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Tre = endothelial damage ‘ey endotonn | -anttocy pins poner : : : Soleoves WWF normed ESN OER Ecol wertorm | are ob wu maltimar’> A Pall aches = childen Ee variances |- adult Cemeses [ex olororrnults = capes candvteody = digs - infeckicn, ‘underliooked eet B Skim & mecoral Lleechney * Fever ® Micrwarqopatinic barroly he anemd, x Thromacaylepeng x Blecing hoe ~ Necrred PT! PTT a megakerypostes He peemaprasets FG epeeaty é9 TTP Corhccateronds BiBerass- Souler Syndrome. = gence CPi ddficuncy “> Imperrs) plodeleh cadrenon = MNO Trromboeyto penta (inactive godedets cort Wwe tera) entewcjer) plodelels (Fedve\ien a6 hnamtere Plateless) TElGlanemann Mtatoaousiognine, *hroriaadinero, genetic CPAoflla deleuney = Impaired Plateleh achreacdon kDisoders of Secondary hemerer OE EES ERS — adue to (actor ctonerrat kes, BV im ertrrste, (Gator Si) . e . 2) oS common (IL, * ~ Cerveatlyy —— dep Hige bieding (mactes Bt" movers Geneon) Rebleading alec surgical Procedures PTT. pies (Cam “a cle hela, NN ittoonel een D\Veroghtia B Cennard 2 Weer -Cenehe dedicioney (odor 3 -Cenetic deficvency i» Lecter THE AoT, A XLunked Receriave (omyio ried AH reconorrent Coctoo TL + TA Geaguiosion Retor delioney anitbedies agcinst Ceaguiahon Rector Some a8 Hemoghihe A Mixtwag odes Correct PVT spimpeind Reber Secon am Sacer TH antvloode > Nempfnitin Whe SYmploms “m\ing Shdies Goew4 Corcect PIT ecouse PNY SSlorenese, Nagyn Hernopialte, A> : FAW “von wilogerd Onease (Ines common tnertted Coxgatatin dott) -Cereric WWE dolcarcy “AD wl decreases vWe level ® of the anivbaly Mhreecding hme , . “less Shetoikzoten & ~ iopoured Plated abhesion APTT “ess Seskay = Ne deep Merwe Ueerhva, rormal OT us ceding Go Ronorma Rigracatin Sesh ah ssi ADA OrPIA\Ve™ WF Ylease Worn seabenetin Weak Yo Robbe aaa eee ae ~ cee \oches, Sern ‘96 REC, FE] Vitamin K deficiency + avced by q— Mdelbso lack of UF aolonzaton by Vit K- preducing leaclera advvie Rrcionaf Gaypletin Geors (IC, , IK , XL Petein c4s) fequired Sr (-cortorylodisin oo erePTy Woler (ends fe consomghenf Peles £ coagulahin Stor | Wwosive bleed ne, Croom every orPree > Semadary 40 Slastelre complicakéns Liswe Ahvomboplehin Wy amntetee Choid Sepsis “E.coli Ni menngitds"( endotoxin Induce Assue beter) egtek 2d) by fracrophoces Kwerraneea Node ache Saves NS M8 EH Boote pomyplerytic eukawies Primary Granules Indice coagulakon Retile snake bite Venom achyoses coaqulodter Wiasetes Count 4 PT] PT 4 Borinegen Miacemgiopathic rn Yemalyhic Onarnice _ Filrn spit pedects (inclading D-dimer), Derived spltirg est paael tie Qe dre ts Dc oF cross-tintes! Morin = ies by spltivg Mi — addressing Ake onder lying Coons at Aen 7 adddresting Ake onderyiyg Dose OT briregen wDisoders of Foriretysis Woemolysis = removes Wrorloous atter Veakine of dorraged vessel Prasminagen 4-PA —— Bion Plann ——> Cleaves ¢ Ctorroepn Cooguiosen ctor Imockwesked ley Sdlocks pladele aggre 1m 2-ankipbartin harder & Rbrinalysis ~ de ke Plaamin, overachuy excessive Clewnag of Serum Cormeen < doth +). Dimer net procvees APT)P TT BLtextiries hime, jncrecse Uemliny 4 Rain split praducts “not b-drrer” ved by Racicad prertatertomy ” Reteas of ookiwore Hor Octet Plums Awer cieehess “9 Sradacton of 42+ oarpleaeris MS Aentneaeproe acted Tledks the actucthen © Greranagen Thrombosis ena ~Patholegica Raematon af an intravaccuor bload clot > @ceore In ates NE COUT ig mec) commen toelow He Kine) : Prothote Dishe In, Mca ~ Characterized by x Nines of Zohn (atlernatorg \eert: a0 Sey) retreyoich Noor Grom a MMeachement to vessel wait eC - Risk Carters disreghon th necnad Wed Clow mimmetalirodkon, Cardiac Wal alysPonck ier = anueysm, endorhdial dornoyje -erdothelim oon Awromiocas by mecaemsms fa Roget ~ Cavsed by Mherescleenss XS Nascutitis 4 Romocysicine a A Br2 4 Mate delreverey Cystedhionn beta syithse archythrnia, Ned elrorancy — menial retardidion VWyperenaqulable state, ef a : nent "Ares Nerse dislecedton | Protein Ce S debicrorey, eh eel | Cecker GF Leiden Prt rronbn 222104 ATH delicercss oc? @ w\iypercoagulable Shake’: due to excesswe Procoaqulant Pruley = Present w/ — Recurrent DVT N defeckre Anticoagulent Proteins DUT ak yoorg age G@Protein Cor S defidrency -AD “decrease ve Ceadlaxk tn coacplation carcade (rotmally —s inact. Sacto \ wv SM NReaw of Uorlorin- induced Skim necrosis Se & — “Conprectit Ss v2 Warlarin trdoced Skin necronis Secor? = Warkerin \eade FO —= honcient Selicerey of Polen CAE S = by Protein Ce s deficoncy —> worllorin leads be Severe delcery \ Nnvemtoais in he Skin Orfarn deactuts Cocos 6, Ree Lim teat verally te orsent peccongyiale So, actor W Leiden _ = mvteted form of Sacer T = Lacks the Cleavage site Gor deactivoien By Prokin Ces most common trnerited cous of Wypercongualle Shotte Sky recrosy GOPreshwamtan 220A “Paint motcdion In prethromiin <> Incraxed Sere expressih = & Protirromton v @Mitworton DW debieeney PIT doesnt rise sy Heparin, doury Veparin ackvotes ATT HHL Coumadin, Goce igh leval of Heparin — induce the ferrorent ATUL ~ estragon —= 4 Production of coagulation Cacho 2M Rak of 4 *EMROLISUS eae ~Snkrauascutar meer “rat Hrenals & ecctodes downstream vases — Vest Semen couse 1s Hhremboemibaolien ~ Nheraaclerotic emsotus —» Presence of Chotsteral clefts In the enaotus, + Fat embolus ——~ Rae Recigre of Sott Mieve Cenc tore. Dyspnea detects On tre heat Xx Jeing &rmuscte pain Resp rdery Symptons ~AWwone form (Caisson duecnse) Multifeced igchermve wecross of bone due to Nitrogen ges precipitase oot of lead due 40 Ragid ascer oy a diver. ~Olso accae alter apareacopre Suey = Gas ernzotus —s-decompnession sKinecs -Amatchic Slud emsolus — during Labor or delivery <= S68 = Gqpormous ceils © Keron, Nevealeacad symptoms es elosis Grom Ferd SKin DIE “dee te amnieric. Fut @) ~ PUlmonory emaohsen® = dve te thromooembotus: > due to PUT io the Nemo Vern =Chnteaally Silent deed lead supply . 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SB —> production of cytokines “hed init BU rophanes Nyplotoreie ea =Severe Movedie of Yoone vrarmows Jue to exceriwa PDUF prediced) by Mecpko youstes = Spleromenaly ( extomeduslouy hemateparesis) + Meon drop RECS ~ ty top aH CRPGOD Paes cloral dem ce ducer Uyeoprcilecosive secretes Matson mentin Mels Com << Sens ~immotore prewrue cals aw Cand i Creubotion << @liver Rabuee, Predvce: cytokines —— BA i Berehepe eM sopprction m4 = Mecreeytc. ovaries aa tanec, ty Peat commen Teteadive Wanting, & Come Soar A@ hove Reva store, ~erytrvopoielin Gefrcency = toric Bobstances in bleed — hema Bare) cells Retrewlorytey (Leukoery\inetsaxtesic) x Poraulopeda =Pone Narrow — related = other Han kore Wrerrews Ys Aplestic cunervio, \Splerown aw Rdetudion Alytdiovere SS aaa “ee BMyeoduspasa, 3 saGeckions FTE Ge ae Lasher soins S Uegalidethe onan: Reucetiois © rrki\yosive Cordihers Rarvovins CA(m pie vl 7 + Mees exeitey BH Wes Te Cory cet teskernter Aroma Redoetion ia We Aceulodney macs of WECs (AfCeut 40 Bess) Heeracghe Mev>se0 | -delined as — As 4 135 (nor 125-13.) _ aesilied as Ckbrmonyte ey =90-00 Qe 6105 Cee 16-16) Mecreyhe Mevdeo | * hic _anernc' | sin BID & (olate deliccencys xz syntreds of ATMO Lio naclacr maori, SOMP SM sypidenzed —— Cyleparre 9 ~—— contowes eC) RR ey, esttoyed ts BM = Loge ndans sores ~ Wel engined) ear A Ra <2 continscs te fenghordl (Wegaleblacts) Citeulike ne yo nota cat (afessitc) - | | “it alco affads She rapdly dvichg celle <= Neglobleske chores (large calls) . 2 [ers common then Clete #W2 -defiaerey “Ses aReded inte TOs esval couse beccase its preient coonter woccore. in Skcek Veqetorians Sr any wears = Stores oe encogh Rr Several year sTreranee) dered Smet a esol IC Pee Bel cosh Br yoo ¥ decraxe) absoipton creat cormmen cane af Br2 dehvang sPemiaous Anema a menh Commen coue of B12 ddcere Jeankipareled cel anbkadies ae ee tee onttedy “Ot atansie. Coetor debresiney «dues (6 FD & emake Onemnia (Rabeutooslesie) 6: Bone mroweou taeithasion BE. any Shing Anat leock to DHA “Sorntcge, we teed © rages 2 eh eet age 8S Le auto\mrine cstacten 06 aes fords & Sterrach( Prwetor cels)) ee mere in ple >4e er + Coctectogy 74° 28 Aterrniral ileom desruchen = Crohns, Gueese Wepicod, ‘Spe. , inteshined 7B = Diphyllebethrive urn = denervesiee ate Morn proteing ro Tacthatien 28 peprnegen ane rmteens: of IRE Term Pe - wl PPT ve exmwrpien Pancreatic defone a Y cape ene eieye of B2 SNR bs = ne Yareventhic PO wn 5 aBackeriod overgrous> Nremia ———> Kedray reduce PO > 4BM eculooity iy 0 Ae Wpeoniwsill reek he Gree, Yuk wah wot correct the mecescal alonommasty 1 PRermterous oMerncr 1 Rebinder Protein "Groen SolN. 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Seficares) a So Peopiorn)- \ba Sugalicart mcorgocaded 1 Iedictee Waghin Saths Sin dele cule © ONS pete of ete Serra neh wane \ Gloocute, Secereion Warohin Sates ek wral © \ Aroupcio, YSgniresis of Crohn = Nese A propiocephan contoinines PREG” Aeviorotion Sersotion Lipids Rou pores Sehitleg ie Sra, Nest + -ose) 40 determine The CONS Stoge 4: -oral Madiolabled uit Be 47M ut BID of 81, dhcargy whe cory seborde, We fecepog ® Sex of rodwalad VA Bip App sn the Lane aver 24 ha Hy Y Ena iF C107, Oppeared > Ohworrral olosorpho> Proce 40 Hoge T Srage 2% wRpat test wl adching, Inbrrste Cedor eee ion appeared By Perneos orenia (irieaeicdor icon) if Xtox, red > rralaixerplen q— Glee dss & X10: oom orp! en =. cohigple Gsscose Pocenle to Sop SP it overt Aape worm, Stoge 3 \wer dwecce “repent hea Mer ging aantibiohes Yios Bp beclerad oversyouth K10% > Sade to stor 4 Skege 4: z = repeat tes wl adminaiakion F percreagic enryme ¥FDi Folode deficiency 4 intakted = due to Cookira) af God “THE “is bend Nello. OcPRaloro\ the most commen coors of Rats deReaney Roleohal \eade to TV feed intake Preventing the aosexplion of Galata \\ dermand \uer dicccue “Shores are eragh Rr % months only = occure Pregnancy * delciorey Wigked So neve. Aobe defect Severe Femdlyie Grema Coneers Falak ontagericts (MTI) to Miot or BIA daféroney iF yoo ive Potade we voll Gai) iF wil) Use whadever W2 present -divech erageroson of dmyelirodon PS im pls vol magodsldartic onemicy Se correct the teradobgic Gbrormaliies 34 away from myptination leading “© “Stork Yy ONingy vik BZ D8. Sorom Blade leiok Cuduater Qucoreing to he Wolte A Coecte Wot RBC Clete doesa!® Clocteotte (more seraiby Speuihe) Meroe fic anemia TE) Tron deficaney anemia? Tren metelaotisen ‘Total i = ase ae aaa mien eee alot tion fs Stored in Hoxrophoge fs present as. 46 wr 0 mamas 15% of ingsted YO Se Gps! ott be erbsoreed (207) Fercikin, A treyeshion norma ‘may Hemesidan 5 Gee von is highly tore ods 0 Gormntion of Cee Sra Sle < daongty rodicles i Tron cash be excreated Mom the kody —— Grrales ly mentation (Same es rreies GUS we Lew Hales excratkd ley shading f GI maxsal cells GLO! CLA: Bite oe 1 Miron ty BA eb expression af Apshertitea —aal eon Velen 458) fom doatiorun atron deicicrey ——asvexprsion of Aperetin —ae roy rebisse Inte Bd Com ducerons —— eee Aen abs <> te serum, $a, xz , Tron Trasshion from Cc es ccraan + ails & vegpteldes a 5 “Ke Ueric Germ) deberom ate © 7 wins wegen aoa z Rookereitin Shedding <—— Sted in. 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