Hypercalcemia 


Volume repletion with isotonic sodium chloride solution
Loop diuretics
https://emedicine.medscape.com/article/240681-overview
Practice Essentials  Bisphosphonates
Hypercalcemia can result when too much calcium enters the extracellular fluid or when there is insufficient  Denosumab
calcium excretion from the kidneys. Approximately 90% of cases of hypercalcemia are caused by  Peritoneal dialysis or hemodialysis
hyperparathyroidism or malignancy. [1, 2]  Surgical correction of hyperparathyroidism
Signs and symptoms Pathophysiology
The severity of symptoms is related not only to the absolute calcium level but also to how fast the rise in serum
Calcium plays an important role in intracellular and extracellular metabolism controlling such processes as nerve
calcium occurred. Mild prolonged hypercalcemia may produce mild or no symptoms, or recurring problems conduction, muscle contraction, coagulation, electrolyte and enzyme regulation, and hormone release. Calcium
such as kidney stones. Sudden-onset and severe hypercalcemia may cause dramatic symptoms, usually
metabolism, in turn, is tightly regulated by a series of hormones that affect not only the entry of calcium into
including confusion and lethargy, possibly leading quickly to death. Serum calcium levels greater than the extracellular space from bone and the GI tract but also control its excretion from the kidneys.
approximately 15 mg/dL usually are considered to be a medical emergency and must be treated aggressively.
Hypercalcemia affects nearly every organ system in the body, but it particularly affects the central nervous Calcium hemostasis
system (CNS) and the kidneys. CNS effects include the following:
Ninety-eight percent of body calcium is found in the skeleton; this is closely related to the extracellular
 Lethargy concentration of calcium. Intracellular calcium is less than extracellular calcium by a factor of 100,000.
 Weakness Intracellular processes, including the activity of many enzymes, cell division, and exocytosis, are controlled by
 Confusion intracellular calcium. The primary mediator of the intracellular effects of calcium is the calcium-binding
regulatory protein, calmodulin.
 Coma
Renal effects include the following: Plasma calcium is maintained despite its large movements across the gut, bone, kidney, and cells. Changes in
 Polyuria calcium ions usually are accompanied by changes in total calcium in the ECF. In plasma, calcium exists in 3
 Nocturia different forms: (1) 50% as ionized or the biologically active form, (2) 45% bound to plasma proteins (mainly
 Dehydration albumin), and (3) 5% complexed to phosphate and citrate. Because the proportion of bound calcium varies little
within individuals, in the absence of severe acidosis or alkalosis, the amount of albumin is the major factor
 Renal stones determining the amount of calcium that is bound.
 Renal failure
Gastrointestinal effects include the following: Very little evidence suggests that intracellular stores of calcium contribute in any way to plasma calcium
 Constipation homeostasis. An exception is in the parathyroid gland, in which the intracellular concentration increases in
 Nausea response to changes in extracellular concentration, which in turn alters the rate of parathyroid hormone (PTH)
secretion. Any decrease in extracellular calcium ion concentration leads to an increase in PTH secretion. PTH
 Anorexia increases distal renal tubular reabsorption of calcium within minutes and stimulates osteoclast activity, with
 Pancreatitis release of calcium from the skeleton within 1-2 hours. More prolonged PTH elevation stimulates 1alpha-
 Gastric ulcer hydroxylase activity in the proximal tubular cells, which leads to 1,25-dihydroxyvitamin D (1,25(OH)2 D3)
Cardiac effects include syncope from arrhythmias. Calcium has a positive inotropic effect. Hypercalcemia also production. All these mechanisms help to maintain the serum calcium level within normal limits.
causes hypertension, presumably from renal dysfunction and direct vasoconstriction.
Diagnosis A normal serum calcium level is 8-10 mg/dL (2-2.5 mmol/L) with some interlaboratory variation in the reference
Hypercalcemia may be classified based on total serum and ionized calcium levels, as follows: range, and hypercalcemia is defined as a serum calcium level greater than 10.5 mg/dL (>2.5 mmol/L).
 Mild: Total Ca 10.5-11.9 mg/dL (2.5-3 mmol/L) or Ionized Ca 5.6-8 mg/dL (1.4-2 mmol/L)
Hypercalcemia may be classified based on total serum and ionized calcium levels, as follows:
 Moderate: Total Ca 12-13.9 mg/dL (3-3.5 mmol/L) or Ionized Ca 8-10 mg/dL (2-2.5 mmol/L)
 Hypercalcemic crisis: Total Ca 14-16 mg/dL (3.5-4 mmol/L) or Ionized Ca 10-12 mg/dL (2.5-3 mmol/L) Mild: Total Ca 10.5-11.9 mg/dL (2.5-3 mmol/L) or Ionized Ca 5.6-8 mg/dL (1.4-2 mmol/L)
Hypercalcemia from malignancy usually is rapidly progressive; thus, rapidly rising calcium levels should
increase suspicion of malignancy. Moderate: Total Ca 12-13.9 mg/dL (3-3.5 mmol/L) or Ionized Ca 8-10 mg/dL (2-2.5 mmol/L)
Hypercalcemia from hyperparathyroidism is usually mild, asymptomatic, and sustained for years.
Immunoreactive parathyroid hormone (PTH) and ionized calcium should be simultaneously measured. Hypercalcemic crisis: Total Ca 14-16 mg/dL (3.5-4 mmol/L) or Ionized Ca 10-12 mg/dL (2.5-3 mmol/L)
Other causes of hypercalcemia usually can be distinguished or at least considered on the basis of history and
physical examination findings. Measurement of serum phosphate, alkaline phosphatase, serum chloride, serum Only 1-2% of total body calcium is in the exchangeable form in circulation, and the rest forms part of the
bicarbonate, urinary calcium, and thyroid function may be useful in some cases. skeleton. Only one half of the exchangeable calcium is in the active ionized form with the remainder bound to
Management albumin, globulin, and other inorganic molecules. Protein binding of calcium is influenced by pH with metabolic
Treatment of hypercalcemia includes the following: acidosis leading to increased ionized calcium from reduced protein binding, and alkalosis leading to reduced
ionized calcium from increased protein binding. Because calcium binds to albumin and only the unbound (free
or ionized) calcium is biologically active, the serum level must be adjusted for abnormal albumin levels.
For every 1-g/dL drop in serum albumin below 4 g/dL, measured serum calcium decreases by 0.8 mg/dL.
Therefore, to correct for an albumin level of less than 4 g/dL, one should add 0.8 to the measured value of
calcium for each 1-g/dL decrease in albumin. Without this correction, an abnormally high serum calcium level
may appear to be normal.
A patient with a serum calcium level of 10.3 mg/dL but an albumin level of 3 g/dL appears to have a normal
serum calcium level. However, when corrected for the low albumin, the real serum calcium value is 11.1 mg/dL
(10.3 + 0.8), a more obviously abnormal level. Alternatively, serum free (ionized) calcium levels can be directly
measured, negating the need for correction for albumin. Corrected calcium can be calculated using the
following formula:
Corrected Ca = ([4 - plasma albumin in g/dL] X 0.8 + serum calcium)
Mild cases of hypercalcemia can be asymptomatic and are more often diagnosed incidentally from routine
blood tests. Because calcium metabolism normally is tightly controlled by the body, even mild persistent
elevations above normal signal disease and should be investigated.
Calcium is controlled by 2 mechanisms. These are (1) controlling or major regulatory hormones and (2)
influencing hormones. Controlling or major regulatory hormones include PTH, calcitonin, and vitamin D. The
image below reviews vitamin D metabolism. In the kidney, vitamin D and PTH stimulate the activity of the
epithelial calcium channel and the calcium-binding protein (ie, calbindin) to increase active transcellular calcium
absorption in the distal convoluted tubule. Influencing hormones include thyroid hormones, growth hormone,
and adrenal and gonadal steroids.
Role of the calcium-sensing receptor
The calcium-sensing receptor (CaSR) is a G protein–coupled receptor, which allows the parathyroid chief cells,
the thyroidal C cells, and the ascending limb of the loop of Henle (renal tubular epithelial cells) to respond to
changes in the extracellular calcium concentration. The ability of the CaSR to sense the serum Ca++ is essential
for the appropriate regulation of PTH secretion by the parathyroid glands and for the regulation of passive
paracellular calcium absorption in the loop of Henle. Calcitonin secretion and renal tubular calcium reabsorption
also are directly regulated by the action of Ca++ on the calcium receptor. [3]
The CaSR gene is located on band 3q13-q21 and encodes a 1078 amino acid protein. CaSR is expressed in many
tissues. Three uncommon human disorders are due to abnormalities of the CaSR gene, (1) familial benign
hypocalciuric hypercalcemia, (2) neonatal severe hyperparathyroidism, and (3) autosomal
dominant hypocalcemia with hypercalciuria. [4, 5]
Etiology
Approximately 90% of cases of hypercalcemia are caused by hyperparathyroidism or malignancy. About 20-30%
of patients with cancer have hypercalcemia during the course of the disease, and its occurrence may signify an
unfavorable prognosis. Of the cases that result from malignancy, approximately 80% are due to the effects of
parathyroid hormone–related peptide (PTHrP), while the other 20% are due to bony metastases. Hypercalcemia
secondary to malignancy may be classified into the following four types, based on the mechanism involved:
 Humoral hypercalcemia of malignancy (HHCM) from an increased secretion of PTHrP - Most common
form, accounting for up to 80% of cases
 Osteolytic hypercalcemia from osteoclastic activity and bone resorption surrounding the tumor
tissue - The second most common mechanism, accounting for about 20% of cases
 Secretion of active vitamin D by some lymphomas
 Ectopic parathyroid hormone (PTH) secretion - Very rare
The remaining 10% of cases of hypercalcemia are caused by many different conditions, including vitamin D–
related problems, disorders associated with rapid bone turnover, thiazides or renal failure, and in rare cases,
familial disorders. Treatment with recombinant human PTH for postmenopausal osteoporosis is also a cause.  [6]
Causes of hypercalcemia that are related to malignancy (lung, breast, and myeloma are the most common
tumors) include the following:
 Solid tumor metastases
 Solid tumors with humoral effects
 Hematologic malignancies
Causes of hypercalcemia that are related to the parathyroid include the following:
 Primary hyperparathyroidism - Solitary adenoma, generalized hyperplasia, multiple endocrine
neoplasia type 1 or type 2A
 Lithium-related release of PTH
 Familial cases of high PTH levels
 Neonatal severe hyperparathyroidism
 Kidney transplantation [7]
Causes related to vitamin D include the following:
 Vitamin D toxicity [8]
 Granulomatous disease (especially sarcoidosis [9] )
Causes related to high bone turnover include the following:
 Hyperthyroidism
 Immobilization (especially in Paget disease)
 Thiazide diuretic use [10]
 Vitamin A intoxication
 Renal failure (milk-alkali syndrome)
Other causes related to particular mechanisms are as follows: from nerve compression and other orthopedic complications. These patients may live longer but still have a
 Increased intestinal calcium absorption poor prognosis, especially if their serum calcium levels are very high.
Morbidity and mortality associated with hypercalcemia from other causes are directly related to the underlying
 Idiopathic infantile hypercalcemia (Williams syndrome)
cause and tend to be less serious. In these patients, hypercalcemia is a reflection of their disease state and
 Granulomatous disorders (eg, sarcoidosis) morbidity and mortality depend on control of the underlying disease.
 Decreased renal calcium excretion Sex- and Age-related Variances
 Familial hypocalciuric hypercalcemia [11] Some studies show a higher incidence in men compared to women, but this difference tends to diminish with
increasing age. One study found the highest incidence to be in women aged 60-63 years.
 Increased bone resorption<
Hypercalcemia from nearly all causes increases with advancing age. That is especially true of hypercalcemia
 Mutations of the calcium-sensing receptor from the two most common causes, malignancy and hyperparathyroidism. However, hypercalcemia may occur
 Familial benign hypocalciuric hypercalcemia in persons of any age.
 Hypophosphatasia
Prognosis
 Subcutaneous fat necrosis
Cancer-related hypercalcemia most often occurs in later-stage malignancies and it predicts a poor prognosis for
 Blue diaper syndrome patients with it. [16]  
 Dietary phosphate deficiency In a retrospective matched-control study of 180 patients with lymphoma, Vallet et al found that hypercalcemia
 Tuberculosis [12] was independently associated with poor progression-free and overal survival. The study included 62 patients
Epidemiology with hypercalcemia, with 118 comparable patients serving as controls.  [17]
United States In a study of 90 patients with advanced head and neck squamous cell carcinoma (HNSCC), Alsirafy et al
Hypercalcemia is relatively common and often is mild but of long duration. The incidence of compared outcomes for those patients in the cohort who had hypercalcemia (46 patients) with those of
hyperparathyroidism alone is approximately 1-2 cases per 1000 adults. Mild cases are often not diagnosed. A patients who did not. The authors found that inpatients with hypercalcemia had a higher rate of palliative care
review of cancer-related hypercalcemia found that rates varied by tumor type, being highest in multiple referrals. Moreover, during the final 3 months of patient follow-up, a greater percentage of individuals with
myeloma (7.5–10.2%) and lowest in prostate cancer (1.4–2.1%). [13] hypercalcemia paid more than 1 visit to the emergency room and a larger proportion of hypercalcemic patients
were hospitalized for at least 14 days. [18]
International The authors also determined that among the study's patients who were referred for palliative care, the median
Screenings of large groups of patients have found prevalence rates as high as 39 cases per 1000 persons in postreferral survival time for those with hypercalcemia was 43 days, while that for nonhypercalcemic patients
Scandinavia. Similar screenings in South Africa showed a prevalence of 8 cases per 1000 persons. These higher was 128 days. Alsirafy et al concluded that if hypercalcemia in patients with HNSCC is detected and managed
incidences may reflect underdiagnosis in the United States rather than a true difference in prevalence. early, this may help to prevent hypercalcemia-associated symptoms and to reduce hospitalization time.  [18]

Mortality/Morbidity History
Morbidity and mortality from hypercalcemia depend entirely on the cause. The mnemonic "stones, bones, abdominal moans, and psychic groans" describes the constellation of symptoms
Hypercalcemia from hyperparathyroidism tends to be mild and prolonged. Morbidity is related to the resultant and signs of hypercalcemia. These may be due directly to the hypercalcemia, to increased calcium and
bone disease. Because this condition is underdiagnosed so often, actual morbidity is unknown. Mild phosphate excretion, or to skeletal changes.
hypercalcemia rarely, if ever, leads directly to death. The presentation in a patient with hypercalcemia varies with how fast and how far the calcium level rises, as
Some studies suggest that up to 20% of patients who present to the ED with hypercalcemia are ultimately well as the sensitivity of the individual to elevated calcium levels. Mild prolonged hypercalcemia may produce
diagnosed with hyperparathyroidism. Royer et al performed a retrospective review from 2012 to 2013 of mild or no symptoms, or recurring problems such as kidney stones. Sudden-onset and severe hypercalcemia
patients with hypercalcemia in the ED, and a definitive diagnosis of hyperparathyroidism was identified in 3.5% may cause dramatic symptoms, usually including confusion and lethargy, possibly leading quickly to death.
(6 of 168). According to the authors, 24% (41 of 168) identified with mild hypercalcemia were discharged from Central nervous system effects include the following:
the ED with no definitive follow-up plan, and although mild hypercalcemia found during ED workup rarely  Lethargy
requires immediate medical treatment, many of those patients may have hyperparathyroidism amenable to  Weakness
surgical correction. The authors therefore suggested that an appropriate mechanism for outpatient  Confusion
hypercalcemia workup should be integrated into the patient's ED discharge plan.  [14]
Hypercalcemia caused by a neoplasm tends to be much more serious. The mechanism of hypercalcemia in  Coma
malignancy can be from the ectopic production of a PTH-like factor, PTH-related protein (PTHrP), or osteolytic Renal effects include the following:
metastases. Cancers that produce PTHrP include breast cancer, lung cancer, prostate cancer, and multiple  Polyuria
myeloma. [15]  Nocturia
PTHrP increases the expression of receptor activator of nuclear factor kappa B ligand (RANKL) in bone. RANKL in
 Dehydration
turn contributes to the development of hypercalcemia by binding to receptor activator of nuclear factor kappa
B (RANK) on the surface of osteoclast precursors, leading to bone osteolysis.  Renal stones
Hypercalcemia is often the immediate cause of death in patients with ectopic PTHrP production. These patients  Renal failure
rarely survive more than a few weeks or months. Osteolytic metastases tend to cause morbidity and mortality
Gastrointestinal effects include the following:
  Constipation
Hyperparathyroidism is the most common cause of hypercalcemia in the population at large and usually is mild,
 Nausea
asymptomatic, and sustained for years. Immunoreactive parathyroid hormone (PTH) and ionized calcium should
 Anorexia be simultaneously measured. PTH levels should be suppressed in hypercalcemia; thus, the combination of
 Pancreatitis normal PTH levels and elevated calcium levels suggests mild hyperparathyroidism. Hyperparathyroidism may be
 Gastric ulcer part of multiple endocrine neoplasia type 1, (ie, Wermer syndrome).
Cardiac effects include syncope from arrhythmias.
Other causes of hypercalcemia usually can be distinguished or at least considered on the basis of history and
Physical Examination physical examination findings. Measurement of serum phosphate, alkaline phosphatase, serum chloride, serum
Most patients with hypercalcemia do not have any specific findings on physical examination. Those with higher bicarbonate, and urinary calcium may be useful in some cases. Renal function should be evaluated and thyroid-
calcium levels may have findings that are more striking. Evidence of the underlying cause may be found, such as stimulating hormone should be checked to help rule out hyperthyroidism. In rare cases, measurement of
a suggestive breast mass in someone with hypercalcemia secondary to malignancy. vitamin D and its metabolites and measurement of parathyroid hormone–related peptide (PTHrP) may be
Nervous system findings include the following: necessary.
 Confusion A flowchart of investigations is depicted in the image below.
 Hypotonia
 Hyporeflexia
 Paresis
 Coma
Renal findings include the following:
 Volume depletion
 Signs of renal failure
Gastrointestinal findings include the following:
 Fecal impaction (from constipation)
 Signs of pancreatitis
 Signs of malignancy (eg, enlarged liver or masses)
Cardiovascular findings include the following:
 Arrhythmias
 Hypotension
Ophthalmic findings may include band keratopathy, which is calcium precipitation in a horizontal band across
the cornea in the palpebral aperture.
Differential Diagnoses
 Hyperkalemia
 Hypermagnesemia
 Hypernatremia
 Hyperparathyroidism
 Hyperphosphatemia
Approach Considerations
Malignancy is one of the most common causes and must be excluded. Hyperparathyroidism and other causes of
hypercalcemia can coexist with malignancy. If calcium levels have been mildly elevated for months or years,
malignancy is an unlikely cause.
Imaging Studies
Hypercalcemia from malignancy usually is rapidly progressive; thus, rapidly rising calcium levels should increase
Chest radiographs always should be performed to help rule out lung cancer or sarcoidosis. Other radiographs
suspicion of malignancy. If calcium levels have been elevated for an unknown duration, the patient should be
evaluated for the presence of malignancy. Breast, lung, and kidney cancers should be considered, as should should be considered to help evaluate for possible malignancies, metastases, or Paget disease.
multiple myeloma, lymphoma, and leukemia. Testing in such cases might include a peripheral blood smear
Mammograms should be considered to help rule out breast cancer. Computed tomography (CT) and ultrasound
and/or serum and urine immunofixation electrophoresis. Biopsy samples may be taken from a solid tumor or
should be considered to help rule out renal cancer.
from bone marrow for tissue histology studies.
When a biochemical diagnosis of primary hyperparathyroidism is made, CT scan, ultrasound, magnetic
resonance imaging (MRI), and radionuclide imaging of the parathyroid gland may be helpful to assist with
preoperative localization.
Electrocardiography
On electrocardiography (ECG), characteristic changes in patients with hypercalcemia include shortening of the
QT interval. ECG changes in patients with very high serum calcium levels include the following [19, 20, 21] :
Slight prolongation of the PR and QRS intervals
T wave flattening or inversion
A J wave at the end of the QRS complex
ST elevation mimicking acute myocardial infarction
Medical Care
Treatment depends on the severity of symptoms and the underlying cause. [22]
Volume depletion results from uncontrolled symptoms leading to decreased intake and enhanced renal sodium
loss. This tends to exacerbate or perpetuate the hypercalcemia by increasing Na+ reabsorption in the thick
ascending limb of the loop of Henle (TALH). Thus, appropriate volume repletion with isotonic sodium chloride
solution is an effective short-term treatment for hypercalcemia.
Once volume is restored, simultaneous administration of loop diuretics blocks Na+ and calcium reabsorption in
the TALH. Replacing ongoing sodium, potassium, chloride, and magnesium losses is important if prolonged
sodium chloride and loop diuretic therapy is contemplated.
Immobilization aggravates hypercalcemia. Whenever possible, weightbearing mobilization should be
encouraged.
Reduction of dietary calcium and vitamin D intake is effective for treating hypercalcemia due to increased
intestinal calcium absorption (eg, in idiopathic infantile hypercalcemia, ie, Williams syndrome). In vitamin D
toxicity or extrarenal synthesis of 1,25(OH) D3 (eg, in sarcoidosis), prednisone may help reduce plasma calcium
levels by reducing intestinal calcium absorption. Oral phosphate also can be used to form insoluble calcium
phosphate in the gut.
Bisphosphonates inhibit osteoclastic bone resorption and are effective in the treatment of hypercalcemia due to
conditions causing increased bone resorption and malignancy-related hypercalcemia. Pamidronate and
etidronate can be given intravenously, while risedronate and alendronate may be effective as oral therapy.
Calcitonin can be given intramuscularly or subcutaneously, but it becomes less effective after several days of
use. Mithramycin blocks osteoclastic function and can be given for severe malignancy-related hypercalcemia. It
has significant hepatic, renal, and marrow toxicity.
The US Food and Drug Administration (FDA) approved denosumab (Xgeva) for treatment of hypercalcemia of
malignancy refractory to bisphosphonate therapy in December 2014. [23] Approval was based on results from
an open-label, single-arm study that enrolled patients with advanced cancer and persistent hypercalcemia after
recent bisphosphonate treatment. The primary endpoint was the proportion of patients with a response,
defined as albumin-corrected serum calcium (CSC) < 11.5 mg/dL (2.9 mmol/L.
The study achieved its primary endpoint with a response rate at day 10 of 63.6% in the 33 patients evaluated.
The estimated median time to response (CSC < 11.5 mg/dL) was 9 days, and the median duration of response
was 104 days. [24]
Peritoneal dialysis or hemodialysis against calcium-free or lower calcium concentration dialysate solution is
highly effective in lowering plasma calcium levels.
Surgical Care
Surgical care is directed toward reversing the underlying cause of hypercalcemia or repairing the orthopedic
damage, as follows [25, 26] :
Prolonged hypercalcemia due to hyperparathyroidism may warrant surgical neck exploration and removal of
one or more parathyroid glands; this is particularly appropriate if evidence of nephrolithiasis, osteoporosis,
reduction of renal function, neuromuscular symptoms, or radiographic bone disease is present
Hypercalcemia due to malignancy, especially a tumor that is producing parathyroid hormone – related
peptide (PTHrP), may necessitate surgical resection of the tumor
Orthopedic complications of prolonged hypercalcemia (eg, osteoporosis), complications of Paget disease, or
complications of bony metastases may require orthopedic or neurosurgical intervention
Medication Summary
The first therapy for symptomatic hypercalcemia is volume repletion. More severe cases require saline infusion
with concomitant loop diuretics (eg, furosemide) to increase calcium excretion and lower levels rapidly. Other
therapies, outlined below, are for longer-term management. Note, however, that no current therapies generally
are effective for long-term outpatient therapy. Definitive treatment often requires surgical management of the
underlying cause. [22]
Bisphosphonates are effective in the treatment of malignancy-related hypercalcemia and hypercalcemia due
to conditions causing increased bone resorption. Zoledronic acid is 100-850 times more potent than
pamidronate and may be given as a bolus rather than an infusion. Clodronate (not available in the United
States) can be given either intravenously or orally and may represent a better alternative in the future. The
monoclonal antibody denosumab is approved for the treatment of hypercalcemia of malignancy that is
refractory to bisphosphonate therapy.
Bisphosphonates
Inhibit bone reabsorption.
Pamidronate (Aredia)
Used after initial hydration to inhibit bone reabsorption and maintain low serum calcium levels, especially in
hypercalcemia of malignancy and Paget disease.
Etidronate (Didronel)
Reduces bone formation and does not alter renal tubular reabsorption of calcium. Does not affect
hypercalcemia in patients with hyperparathyroidism.
Alendronate (Fosamax)
Available in the United States, but not yet indicated for treatment of hypercalcemia; alendronate probably is
useful for long-term prevention of recurrence of hypercalcemia following use of more conventional therapy (ie,
hydration and pamidronate). Useful in preventing and treating osteoporosis, which is a complication of
prolonged mild hypercalcemia.
Monoclonal Antibodies, Endocrine
Binds RANKL and thereby prevents osteoclast formation resulting in decreased bone resorption and decreased
calcium release from bone.
Denosumab (Xgeva)
Denosumab is a monoclonal antibody that specifically targets RANKL. It binds to RANKL, a transmembrane or
soluble protein essential for the formation, function, and survival of osteoclasts, the cells responsible for bone
resorption, thereby modulating calcium release from bone. It is indicated for hypercalcemia of malignancy
refractory to bisphosphonate therapy.
Antidote, hypercalcemia agents
Inhibit bone resorption and increase renal calcium excretion.
Calcitonin (Miacalcin, Osteocalcin)
View full drug information
Lowers elevated serum calcium in patients with multiple myeloma, carcinoma, or primary hyperparathyroidism.
Expect higher response when serum calcium levels are high.
Onset of action is approximately 2 h following injection, and activity lasts for 6-8 h. May lower calcium levels for
5-8 d by approximately 9% if given q12h. IM route is preferred at multiple injection sites with dose > 2 mL.
for secondary hyperparathyroidism in patients with chronic kidney disease on dialysis and in hypercalcemia with
parathyroid carcinoma.
Further Outpatient Care
In most cases, follow-up care is dictated by the etiology of hypercalcemia. If the hypercalcemia is related to
malignancy, efforts are directed towards treating the neoplasm.
Oral phosphates have only a limited role in the treatment of hypercalcemia and are increasingly replaced by
bisphosphonates. However, when phosphates are used, especially for treating chronic hypercalcemia, attention
should be paid to hyperphosphatemia and the calcium and phosphate product because this tends to increase
the risk of metastatic calcification.
Restriction of dietary calcium and administration of glucocorticoids remains the preferred treatment for
hypercalcemia due to sarcoidosis and vitamin D

Glucocorticoids
Inhibit cytokine release and have a direct cytolytic effect on some tumor cells.

Prednisone (Deltasone, Orasone, Sterapred)

Immunosuppressant for treatment of autoimmune disorders; may decrease inflammation by reversing
increased capillary permeability and suppressing PMN activity. Stabilizes lysosomal membranes and suppresses
lymphocytes and antibody production.

Minerals
Phosphate inhibits calcium absorption and promotes calcium deposition. Theorized to help bind dietary calcium,
thus rendering it an unabsorbable calcium-phosphorous product, but used rarely.

Potassium phosphate/sodium acid phosphate (Neutra-Phos-K)

Increases urinary pyrophosphate and complexes with calcium, thus decreasing urinary calcium level, while
pyridoxine results in a reduction of urinary oxalate excretion. All dosage forms must be mixed in 6-8 oz of water.
Never give IV. Never give if renal function is abnormal or if serum phosphorous levels are > 3 mg/dL.

Calcimimetic Agent
Class Summary
Binds to and modulates the parathyroid calcium-sensing receptor, increases sensitivity to extracellular calcium,
and reduces parathyroid hormone secretion. [3, 27]

Marcocci et al performed an open-label, single-arm study to determine how effectively cinacalcet, a

calcimimetic, reduces hypercalcemia in patients with intractable persistent primary hyperparathyroidism. [28]
The investigation, performed on 17 patients, included a 2- to 16-week titration phase and a maintenance phase
of up to 136 weeks. By the end of the titration phase, serum calcium had been reduced in 15 patients by at least
1 mg/dL. Although 15 patients suffered adverse events related to treatment (most commonly, nausea, vomiting,
and paresthesias), none of these were considered to be serious.

Cinacalcet (Sensipar)
Directly lowers parathyroid hormone (PTH) levels by increasing sensitivity of calcium-sensing receptor on chief
cell of parathyroid gland to extracellular calcium. Also results in concomitant serum calcium decrease. Indicated