Amines | @ © ae ~~ 10] gifs Nia, Arnmonias a. a4 J elie ° Nis ¥ chy 4 CHNH, + HR Colts NH, + HY rAnme out {cree U7 CR NACH FRE Cong NH- Cony EHS 2 Arm J . K Cine -N CoH FEY CMON YY oY eo C/O jens 4 PO Ch- -N— Ch, +HOp 3 ee < ‘ 5 ch, é ° 3° Arime = Cate hk 9 $ ohe LO © U Cryo & Cake —s Zane +ky r chy UO ‘ hy 2 Nt cw / : rect oe A x CH, C2 NF oy = Shoterne | Amrrovit L e Selb, CAN e 3 +H + type a AES e aa erst e 2° 8 Wie GN NIA CHy “one H tio Ahoy & Prt “ator of H H ike © Nity 38 AFOMS hanes xy Cth = seplaud iP. “y ; Ch —N CHK 4 hd[2/32 ines ast. Bomers fo cack offer. folul tg Cmetamers ot fonctoned Jsamens) / GB: Prepanamme — CH ch, Cha wis, r ny, - NAW CA, Cry 2 Ch NTO : on mend atuer: Dorac vomer Fame] [rare] | Qok andamme J [N- Algal anomnine— Cra Nr Cr NH OH Me 3 methanammt rTROANnNH HH HAOABenH AREA RA SC . the ethanarine Ch, on en, aed we | 2-areme 5 Prepon s-amiee Tay Alege NOTE OTS bigot = € AN — Chyct, - NH, = — Cah: us ate Me Sy ar Etkon-l,2-diamme Gied ‘ wu é eC : CT re eRe omg popes ot ructure, of Ammer e e Q 9 g ® ‘ nope eo a a @ ana . “a H RM : DB RAN-H bot ange Lass Hon normel Cetrahadrag LZ. Lhe ' = Ans, to tna of lone. pair gem Nato —‘ . Te tion Amn ® Of . poration of cAmines, DO: ~ ®y Reduction of Nitro Compounds ; : ae tlre NE. OT a? CT at y Nidvodenzent co Aniline Y Convert nitro ethane Je efhanamme . Bryon, NOr Hold. Cra CH, NH v Ethan. ¥ 6 ' Bene 0 ee ce D ee aed og > . BI. Why WE use {e+ Hu je reduction fy % nifrocompds: bo amines . Bin 12 1s cheap. s ie ds e -. Uy, this fet fe reack with Hu fo Con fe se sek A sain fep,+ Hf apein fe Un +hHzO D2 Pe,Os + HD) v._OitHe amount HY i, She hoSi dar: Se need © v = 2 2 r 7) ey carmen one a8 fc) ay NF5 lime, = 5 chs crc] cig -cn, NE Ch v 1 - ig Muorterna cH -Ch ’ CHCIKNK, | A a : ee ae 5 crcr, 7 cH, o 3 Cry Ch, NH CHL H ates Cache ne CHK a Pe a - 2 g® x = B ammonium Salk con Suuortemery dx conver breaheg wih a bose. ea to arime 5 Hl R-Niy-% — NOOH PNA, + Noe + 29 & 5 Q 9 a 9 3 3 3 POND KH EE HOHE OK RS «Jf qpiedals O mixtert t roar at a Ougrterner Amines aoe C colleanes fou canes 19 & Na to | Gahson Tas METHOD CAN BE USED To PREPARE / ONLY. ° ANINES Orcs 4 Reoohiity § holo : a ers f © 7. CH, cht one < HS AS at Lockie 5 Qu bo lov, size e “r"atou, flow = honk ently. c Ail SS Recducton of Mitdles E Lone S fhanampy : mitsile_ ; : H./ni NH . On CAN fo = ¢ c‘ . . @ Recluction of Glmides ei? . . y “Peeponamida LAH (Peopanarine : 4, CH, CONH, 1 > Ch, ch CH, NH, » , HoH 2 ¥ u ¥ "© o racladian (sa ape OC eH obZs! ) : of omices > Hol {mann Bromamida— y wvadak™ » Legradel Ethanarnine > 2h Ch CONK, 4 Br, HNooH. —3 Ch Ch Nit 4 ANake + HOF : Prop on amid Na, 3. oe e SS Ter Down | of es coe S > ®™ Losael Ph thadems do Con thesis a jp 5 > 2 a a a : Bod. Phthalate. D cyacestke Noh 5 Tne . I . . + [CRN - 17 Amine.‘ & x 13. Convert | 0 € Gfilts G “eh oO ye 2 i Ce é cel cit,” ss ee o} Rencene : eS < + HU © Wi) Rencene to N, N -dimelty) aniline ce q Ch, — N- CH « Co] e +H +0 z : Alty NA NaH CHa, < Qa \ CH Cs 2 € Cy I Ce) : FHA FHA ¢ ane ° Gi) Ct Cry te erates Ole Ch, - CHy-CH, -CH, -Cl Ni, — CH, cH, cH, HH CH Frat KCN Lille > 1 eM CN -CH, -CH, — cH, -c S Fy stead Propertes of, Arsings, : ° odours; Lower amines have hee odour ¢ - lamimes up 3 Catom are SLiguida & S higher on Adiel. ‘ » foases aliphatic Omine?) OF Aotubse in toakes Ancause He carn fam H- bonds with cuater. Buk higher amines & Online, ¢ Ow ingetuble in water ; Buloyat ot Z Betan-laming Kor Actudle sn csatty clus fo greater Poledfy - we NASIe eeu uae eee TS hLU TT rhULThC!hD - ewe reer ef ee a easing poms oF isomeric amines: ® ® P72 73" Q.Hhy? I" amines ha dul od Hatom & 2° hove i, ah attaded to Clecho-re N atom. So they Can forrn inteyrmolecwlay H- sonal 2 this BP. 07% high. Bur 8° amines hare No ‘H' Qo attacked to N atom Ae Hay can nok forw Tnter- -mMolecwWar : H- botdin 2. hiv dp. Oxt hon | Chernical, Reactions of amines |. Arnines are Lewis Sose dus to (ne pair of, eon A airs Heat con_ba donate . zp 8. x2 R Se! NH - x o) RNA, RB 2 Animes art Arrkeriud Saxe because 107 release OH In caater. ®@ oT +.0On » Cr,NH, + HOH > CANA, On 3. Qlrnines art Bronsted - Low bose. Agcawe Linge Baas OG acopt pt ¢o adds. P ” fA Cr, NK ¢HL > CHM Wg 8- Base Ack H e (Cini, | (ar] St a Aadic nee Pon x 1 Pka ¢ 1 _ BZ Basic nature Acide natur Pee Oe £ Basic nature\ Cemparison of basic streods op WA i Various artimes: tb Resonant Ldosic nature Aacosmse gnb ™ dup fo yesonana , done parm o Se es N- afom dscomes unavalladia ie ct denafin. € Qe « ~ e Gs Sass bask tRon Ch, NA Cc abiphabe arsine CQvornahe) yo Releasin ps. Glew © a Gy—H CSF —Chh et —OCh eta Me. & Crz efkeeh) basre nofert “4 S aul tating Co (pare adonahm. . Se Withdrawing ffs: Dilee -N0. Ce mm) Sasic nofurt dus fo —T ad. e cyt g Cases Sele ae Nie « ri g Q Q & ce] < NIK = CH NAS cn ans Ono te Hin boske ze Ch, se . Gus : © Max. no - : yesenand ~ k gps . . - on *Mox.4+L & a, Dl > NK >Anihine Of fet S * Mosk S osicOw Aqueous state . b ' ralnhd , hn In Ag. state 38° ammes ort Soosk hs let » ds to mox. no chrophosie al lyf chams. rt BP ammes xefeosxe N— (CK y min. no 4 onims & G3 e y gre Deas basic. (CH) , S36 cumatatye effet 4 ar £ hyd2- ; | » — Phobic nature SR gP: prevails, 2 aI, y > Q >a pl PNK >a) a : NT Mofh 42 ore , a sips ny elegy 4 4 a Q : NH Ch, - NHL Gi Sy : Less basic More basic : : li Aniline, Armonia Sng 1.4, BD BSN GHyNI NI g 5 - Cec Ch NH, Gre), NH Al wesw we ee eV Ve we VYGeIrAZSTISATION Reaction ok ammes wilh HNO, to four diazonium ‘Solts em 4s called ond diazotsaton. 40 5 HNO, 3s unstabse , It oxidizes fo NOs HNO, JS produad. “In shu" a] seacho NaNOz SH. mine. Aliphake Ammes_ Armes Age OED rprpppppprprpp ppp sin ce onsen ninleeforme J Co eecine] HNO» J HNOy ng Chy CH, NLC i Ctl diazoniem chieridp Purses) [Resenane stash [Kesonone Ses [res gem [HoH Cr,cHoH + HCE F No on hon’ +R [2 rhand? ce) : +¢Ny st | eee? Qmines Oly — Drazeksabay |S Diezonie Blazoniom eobk Ne CO Tix / HBFy [N80 co |. Chemicod Propexbes of ercines. (0) 3. lkglohon = Ctrnmmandlys ven 3 Aah Hon | ci rnines: pod F 7 3 QO. Why we use pyrtine cn, -6- a base luvin Agylahen Regen cn-< -o-¢ -Ch 1 " of Amines? ¢ Any To wemore Hw formedt rat 0 } as mi f the pos So Thof ees “SN prtvented. ' sey app os 4 @ os cht {| Gee Chg - Oy nO) + onc @ Coby -™! - a CH F(t } ‘ a ne a Ne Eth efonamide Cyc ns = GR ; tHe N,N- Nn Ot coe na Aniline ; ; J ey 1 7 G - oS £ CH, , Ne Pan ‘efhonortd_= @¢ BEN ZEYLATION; islnhOe SaiANAy + CTE gu 3 ANF) +Heg HO Benzagteh lotic oe benzoridty C aes. we AL ING ‘ 4) orth ‘amine amme Lest fai = amine Ps NA flea poy ORNH +Ch, + $kKOH ¢ V4. ¢ CrRNG fy 1e) + $0 - TSacyonicle = Corbyhamre 5) Linsey s Test, fee ie Poor le pen] Ye 3° 3 mel € u : om: ct fotide ¢ Hengberg’s Fepent: Benzene eT ‘ 9 ’ cp oe u no n Oo s 2 OhycHy,, NE + OF ) 2 Cn, C1, XS) +H Ho r wn N- Ethel fon cert Bu phonae “rn ¢ Gee eee ead eee tas + O18 — 2S H+ | ae C Ch—N -# <> ; ! 8 ¢ ¢ NLN- Qime =e doneens c ly ) ° Chee Hojo ee Hts Niroben of ative, ay — NO, co Reagent HNQ 5 Hy80y p- Bromo aniline. Ni , NH 7 HNOS oe ro] Co] Hsoy? Ka HysO4 nant = Oz _ jo + Y. a # = pie 1 BLY. nets” Arkaos —_-oT TT co) ae i ni 7 aa? CL ve q m- Nibv aniline) 7 he oF art. Vow wy hea anitine . ~§ Qor* pe ch te cle joe dot Rot Ni ap ® Lhy J me Ny) nny: +o fem fron “4 2 Aniliniom im pas"Cle Sle clrophiic Su ihe Substhsthon _ Reaches) Fe oe ae sh & NAL JP Jas Lh achvakn A oy Tl q h ache makes hang a e fowards elechophiic ~ Subs IAM, @ i, gP ot/e ose NKL | a ~ Oi = a Al echophile e Pp = mores evar: antto & pore : yf € an postens. AxOs ¢ ¢ a Brominaho 7 NH NH . me ayy i - Coq Bromme i c sate m 24,6 {ribromae. nifine_ BE blo mono ausshiated [osdite PP v ae Produc, reachvity PAriling has fo bo seduucd. © Br fis NA GP as Protected 4 e latsay » Rysidine nnn Nita, Cn-¢-0- SF -h = $ Oncor! io : st " H 9 7 fe ck & ° Csi utd yea “¢ ' ee ee re: BO S Setphenaton of strins fete hie Y ‘ H,SOy MI HS" Ni n® . cr = Coy 7 O) a a » Anihiniun hydrosey T Be v6 “ealphet a au oe y Why Aniline does not get pSaipronie odd] re (Bipolar ton) 4 Friedel colt ally tabon 2 acylation ! &® Ans: “Aniline JS bose (tears) eC 4 AIG (used a3 combine to y Cotakasst.) dp o Pusu acid, Tay ¥ form “Sault. ) Dus to salt formeton N' oO us oye . fve Char » ak becomes O ackvahi e. 7 “gs . ee o Cc 1s ok ° “ed ae test] - ee Oy Ne ACO ‘ [ow Aniline, , Vv : CO NEN {ON Yells DYE CP- Amincazebenceny Ex: Cop—fa se KES OH Phin : yor . ce) hee oO rox, azobement ORANGE DYE Pray ser]@-o : « i elt @& e& CoG | Cen) e ec ax oh 2 Cuby/Hm 9 oy tN < Qw]Kel 9 GS & a fe why tm tee ae wm + nee oe Cu | HOw = cy aND € ‘ - oe Te e Neu ae ca ia CF +P HBFy 5 mye S CH, CHO Cy tee + cree Q- lin => 4. | Hs PO eG ? 3 : & oh ° No’ & ' HoH (Norm) —3 a ah 7 NDB Fy ET — oe 7 Ne RS ? a7 3G] tmr § NaBfy ¢! + pera c Example 13-5 cS 4-Nitotoluene Q- Bromobencoic ak& CH, CooH os mor" ayes Ni Alek. & N02 KMnOY @ | H2/Pl- Ch ans wu — re BA FINO) Ley Gy Nu Mune 6b 24%. 64, Covwrest : nia ys S-Methylaniine @) Ce} Aniirg , ) ) Ny \ 3Bee ay 3 ae ) NOL , = ) Nop ‘ "oy oO Bx Be heFY_ Br ’ 3- Nibokoluont oa enon . zu ) 7 aie ) cu ‘, . Nit _ iv ) 1) @ rain co Qi) Cry NO2r » HH, T yen J ken ° ° J Nacn en once" [pela U Cy Chen, cel Juste fe : tt yeu By > tot cool CHC CNH Nan] > Oh, CH, CONT, Co] A] rssalee J Hq Ney ft Naoh/gy. : J ie nes crercrnsa? Col > a. unstable + : Ch, CH) NH) ay od rn ~ 7 City CHCH2 OK (&) Ch, Coon “ Ch,CONH, ane Cra NHa oJ J Nano,/H¢ 1 p 2 fea Chon +) q & oi, = GQ) ae canes DYE.*~ O« Ret CHACN meee Bhp Gol, ib Hous sill ou convert: aha t ci Ethanoie aad a Hethanamine & Chy Coon Nits y CH, CONH, “SS OrgNih © tn (ii) Hexane nibile |-otrninopentang HoH Clty CH,CH,CH,CH.CN ——3 CH cng, cHeh connie, C HoH, CH, CH, NG Cs © ye NaOH Giiiy MetRang Or : Chon i” Etfororc ov lH : ¢ Cu Ranamine Methanamne € ia : . © Hy CH, Niky ua C {Hsen Bry & c CH, CHO 5 Cleo Ho ChContn | KrtnO4 ° 1 € . anoic au © Etkancie add xopon ¢ OH, COOH ] thot & (peanty s Hon © Ci Chon KON Om CHEN oto CH CRCONTL. | ce (vi) Methanomine Ethanamine sg Ch ie fe A CHOWN seth, « | HNOL ra c ui (edn J Ch, OH c | kav : NU c c «8 @@ . Wi) CH NO, Oty-NH- SiH, afulig » NiPometh ano Chyn v Le, Cry Ni, v Pa evi) Sac Ethanoic aud . Propancic add eon aenee » Chych, coon » | NH Ode Key v v ls oH Y 5 CH, ChE y L . nO oan Yais8 sO3_ to ! HNOa, Crs > fo) —— 38 CO) ae C1 a wy Nib benzene w AQ ChyChow 6 © oy, SS ee w ny Bencore eG HNO ia yo = Co HiSO4 [2 Cla eS Bincens — llls | Bre ~ 2 HOK ~ a Viele No Nawes 2 Tek 2 és hy am a te 7 NO eS fy Cl INS ” . x PL h Aa) Benzoitaud, A CoD CONH NA - @) Ms) “Bb ; ol = 4 i 4 Anil a13 [ahd © Me er @ : He Ms) Anikine 2,46 - tanore fon of [ boncem & ak S J" __ bee Be By cee « " eo ‘ S ™w chletida a- Phen arom ony cH, Gr Ni — C oa @ NP Chloto bonzera io, p- -ChleoGni a wt ie Nm Te Erts02),0 He f os 6h Se ll i i) 2 g £ nD xz G MAMA PNDPRNADTNNN ONAN LH TO|D O80 : i Nie Nanior erate Naot aa ° | Cyne oH =? {a | aa? “AldsGx) Aniline to Bene) alechst O99) raf Cy a oe “6 F aus on . Ig. a) PRD of, Aniline 5 Aniline JS Sass base than amettLamine a CSM eo 0 0 ee more, than methy [arn Me becomes Lass avallabbe fo donaton | poor while ufeailine as fer ansoluble . 5 couse fone pore ¢nk a on 'N' atom 4 N i So) EthyLauine 48 Bo vo : non phos ¥c) PeUy ds a Sous add they weak fo form es Cain = | Gears BOSS _\ pp 4 Fe 6H), ¥ 4) Qu fe qetrnctsan oh Aviliniaw io O ee go 4 olys med amount o m-Nitro aniline AS dur nipsation % aniline. e) Nias fess base , it reads wiFh dere ostd_ CJ thot aes os catalat. i sy Mort Stable thon 1) Dus fo resonance a) SVeuvtod t vD 2 CHANiCR , “ . Y) an haloorenes, ect Send if 4 esonann stoblized_ “t Ss baw He a ink ef ap ae es o a 35 j>, Oro =A) Ceol a) ry Beneare salu aud a | Ni, ©3) YU ( Arnie) gl Gone fy Benzomde v \ By, KOH NA Amine gj = CohgN Co} Aniline, 13.4. Explain : Arnnce are Sass acidic tha PONT Een OH Roe 0 7 aluwhas Aromes fox ~ Amide mm Rui 4 ‘hile aleshots 7otm RNF _ RO” » Ht Ron But amide im ts fuss stable the CT aii Qudic. Shen alin) () Tl’ ammes C9” m Inter mleclar ea toile 3° Can nok, fa mp /»p. [ [ammes ¢_ ds weaky fhon 3° amiver. o r® alleoxide im AON Kee Orme ore Las Aromat: ammes Ore Ass asic a (iD Jone. pow on Nikrozen atom Attomes fass — avello bbe jp donatsay dus 40 rxh0n DP OPAPP PON