vee th ey 8 Ta at ne 828 Bimatoprost sustained-release intracameral implant reduces episcleral venous pressure in dogs ‘Susan $. Lee," James Burke* Je Shen,* Slewndra Almazan,* Werhmer Onils.* Patrick Hughes,* one Ahsoy,* Hhesjimng LL Craig Stevble,) Paul B. Miller} and Michael B, Robison “icy als ns, EN, (Came Labi Men LS dj! Vieiry Mabe. Ure of me in, Mato CR str sa Abstract SK bee Objstice To Sesrmiine the eect of w bimsoprt sustained-refcae inirscameal Take este ‘noplast (Fhatprone SR) on epiceral vents presatire EVE) in oneal degs ria le saulyinsome Meth Normoiensive eagle digs ware ramlornira tv eee Miata SIC 30 jig (= 7} ee shuns injection (nee ener sly, = 7) ih me eye day FEV yom smastured with ap cpikcleral vencmansanzter though day 85, Epelerl agpicoge act ive vessels were Acie sing Hore mam flout Wracaneca! ae two of eueyanine grea i me asta snimal A uparate cohort a hs Hat fa ‘nue rated frescos mean pressure (IOP) eneasirentents receive into pros, S30 pg (= 9) at ne ey; FOP wax cealucted try ay 66 frets Moueline quean EVP wa 104 meng st dhe Tinsanyproe SR youu aru 1 my tm the shar group, Byes area wath Bimatopent SK cabbie eat stun incite in rosan EVP tht peak at diy 3, flawed by a dereane to bevel fuel fusefine. From aay 29 ca day 68, she change in mean EVP from baseline range fiom 24 10 39 mally (P « 0.05 we ehaw), Haseine raean ECM? in epee mest swith Mimatopronr SR woe 149 sug, ard a sty TOM reduces wa nena sro day 6% Bimatoyre SRteatal eyes exksbsted a aelectve, seein dation gavin cnaw nese shat wat tot olaerved i shaen-teate eye Conefurius Ut normal dys, Bimstoproet SR was seoeiate wick a tment increse in EVP follows! by 1 sumac decreas Changes in EVP were accompanied iy « aie tained dilaton oF aqacous onlow veel Key Words: Winstoptiot spicleral sents pies, airneiaieral earl ressure, prostaghindia analog, aurtaed-releave ego INTHODUETION Aqueous fame ouow lmotaly rune san, se ay tenes cairn via the cpecer) weenie! Come fqnerh episclel ances prem (EVP) a impo sksurmnan of nae rena OP 2 ema ‘ie eae! Clima eget 0 = EVP 8-0) Evie Q i aque loon producto U ie aeuce. ran, C td fly." Cen abi nae dogs EYP is teen rept to be he eae a T1411 mumble JOB tm aerage 19 sun nen arin be EVP acai toe apprsinatly es of 1H ia age unleniors, seated EVD, cir ilo {hic arate wih Sunge Weber pedro, es ai with ine HOP a plans ea Sc! uti ns gl EV a feet br topical cole brpseemne een ‘cron ona ne" ht ok foplnmtin analogs (MAR) = As 2 remit, ENT pearly fe been seul a remain coowant, fs arly been fmrenure, sl ov ot been eveilered 3 yomiing target ff 1OP-lowering. tieapy, We reetly demurred, wesc that taps laanupec procs sail ag tufcam aacrenes in EVP in sural loge” Dring 29 ayy of ing toad OER ance aly te ora irene i EVP ranged funy 22 a 6 oa ‘vids manana ineseae uf 38%." Neverthe. there w set eating of HOP Whey dw teal tunel (aout ear ure Say aly mana wich 2 tujeat PGA!" The huge tn EVP wih « wpial ary nny ped y Wei, a tinal ol ian CaleTaga 1 Rese escent na er gules omc erence faite we Tote or ES eee Wisin SR, th spockeral aqienm metiow yee sppeced ms Fig tah Ths sueeiasons yaaa osha the ssiny period ‘There were no chang im the cic appearance of the epicleral mci out resele shame ayer CF ab lewrucmeral dosing nk Manage SB fil hipha hata Fy, weamiene wacrease in EVP wath the St Yee pearerenmient,fallowed by 4 sustunedl decree io EVP lacing fiom 4 weeks occ lei 7 weeks put: ent. Changes ay ENT a sus-esed animals ete ieclicning that the effet af Hiawpace SR om EVE ora nt ie wo scl entry inthe atest ca be Aepurate cater ef anita ated with Monaco SH cahlitesd nlereaee an IOP tet mam arn rg We koe 7 week posters The rast x EV er Bimatpsent SR line tom ie tn comeaet tthe tncrewe in EV hit mam te cured shrsap slowing with the tical PGA. etn (8.005% tn ear entice obi sted eral eagle ‘Mig Hine wil aed ot the wer Rede th sry) Hew tenis maggeet that inracemera debe et ayer ill aro ene alee fof. BGA ising inmost SE ona a fon EV na pom with cal PCA Te deal vacate a changes i EP posted matey ad peony ol the pie tee exp te fenencer a he feel by peal ariel PGA soving. fn vero species sch ings snd fommams, ke episleril yiselaiars comamusioting (ith the apna deaiuye fons the amet chutes ariterse by 4 lek of explates ana a pales of freiomeai anawemacecs th allow comples be fuente epic grevilin ued vemuen.* iio, the epicleal emculture iy highly Fehiy iunervst wiek tmalltive am guccunwmiee Fro the art lata shoo she neon pre hes a shire lewd to am aceme in och EMP and IOP im a rabbit fv toda" Conversely sntacameral CA. delivery Ste Bistapeon SKC wold elt in ara expoeare