w 7. 10. SS Pharmacology —MCQ GENERAL PHARMACOLOGY The most importan; it fact in the brain is: ‘er which governs diffusion Of drugs across capillaries other than those A. Blood flow throu, igh the capill 8. Lipid solubitity of the she ms C. pka value of the drug Answer: & D. pH of the medium If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration j core S25 g/ml, its volume of distribution 1: oon 60L Answer: B ote Pick out the appropriate alii mentary route of ad; f hire Ivers urges f administration when passage of drugs through 2S o ©. Rectal . Transdermal d. Intraduedenat Answer: C A hydrophilic medicinal agent has the following property: a, Low ability to penetrate through the cell membrane lipids b. Penetrate through membranes by means of endocytosis ¢ Easy permeation through the blood-brain barrier d. High reabsorption in renal tubules Answer: A Biotransformation of a medicinal substance results in: a. Faster urinary excretion ¢. Easier distribution in organism b. Slower urinary excretion d. Higher binding to membranes Answer: A. ‘Conjugation is: a. Process of drug reduction by special ¢ Coupling of a drug with an endogenous substrate enzymes b Process of drug oxidation by special oxidases aera following processes proceeds in the second phase of biotransformation? a. Acetylation ¢. Oxidation b. Reduction d. Hydrolysis Answer: A Half life (t 4) doesn't depend on: a. Biotransformation b. Time of drug absorption ¢. Concentration of a drug in plasma d. Rate of drug elimination Answer: B It's called: imal effects and has moderate efficacy it’s ca! If an agonist can produce submax c) Agonist-antagonist s ra eo ) Full agonist gonis ‘Answer: A jrug Is taken continuously or repeatedty? Which effect may lead to toxic reactions when a di a) Refractoriness b) Cumulative effectOe aie ee ee ¢) Tolerance d) Tachyphylaxis 1S “ays or weeks to develop? a) Retractoriness ¢) Tolerance ) Cumulative eltect d) Tachyphylaxis Answer: ¢ 12. What term is used to describe a decrease in responsiveness toa drug which develops in afew minutes? a) Refractoriness ¢) Tolerance 5) Cumulative effect < _ d) Tachyphylaxis Answer: 0 13. Whatis the type of drug-to-drug interaction which is connected with processes of absorption, blotransformation, distribution and excretion? a) Pharmacodynamics interaction c) Pharmaceuticalinteraction b) Physical and chemical interaction d) Pharmacokinetic interaction Answer: D 14. What is the type of drug-to-drug interaction which is the result of interaction at receptor, cell, enzyme or organ level? a) Pharmacodynamic interaction c) Pharmacauticalinteraction b) Physical and chemical interaction 4) Pharmacokinetic interaction Answer: A ‘ 15. What phenomenon can occur in case of using a combination of drugs? a) Tolerance ¢) Accumulation b) Tachyphylaxis d) Synergism Answer: D 16. If two drugs with the same effect, taken together, produce an effect that is equal in magnitude to the sum of the effects of the drugs given individually, it is called as: a) Antagenism . <) Additive effect b) Potentiation d) None of the above Answer: C 17. Idiosyncratic reaction of a drug is: a) A type of hypersensitivity reaction b) A type of drug antagonism c) Unpredictable, inherent, qualitatively abnormal reaction to a drug d) Quantitatively exaggerated respons. Answer: 18. Glomerular filtration of a drug is affected by its: a. Lipid solubility b. Plasma protein binding Answer: B 19. The loading dose of a drug is governed by its: A, Renal clearance B. Plasma half life “Answer: C 20. A partial agonist can antagonize the effects of a full a a. High affinity but low intrinsic activity b. Low affinity but high intrinsic activity ©. Degree of ionization 9. Rate of tubular secretion C. Volume of distribution D. Elimination rate constant Bonist because it has:an 22. & High affihiegy, Answerit A HUEY Heine Weta? a s9wanA WR DULA ce brady on anves, 1 OOM SAF to exhibit: ss eemAW wien el Bove Lipid a id ’ A 9 es A. Ceiling effect n991 8. Desensitization , o oe Window phenomenon lon-receptor medifitte: ViteayhOD Muse Ni oviizalte dn sttanuib 2 Answer: ¢ Rt ; sh 1A If the dose-res Ponse cuAei bE Urugtor e widel rated the dose axis, the drug is: i@ for producing different actions nA A. MEAIB MEOW iw ytieuens oft of guard oe thignipdgigtiog to 9262 batzaqeuz A OL Sr6HRAPEMARIAEY .noitvile nideawe seviov clgchreny selbeanesatezea vieInulovr Answer: D ANinoziag to Sqyi ylosll tear ail} 2i riainW .basittenos lique 29¥3 23. The therapeutic i i OFF'a GPUg''G measure of its: ik Safety (Ta qosid .d ¢.efficac B. Potency sev 2 3. 4. 6 beg nilistbanttoviizagn0> raver D. Dose variability ib ert Answer: 'ANinoziog ‘sn ay 310 Yo Inam: Which of the following cholinomimetics is indirect-act a) Lobeline 6igalgolay> 220 Rp PUdes pH b)Edrophonium —®slosnaqolay2.2 4d) Carbachol Answer: B sniqovismoH .G Indicate cholinesterase activator: Jiqovion! mat-nogy minschasIe’ rizirivy gut (1036 2igranimsgob on Jud ysividayANGREpHATE: 20216 vi b) Edropitiéritami Answer: B anon Indicate the organophosphate tholides:erase inhibitor, which can be made up War-stuedus solution for ophthalmic use and reizins Its 2-t'vity within a week: a) Physoctigmine 2guib to 22cl> ary pARBthtépRIR#ND 206 orien — 'b) Edrophonium egslowey 4) Neostigmine 29 Answer: B zsviensfraqydiinA 2 Which of the follgwing cholinomimetics is a drug of ci.c'ce for reversing the effects of =" nondepolarizing :.Juromuscular retakaArs?>) 916 29! 2eur" 2116: a) Echothiophate1og6 Sp aig79n91bA 2 ¢) Edrophoniat® b) Physostigenmis ine So sigyanaybA.o d) Pilocarpineioae . Answer: C Gxawend Iridlestedhelnevsrabre cholinesterase IA hibitor, whith penetutes the blood-Braik bartiers! a) Physostigmine 3nisngitzoeyl4 (> ¢) Neostigmine snimgueesit b) Edrophonium gnitedod (b d) Piridostigmine : 2 srswend Sma followiIrip isa falavivel) cerebro selective ‘antichvotinesterasefourid te birdy! symptomatic improvement in Alzheimer's disease* \ vedhuizib veluditeay = S animelog: C. Pyridostigmiine SOUA See cet snigawenolt (t D, Pyritino! lower: 4 air F fortherapevtle eMbet Manglé closure glaveomaltano> einaiie8 91 The site of action oftmiatied f cer Pace a iit A, Canal of Schlemrt!\"20. 2 22. 23. a 26, d) Carbachol ¢) Pilocarpine rat lective M1 blocker? timuscarinic drugs Is a select , mnie of the following ant Oa Boon d) Homatropine b) Scopolamine ) ip Answer: C , Which of the following drugs Is useful In the treatment of Parkinson's disease? ¢) Succinylcholine a) Benztropine ol Hevetiethontunt b) Edrophonium Answer: C . 2 Which of the following agents is most effective in regenerating cholinesterase associated with skeletal muscle neuromuscular junctions? a) Suscinilcholine ¢c) Pirenzepine b) Pralidoxime d) Propiverine Answer: B Which competitive neuromuscular blocking agent could be used in patients with renal failure a) Atracurium ¢) Pipecuronium b) Succinyicholine d) Doxacuriym Answer: A Indicate the neuromuscular blocker, which causes tachycardia: 2) Tubocurarine ¢) PancuFonium b) Atracurium d) Succinylcholine Answer: C Which of the following sympathomimetic is preferable for the emergency therapy of cardiogenic shock? a) Epinephrine ¢) Isoproterenol b) Dobutamine d) Methoxamine Answer: B Which of the following drugs is useful in the treatment of pheochromocytoma? a) Phenylephrine ¢) Phentolamine b) Propranolol d) Epinephrine Answer: € Indicate a beta-blocker, which is particularly efficacious in thyrold storm: a) Pindolol s ¢} Phentolamine b) Sotalol d) Propranolol Answer: D CARDIOVASCULAR SYSTEM Angiotensin l plays a key role in the following risk factor for Ischaemic heart dleeaees : Cea nreteria €. Carbohydrate intolerance . icular hypertrophy i} ee ypertrophy \) O, Cardiac arrhythmia The following angiotensin convert! enzyme inhibitor can reduce cardiac contractility: 4. Captopril C. Perindopril ; B Enalapril D. Lisinopril Answer: D An elderly hypertensive was treated with Even after a mont! his BP was not reduced to the desired oon ett : 3 her antihypertensive was added. Afteroe ES ee sly. The most likely other orug iiven to him awend hours of taking the other drug his BP fell precipitow iF aiold tM ee reenyld pa” 1 D. Amlodipine aniwoliot ord to fait er A Atenolol 8. Captopril Answer: B : 2 rowan 4 Digitalis slows the heart in congestive heart failure BY: ou of equab gnivallat ott to dai og A. increasing vagal tone B. Decreasing sympathetie overactivity €. Direct depression OF sihoatrlal hade 0. All of the above j ‘ niwollot # Answer: D 3 9) a 5. Digitalis induced increase in refractory period of reat fibres 15 ib Consistent and pronounced in the: i; ‘ 0 A. Atria aaa C.A-V node Purkinje fiifesmey PEE EEG now etmoines ni baeu ad bluce ansge gaootd Seluse gaa 6. The most important channel Of elimination ‘of digoxin is: horsiphk A. Glomerular filtration “"'" C. Hepatic metabolist |"! Noes & Tubular secretion D. Excretion in bile— = pees cibrsayrioct eszues riaidw IaA201d vy uozuINO Teh aakomigoibal £8 7. Select the most suitable antjarrhythmic drug for counteracting ventricular extrasystoles due to digoxin toxicity: a ShonnA = C, Verapamil eet) ad rol al 1g 2h aisanaing atures OVEN Bits Yo a “ Answer: A peer a a 8. Digitalis is most suitable for treatment of CHF when it is due to: gic id A. Cor pulmonale D. Long-standing uncentfoiled’ om a rswenl B. Arterio-venous Shunt ©. Thiamine deficiency Answer: D : 9. For digitalis-induced arrhythmias the following drug is favored: hypertension 2 rawend dbold-eted 6 stssibal 2 a) Verapamil b) Amiodarone MaT2v2 RAIUD2A\ 1 This drug Ry termina na aa a ygihs.2vEIg Il nienstoign’ 2)fecande Bean giidoaine “ms oe iaemeat : ) Sotalol a) Verapamil (OV aN" then” Boawenk 12, adel pahl get ptididpl amysne gnityoynos Wagininnsanyyale nN ANiigdipine ne direct 'effect on chronatropy and dro normal de se b) — Wigenies a ¢) Verapamil 8 d) All of the above aes 7 H spel Isaorbyrl rit bateont vhabie OEE Ribovbyd rltiw batort esw avienosmayri yivabis Nt ied 2 Botassiumh chan ‘ oe Dns level baveab gel? ai bsaubss ton saw @8 aie b) Aig ‘Y'BlazokldeAnswer A v1) eadear that can stimulate aldosterone release from suprarenal glands: jasocon: Aq gtensin I tl 14, An endogenous ¥ i 121i ANSE SD fae esitenulb abiceidr al ansipgsnsineeea) “ir vol zovienshnaqyr" d) Angiotensin: converting ea cg bv) mee vienoneqyd gnuoy A Answer H “a 16 yileaiayel4 a h releases NO} 1, v2 brie yllesiay 15, Choose the vasodilator whic! "6 | Hydraldzine eae vinot s a) Nifedipine d) Sodium nitray FUSSIGE i sodsidl a c) Minoxidil DnewenA ‘Answer: D 16, Generalunwanted a 07 peratlurs nis} uaa blow oa OBA as nal GRR g Her ALLENS a imho cam og Al | 85 iat ats bad LO eergaeg af rerPnerAL lee HOW si ioon oxsw SION Tease ar bleed lame wast tei tie ee edited URISNE Bidoe 47. Tick the group of drugs for treatment of shock with hypovolaemis res iat ng bl volume): tata constrictors a) Positive inotropic drugs b) Vaso ) peepee Usscbe d) lepties, Aonics in cade te ahs eae nS Answe rer: C 1 OD, j 18. Which of ihe Yollawilng drips dopresies automaticity of SA nade 33 Well as ectopic Fac, abbreviates action potential d d ration of Purkinje fibres, and slows atrioventricular conduction: A ; I fn inoiged a ; A. Propranolol B. Lignoéainé ; D. Bretyliuns o-gEPe RAMUS vo noad zed solove lear Sj Sa TREN Noaicr4 ss, Te olanlie gel Where ane ia alice ‘Prophylaxis of paroxysmal supraventricular tachycardia: A. Digoxin 8. Verapamil eer Answer: B ne 20. The dihydropyridines block the following type of calcium channels: A, L-type voltage Sensitive channe! wot & Nit¥pe voltage sensitive chan B. T-type voltage sensi Nes eae 730 og Be Ge nee channels Answer: A layserane 21. ‘Coronary steal phenomerién’ has been noted most reuenty with psponoub ts A. Glyceryl trinitrate ii 2:8 rida ole Asawer sieiwib al eer a iz y 1k 21 oF pe nosh 8 8! tae em SE eae ce 2. hoose the most suitSble antihypertensive drug for a 45-year-old male company ¢ ex lling job. His blood ure is 160/100 m and “tht Aaa Uae Ear iclee Saige tut 60/200 mm Mg, anche isa diabetic Pr peer snotoslonaiae 8 Sembee arse anal oun tisoa D. Hydrochiorothsside sae +64 2, Persistent dry cough igh may occur as a side eff ee INOLBTIKS No To sti te ort ang ertansve a i a1 obit iiftaers Oth Jud naitayxs hes NOWSIDKS ine ee x aan rio sh 24. Furosemide is to be preter ca’ SA Asthma rathiazide when Rypertanstah i 8. Hyperuricaemia25. 26, 27. 29. 31. 32. aa ee D. Congestive heart fallure Answer: D Thiazide diuretics are the preferred first line antihypertensives for the following categary of Patients: A. Young hypertensives 8. Physically and sexually active male hypertensives C. Elderly obese hypertensives D. Diabetic hypertensives Answer: C A 40-year-old politician suffered fram attacks of chest pain diagnosed as angina pectoris. He had a tense personality, resting heart rate was 96/min, blood pressure 170/104 mm Hg, but blood sugar level and lipid profile were normal. Select the most suitable antihypertensive fo initial therapy In his case: A. Nifedipine 8, Hydrochlorothiazide ¢. Atenolol D. Methyldopa Answer: C Awoman in the 28th week of pregnancy has developed pregnancy induced hypertension wi a blood pressure reading of 150/100 mm Hg. Select the most appropriate antihypertensive drug for her: A. Furosemide B. Methyldopa € Propranolol D. Captopril Answer: B A semiconscious patient of haemorrhagic cerebral stroke has been brought to the emergeng His blood pressure is 240/120 mmHg. Select the procedure to lower his blaod pressure as rapidly as possible: A. Sublingual nifedipine 8B. Intramuscular injection of hydralazine C. Intravenous infusion of sodium nitroprusside D. Intravenous injection of clonidine Answered: C Furosemide acts by inhibiting the following in the renal tubular cell: A. Na+-K+-2Cl- cotransporter B. Na+-Cl- symporter (C. Na+-H+ antiporter D, Na+ K+ ATPase Answer: A The primary site of action of thiazide diuretics Is: A. Proximal tubule fs B. Ascending limb of loop of Henle C. Cortical diluting segment D. Collecting ducts Answer C Select the diuretic that can cause gynaecomastia, hirsutism and menstrual disturbance as @ side effect on long-term use: A. Amiloride B. Spironolactone C. Metolazone D. Acetazolamide Answer: B Amiloride has the following effect on urinary cation excretion: A. Decreases both K+ and H+ ion excretion B. Decreases K+ excretion but increases H+ ior excretion C. Increases K+ but decreases Na+ excretion D. Decreases both Na+ and K+ excretion Answer ACNS PHARM ee aa n inhalational anaesthetic Is a measure of water partitior A Potency coefficient Answer: A The following facto A, Alveolar perfusion-ventilation delays induction with an Inhaled general anaesthetic: r de mismatch 8, Kyperventilation C. Low blood:gas partition coefficie D. Inclusion of $% carbon dioxide int efficient of the anaesthetic he inhaled gas mixture Answer: A lothane: "Second gas effect’ Is exerted by the following gas when coadministered Neate A. Nitrous oxide —_B. Cyclopropane eMinoe Answer: A The minimal alveolar concentration (MAC) of halothane Is: A. 75% B. 25% C.7.5% 1D. 0.75% Answer: D / Malignant hyperthermia is.a rare complication of use of the following anaesthetic: A. Ketamine B. Thiopentone sodjum C. Halothane D. Ether Answer: C “Dissociative anaesthesia’ is produced by: A. Ketamine 8. Fentanyl ea D. Both ‘A’ and ‘B’ are correct ‘Answer: A Effect of alcohol on sleep has the following feature: A Itis a dependable hypnotic but is not prescribed because of abuse potential 8. It consistently improves the quality of sleep C. Itean disorganise sleep architecture D. It suppresses sleep apnoea Answer: ¢ Moderate amounts of alcohol produce the following effects except: A. Flushing 8, Tachycardia C. Diuresis D. Rise in body temperature Answer: 0 Disulfiram is used for the treatment of: Acute alcoholic intoxication 8. Both ‘A’ and ‘B’ are correct C. Both physically and Psychologically dependent alcoholics D. Alcoholics psychologically but not Physically dependent on alcohol Answer: D . Ethanol is used in methanol Poisoning because it; A. Antagonises the actions of methanni[OSB stimetates the metabotismrot methane! ani redutestts blood tevel = === Golhibits the metabolism.of methahal and genuralion at toxicmetabolite 5 ihaelada acs nce Saati roiteuinssras 16l09vl6 leeninien sty 4 v3NSto4 Answiee O89 low | mit bri sHUSqBY 11. Currently barbiturates are primarily used as: JngIIM S05 A. Hypnotic B. Sedative C. Antiepileptic D. Preanaesthetic'neeiedht 6 Ic19n99 balerini ns tiv noitsubni zyelob 10f6t gniwollo} st Answer: sitarireann 12. Benzodiazepines differ from barbiturates in the fOllowitig wspeets! eXcepti2UI190 THlosviA. A noitéliinavigqyH 4 aioittses noititieg 269:boold wod 3 jsrini 93 mi sbixoib nodv62 82 to nolzuionl a Asowenk A. They have a steeper dose response curve 8. They have higher therapeutic indew? C. They have lower abuse liability 1U2ximn D. They do not induce microsomal drug metabolizing enzymes sort) Angad ies titiw barotzinimbsos aadw 26g gniwollot silt yd ban9x9 ai * borse 13. Hypnotie dose of diazepam produces the following action?» 1/0 © bio 2uoin A A. Tachycardia 8. Constipation m/f owen ©. Hyperalgesia ei saerijalad to (2AM) ni) Odordasead nocrutndtbastne ont 2 2 pac ch secretione\.0 0 ‘Answer: D ‘1 Masui 14, The barburtesaving igh nt donvatia ethereal» ys ae z A. Pentobarbitone muiboe or GoinT 2 8, PhenoBarbitone saci 151A C. Butabarbitone yoda .2 D. Thiopentane Sner 3 Answer: B 2 swank 15. The most probable mechanism of anticonvulsant action of phenytomiseosne svitsizozzi’ 3 A. Prolongation of voltage sensitive riégrofial Na+ channel inactivation sninetoy A 8. Hyperporarizatibr of neurénd lologors. C. Facilitation of GABAergic inhibitory transmission A mewenk °D. Interaction with Ca2+ channels to promoteGaz¥ mf) 9112 26ri qoaiz no lodosie to mata Answer: A Isiinaioq s2ude to s2us7ad bodi122919 fon ai tud Jongyd oldsbnsqsb 6 aif A 16. Phenytoin appears to derive its anticonvulsant‘actibn fromp 9:1 29vorgmi yMnateiencd tl 8 A. Selective inhibition of high frequency neuronal discharges!ir'215 9951z 92inegnosib nso i! 9 B. Selective inhibition of epileptic focus 630Ng6 qaal2 2o22a1gque tO C. Selective inhibition T-type Ca2+ current in brain cells sewend D. Selective enhancemernastenhibitdryarransinastolt inthe bedinicals Io 2invome stexsboM 8 SrwinsonencA ybod ni sz O cizawid 2 sibresyrioeT 8 anideult A The drug of choice for trigeminal neuralgia is: Gowen A. Aspirin Jo JOBiMipramipeot beau 2i meriliveid © ©. Carbamazepine D. Valproiiexieptn| ailodoale 91024 Answer: C 9n02 916 ‘Gf bne ‘A' 08 17, Select the drug having a narrow spuutruin antluplloptic activity testeicted téabsehed veleures: A. Lamotrigine lorosle ao inabnagab yilérizyriq [0B BrMadticetNiddoy2q esilorosiA 0 C Sodium valproate D. Primidone @ syowenA Answer: B 41 seu699d gninoziog lonsriiom ni bozu ai tenet onsrtiam Yo enoitas ori? eszinogemnA AWe 1 il is: ferred drug for suppressing febrile convulsions? Pre HTPENONTNTIST#TER rT 18. The prefer? one Se YADTAAT v =r HUERIT AETIOBATET NS 02 AWA BIE odiumwalproate: ee saepnneal ean 2 aie 3 Via ; ae sn nrg BRERYIERT RAERBY ebR VEE Wi me) eae a é 19. An epllept: SN colt noitardenozoesv Ievartgii94 (2 measuresis most aPPFOPFAE: 50m vid (b Bowen ermination of pregnancy A. Medical terminatt eotherpaties bozu 2 e093 gnidzotdonitora-M griwollot sAs 30. Abid B.awikhalre AAD YOK digaqodhe(towest effective lawelerql (d sniqovsA (6 C. Gradualby.taduce phenytolo) ; Near D Substitute phenytoin with 2 of carbamazepine and sodium valp oatbi19wenA stitul iytoil combination mm of gnignolsd gunb ari 20072 -ajnage gaitilidese snevd 151 Set “gaia bla al 769 89H PAI Wel uttering fro UbdEne 20. Which of the fohOWing the eee seizures with occasional generalized tonic-clonic seizures: F Carbamazepin A Ethosuccimidec mcfs SAG YaIProate cc A Answer: 8 snosstsmolasd (b 21. The preferred drug for status epilepticus is: CA Ix A. IhvirhaventoLal eterrgpaia mol qmye to Isilay baniet2u2 bncphaatragendusiphaayteia SoeTu m!T 2 6 2i Aoirdw gub 91d AdI4 D. Bhenytain pangairol's 21 smdize Intramuscular phenobarbitone D, Rectal diag pat?” 2aigisnilangiinA 8 aphac mort Arua 3/8 ein meioo dl oTpowlgo tie 22, The usual cardiovascular effect of levodopa is: ots A, Bradycagdia, dueite increased yagahT@Red balcrini to daits obie nosumpa Jeort Srit io B. Rise in. bloodpressure duetmingreased noradrenaline content of adrenergicnemavendings C. Fall in bloodpressure due to-decreaselinisympathetic tone eitinirh JidgowA 9 D. Both ‘A’ and ‘B' are correct A nsweod ‘Answer: C 26 yiledinils bseu zi anisboD 23, Tolerance to the antiparkinsan|an aelon develops most rapidly in the case gf: 2!" & rinsibiinA 2 A. Levodopa 8. Levodopa + carbidopa OnewenA ‘C Amantadine f O>v> A. Prola Hainogeine roiqBeGenadetropiny suib ori s2a0rl> C. Corticotropin onigasnaud (d D. Antidiuretic hormones) Answer: A enibitines (b snoloxonad: > 25. The following antipsychotic drug has weak dopamine D2 but addit A t dopamine D2 itional 5-HT2 bldticin| it aha Ben BEE Bate dha hate Symptomisior’ ehleophrefla!® voinestineee ‘ Laine ee ove ergoNe 26A1 BNE noijs1292 stenodiszid eee slosexqam0 (b D. Penflurido 26, Which of the following is a nonsedative anxiolytiei 2ovizcgvuq inslumite t . A. Chlorpromazine jo meinstissm ont cae aubi297 biloe sidechordsmapieaguloy ad? gnizsarant (s i ‘CO 'NISE IgA Vtilitom anizesyaa ‘Answer: B agaat Mp y ‘ e aignos ar¥ gansila (> Instnos yI6EW arity N09 I9IEW Ont SHjeRaqrani (bhes RESPIRATORY PHARMACOLOGY x she the side-effect characteristic for non-selective beta2-adrenomimics: in Pression of the breathing center b) Tachycardia €ripheral vasoconstriction d) Dry mouth Answer: B 2. Which of the following M-cholinoblocking agents Is used especially as an antl-asthmatic? a) Atropine b) Ipratropium ¢) Platiphylline d) Metacin Answer: B 3. Choose the drug belonging to membrane stabilizing agents: a) Zileutin b) Sodium cromoglycate c) Zafirlucast dd) Montelucast Answer: B 4. Pick the drug which Is a 5-lipoxygenase inhibitor: a) Budesonide b) Sodium cromoglycate ¢) Zileutin d) Beclometazone Answer: C 5. The most consistent, pronounced and sustained relief of symptoms In chronic bronchial asthma ls afforded by: A. B2 sympathomimetics. B. Anticholinergits C. Sodium cromoglycate D. Corticosteroids A. Pneumonia B. Oropharyngeal candidiasis €. Atrophic rhinitis D. Pituitary-adrenal suppression Answer: B 7. Codeine is used clinically as: A. Analgesic B. Antitussive C. Antidiarrheal D. All of the above Answer: D 6. One of the most common side effect of inhaled beclomethasone dipropionate is: Answer: > GIT PHARMACOLOGY Choose the drug which Is a H2-receptor antagonist: a) Omeprazole b) Pirenzepine ¢) Carbenoxolone d) Ranitidine Answer: D 2. Choose the antiu Icer drug that Inhibits gastric acid secretion, stimulates gastric mucus and bicarbonate secretion and has cytoprotective action on gastric mucosa: a) Ranitidine b) Sucralfate ¢) Misoprostol domenraitla Answer: C 3. The mechanism of stimulant purgatives is: a) Increasing the volume of non-absorbable solid residue b) Increasing motility and secretion c) Altering the ‘consistency of the feces d) increasing the water contentpave cour as a side effect of: 4, Gynaecomastia can o% B. Cimetidine "x, Bromocriptine D. Levodopa Cc Famotidine wer: B d for: 5. ae ulcer, antacids are NOW primarily use Se neane A, Prompt pain relief D. Control of bleeding from the ulcer lapse ¢. Preventing ulcer rel ayes sucralfate In the treatment of duodenal ulcer is: 6. The most Important drawback of A. Low ulcer healing efficacy 8. High incidence of side effects C. Poor relief of ulcer pain D. Need for taking a big tablet four times a day Answer: D 7. The most effective antimotion sickness drug suitable for short brisk Jaurniesis: A. Promethazine theoclate B. Cinnarizine C. Prochlorperazine D. Hyoscine Answer:D 8. Select the prokinetic-antiemetic drug which at relatively higher doses blocks both dopamine D2 as well as 5-HT3 receptors and enhances acetylcholine release fram myenteric neurones: A. Cisapride C. Metoclopramidé 8. Prochlorperazine D. Bomperidone Answer: C 3. Activation of the following type of receptors present on myenteric neurones by metoclopramide Is primarily responsible for enhanced acetylcholine release improving gastric motility: A. Muscarinic Mi C. Serotonergic 5-HT4. B, Seratonergic 5-HT3 D. Dopaminergic D2 Answer: C 10. Which prokinetic drug(s) produce(s) extrapyramidal side effects: A. Metoclopramide B. Cisapride C. Domperidone D. All of the above Answer: A 11, Which antiemetic. ‘Selectively blocks levodopa induced vomiting without blocking its antiparkinsonian action: A. Metoclopramide B. Cisapride ieee D. Ondansetron 12. The most effective antiemeti A. Prochlorperazine C.Metoclopramide An lc for controlling cisplatin induced vomiting is: 8. Ondansetron D. Promethazine wer: 13. A 70-year-old patient Presented with weakness, tiredness and mi : fi uscle cramps, my Prolongation, flattening of T wave and ‘occasional A-V block. His seru aie ae ae @/l), He admitted taking a laxative every day for th he WES ae be responsible for the above candition? ‘© Past several months, Which laxative isacodylAnswer: B : Gynaecomastia can occur as @ side effect of: B. Cimetidine ‘A, Bromocriptine D. Levodopa C. Famotidine Answer: B now primarily used for: B. Ulcer healing D. Control of bleeding from the ulcer 5, In pepticulcer, antacids ai A. Prompt pain relief C. Preventing ulcer relapse Answer: A : 6 The most important drawback of sucralfate In the treatment of duodenal ulcer is: A. Low ulcer healing efficacy 8, High incidence of side effects . Poor relief of ulcer pain : D. Need for taking a big tablet four times a day Answer: D 7. The most effective antimotion sickness drug suitable for short brisk journies.is: A, Promethazine theociate B. Cinnarizine C. Prochlorperazine D. Hyoscine Answer:D 8. Select the prokinetic-antiemetic drug which at relatively higher doses blocks both dopamine D2 as well as $-HT3 receptors and enhances acetylcholine release irom myénteric neurones. A. Cisapride Metoclopramide 8. Prochlorperazine D. Domperidoné Answer: ¢ 3. Activation of the following type of receptors present on myenteric neurones by metoclopramide is primarily responsible for enhanced motility: A. Muscarinic M1 B. Serotonergic 5-HT3 Answer: C 10. Which prokinetic drug(s) produce(s) extrapyramidal side effects: A. Metoclopramide acetylcholine release improving gastric C Serotonergic §-HT4 D. Dopaminergic D2 8. Cisapride C. Domperidone 0. All of the above Answer: A 11. Which antiemetic Selectively blocks levodopa induced vomiting without blocking its antiparkinsonian action; A. Metoclopramide B. Cisapride C. Domperidone D. ee . Ondansetron 12. The most effectiv intiemetic for controll ing cisplatin induced vo: itir : A. Prochlorperazine B. Ondansetron mbes C. Metoclopramide _ ioe D. Promethazine 70-year-old patient presented with weakn at Prolongation, flattening of T wave and MEG/L), He admitted taking a laxative every day for the past Could be responsible for the above condition? A Bisacodyl©. Methyiceilulose ©. Bran Anieen neat roman ae o pola sbie 6 26 14220 1189 bltesmmoasenya cea on lowers blood ammonia acelin hepatic encephalopathy, vac. é ea : B, Liquid paraffin omer 9 actulose Magnesium sulfate reas D. Magi __ 8 mang goileod ENDOCRINOLOGY isiiay nigq.iqmord a Answenk 1. Serum TSH HeSiS Resbla nove FEST Mis ol gploraue Ig oederb tnenoarnl Yeom art AM pi 1g: 1 tyxoedema Grave's disease), goileari 193lu wal a Cc ‘ oe thyo ©. Toxic nodular BOI, 5 sbiz to sansbiani digi g Answer: “ fig 199lu to t9i19 1009 5 2. Octreotide is a tony ig acting synthetic analogue : Rp alacta Mths gamit Ayo} daldeg aid 6 antler at isi a ©, Somatostatin D. Gonadotropin releasing hormone ""°* Answer: C S¥i79a}13)120m il A 108 aldetiue guab zzarmbaic naltemie: Hi 3. Carbimazole acts by A. lodide trapping : Proteolysis of thyroglobulin ee nate ihe eaten of choles Yor the guide nda ta the fella ne 8, Young adults with rec feeen! C. Pregnant women 3 swend oe seen Patients with ischaemic heart disease ZahoWaN wNsNsyin fo Hse51G 2103q9991 To sqys gniwollod anid Yo noisEviIDA & wer: D sis Sh i Wa cP Re Bg Shas ih ae RS of insulin: aco. B. Oxidation of iodide. “08 Synthesis of thyroglobulin protei Gnewend, te a t oneset of Grave's disease a f ATH-2aigysrioloise 2 é EN siniessuMie A, Brain sats eitheqod a © Adipose tissue D. Kidney tubules nas @ ene 3 rawend 6. The most common adverse reaction to insulin A.Hypoglycaemia 8, teed Sea me Hearne fe)eoubora elu bala aia at The natn prepa hea ilar 7. The insulin preparatl ice In diabetic ketoacidosis is: NE 19 A. Regular ins¥liN ys odslw gaitimoy bs: ay pte insulin, A pbold Pemsiins fait ° c sophia tea A B nase mixture of pl in‘an Boph ane | Bl Gan Answer: A ephase 5, a m a wer ‘i aie efe fe formin because: sbirne goals &._ Metformin preter FR neh A. It is more potent : 8. i jess liable to cause ieee Je acidosis 3 vawel i is yaa H61q2i9 seillovinos 101 ait: it itSrnviins aviiasHs feom 8 ci woes not near IR a Vai2a corgition avinstts pe shissyeqralibo" is not cantraindicat .d in'pati ith ‘idney disease Ba vif ae ee sonnei Answer: B olut aa S oNS Fen lucprgase earimgsn bE ae Sh Bi ela SEO eos nom \argva ai rgtveb siege! at H .(u\pam 3) ‘i i Werihances Hat reabsorption in'rendl tubules bx! © Stier baxtinbs 9 10. ene w line nase 46 9111 102 aldiznogesr ad DIU? | A, Stimulating carbonic CO ed biuplisa) neei A ve We Nae Ke ATPase SSW?! (s inducing VRe syithesis Ce a aan re Jandin syn' igadsib of 93 ries 10 920b yrotemmeltni-iinA, D. inducing renal prostaglanen.Toyg ai zaisadeil 0} n 1 Eien poActivating Nav Kt ANFOr ic g ids thineralocorticoid action include the followingeicept: ” ° C. Rise in blood preseure’” brigiimos 2i nitiqeA sto dain bezea1oM to. Answer: C 11, Adverse consequences Of Rise oa ra a or tea TRE nab KEE? erapy in Addison’s diseas®'122210 273260 A Answer: D : gy pia . apererved Jacement thi aT 8 12, The corticosterofd préetred ee pi Fe udiocorieos aineHonyaouria) 2 A. Aldosterone ewer D. Betamethasone P 4 > C. Hydrocortisone oj anit 2i boriupst mitiges 10 ‘S2ob arti daidw 10 noit96 947 9200 Answer: C setae) i tive in advanked Earéirion 13. Which of the follo' ira jn éroldal antiandrogen that is palliati ae ae prostate wien conibined witha GnRH agonist: Seanie op. eure” 1 ‘inasterit ti sompigtganiegy 39 buon gu sb oan Hahins lsbiovsse-non griwollot anit gabis? Insiteq 247 14. Which of the following is a steroid Sa-reductase inhibitor that has pedhfbUntP 2etat tA ibehig prostatic hypertrophy and (Hale pattern baldness: cra A. Flutamide aremmenge’"? 2c Prazosin B MiRexid eee Answer: B i 145 Rela eRe Urry BARHAARORN 2a Geli 2RISER BEV! BUH TRBPERRAR EMER ta” facilitate surgical abortion or induction of labour: puidiciny A. Mifepristone POC 2889101210 8. Raloxifene veg a C. Natural progesterone 12190'9% 4 D, Levonorgestrel Answer: A ; 16, Which of the following oral hypogfvesétnie'GMuge Sel didlated both Synthiestd And’ reledsé of? insulin from beta islet delis:) 2°" > dixo29192..A maaixo!: a) Glibenclamide S1O°4)Bhenformin —¢) Buformine UBRmeRRoP AS 3 AweerA 3 n9wenA 17, Giiesban Wedaed Wie Guta Watiabistuatye methine gniylibom seseib ort aroma A. High blood glucose level !82h"2 7 8 Insulin nilonewA A Cceniediatin ojexattoriam .o D. Adrenalina™UporolrayxorbyH ‘Answer: D G nswenA 21035 101 gurb saioria fait ait Jaalo2 NSAIDS, ACETAMINOPHEN, DRUGS OF RHEUMATOID ARTHRITIS, GOUT Di: 1. The prostanoid that consi A. Prostaglandin E2 B. Prostaglandin F2#2¥!6%69 siseuM 0 stit hy Ubnistritts BRDU VERIRIG faz? S205 Pen fogm| sor ort6id " C. Thromboxane A2 yi ‘Answer: A D. Prostacyclin smb yanbi 2. Low dases of aspi re 2 ewan pirin prolong bleeding time mediator in the platelets: by selectively inhibiting synthesis of the followin {e)nai36 ani ; A Thromboxane AD26 ("sll ai-1i04 3 aniwollot oft 261 snoseayqnitiue B, 5-Hydroxytryptamihe"s ‘A’ roa a C. Platelet activatinigictale/5!q14 ./ Answer: A D. Prostacyclin aiweadhU 8 Jqaaxs enoliibnes pniwollot edi al sast 2 newena 's siveqsrads 6 26r8 loniu Ms olla .er \eonithdetion "! abiscirito10ld20xbyH A B, UteriAKT963/UI90Vr hawihaltineredscic a. ‘The mist’ prdinilnent action of le 4 A. Vasodilatation on of leukotrierie' 83:10. 11. = Pneateret Answer: p Anti-inflammato, ABBregation D Chemotaxis of neutrophils and monocytes ry. dose of aspirin given to diabetics is prone to cause: A. Hyperglycemia : 8. Hypoglycemia C Ketoacidasis D. Alkalosis Answer: B Aspirin is contraindicated in children suffering from influenza or similar viral infection because Of increased risk of; A. Gastric bleeding C, Fancony syndrome 8. Thrombocytopenia D. Reye's syndrome Answer: 8 Choose the action for which the dase of aspirin required is the lowest: A. Analgesic C. Anti-inflammatory B. Antipyretic D. Antiplatelet aggregatory Answer: D The patient taking the following non-steroidal antiinflammatory drug should be cautioned not to drive motor vehicle: A. Celecoxib B. Indomethacin ¢. Naproxen O. Diclofenac sodium Answer: B The following nonsteroidal anti-inflammatory drug is a preferential cyclooxygenase-2 (COX-2) inhibitor: A. Tenoxicam €. Diclofenac sod, B. Meloxicam D. Ketoprofen Answer: B For a patient of peptic ulcer, the safest nonopioid analgesic is: A. Celecoxib C. Paracetamol B. Diclofenac sodium D. Ibuprofen Answer: C Among the disease modifying antirheumatic drugs, fastest symptom relief is obtained with: A. Auranofin C. Sulfasalazine B. Hydroxychloroquine D. Methotrexate Answer: D Select the first choice drug for acute gout: A. Cochicine 8. Indomethacin ¢, Allopurinol O. Dexamethasone Answer: B The most important dose-limiting adverse effect of colchicine is: A. Sedation ©. Diarrhoea | 8. Kidney damage 0. Muscle paralysis Answer: C | Sulfinpyrazone has the following action(s): | ‘A. Antiplatelet aggregatory ©. Anti-inflammatory | B. Uricosuric D. Both ‘A’ ang ‘Bt Answer: C 14. Allopurinol has a therapeutic effect in the followin, " (,, Hydrochlorothiazide inducedhyperuricaemia B. Radiotherapy induced hyperuricaemia 8 Conditions except: C. Acute gouty arthritis 0. Kala-azay