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Interpretive Guide
Although LDL cholesterol is the primary target of therapy, other lipid risk factors besides elevated LDL affect coronary heart
disease (CHD) risk. Among these are low HDL cholesterol, elevated triglyceride (especially VLDL remnants),and possibly
small LDL particles. This "lipid triad" has been called Atherogenic Dyslipidemia. It commonly occurs as one component of
the metabolic syndrome. In persons with high triglycerides, ATP III (Adult treatment panel III) identifies the sum of LDL
cholesterol + VLDL cholesterol ( termed non-HDL cholesterol) which represents Atherogenic Cholesterol. non-HDL
cholesterol thus an important parameter used as secondary target of therapy (after LDL cholesterol) when triglycerides
are elevated.
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Caution
Serum lipid concentrations and lipoprotein patterns are labile and affected by eating, smoking, alcohol intake, stress and
changes in posture. Although plasma cholesterol concentrations are not significantly affected after a fatty meal, plasma
triglyceride concentrations are. Therefore, specimen for analysis should be taken after the patient has fasted for 09 to