Ca Valentis’ for life Viscosity Molecular Weight ‘4Cw Valentis’ ea life www.valentis,com.tr Viscoelastic Solution for Intra - Articular Use Sodium Hyaluronate is found in the human body as well as in animals and bacteria. In the human joints, Na-Hyaluronate is a thick, slippery fluid that helps cushion, lubricate, and protect the bones and joint tissue. In patients with osteoarthritis of the joint, the Na-Hyaluronate gets thinner over time and becomes less able to provide protection. CrownFlex® is used on the patients with degenerative joint disease (osteoarthritis) which allows reducing mechanical stress on the joint and increasing the joint mobility due to its reliable lubrication and shock absorbing properties Osteoarthritis > CrownFlex® > Wectthaa CrownFlex® is used to relieve osteoarthritis joint pain in people who do not get enough relief from simple pain medications or from exercise and physicaltherapy. When CrownFlex® is injected into the joints, it replenishes — the Na-Hyaluronate you have lost, helping provide pain relief.Valentis’ for life www.valentis.com.tr CrownFlex Viscoelastic Solution for Intra - Articular Use STERILE VISCOELASTIC SOLUTION FOR INTRA-ARTICULAR INJECTION CrownF lex? is a sterile, non pyrogenic viscoelastic solution containing high-quality sodium hyaluronate derived from bio-fermentation. CrownFlex® is used on the patients with degenerative joint disease (osteoarthritis) “~ which allows reducing mechanical stress on the joint and increasing the joi mobility due to its reliable lubrication and shock absorbing . Itis offered with 4 different concentrations: Vv 4 CrownFlex® 20 mg 1.0% 4 CrownFlex® 32 mg 1.6% 4 CrownFlex® 40 mg 2.0% 4 CrownFlex® 60 mg 3.0% Features W m Easy controlled injection @ Reliable lubrication and shock absorbing properties m Reduced pain and improved joint mobility following the intra-articular injection @ Highly effective to improve the quality of the joint's Li m Steam sterilizedTechnical-Data CrownFlex Classic Plus Ultra Ultra Plus Classic Weight Measure 20m same 40ma coms Sodium Hyaturonate 10% 10% 20% 2.0% MoteciiGEWOBRE] 11-2.6millon daltons 1.1-2.6millon daltons _1.-2.0lllon daltons _1.1-2.6 millon daltons Viscosity 20-60.000mPa.s 90-140.000 mPa.s ‘90-150.000™mPo.s 150- 250.000 mPa.s CGI] §— 270-400mOsmag 2710 dod mOsmg 770-600 emg 270 -400mOsmiK9 Storoae 22s 2280 20 225-0 oc) 88-78 68-76 se-76 sa-75 nin Stermantation Btermentation oterentation Blotermentaion Youre 2m amt amt amt Composition 2 mt) Ses HRS) 200009 s2099m5 4000079 0.0 mo Salum corse 37.000 me 270009 17000 re 37000 9 Ossi Line = item Stam Diycresen 0000 m 0020 me 090 m5 0.090 mo Weer for injection as as as as * HA in Crownlfex is manufactured in France Ga Valentis for life Serifali Mahallesi Barbaros Caddesi Kutup Sokak No:17 Seres Plaza Umraniye-istanbul Phone: +90 (216) 661 46 47 Email: bilgi@valentis.com.tr www.valentis.com.tr