1. Disintegration of Tablets and Capsules!
(Ph. Eur, method 2.9.1)
‘This tosis provided to datermine whether tablets or capsules cisintograte within the prescribed time when placed in a iquld
‘medium under the experimental conditions presented bolow.
Fr the purposes ofthis tos, ishfegration does not imply complete dissolution ofthe unit or even ofits active constituent
Complte isinfagralion ie defined as that stato in which any rosidue of tho uni, except fragments of insoluble coating or capsule
shell, remaining on the screen ofthe test apparatus or adhoring to tha lower surface of the discs, if used, is a soft mass having no
palpably firm core.
los uso apparatus B.+
+ Use apparatus A for tablets and capsules that are nol greater than 18 mm long. For larger tablets or cay
TEST A - TABLETS AND CAPSULES OF NORMAL SIZE
Apparatus
“The apparatus consists of a basket-rack assembly, aL low-form beaker, 149 411 mm in height and having an inside diameter of |
4106 8 mm forthe immersion fd, a thermostatic arrangement for heating the Mud between 36 °C and 99 *C, and a device for
ralsing and lowering the basko in the immersion fluid at a constant frequency rato between 29 and 32 cycles per minut, through a
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