A last word of caution to all those pretending the Covid-19 pandemic is toning down sepsis ‘Analysis of curent evolution of the pandemic and impact thereon of mass vaccination campsignsct the ot hatinmurlogcal ta re ftertinesigoted take cut of conet Iinrpeted ont undertod,Io nt conc it expan ho pretend tht he ardemichas nw stated Yansitorng into an endemic phase and that th rus ‘vcr sporaneotly grade nto yt anther coon cad Co thai ono met ‘once to publicheath scm, nee, Ie ome experts now tendo able ‘Sirisha severity of cave and decling moray testo Goning Hand cr waning al veviece A illbe exelaiedbelon, the predcons hey make erating into sccantthe complex tei beeen the gannginlctous pesca mote infectious rctng valves and th ring mune slacon presse eae onthe vu bythe rapidly expsncngierurieed popustion. The precicons re ao net nine ‘sth eceraypublehed data tom mole’ genome epsdeclegits showing how hey (Cv vais oe my econ conibten: Why ie anos mass accion agate shi aid etinan pata al SARS COUT Its simply min owing tht some spars sl contin toignore he raga inact of ‘mas yacanaton onthe elution of ths pandemic. On the cova. some hem exer Fetand thatthe weak ink betneon the ruber ofifectous cze and maby? Ineptaintion ates sew cbsoned in ener exunnaein Europe andi he US prose thorvorans donot escape the immune ystam, Thy tribute thse eknderbready ote hatha en acquired trough previous exper ocoron eck CV ‘cle poviau xymptomate hin ith Sere Ca 2 andr lace och) Cv ‘vacation Some experts een contre to emphasize the rl of crssseacive cols tte one ore ofthe aboe- deed murano evento ay conto to Hi That cezeeactve memory Tells woudprever spielen immune ezape en ‘haste. provetSdrecad mune eeaps variants rom propagating and ating to ts hostpepuatonfnetbaceon ay conic evidence. Thee need, no eer root shove at cosereacwermarary Teall previously exposed x vaccated individual local conto eliminating ling Cone cle. Tho icra even root hat any ind of Tea els posi sliminat Coknfeced hot clin the aban (ot Sapecticmemar 8 cls. Thee teefore, no selec ewdence that coseeacte, ‘erent ronepetie Tell corre octal x mnishing wal vanamision and hy Contrbyte eH: the oppose woul pp one would net understand why at Its SoRe cof tho pandemic some presi aommptomatialy nfcted ubjac al ofa audéen etoct Cov 1 ena! But oven an Abs gnerated upon prvcus expat commen el Ca or ypon prevouseymptomaticinfecton with Sra rater rmunzation wth Con 19 (cone fal to corral vl arson Tisizbecaine 1. Ants Abs ected by previous exporure a commen cold Ca¥ do notreviize Sr cous 2. tS Abs eited by aerptmaticineton are shor ved and ot aly fiona (there ra euence mat agjptemati econ wth at C2 induces emery B cl thas baeneporta hat these ete Ab re nal espana vie lninaon the ator ecu aver Batre ant S Abeta pak 2 nS Ab ote by acini le thar reuaing capac oars mare Infectious and nosing 8 Abresartvarants hence, exploring the stoady incesng ocurance of eavough cad, Bu, evn mor importantly: How do these expen recncoan lgedy growing wth ring eet ates hata curry bzonedin many courts det earod Creltion of he dea variant? Would is eu for 2 ing rosin athe than fo 2 corsadaton of HI? This eration carn ram ncaing hat the pandeicie ‘rent Yancining into exci o,f eanotaezout er reduced sent fhe dase, then mayb spontaneus treed deserdar vara tht reno more har hana common cold CoV? Ves can nirepate, mutate orhde Selection and adaptation of the mutts they produces cin lection pressure plocecon specie hnotpi festunes of he wus Butwhat ‘indf elton preaue woul foro thera atruati? Ar hw could hat harpan. oven that he ent selection presse on Sasa repay known tobe ‘exerted bythe poptons ovr rane status and i eco eS prt ie known to ana a infctournece Wan how dosent mee snection pressure onthe inecouressof apsthogen case mised tdence W hese mas ‘ecaraton campaigns ware realy dng the propagation of Sterusted al vans that ‘ee rolonger ef pbc hats concen ould rather weleome thr ae a blezing ther, ‘han ejecting them 89 cogs However a fr oxfam nar, no genomic wince hasbeen provided sro show tt the a variant or anyother ore facts vari Curent evling mations that woud meine ere benign course othe eee cr nab tho vu to bacoms inal mere infctcu er Younger 99° ous ‘These mareplausbleenplanation fr he ebzened dain naan severe ‘he nance nha tha etait of any thermore nectoue variceal affects younger age gous (6.9. young adults Younger age roupshave higher levels oF‘hierar mci with uncer dono re sence fm hs tis ony bee ur opel Tisakeady eps Why the daa arnt seernay Ts ruler Buty does the delta vairtor thr mere inectous vriats) meray tet young ‘oii oaeladute? Th st aly, as odo wth Kshighe lanl of wveciauress ‘athe han ith inte ince Higher ral nfcouress imps enhanced afin of ‘he varant spe potein forte Ace-2ongotnsnconveing era 2 ery rece: Enharcedafingy ets in drinshedcaptice of the vis by ata valet respecte [Abe Theres abun and campeling sere evidence onthe protective fect ot Polreacve, mtr bs, neuding the protective ect apts number of wal infections (ee sens tm tha teas on my website unde topic) Elta levels cf hese Abs ‘eto be consiced a hllar of natural protectinftem amporaiifecton upon Sa- love of natal Ab willbe more prone to cxnvacting severe Cove 9 dase, Buthon ny do moreinecour atarts wie? urna the is ten months ef the panda hgh waves of fects cases that occured in ‘ererconced eeu (slum fav, ihly populated cies. acted by the pandemic ‘raphe cazed mune resis on vn inkctoumes, expecially pen re-enact revouly oympromaticaly nected india, posal that uch avers hao bon ‘Sing rata selection and enhanced chedaten of moreniectious Sdrecteinane ‘spe rian The highs andere widespread the isles prcrur,the higher ‘he tno hat prevcus asymptomatic infected subjects become e-expoed tothe usta poirt inte where thor tars elon tiny Sracted Abs ae stil Ngh enous {oconpete th thar natu paroacive A orbnding toe cating Sar-C3V2 lineage G20 Fig. in previous orribvtons Rav expt exhined why Specie Abe have Mer afin fr preter tan natura Ms, which bind ov sutace-onpeted rou hough multhsesinersetos) Cersaquey,enhncadinfecty rts culd ead to. arsentincearo of th xcept of younger age group |< 6045 you to Gove 17 Ses9 are may, hres, ase motity aed Raplzaton oes in these ag2 groups at ls cen beredin many Ercocan cout wl es the US So, the eran ror idesprend the irl infectious prnue the mare produce he brecng rune er ‘mor infects vain andthe hgh the isinoeg or ar cleo fc rect rune e:cae vara, euch hat eve uations capable of eng sbeptnalimerune peste co al nacounes| mire expe a that we ‘lected becass of ta capac to overcome such inmune route ett higher val ‘tinfctiuenas Tse how high nective ola breeding af neenanghy infectious il Yai Dating the it yea fe pando, eral af 2m Infectious’ mune excep aturs heveemerged eg. ieZ beta guna, delta Depending on the remaining prtecveefatprovied by natal Abs, yourger and heathy ge ups, widen parteala may nt ean sow ay sympions a lesan haus Crinant elton af mars infochour aes ag, a arr s row nazar, Incesngthe riko apes poe Ti akeadyexpline hy Coe 1 dren in the nonsercated primey cbserved in young, micce-aged ats Since younge age (goupsoe genealy bier protectors poyoutve Abs. comes fais onace inthase groups ae athe rae Tho severity ofthe disase in tess ejects is ought © Cepand on he tine porto e-expone sa he previous infection. theshater ‘haratythe higher he concenation af bodeng Seat Ab, the higher the keto for conracing more aver seca cause oth bind of natural Coirorspelic Abs to Sar-Col2 and ining of Sas CoV 10 the Ace 2 erty teceptris mest by mutilet interactions, resonable to sir that the blocking oer of otra, Colerenspaiie Abs onthe interaction batsen ‘he Ace-2recepte anda given SCV? inaage ran depands on the funciona! ‘canceiation ofthese natural Abs Thr would een expin wy, under normal reumstncs ie. retsuppresadby Specie Ab) young and or heathy indus ‘an efectnaly dal whl Sr-Co¥2 ural vara. The higher the ai of for Ace2 {ce the higher the vel of ise vrinfcteuses| andthe older te ge up, he lencr the reid, non suppressed fneina capi oft Abs. Inconvas, vce Abs are tected at alin set of dred SersCaV2 matic pitope primary compra within he rceptorbinding deman| BD) ofthe pote Hens, on oximatsons sin islmited et of sptapes il okey suo, Comich be tiny ofvacial Abs or binding te Sa-Cov2. Ts, howe, doe ot apy to Sapedtic Abs acqued upon covey om ntl Cov 2 daeate a owe ae ‘Srecied at a much broadar and verted spac of Beall spteper. Thi woul aay tsipain why more inectous Sr-Cal.2 arts mre racy capa om wach Spc [Abs than fom natal accuited Specie Abs and alg wy we aterow sein more and ror beitvough eae caer th he mote nfs des variant voces hates Yours and rhe nso or prescisy yptomatclyierecneopl oises sexeneoatn or Spotl (3) ran age protected tom Gov? dace Mole epdorislit condudo that, boca ofthe tay erssing Sect immune pressure xaredby he han population, crating varia are now aeresngy cling mutans that dive retance to Speci Abs, pedal to thse recognizingiernodoriant pitopes that ar ts wihin the RED an terminal arin NTO) of ‘he Sproten ihc urBaly tht natural acted spec Abs a veporsble or thissrmune pear as people who reaver om Coc 9 eat ely cere a ‘aatalyemalleubet of te poplin nd mount Abs agit uth broader and mare (Stories panel ofS deruedeptopss Giventne nar fhe acai Abr anche ange ‘cone coverage rates hmor coun, thee canbe no dou that he tay ieeaeing peputin ee merune pest ound tobe exertad n RD, fr expe caused by ‘ecsratonolarge maser of people a previ contin, thaveepresze my ‘etoritment abut he fort hot these rll sates didnt even mention mae ‘constr’ al aa potertid cae me masse increase in Siected mune res: ey cent contibuten "Why is coaging massac esimant is rapid oulutonsy epanss of SAES-CoV.Z), This evoluton i of cours, enone worrcome, Whores progressing cnvegantsohrin tora: tesa esanceagat futtonal Space etd by the vaccine ay ot acest futher ncaa the ffi ofthe visor the ce. eet and hance, not common euze moe sain yourg andheaiy indicus t's easnable to assure that such evolution wil apy Fase he number ar sven of zea caes inthe vaccated pa ofthe population Tha 's because crowing Wecape wil enue vrcrecs toe ther ace ect mane rotscton wishing re natal. COW nnepectie natal Abs uppesceby high ies long ved, pec vaca Abs) W earonable to azume ta a 3 geneal ue, {he elo auppresion frat, Cov-norpecte Abs wl crease wth nzeasing seth (adrian quan) and coverage at of bocrter rion Gnlsing 2d ‘eration cena). Niacin speci Ab canna cutcompete Sapacic Abs om prscuyaymptomataly infer for bincing to val rots do to ular el epape ecsanton| bythe rata pmeclimmune gem, On the ether hand rerun aequted eon recovery om naual Coud-9 ease every robust enc rapestely ben reported to be capable of desing vr effec with venecrange ol atigeicvarats upon xpos inlcing arias of concer VoCs) Non atigen g-pecc nat inane ‘djurneaton enables epitope serening acs thelr aly taconite to bead irerune recon Naural cured ian thle en almost "mrt cameonent to hed immunity. i honevar incerta wether binding of pace Abe fram teiouly symptomatic wectedindidual to chealatg Viexzaping Wal vars cul ender hae mahiuo mere usp to Ab dependent enhance of Scene 08 Basecon lof the above, i becomes ahead apparent hat nas vacation campaigns conductin the mie of pandemic of motinlectous varars wl py ane ‘rama ween instead o svengthen the pepusions ovr immune prtecton sts ‘rc thetefre, not conte to ganeratig had mmunty, Ti sbecaze mus val {taimason between the nerstchted and vacated population enables oa plying, sera ect btwoen high vil infect tes [to more infectious retin vats and high vaccine 2rea9@ ates (ve to mas vecnaton Tis oss in erhanced expansion mare ifectous, eteasngy V-ecaping atin as depicted nF, + Hunt rates tum the nonsaccnated population fo abresing ound for incessant vats nd afactoy for the produon and version of uchinfctous variants Du tthe increasing infectunes and expansion Preval, infocon an wanemision te raps inerese and th oc natural meruny na uber of previous apmmtonatily infected indcul . "ting th heathy, middle-age edit nd progenselyeching younger and Younger neal} Th, nt, ota Sectod mune clas resize a wos natural election and possby adaptation of ven mere inectou vast + Hi vacine coverage rates un the expaed vaccnstd peplaton into 3 bowery for more Vietaping sil viens pen th transmission tacos, more nfs vant that il woke | ‘ional muti conoring neaning estan to funn Set acc [Ab ilo slated a thos gun acompetineaxkantags mvociae and il therfore, erode mor asctvely, Susequsnt tanemen eth V-escing ovens to nomvaccnated subject vilenabe hema pi expardin prevalence na tarts, elo se dorset pricy reusing aan ‘Theinerctins desorbed dove allow to undestandhow mass acciaten on background of enhanced vil infactiounes pander) engages both the vaccnated nd nisearatadpapultionto sipeds natura lactan src adeptasan aime a=3p6 ‘lant aforng adatona RED stolsed mutator hich neasngh ft VM. Te Istosay hat mas vaccination campaigns conducted ving epandenic of ov infactiows ‘ero wil pret estan of mere infecus Sars Cov Dvr to S based Co 9 ‘The more mote fectou vain exsun and dena anc the more hese vats we _nbjectto vaccine mediated immune election reas, there rapidly the bene fect rom mass \achation eduction of Wal taraision andprvertion of dees) tile replaced bya gong eure ofthe vaccine to protec the veces and of he \ecsrocsto prota the nacratd. Th eoltion caren epee by lean ofinfection prevention mesures, rcduding more Hequet conta arcngheaiy nd "Mora aque contact between seympeonataly nected vaccinted and non-acnated abject) il ery promot resing of new vars that re bath more rections an ‘mor ren escape om vaccine mmunty ec lbh arin. Senmary Insurnmany, ts eoonablto postlt tht th expansion oa eres more ncn ‘valent andthe cencomitart explosion of iecton rte due to sat ampiying nar {lection nd ceptaton of me infetou celtng variant sre wich ly ‘morged ae pcpogsted asa est tom overronsing, he moe rou pha bet, ‘garner deta varartsemergee pore the deploy of mow vacation eampoens, {he eter deed not be the ve of these vrais Hwee athe eran population hive rcoy been eperteto star mot and more mune preairon Imerunodominant sptopsr compris hin the RED, is warorble tosis tat the ‘eltonal mare pressure eau fem mas vacation because acc coverage aes (Se stendy growing Mors infaciousvarants that have soe ta arbor natal clea Screed inmune scape mutation ileal na compative advantage a contaued ‘as yacanatoncanpalgnswth cet based Covi vaccines ous vaccines to ‘uorant and broaden immune secon presse on iy portant imurodemint pope corprzed within thas acc Duo to nero inne sation prevae anedvth a high valinecton ate and more requrecomact between Nea \ecstsed and wn-acciated peape, mereinfecous nmane escape vais wil No ‘epi hrter ere oly exzape YM whe expancngin prevalence. Titan that new immune cape variants ha canno longebeeimiated by any Keo Rw oon ‘come the donnantreuting sis Inher wor high wal ifstonrate dient ssacion and at mpting expan of more ad mote feo ar CoV. 2varars nthe nonaccstedpat ofthe papain while hich veccine coverage ates ives natal election fncreasngy Vi ‘Seaping Sar=-C0V2 variants Ths exciton naw cing erence aes fant in ath Fepultons Coraquant, mss vaccintonceing» pandemic of mereineciour orate "tapes natural alaction andexpanscn of mote nec ircesingly Veesapng Sur Carrs. Soh the accrued and nonvaccatad pat othe population ly contbste tote vain, ecoise fala the above can carry nat ede the pinion af thase wh thnk tha ‘he dees in doar ety and hosptalzatons that snow ebamedin several ‘counties hare ies eecrotion wll aanced would be dst som Kindo ‘atensstin ofl vars o fo somekindet groin One ater conden ha tis pandemicis fr fom over rem tanstonngint endemic. Thee canbe no dou tha tins sae, th pandemics gsrng up er bresing vaccine eisart supenon 3 Phenomenon hati atriak of elng an eve larger wave cnet, ogptalation id Unfonunate, ho deth nt est te vacated part ofthe popu ‘The ongoing mass accion campagne must inmacataly ba abrogtedbacae the cana fl to block vial wansision andthe largescale use ding pandemic of more infectious arate il neta ed a veccne eitance of caoing Se CoV? ont. Instead, mss chrsoprephns campaigns shuld corded at rear intanl to ‘ecuce Wal feos pret ata Vananion ana prevent mote rfcious wal tants ‘rem facing he been and dominant propogaon afore mlectous,voccneesetant \aronts Fatherore poop shautboos the heath air horse ey eatmet o Patents ho coma dour with Cove eee or more fomaton plese connor ‘rare pol De P McCullough presents and publestons) would rt on prevet {evre docee and hoxton but aao ere ten patents ta mere apy ee brood protect Abs fitting’ elinaion of iusinected host els a therfore dmineh wal waamkaion and correo herder, The aoe ‘mented interventions have been aurmaraedin ig. 3 ‘ewe are now doling wth 3 panderc thigh infectious vias te, dats variant. we ‘cae ford any lange toga heed rmiy whut eying on large cle antral chemoprpyln cobinad th cathy wextmat of Covi 19 ecazed patent Ti, together vith an immediate al of all Covi mass echration campasgs, sholdnow conte the main ils of ou bate aginst this cherae totaly unconaable ‘much a5 alow reports on acieefty ses wth rat dal of cone, wey and ‘vison, tanta belies that th poeta epdeniclgal ypc of hse vacation Campion on human ver oube or of magrit lager than hat ofthat poten Sher of longtarm sequel. | an, therfore, begging the WHO anda stakeholders of ‘have capoigs to mmecatlynterene a proposed above. farthest expetmant fae intact generating hers nmunty ma vessnaon nom turing ecracs mt etenal proacer of<:caping vin). ou umanracscanot afford 3scond ge ‘eae oxpenman that ne at conning maze accion whl romain exoooue othe population toa evenhighernfecous peste aneted by veh moterecows muneverl Condi Both long ved Sr CoV specificity sured upen recover Fom doses and Inve Cv norapecte Abmedited munity normaly oreibte to astblshing broad protec hers mun ard tary ena a rata CY panda fx hat me, [Sy pace ofan ete, ing al eset returns no an ence Phare Honey, relation of mazinfectious varias comes wth high pice to payor herinmtyto esas as high fect ates af te hey to wade rata, Falpeacve i. Conorspeci)immury in young and x helhy neice are, mobi and hoaptalzation tes, nd tna ao te numbor of deo, linea, Thsseampliyng ee of enhanced val nectousesseatingin enhanced ial nective would only comet an enh the populten deny uted own to lool enauah fora waramizsio 2 iy tanemanble! nestcunarat) eo subtly amish Wheres fast an dominant prpagition af ntl slated, mere inecous tants antinoeo srode te aia fist ne of vrir-nonspecc inne dene in the on ‘conte pat fhe popu vacation flare par oft populton and cmtacts ‘erong ached and nonaccisted jc we dking natural elacon and adaptation ingen V1 eeeaping vara od ects, incresingly compromising VM Nether previous CoV infction Including Sas-C2¥2 nection ner higher vac coverepe rates can compensate forthe lstimerunologies capaty deed, era Teall listed pon pris CaV inet or vaccination ae ot epetcy Enon tobe enacted with ‘foto acy tomar Confer cals, nor can Sapa Ab htecpon peu Cov nection or vaccination prevent spreading of more nfectious Sar CoV 2 van Mole epiericiits have suggested hot mane ale to lock al tansmision [69 nimmurosupprenadpstnt caus variants to convoy sain spstaly selected mutator, hereby enabling excpe eon VM Vi escape together wth sppeesion fatal Covrorapctie baby vz! Abs wll make vacant high susceptible to contracting Cod 19 scare Denna propagation fee nection elvis coud be mitgeted by mass cheroprepylns usingaotert antl Ate some ee, mune penis on ec S peti optapes mit be gpd by cling immediate hat to mase¥aeanation campaigns, Fathermee ear vestmort of toma obj can revert 0% Seeae ar provide than ith abi petecon oan a erie’ specu af more infeour atric anc heey, ako edice val vaamizion Hower ise eet, opportuni tol he dasrous consequences of mss vccinstion Indeed yet uncartsn andunexpored to what exten arly elecadierne acape ‘ations can ecombine upon co-infection an generat ven mex compen varias, he Phononypicchasctrsis of which we totaly urpreitabl ao ces whether ea {reatrant could prevent vaccines who hve become igh susceptible o Covi 1 ae (ey dus tovrl estan to VM) fom suru to mre daer in con i camps uniooam hte vaccines and ven Indie who prevouly contracted ‘smptamtc faction are moral alicia erbanced Cov case fe, ADE) {thee vocrinal Abs mayne longer sb to natalie the i but cul ail bined “Teatmert of patent ith ADE may be much more dif and the outcome ass preaicabe ‘hemor Sars Col.2 ovo to setrngVesoping proper, the es ily acing wsilbnet om the sbove proposed tatgy, This bacave even low infect rte of ‘retin vars could aufies oboe tha vicinal Abs and hen, upp ate terns defrce. Such estimation caulceny be prvertedy erecting l lhe rant credsing Sire Co. vars Eaccaton here could be achieved ng ‘ners vanes tat induce stekainginmurty. The development such aches ‘ayrecuiteafunderartaly iret approach oimrvuneintrerseninhatnduce immune sector call ought tobe capobie of Gal.zonsasic iting of CVineted cals 2ndproco dbl retecive Inmunty inalsubies of te papulation (ogee flr Imerunaton hse ancinmureganaticbackgourd) I goes without ying that uch ‘charstrsis wou andr a vaccine highly ae craty fli cven whan ued in mass ‘conan campaign the mist of pandemic high aaable ina, nd even ‘ror infectious va vient woud akeody be calaing Voeane safety reas of couse aromourt aed annot be abject any compres, ep not hen ast Cerrbmaton of rtilchomoprephfo,focionprevrton, oy trestmsnt and ‘ehornce to haath strengthening ating adie se hat oul stl be sao and ‘fev in preventing cso ovate dasa and prevent Vescaping vats fom Unless continua as achat wth bana vac npupustionsexponadios CV pandemic cal be proven tog nine mane aeectionpenarcn the fcr of ‘hesarcal Abs and los Space ee obs power tase compete wth roa Co¥nerapeciie Abs for binding to Sars CaV.2 massvacchation carers dings panda especialy dingo pandemic of mere infectious vats wl nthe enable herd Irevunty nor most ure nav of aca unos anenirion bocing acca ae na nfs they have enact he ceca ofectin that hey oromote the sored ofincesingly Venaping varias and press natural inmuniynvecinee, Thay reultin her mori ard matali rates he pt he population that = naxmaly rat potacted fom Gone, he vast majority ofthe poplin. deine ot ‘severe moby and moray ates sony saved nthe ele ania people wth seme Uderhing zeae, Th ctcome, threo ofthe mass accraten campus very (Soret fame niga cbc, which war to protct tha at maj f peo, Inclodn toee who ao immunological Sars CV-2 naive nmi), Seely Speaking tisha to wrderstndhow the ceuliting, mare infectious Sat-CoV2 vans ‘relent api evoho to oetome the RAD-arected Henin posure thet 2 cet ‘sterd by lags pars of th haan ppulton and mgs into supenaian tht ac ‘he mune response nduced by ale the based Covi 19 vaccines Elasmely irae thet the engoing mess accion camps could gat, tale ‘emia, this pandemic of marinfciou Sr. CaV-2vonts nar th in t| ‘elopting mide stad of even mor problematic fetes | thetfote rere hat the ery cbeoried converges of ntl elected rasaions torte Sve artigo sites that lta or are rectly rerporbl for ‘ining tthe Ace? entry receptor cambindwth the velocity at which hs elton curren take place poss huge aeimminent teat tothe human population and hos bac we corsnus mass vaccination on absckound of high ilinetion ates ‘hl rgey relaxing fection prevention meanzee. Lt but not eas, must be emphsrized tht hore cling herseher‘apert whe tending that hs pandas pandemic among he r-vaccnated ave cave o ary Selec sight inthe eeutionarydyramis of Sas-C2¥2 as cnet shaped a Cerbiton ef igh linet anc ecrine coverage rates Nether the vat (nho rae baoved re acsine woul prose tham om Covi 19 desea) or he ren- ‘caratad (ho inp bale here sno need fr them to ake the van in det say protscie) ate be Bare fr he eclaon of tis pandemic Mats acration the one conic ‘Note: copy fi etc hasbeen Set to WHO, MN. CDC He BA Malin Gates ‘Fexnditon, GAUL CEPL FDA, EMEA and to RED lec rm Pier Madera, tr Zeneca, J, Novo and GSK Fig: Nere infectious inure cape vans ovtecrpst the gral vis ngage On | sain forbid to Ace ety ecepto:Arigen Aghspei lg antboces Abs) ‘cutcompete naturel plyreaive fr Aa-specte aM Abs er binding to Sar-CoV2 Doo 2 euteorpetes Aa specicbut nt rats pabresctve Absorbing a mare Infecour erat, ( higieweewsrisney Sercactenee! omnes + (plstenweasetonns ate’ mate mary Namaccncoveerae eae, “Sweets teeter a (Sarre = Were teotefoe ie feettcltsreawens PTT eewetteniemeny Memes Fig? Ect f Spe based Covi vaccines on el elton when ued for mass ‘Aatiiralchemoproahylanis Meslth + infection prevention + trometry ae rece Stop mass BE et (re-vacination ss ary ueatment Fig3 Interven aimed at centoling propagation of more Vesaping Sa-COV2 ‘asian auch sto prevent cian ction of vaccine estar vara: Ely eaten Contrbuts to stangthaning ready proce immune mada hough acquired 5 sect Abs (0 Seer experts he have stated that rent culating lat te evohing mere "beri features have an tated that mcs vacation must sop cau accion ficiency dinishing detour stape and, therefore, does ot sty he Sedriataton ofan that hve 8 ruber of sey concer (2) One caste auth age cl conn anduieorand aos of marke could ao be response for ata clacton and propagation of enhanced walifctowsnes is indeed plausle het ac of eee coupled ith ow expose enorme ‘mul ung mobor and ether eign artigos cul eat porting frat imerunty an, here, minined aint of ocr natrl Bt Abe he leva ofthe ‘espe mucosa. 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