Immunology, 2010, 125(): 73-580. [8] BAR, SPAR, She IgR tome Bon Hm hat AHA AL, RMSE EA, 2011, 18 1100-1103, [D9] Eke, BM, A, , dene aeeahede pes Hida AAA IGTE TILL). PH, 2009, 110): 721-724, 40] MV, AL, Allergy and Clinical Immunology, 1994, 94(6: 1289-1293, fan) RH, SRE, A, Hh eR ATTNF-o Mi HaCaT A A RM RAL AM al), ARS HO 2, 2019, 3719): 211-213, [2] Aah, FAR, 2, 5 SLR ARNE ih HaCaT ak FAL]. POPS IR A Get al. Cytokines and allergy{J. Journal of| £, 2019, 118): 15. 9] ALATA, PARR Sabah ABS F HOR AW264 TER RAO AASHNID] HE: HELA, 2019, fi] 365, SOMMER) klk lee BAA 2018, 5] 3H, MMM, AR, AP HO RIS a mS aR FORAW2047H0R RE MEM-AIEL], DUS PF RAT, 2013, 29(7)- 681-684. (6) #5Sk. in SACRA GHAR). OH: #2TAF, 2007 (7) 69%, st. 8 a IAP ALMAITAD) Pls FR LAK, 2017 [48] ALAWLK, KEEBLE J, The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation() Pharmacology & Therapeutics, 2010, 1252): 18-195. [9] TOMINAGA M, TOMINAGA T. Structure and function ‘of FRPVILJ}. Plugs Areh, 2005, 451(1): 43-150, [50] Abe, FAI, Mebe. MhibeA Ree CTRPVIA A AE eM AS eA Rothe A TAR, oR aR AAR ARAR, 2011, 28411): 917-926. 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