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MECHANISM
Reactions and Introduction of Acyloin Condensation
When carboxylic acid esters are refluxed with metallic sodium in aprotic solvents such
as ether, benzene, toluene or xylene. free from oxygen. a-hydroxy ketones called
acyloins are formed. This is called acyloin condensation.
To account for the ready formation of large rings, it is suggested that the two ends of the
ester are adsorbed, albeit weakly, to nearby sites on the surface of the sodium metal.
Thus, the reactive ends are not
available for intermolecular coupling to compete with cyclisation. Do follow other Name
reactions of organic chemistry prepared by Physics Wallah.