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Journal of Psychopathology and Behavioral Assessment (2020) 42:500–518

https://doi.org/10.1007/s10862-020-09794-8

Psychological Treatments in Adult ADHD: A Systematic Review


Tim Fullen 1 & Sarah L Jones 1,2 & Lisa Marie Emerson 3 & Marios Adamou 4

Published online: 18 March 2020


# Springer Science+Business Media, LLC, part of Springer Nature 2020

Abstract
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, characterized by symptoms of
inattention, hyperactivity and or impulsivity. First line treatment is medication; however, medication alone may not provide
sufficient functional improvement for some patients, or be universally tolerated. A recent surge in research to treat ADHD using
non-pharmacological interventions demands a comprehensive, systematic review of the literature. The aim of this review was to
examine the evidence base for psychological treatments for ADHD management in adulthood. A systematic search of PsycINFO,
MEDLINE, CINAHL, AMED, PubMed, and EMBASE was undertaken until January 2019 for peer-reviewed articles exploring
psychological interventions for adults (18 years with no upper limit) diagnosed with ADHD. A total of 53 papers were identified
for inclusion. Collectively, 92% of studies (employing various non-pharmacological interventions) found a variant of significant
positive effect on either primary or secondary outcomes associated with ADHD. The strongest empirical support derived from
Cognitive Behavioral Therapy interventions. In addition, findings indicated support for the effectiveness of Mindfulness,
Dialectical Behavior Therapy and Neurofeedback. Other types of interventions also demonstrated effectiveness; however,
support was limited due to lack of available research and methodological rigor. Psychological interventions should be considered
a valid and useful addition to clinical practice. Implications and areas for future research are discussed.

Keywords Adult ADHD . Non-pharmacological . Hyperactivity . Inattention . Psychological intervention . Clinical psychology

Introduction with these three main behavioral symptoms, ADHD also com-
monly presents with deficits in executive functions, emotion
Attention-deficit/hyperactivity disorder (ADHD) is one of the regulation, and motivation alongside other secondary symp-
most common neuropsychiatric conditions with a pooled toms (Asherson et al. 2016). Many adults with ADHD who
worldwide prevalence estimated at approximately 5% in are accustomed to their lifelong symptoms have a limited
school-aged children, with persistence of impairing symptoms awareness of how ADHD adversely affects their life. Some
in adulthood in up to 65% of cases. The pooled estimated report higher symptoms but lower impairments or vice versa,
prevalence of ADHD in adults is approximately 2.5% which often affects diagnostic accuracy and requires individ-
(Thapar and Cooper 2016). ADHD is characterized by a per- ually focused diagnosing and holistic treatment plans.
sistent and impairing pattern of inattention and/or hyperactiv- Secondary problems associated with ADHD that must be con-
ity/impulsivity that causes significant impairment to daily liv- sidered in treatment strategies may include difficulties with
ing (American Psychiatric Association (APA) 2013). Along timekeeping which can subsequently effect maintaining em-
ployment, alongside issues with addiction or anger. Social and
relationship difficulties are often reported, also sleep-onset
* Sarah L Jones insomnia, amongst others (please see Asherson et al. 2016;
sarah.jones1@swyt.nhs.uk
Fields et al. 2017; Kolar et al. 2008; Weiss et al. 1999 for
further discussion).
1
South West Yorkshire Partnership NHS Foundation Trust, Further to this, best evidence suggests ADHD is a hetero-
Wakefield, UK
geneous condition, known to be highly co-morbid with a
2
Manygates Clinic, Belle Isle Health Park, Portobello Road, range of other conditions (Jarrett and Ollendick 2008;
Wakefield WF1 5PN, UK
Jensen et al. 2001; Jensen et al. 1997; Nigg 2006). For in-
3
Griffith University, Mount Gravatt, Australia stance, as many as 81% of people diagnosed with ADHD will
4
University of Hudderfield, Huddersfield, UK also meet criteria for a substance abuse, anxiety, depressive
J Psychopathol Behav Assess (2020) 42:500–518 501

disorder or other mental health concern (McGough et al. pharmacological treatments. One of the earliest reviews un-
2005). This high comorbidity is one of the reasons why the dertaken by Jadad et al. (1999) reviewed the evidence for
diagnosis of adult ADHD can be difficult and on occasion pharmacological versus non-pharmacological interventions,
missed in clinical practice (Jacob et al. 2007). concluding that pharmacology is consistently more effective
In terms of treatment options, pharmacological intervention than non-pharmacological management. Whilst useful, this
is the primary line of treatment for adult ADHD (NICE 2018). review is now out-of-date. Davidson (2008) offered a review
Medication is safe and effective, with 70% of patients in which all methods of assessment and treatment for adult
reporting improvement compared to 7% of controls (Fields ADHD were considered. However, it could be argued that the
et al. 2017; Spencer et al. 2001). As a consequence, this is lack of a systematic method resulted in a superficial review.
perhaps the reason that the majority of research has tended to Knouse & Safren (2011) reviewed CBT based interventions
focus on the efficacy of the different classifications of medi- for adult ADHD; however, this review was also limited as it
cations available rather than non-pharmacological interven- did not have remit to consider different forms of psycho-social
tions (Fredriksen et al. 2013; Mészáros et al. 2009; treatments. More recently Vidal-Estrada et al. (2012) conduct-
Ravishankar et al. 2016; Wilens et al. 2001). Subsequently, ed a review in which they included all forms and modalities of
for clinicians wanting to employ psychological interventions, talking therapies. This review is the most inclusive to date and
such as Cognitive Behavioral Therapy (CBT) for example, included RCTs, controlled, and non-controlled research.
they have a more limited evidence base when compared with Nevertheless, it excluded potentially rich sources of data such
interventions available for mood and anxiety disorders for as studies which focused on secondary symptoms of ADHD
instance (Sprich et al. 2012). This is an interesting concern and data provided by adults below the age of 19. In addition,
for the field of adult ADHD, as in a review of practice guide- Estrada et al. (2012) did not utilize a comprehensive and in-
lines, Gibbins and Weiss (2007) found considerable agree- clusive methodology. Young et al. (2016) conducted a system-
ment amongst Western practice guidelines that a shared care atic review and meta-analysis on the efficacy of CBT for
approach, which includes medication and some form of adults with ADHD, concluding moderate to large effect sizes
psychoeducation, along with follow-up procedures, is widely supporting the efficacy of CBT. Whilst Young’s et al. (2016)
recommended. The problem, they suggest, is that these best review is a welcome addition to the literature; it is limited in its
practice guidelines are based on clinical consensus rather than approach to the question of the efficacy of psychological in-
evidence. Nevertheless, the most recent UK guidelines from terventions for ADHD for two main reasons. Firstly, it in-
the National Institute for Health and Care Excellence ( 2018) cludes only RCTs, and secondly it is specific only to CBT.
advise psychological interventions are recommended for Lopez et al. (2018) conducted a Cochrane systematic review
symptom reduction in adult ADHD. They suggest considering of CBT interventions for adult ADHD; they concluded ‘low
non-pharmacological treatment for adults with ADHD diag- quality’ evidence from RCTs that suggests CBT treatments
nosis when patients (i) do not wish to take medication (ii) have may be of benefit for ADHD in the short term only. Again,
difficulty adhering to it, or (iii) when medication is not effec- whilst welcome, this review was strict within its scope. Lee
tive. These guidelines are reflective of the growing conversa- et al. (2017) conducted a systematic review looking at
tion surrounding promoting the importance a more multidis- mindfulness-based interventions for different age groups.
ciplinary approach to the management of adult ADHD They concluded mindfulness-based interventions were effi-
([REMOVED]; De Crescenzo et al. 2017), rather than focus- cient in improving attention; however, this was only based
ing on medication. The recent NICE (2018) guidelines are a on five studies, and focused on primary ADHD symptoms
welcome addition to the conversation, however, notably the only. De Crescenzo et al. (2017) conducted the most recent
NICE Guidelines only report studies which met a narrow review of treatments for adult ADHD, finding that evidence
search protocol, by including only Randomized Controlled for the effectiveness of non-pharmacological interventions is
Trials (RCTs), matching the protocol used for medicines, only at a preliminary stage; that when compared with pharma-
which precluded the identification of all available published cological treatments, much more empirical evidence is re-
literature. quired before support for the efficacy of psychological inter-
The current review aims to consider the wider evidence ventions is yielded. The accelerated rise in research exploring
base, a full consideration of the literature investigating psy- psychological interventions for the management of ADHD in
chological interventions for adult ADHD, in order to develop adulthood is welcome and requires an up to date comprehen-
a narrative that considers the potential usefulness of fully in- sive review.
corporating psychological treatments in ADHD management. Here, we report the findings from a systematic review of
Recent years have witnessed an upsurge of studies exploring the research for psychological interventions for treatment of
the efficacy of non-pharmacological treatments of adult ADHD in adulthood. A broad definition of psychological
ADHD. Several reviews exist which have attempted to repre- treatment is employed to include a range of therapeutic
sent the current status of the knowledge for non- models (e.g. CBT, 3rd wave approaches), cognitive and
502 J Psychopathol Behav Assess (2020) 42:500–518

behavioral interventions, including those delivered by a In order to identify relevant primary studies, databases ger-
trained therapist, self-help and technology-assisted. mane to the research area (PsycINFO, MEDLINE, CINAHL,
AMED, PubMed, and EMBASE) were searched. Final
searches were conducted in January 2019. In addition, hand
Method searches of published systematic reviews, and of key journal
publications were undertaken. Finally, following the application
Inclusion Criteria of the inclusion criteria, citation searches concluded the search.

Quantitative reports of psychological interventions for adults Study Quality Assessment


with ADHD where outcome measures have been obtained
were included. Criteria stipulated that studies appear in peer- The study quality was assessed using a standardized quality-
reviewed journals in English language. Case studies are ex- rating tool. The Downs and Black (Downs and Black 1998)
cluded. Due to the relative infancy of research on psycholog- method provides a framework for assessing the quality of ran-
ical treatment for adult ADHD, studies of controlled and non- domized and non-randomized trials. The quality rating check-
controlled design are included here. No time limits were ap- list considers the following areas: (i) reporting (ii) external va-
plied to the search parameters. lidity, (iii) bias, (iv) confounding variables, and (v) power. Four
ADHD is a multidimensional construct represented by of the five subscales demonstrated high internal consistency
core/primary symptoms yet commonly accompanied by sec- and the quality index correlates highly with existing standard-
ondary problems affecting the individual’s mental state, life- ized appraisal tools for assessing randomized studies (r = .90).
style or social functioning (Rucklidge et al. 2007; Bachmann Papers rated as poor quality were included in data extrac-
et al. 2018). Therefore, this review considers all outcomes tion as our primary search objective was of including all avail-
relating to primary symptoms of ADHD, as well as psycho- able research. Poor quality papers were notably limited in the
social outcomes that capture secondary impacts of ADHD. quality of reporting and internal validity due to lack of con-
Studies may or may not include follow-up of various lengths. trolling for confounding variables. Out of a maximum score of
For the purposes of the review, adulthood is defined from 27, classified as excellent were 23–27, good 19–22, fair 14–
18 years old with no upper limit. Participants must have met 18, and poor <14. Quality was assessed independently by two
diagnostic criteria for ADHD confirmed either by clinical as- authors; any uncertainty of rating was discussed with other
sessment, or as reported using a cut off on at least one recog- authors in order to achieve a consensus and agree a score.
nized diagnostic tool. Participants could also report any co- Whilst quality rating was useful in giving an overall evalua-
morbidity commonly associated with ADHD (e.g. bi-polar); tion of the literature, it was not a used as an exclusion criterion.
however, any diagnosis that might take precedent (e.g. More than 20,000 results were identified through database
moderate-severe intellectual disability) was excluded here. searching, along with 59 papers through other methods such
as hand searching. Of these, when duplicates were removed
>15,000 results remained. Results were screened, determining
Data Extraction 396 results as inappropriate. This left 94 articles to assess for
eligibility using PICOS methodology, 41 of which were ex-
Where reported, the following data were extracted from each cluded for reasons cited in Fig. 1. Finally, 53 studies were
article: author, year, country, participant demographics (num- included in this systematic review.
ber of participants, attrition, gender, and age), design of study,
conditions, interventions, and main findings (including signif-
icance value, and effect size). Results

Search Strategies In terms of quality rating, 13.2% of papers included in the


review were rated excellent, 39.6% good, 35.8% fair, and
The following terms were used for medical condition (OR) 11.3% were rated poor. The median quality score was 20, with
across databases: attention deficit OR ADD OR adhd OR a range of 11 to 26.
addh OR adhs OR AD/HD OR HKD OR hyperkin* OR hy- In terms of the psychological approach reported in the stud-
per-kin* OR hyperactiv* OR hyper-activ*. An exhaustive list ies included here; the most common was CBT (including both
of search terms was employed for intervention including; group and individual sessions) with 23 studies (Anastopoulos
structured psychological treatment programs delivered as et al. 2018; Bramham et al. 2009; Cherkasova et al. 2016;
self-help, individual or group therapy, technology-assisted in- Cole et al. 2016; Corbisero et al. 2018; Dittner et al. 2018;
terventions, and digital technology interventions (see appen- Emilsson et al. 2011; Hiltunen et al. 2014; Hirvikoski et al.
dix 1 for full list). 2015; LaCount et al. 2015; Nasri et al. 2017; Pettersson et al.
J Psychopathol Behav Assess (2020) 42:500–518 503

Fig. 1 PRISMA flow diagram


(Moher et al. 2009) Records identified through Additional records identified
database searching through other sources
(n = >20,000) (n = 59)

Records after duplicates removed


(n = >15,000)

Records screened Records excluded


(n = 490) (n = 396)

Full-text articles Full-text articles


assessed for eligibility excluded, with reasons
(n = 94) (n = 41)
Age criterion = 4
Comorbidity criterion = 2
Intervention criterion = 18
Studies included in the Outcome criterion = 5
systematic review Population criterion = 6
Study design = 6
(n = 53)

2017; Ramsay and Rostain 2011; Rostain and Ramsay 2006; Discussion
Safren et al. 2005a, 2005b, 2010; Salakari et al. 2010; Stern
et al. 2014; Vidal et al. 2013; Virta et al. 2008; Weiss et al. The development of an evidence-based narrative surrounding
2012; Young et al. 2015, 2017) followed by Mindfulness ap- the value of psychological interventions for adult ADHD is
proaches with 9 studies (Bachmann et al. 2018; Bueno et al. imperative for comprehensive ADHD management.
2015; Edel et al. 2017; Gu et al. 2018; Hepark et al. 2015; Psychological treatments that are effective and reliable will
Hoxhaj et al. 2018; Janssen et al. 2018; Mitchell et al. 2017; enable clinicians to carefully manage adult ADHD within a
Schoenberg et al. 2014) and Dialectical Behavioral Therapy flexible, informed approach. Continuing to build this narrative
(DBT) with 8 studies (Cole et al. 2016; Edel et al. 2017; will allow knowledge of a range of treatment options that can
Fleming et al. 2015; Hesslinger et al. 2002; Hirvikoski et al. work alongside psychostimulants, or instead of them. Such a
2011; Morgensterns et al. 2016; Nasri et al. 2017; Philipsen narrative can offer patients a holistic approach to their condi-
et al. 2007). Neurofeedback (NFB) with 5 studies (Cowley tion and potentially fit in with their treatment preference and
et al. 2016; Mayer et al. 2016; Mayer et al. 2012; any expectations they might have of their care.
Schönenberg et al. 2017; Zilverstand et al. 2017), With psychological treatments being the mainstay of inter-
Psychoeducation approaches with 3 studies (Hoxhaj et al. ventions in mental health, collecting, synthesizing and pre-
2018; Salomone et al. 2015; Vidal et al. 2013), senting the evidence base relating to ADHD is necessary, as
Hypnotherapy with 2 (Hiltunen et al. 2014; Virta et al. not only will this help clinicians identify the modalities which
2015), Metacognitive therapy with 2 (Solanto et al. 2010; they can apply in practice, it will also allow researchers to
Solanto, Solanto et al. 2008), CogMed training with 2 identify where further research is required. Currently, psycho-
(Dentz et al. 2017; Mawjee et al. 2015), Cognitive remedia- logical interventions as applied to adulthood ADHD can only
tion therapy with 1 (Stevenson et al. 2002), Goal management fairly be characterized as nascent, as the total of the studies
training with 1 (In de Braek et al. 2017), Psychotherapy with 1 which met inclusion criteria, here, was quite small (n = 53).
(Philipsen et al. 2007), Self-directed psychosocial intervention Yet promisingly, half of the studies included here were rated
with 1 (Stevenson et al. 2003) and, Stress management train- good or excellent using the Downs and Black (1998) quality
ing with 1 study (Langer et al. 2013).1 rating system, suggesting these findings can surely influence
the narrative pertaining to the evidence base for use of psy-
chological treatments.
This review suggests that whilst a variety of different psy-
1
Studies may be listed in more than once, if the study explored more than one chological interventions have shown significant improvement
intervention.
504 J Psychopathol Behav Assess (2020) 42:500–518

of ADHD symptoms (please refer to Table 1), it was CBT, Mindfulness


Mindfulness, DBT and (cautiously) Neurofeedback, that have
the most empirical support, establishing themselves as poten- Mindfulness is underpinned by the core principles of accep-
tially effective interventions for primary and/or secondary out- tance, present moment awareness and self-compassion devel-
come measures of ADHD in adulthood. oped through a process of meditation. The emphasis of a
mindfulness approach is on the experiential process. The ori-
gins of mindfulness stem from Buddhist practices, however in
Cognitive Behavioral Therapy recent years it has been secularized and used in a variety of
forms in mental health services (Mind 2018). In terms of
It is useful to be reminded that CBT is a generic term mindfulness interventions, all the studies included in this re-
encompassing a range of approaches (Grazebrook and view were in group setting using a variation of the Mindful
Garland 2005). A unifying theme of this approach is a focus Awareness Practices (MAP) approach (Kabat-Zinn 1990;
upon cognitive restructuring and changing maladaptive be- Segal, Segal et al. 2002; Zylowska 2012). Each study reported
havioral strategies underpinning and maintaining psychologi- positive effects on primary symptoms of ADHD, with the
cal distress. CBT can also be distinguished by its structured exception of one (Mitchell et al. 2017) who reported positive
approach which includes agenda setting, reviewing progress, effects for ADHD symptoms but not on secondary measures
content and setting of tasks between sessions. This structure of executive function. Eight out of nine studies had a control
was primarily devised with the intention of treating affective group (or other interventions as control), however a design
disorders however it has been adapted to treat a range of other weakness here was that only three out of nine studies included
conditions including the primary and secondary symptoms of follow-up analysis, so we cannot confidently determine if the
ADHD using a modular approach (Young and Bramham positive effect lasted beyond the period of intervention. The
2012). In terms of the CBT studies included in this review, positive effect of mindfulness reported here, supports previous
more than half of the papers reported that CBT was adminis- reviews which have found mindfulness-based approaches to
tered in a group format; with most CBT studies reporting be an effective intervention for ADHD (Aadil et al. 2017;
effectiveness of intervention. An important consideration is Cairncross and Miller 2016).
that whilst there was much heterogeneity in the studies in
terms of content, approaches included various modules rele-
vant to living with a diagnosis of ADHD, involving objectives Dialectical Behavioral Therapy
such as goal attainment, interpersonal skills, coping strategies,
problem solving, cognitive restructuring, distraction avoid- The five DBT studies under review employed group interven-
ance and motivation. A focus on executive functioning such tions as opposed to individual courses, and all studies reported
as organization, time management and planning was also a a significant positive effect of DBT on core symptoms of
theme. Frequently, manuals by Safren (Safren et al. 2005b), ADHD. This cognitive behavioral psychotherapy model was
or the R&R2ADHD program (Young and Ross 2007) were devised for use in group settings with a view to helping those
employed or adapted to meet specific objectives of the indi- suffering with emotional dysregulation and relationship diffi-
vidual studies. Regardless of the approach, most studies under culties. DBT shares characteristics with CBT in that it encour-
review found CBT to be an effective intervention on vari- ages awareness and change of maladaptive thought and be-
ous primary (inattention, hyperactivity/impulsivity) and havioral processes but also employs the use of mindfulness
secondary (psychosocial) outcome measures. Most studies and acceptance principles. The DBT approach was originally
had control groups (or other interventions as control designed to be run in weekly groups of 2–3 h with individual
groups) with a relatively high sample number adding to support in between sessions. Of the studies under review here,
the quality of their findings. Collectively CBT studies with adaptations and additions to manuals by Linehan (1993) and
varying design quality demonstrated a high rate of positive Hesslinger (Hesslinger et al. 2004) were frequent. Whilst, this
effect and taking heed from the highest quality rated stud- intervention group included two RCTs, samples were relative-
ies in this review, a confident picture surrounding the use- ly small and whilst we found support for DBT’s positive in-
fulness of CBT approaches in adult ADHD emerges. This fluence, this is not based on best evidence. Improving sample
narrative is in line with previous works which suggested size to provide better statistical power in these studies would
that CBT is an effective intervention for the management be a welcome addition to the narrative here. Another concern
of ADHD (Jensen et al. 2016; Knouse et al. 2017; Lopez is the non-specific confounding effects of group interaction
et al. 2018). Whilst this is a positive step forward, our and controlling for this in future studies would be an important
findings however suggest that although there is evidence step. Nevertheless, DBT positions itself as a potentially useful
to support the efficacy of CBT, a unified approach to its psychotherapeutic approach, albeit requiring additional
delivery has not been settled. research.
Table 1 Characteristics of the studies included in the review

First author, Participant details Intervention (type, mode of delivery, Design Main findings (effect size if reported) Quality rating
year, country no. of sessions, duration)
n Attrition Female Mean
% % age

Anastopoulos, 106 16,9 59.1 20.2 CBT (Group program + individual Open clinical trial, pre and post Pre and post: significant reductions in IN symptoms (d = −.78), HI 20 (good)
2018, US sessions [ACCESS]), 8 phases, assessment. symptoms (d = −.83), behavior regulation (d = .64),
tapered over 4 years) metacognition (d = .66), and declines in anxiety (d = .42) and
depression (d = .34) symptoms.
Improvements in IN (d = .83), HI (d = .43), behavioral regulation
(d = .64), metacognition (d = .58), anxiety (d = .58) and
depression (d = .35) remained stable 5 to 7 months after active
treatment concluded.
Bachmann, 74 54.09 55 40.13 Mindfulness v Psychoeducation (as Randomized controlled trials. Pre Pre and post: significant reduction in ADHD symptoms* 20 (good)
J Psychopathol Behav Assess (2020) 42:500–518

2018, controls) (8 weeks, 2.5 h per week) and post. (CAARS) for both conditions post treatment. Decrease in
Germany self-rated memory problems post treatment for mindfulness
condition*. See paper for neurobiological results.
Beuno, 2015, 60 – 50 29.6 Mindfulness v control Non-randomized controlled trial, Treatment v control: NS difference between groups on affective 17 (fair)
Brazil (Group program [MAP], 2.5 h sessions pre and post assessment. ratings, QOL and attentional measures.
+ homework, 8 weeks) Pre and post change: ASRS inattention***, HI***; BDI*
(g = −.07); STAI-T* (g = .08); PANAS on (negative affect**
(g = −0.7); positive affect*** ( = 1.3); sadness* ( = −0.6);
joviality* ( = 0.7); self-assurance*** ( = 0.9);
attentiveness* ( = 1.0); fatigue* ( = −0.8); serenity* ( =
0.8); shyness*** ( = −1.0); fear*** ( = −0.5).
Bramham, 61 32.8 34.4 33 Group CBT v controls (6 sessions Non-randomized controlled trial, Treatment versus control: Treatment group showed significantly 15 (fair)
2009, UK & (across 3 one day workshops held pre and post assessment. greater improvement on knowledge about ADHD*.
Ireland monthly for 3 months). Pre and post change: for HADS anxiety and depression variables,
main effect of time but not group for anxiety** and
depression**. Self-esteem improved for both groups**, but
significantly greater for the treatment group*. Self-efficacy
improved for those who had received CBT**.
Cherkasova, 88 27.3 29.5 34.63 Group CBT + M v CBT (1.5 h group Un-blinded randomized controlled CBT + M group showed greater improvements compared to the 20 (good)
2016, sessions plus individual coaching trial. Pre, post, 3 and 6 month CBT group on self-reported ADHD symptoms** (d = .99),
Canada sessions, 12 weeks). follow up. observer-rated ADHD symptoms* (d = .64) organizational
skills** (d = 1.02) and self-esteem** (d = .67). Group
differences were ns after follow-up.
Groups did not differ in effects of global functional impairment
(SDS, BDI, BAI, SCL – 90, GSI, AXI).
Cole, 2016, 62 14.3 46.8 37.8 Psychotherapy (CBT/DBT) v controls Non-randomized controlled. Psychotherapy group showed significant improvements in all the 13 (Poor)
Switzerland (Individual and group sessions, Baseline, 3 months, 6 months dimensions*, most significant changes where demonstrated for
weekly, 12 month period) and post. BDI-II*** (d = .85), ASRS*** (d = .63) and KIMS AwA***
(d = .61).
Ns differences between groups.
Corbisiero, 50 4 44.2 32.05 CBT + M v M + SCM (12, 120 min Randomized controlled trial. Pre, Ns differences between treatment and controls. 22 (good)
2018, sessions over 10–12 weeks) post and follow-up assessment.
Switzerland
Cowley, 2016, 54 3.7 53.7 36.1 Randomized controlled trial. Pre Ns between treatment and controls on TOVA performance. 24 (excellent)
Finland and post assessment.
505
Table 1 (continued)
506

First author, Participant details Intervention (type, mode of delivery, Design Main findings (effect size if reported) Quality rating
year, country no. of sessions, duration)
n Attrition Female Mean
% % age

Neurofeedback v controls (~40 h long Treatment group demonstrated higher reduction of inattention*
sessions 2 to 5 times per week over and HI* compared to controls.
2–4 months)
Dentz, 2017, 55 20 49.1 41.7 CogMed training v controls (Mean Randomized controlled. Pre × 2, Time main effect was significant on verbal WM (DS)** for both 25 (excellent)
France session time of 42 min, 5 times per post assessment and 6 months groups. Main effect of group x time was reported for treatment
week, for 5 weeks) follow up. group only** (d = .06). Improvements continued to follow
up** (d = .63). Ns effect of group.
Letter sequencing task also demonstrated improved scored for
both groups**. Main effect of group x time for treatment
group** (d = .83) for visuospatial WM, plus at follow-up**
(d = .71). Ns effects for WM and EF in daily life or ADHD
symptoms.
Dittner, 2018, 60 23.3 25 35.9 CBT v controls (15 sessions over Proof of concept randomized Treatment group improved relative to controls on the CSS at post 26 (excellent)
UK 30 weeks. Plus follow up session at controlled trial. Pre, post treatment*** and both follow-ups**. Treatment group also
42 weeks) (30 weeks) and 42 weeks. showed significantly different scores on the WSAS compared
to controls at post treatment** and at 30 week follow-up**.
See paper for secondary outcomes.
Edel, 2017, 91 – 39.6 35.3 Mindfulness v DBT skills group (2 h Open study. Non-controlled, Treatment comparison: Ns differences by group. 18 (fair)
Germany sessions for 13 weeks) non-random assignment to one Pre and post change: WRI total score*, mindfulness* and
of two treatments, pre and post. self-efficacy* for both groups.
Emilsson, 54 26 63 33.8 CBT + M v M as controls (15 session Randomized controlled trial. Pre, ITT analysis. Ns differences between groups at end of treatment 22 (good)
2011, integrated manualized group and post and 3 month follow up on CGI, BAI, BDI, RATE-S. CBT + M had lower scores
Iceland individual program) compared to controls on inattention scale* (d = .94),
hyperactivity* (d = .32), BCS** (d = .76) antisocial scale*
(d = .84). At 3 month follow up: CBT + M group lower scores
on inattention* (d = 1.14); hyperactivity** (d = 0.58); BCS***
(d = 1.08); BAI* (d = 0.83); BDI* (d = 1.32); RATE-S
(d = 1.08); RATE-E* (d = 1.12); social functioning scale*
(d = 1.24); antisocial scale* (d = 0.89).
Fleming, 33 6 42.5 21.4 DBT skills group v skills hand-out Randomized controlled trial. Pre, Treatment comparison: DBT group showed greater treatment 20 (good)
2015, US (90 min sessions, 8 weekly post assessment and 3 month response; BAARS*** (ES = .55); BAADS*** (ES = .94);
sessions) follow up. AAQOL** (ES = .90).
3 month follow up: DBT group showed greater treatment
response; BAARS* (ES = .09); BAADS** (ES = .15);
AAQOL** (ES = 0.10).
Gu, 2018, 54 3.70 44.4 20.3 MBCT v controls (1 h weekly sessions Randomized controlled trial. Pre, MBCT showed an overall trend toward lower ADHD inattentive 20 (good)
China (+ homework)for 6 weeks) post assessment and 3 months. Symptoms** and greater improvement than controls on HI. At
follow-up, 71% of treatment group showed recovery compared
to 31% of controls*. Main effects of time on BDI (anxiety)*.
Main effect of group on MAAS at post treatment** (d = 1.06)
and follow-up** (d = 1.03). Treatment group also
demonstrated better performance on neuropsychological
tasks* (see paper for detail).
103 17 54.4 35.9 MBCT v controls (12 week program) 22 (good)
J Psychopathol Behav Assess (2020) 42:500–518
Table 1 (continued)

First author, Participant details Intervention (type, mode of delivery, Design Main findings (effect size if reported) Quality rating
year, country no. of sessions, duration)
n Attrition Female Mean
% % age

Hepark, 2015, Preliminary randomized controlled Treatment v control: treatment had less ADHD symptoms on
Netherlands trial CAARS-INV** (d = .39) and CAARS-S** (d = .78).
Improved on BRIEF-ASR** (d = .43–.93) and KIMS*
(d = 0.54). Depression/anxiety/patient function showed ns.
Moderation analysis showed improvement was independent of
medication.
Hesslinger, 18 38.9 27.8 32.3 DBT skills group (13, 2 h sessions over Non-randomizes assignment to one Treatment group showed improvement on BDI (p = 0.05, 18 (fair)
2002, 3 months) of two conditions, pre post ES = 99); ADHD-CL** (ES = 2.22); SCL-16* (ES = 1.35);
Germany assessment. VAS** (ES = 2.09); selective* and split attention*.
J Psychopathol Behav Assess (2020) 42:500–518

Hiltunen, 17 – 64.7 35.6 CBT v hypnotherapy (10 weekly Randomized controlled trial. Pre, Treatment comparison: Both treatments brought significant 21 (good)
2014, individual sessions) post, 3 and 6 month follow up. improvements on ADHD scale*. Greater improvements in
Finland hypnotherapy; SCL-90* (ES = .21), BDI-II* (ES = .18) and
SCL-16 (trend).
Post, to 3 and 12 months follow up: SCL-90 Time x Group
interaction*. Greater maintained gains in hypnotherapy;
anxiety* (ES = .28) and depression* (ES = .18).
Hirvikoski, 51 20 59.2 38.9 DBT skills group v discussion group as Randomized controlled trial. Pre, Treatment comparison: significant reduction on the ADHD 22 (good)
2011, controls (14, 2 h sessions) post, 3 and 12 month follow up. symptom scale* (d = .57) in the DBT group only. Participants
Sweden in both groups reported increased well-being*** (d = .53).
Follow up: participants in skills training more able to cope with
their deficits after treatment* (d = .67). After completion of
treatment, the skills training group scored higher on education*
(d = .78) and mindfulness* (d = .67).
Hirvikoski, 108 21.3 37.6 37.6 CBT psychoeducation group program Single treatment condition, pre and Pre, post and follow up: improvements on ADHD 20 15 (fair)
2015, (8, 2.5 h sessions) post and 6 month follow up. questions*** (ƞ2 = .20), BDI** (ƞ2 = .09), BAI* (ƞ2 = .06) and
Sweden perceived stress scale* (ƞ2 = .06).
Hoxhaj, 2018, 81 – 49 39.5 Mindfulness v psychoeducation Randomized controlled trial. Pre, Both groups showed improvement on the inattention scale*** 22 (good)
Germany (8 weeks. 2.5 h sessions [+ 8 weeks, 8 months. and all subscales*. Ns differences between groups on all core
homework]) symptoms.
In de Braek, 27 – 37 36.7 Goal management training with Controlled (cohort study). Random Treatment group improved on CIBIS/C cognition* relative to 18 (fair)
2017, psychoeducation v psychoeducation assignment. Pre, post, follow-up controls. Ns effects of group on CIBIS/C general. Time effects
Netherlands only as controls (12 [1 individual, 11 at 12 and 24 weeks. of SCL-90**, CFQ*** and zoo planning time*, ns effects of
group], 2 h sessions for 12 weeks) group. Ns differences at follow-up.
Janssen, 2018, 120 – 53 39.35 MBCT + TAU v TAU (8 weeks, 2.5 h Single-blind, randomized ITT analysis: both MBCT + TAU groups showed a reduction of 24 (good)
The sessions [+ homework]) controlled trial. Pre, post, 3, clinician-rated ADHD symptoms at post-treatment (d = .41).
Netherlands 6 month follow-up. This effect was maintained at 6-month follow-up. More MBCT
+ TAU (27%) than TAU participants (4%) showed a ⩽30%
reduction of ADHD symptoms. MBCT + TAU patients
compared with TAU patients also reported significant
improvements in ADHD symptoms, mindfulness skills,
self-compassion and positive mental health at post-treatment,
which were maintained until 6-month follow-up. MBCT +
TAU reported no improvement in executive functioning at
post-treatment.
507
Table 1 (continued)
508

First author, Participant details Intervention (type, mode of delivery, Design Main findings (effect size if reported) Quality rating
year, country no. of sessions, duration)
n Attrition Female Mean
% % age

LaCount, 17 29.4 64.7 25.4 Combined individual and group CBT Non-controlled single treatment Pre and post: significantly lower scores post-treatment for 17 (fair)
2015, US (12 sessions, weekly) group, pre and post. inattention* (d = .93), but not hyperactivity (ns). Significant
improvements in school* (d = .51) and work* (d = .63)
functioning scales, but not life-skills/self-concept scales (ns).
Langer, 2013, 18 5.55 61.1 34.4 Stress management training group (1 Single treatment group, pre and Pre and post: Excessive demands at work**, chronic worry 15 (fair)
Germany per week for 4 weeks, 3 h each) post. mean***, chronic stress**
Mawjee, 2015, 97 28 58 23.9 CogMed WM training (computerized) Randomized controlled study. Pre, Pre and post: WAIS-IV: DS forwards standard** and shortened* 21 (good)
Germany (Three conditions: (i) 45 min post, 3 month follow-up. length, DS backwards standard** and shortened** better at T2
session (ii) 15 min session (iii) compared to controls. Ns difference between treatment groups.
WLC. 25 sessions, 5 days per week DS sequencing score: Standard length treatment* group did
for 5/6 weeks) better than shortened length and controls. Ns differences
between shortened length treatment and controls.
CANTAB spatial span forwards: standard*** and
shortened** length did significantly better than controls.
Ns differences between training groups. CANTAB spatial
span backwards: At T2 standard* and shortened* length did
better than controls. Ns differences between training groups.
WRAML forward: standard length did significantly better
than the shortened group* and controls***. Ns differences
between shortened treatment and controls. WRAML
backward: standard** length did significantly better than
controls. Ns differences between shortened and standard and
shortened and controls.
Improvements maintained at 3 months*
BOLD = Significant at Bonferroni correction
Mayer, 2016, 24 20.8 37.5 33.3 Neurofeedback (30 sessions. Non-controlled. Pre and post Pre and post: Improvements on all measures: ADHD symptoms*, 14 (fair)
Germany ~25 weeks, including a 3 week assessment. depression* and anxiety* and Go NoGo performance*).
break)
Mayer, 2012, 18 – 38.9 27.6 Neurofeedback (1–3 times per week Comparison of treatment and Treatment comparison: Difference between controls the ADHD 11 (poor)
Germany for 1 h, over 15 weeks) control, pre and post. group (d = −.84) in contingent negative variation*.
Pre and post: Neurofeedback brought increase of the CNV mean
amplitude from T1 to T2 (d = −.62). ADHD symptoms*
(d = −.73), inattention* (d = −.56) and impulsivity* (d = −.60).
Mitchell, 22 9.1 55.6 38.4 Mindfulness v controls (8 week Pilot. Controlled. Stratified and Relative to controls, treatment group improved on ADHD: 16 (fair)
2017, US program, weekly group therapy randomized. Pre and post. (self-report) inattention** (d = 1.66), HI** (d = 1.76),
(2.5Hours + homework). (clinician) inattention*** (d = 3.14), HI** (d = 1.35),
functioning (self-report)** (d = 1.66), (clinician)** (d = 1.52).
EF: DFES (total) (self-report)** (d = 1.45)*(clinician)***
(d = 2.67). BREIF-A (total)** (d = 1.55). Emotion
dysregulation: DERS (total)** (d = 1.63). Distress tolerance
scale*: (d = 1.27). Ns improvement for direct measures of
executive functioning.
See paper for subscale analysis
98 20 68.4 37.4 16 (fair)
J Psychopathol Behav Assess (2020) 42:500–518
Table 1 (continued)

First author, Participant details Intervention (type, mode of delivery, Design Main findings (effect size if reported) Quality rating
year, country no. of sessions, duration)
n Attrition Female Mean
% % age

Morgenstern, DBT skills group (14 weekly 2 h Single treatment group, pre, post, Pre and post: Barkley current ADHD symptom scale***
2016, sessions) 3 month follow up. (ES = 0.20); functional impairment*** (ES = 0.19); aggression
Sweden and irritability*** (ES = 0.16); BDI*** (ES = 0.14); PSS*
(ES = 0.08); KSQ** (ES = 0.10); SSD** (ES = 0.15);
MAAS** (ES = 0.12); AAQoL* (ES = 0.97).
Post to 3 month follow up: Barkley current ADHD symptom
scale*** (ES = 0.22); functional impairment*** (ES = 0.15);
aggression and irritability mean [trend] (ES = 0.06); BDI**
(d = 0.08); KSQ** (ES = 0.12); SDS** (ES = 0.11); MAAS**
J Psychopathol Behav Assess (2020) 42:500–518

(ES = 0.14); AAQ* (ES = 0.15); AAQoL** (ES = 0.17).


Nasri, 2017, 18 16.67 44 39.7 Combined cognitive and dialectical Uncontrolled pilot study. Pre, post Pre, post and follow up 1 and 6 months: 14 (fair)
Sweden behavior therapy (14 week and follow up at 1 and 6 months. Primary outcomes: ASRS improved** (d = 1.29) and remained
program, 3 h weekly session) stable after 6 months. Secondary outcomes: Improvements on
ADHD-RS* (d = 1.46), MADRS-S* (d = .45), PSS-4*
(d = .72), SDS* (d = .76), DERS* (d = .87).
Pettersson, 45 – 64.4 37.4 Internet based cognitive behavioral Randomized controlled trial. Pre, ITT analysis: significant reduction in ADHD symptoms for the 20 (good)
2017, therapy v controls (solo treatment - post, 6 month follow up. iCBT-S group in comparison with controls at post-treatment;
Sweden 10 computer modules minimum of between-group effect size (d = 1.07). The result was
10 days apart. Group - computer maintained at 6-month follow-up. Ns effects on secondary
modules 10 weekly 3 h sessions) outcomes.
Philipsen, 419 – 47.5 35 Psychotherapy v controls (12 weekly Randomized controlled trial. Pre, Pre to 12 weeks: Symptoms decreased more in patients assigned 16 (fair)
2015, sessions of group psychotherapy or 12, 24, 52 weeks, 2.5 years to methylphenidate group ES = −0.81 compared to placebo on
Germany individual counselling. Followed by the ADHD Index score ES = −0.50**. Ns difference between
10 monthly sessions over 52 weeks) groups beyond methylphenidate and placebo. Follow up: No
significant differences between groups at follow up, results
stable.
Philipsen, 72 8.3 40.3 35.8 DBT group (13, 2 h weekly sessions) Single treatment condition, pre, Pre to follow up: Significant differences before and after 16 (fair)
2007, post, 3 months. treatment*** (ES = 0.67); ADHD-CL*** (ES = 0.41);
Germany SCL-90-R*** (ES = 0.21); BDI*** (ES = 0.31); VAS***
(ES = 0.47).
Ramsey, 2011, 5 – 20 36.6 CBT (16 individual sessions across Single condition, pre and post. Pre and post: BADDS-Total* (ES = .83); BADDS-Activation* 12 (poor)
US 6 months, 50 min each) (ES = .54)
Rostain, 2006, 43 – 25.6 30.8 CBT (16 individual sessions across Single condition, pre and post. Pre and post: BADDS Total*** (ES = 0.9); BADDS 15 (fair)
US 6 months, 50 min each) Activation*** (ES = 0.82); BADDS Attention** (ES = 1.06);
BADDS Effort*** (ES = 0.72); BADDS Affect***
(ES = 0.47); BADDS Memory*** (ES = 0.70); CGI-A***
(ES = 1.29); CGI*** (ES = 1.08).
Safren, 2010, 86 7.2 44.2 43.3 CBT v relaxation with education (12 Randomized controlled trial. Pre, Treatment comparison: CBT better ADHD rating scale** 22 (good)
US weekly sessions of 50 min) post, 6 and 12 month. (d = 0.60) and Clinical Global Impression scale scores*
(d = 0.53) compared to relaxation.
Follow up: Ns difference when examining the post-treatment,
6-month and 12-month follow-up assessment CBT group
maintained gains.
31 – 50 45.5 18 (fair)
509
Table 1 (continued)
510

First author, Participant details Intervention (type, mode of delivery, Design Main findings (effect size if reported) Quality rating
year, country no. of sessions, duration)
n Attrition Female Mean
% % age

Safren, 2005, CBT (+M) v controls (+M) (15 weekly Randomized controlled trial. Pre Primary outcome: CBT lower independent-evaluator-rated scores
US sessions) and post assessment. on the ADHD rating scale** (ES = 1.2) and overall
CGI-severity** (ES = 1.4) at post-treatment, Secondary: CBT
lower on Hamilton Depression Scale** (ES = .65); Hamilton
Anxiety Scale* (ES = .55), and self-ratings on the BAI*
(ES = .43).
Salakari, 2010, 29 13.8 52 31 CBT (group, 11 weekly sessions) Single condition, pre, post, 3 and Main effect of time at post treatment, BAADS*,(ES = .13), 19 (good)
Finland 6 month. SCL-16 symptom elevation 3 months after the treatment*
(ES = .21), elevation ns at 6 months. Fewer symptoms at
3 months*(ES = .17) and 6 months* (ES = .23), SCL-16 at
each time point, main effect of time* (ES = .16), treatment
group fewer symptoms at 6 months** (ES = .37).
Salomone, 51 27.5 29.4 32.2 Self-alert psycho-education and Randomized controlled trial. Pre, CAARS: Significant time group interaction for Impulsivity and 23 (excellent)
2015, biofeedback (2 training session 1 h post, 3 months assessment. Emotional Liability* (ES = 0.12), time group effect for
Ireland 20 min, 20 min of biofeedback and problems with Self Concept** (ES = 0.16), significantly lower
10 min of computerized exercises, scores in the SAT group compared to controls* and at 3 month
5 days out of 15, for 5 weeks) follow up*. Time group interaction was found for ADHD
Index** (ES = 0.22); lower scores in SAT group –training **
and 3-month follow up**. Psychological functioning: time
group interaction for the GSES* (ES = 0.16). Higher
self-efficacy scores compared to controls after training**, and
3 month follow up**. Time group effect for BDI* (ES = 0.13),
lower depression in SAT than controls at post-training*** and
3-month follow up**.
Schonenberg, 113 4.2 42.4 43.4 Neurofeedback (three conditions: 30 Triple blind randomized controlled All treatment groups improved significantly on CAARS between 25 (excellent)
2017, sessions of NFB over 15 weeks / 15 trial. Pre, during treatment pre-treatment and 6 months regardless of condition***.
Germany sessions of sham NFB over 8 weeks, post treatment after
15 weeks / metacognitive therapy 16 weeks and 6 months.
group received 12 sessions over
12 weeks)
Schoenberg, 50 12 46 36.7 Mindfulness based cognitive therapy v Randomized controlled trial. Pre Behavioral variables: Main effect of condition for task***. 17 (fair)
2014, controls (12 weekly, 3 h sessions) post. Pre-post, false alarms means**; correct* and reaction time* for
Netherlands Single condition, pre and post. No-Go.
Clinical effects: CAARS-SV, main effects of group*. Reduced
inattention***, HI*** and global ADHD index***.
Mindfulness: main effect of domain* and time-group***
interaction, reflected mindfulness skills for all domains in the
MBCT group pre-to-post; ‘observe’*, ‘act-with-awareness’
*** and ‘act-without-judgement’*. Ns changes in the WL
group.
Solanto, 2010, 88 26.5 29 41.5 Meta-cognitive therapy group therapy Randomized controlled trial. Pre Treatment comparison: MCT group; AISRS-IN*** 20 (good)
US v supportive group as controls and post. AISRS-TMOP***; Conners-Observer-IN* compared to
(12 week program) controls.
J Psychopathol Behav Assess (2020) 42:500–518
Table 1 (continued)

First author, Participant details Intervention (type, mode of delivery, Design Main findings (effect size if reported) Quality rating
year, country no. of sessions, duration)
n Attrition Female Mean
% % age

Pre and post: Improvement on AISRS-IN*, AISRS-TMOP*,


Conners-Observer-IN*, Brown-Total*, BRIEF-A*, Metacog*
and ON-TOP*.
Solanto, 2008, 38 21 57.9 41.8 Meta-cognitive therapy groups (2 h Single treatment condition, pre and Improvements on: CAARS-S:L DSM-IV subscales; Inattentive** 12 (poor)
US sessions for 8 or 12 weekly) post assessment. (ES = .588), BADDS Total score*** (ES = .669),
Activation*** (ES = .595), Attention*** (ES = .558),
Effort*** (ES = .591), Affect*** (ES = .449), Memory***
(ES = .527), ON-TOP *** (ES = .615).
Stern, 2014, 60 35 56.7 37.2 CBT (computerized) (12 weeks, 4–5 Randomized controlled trial. Pre Treatment comparison: Ns time group interaction indicating both 21 (good)
J Psychopathol Behav Assess (2020) 42:500–518

Israel times per week for 20 min) and post assessment. groups benefitted. Only significant difference between groups
on Sustained attention* (d = 0.38).
Pre and post treatment group significant findings: Total ASRS**
(d = 1.07), BRIEF-A** (d = 0.65), BRIEF-A MI** (d = .97),
COPM** (d = .77).
Stevenson, 35 – 37.1 39.9 Self-directed psychosocial intervention Randomized controlled trial. Pre, No significance values reported. Clinical significance assumed in 16 (fair)
2003, (Three therapist led sessions, post and 2 months. event of 33% drop in symptoms. Improvements in treatment
Australia self-help book, and access to support group from pre to 2 month follow up on ADHD symptoms
workers) mean 111.9 to 67; organizational skills mean 84.1 to 66.1; trait
anger mean 23.1 to 18.8.
Stevenson, 43 – 32.6 35.9 Cognitive remediation therapy (8, 2 h, Randomized controlled trial. Pre, Significant treatment effects for treatment compared to control, 13 (poor)
2002, weekly sessions) post, 2 and 12 months. pre and post, all ADHD symptoms*, org skills*, state anger*,
Australia trait anger*. One year follow up: treatment improvements on
ADHD symptoms* (d = 1.4), organizational skills* (d = 1.2),
anger* (d = 0.5).
Vidal, 2013, 32 18.8 46.9 39.5 Psychoeducation v CBT (2 h, 12 Randomized controlled trial. Pre Treatment comparison: Ns effect of group. Both groups showed 21 (good)
Spain weekly sessions over 3 months) and post assessment. reductions on all outcomes. Pre and post: ADHD-RS**
(d = .12); CAARS inattention* (d = .15); hyperactivity**
(d = .19); impulsivity* (d = .32); self-esteem* (d = .12); CGI-S
self-report** (d = .32); clinician** (d = .34); QLESQ*
(d = .33); STAI-S** (d = .35) and BDI* (d = .10).
Virta, 2015, 58 – 74.1 28.5 Hypnosis and hypnotic suggestions Controlled trial. Pre and post Significant test condition × group interaction in mean reaction 13 (poor)
Finland (30 min session followed by a hypnosis, after suggestions, and times on CPT*. ADHD group were slower in reaction times*
continuous performance test) after study.
Virta, 2008, 29 – 48.3 31 Cognitive–Behaviorally Oriented Single condition. Assessment Three months before treatment to post: Reduction in BADDS 16 (fair)
Finland Group Rehabilitation (1.5–2 h, 11 3 months before treatment, pre activation**, affect mean*, total mean*, SCL-16*.
sessions weekly) and post.
Weiss, 2012, 48 30.5 20 35.6 CBT with M v CBT without M (9 Randomized controlled trial. Pre, Both groups showed improvements in outcome measures. Within 23 (excellent)
US & weekly individual sessions, booster 15 and 20 weeks. participant effects of time: ADHD RS-Inv*** (ES = 1.1) at
Canada sessions week 15 and 20) 15 weeks and maintained at 20 weeks. SDS*** (ES = 0.5) at
15 weeks, (ES = .44) at 20 weeks.
Young, 2017, 95 60 65.3 35.2 CBT + M v Treatment as usual Randomized controlled trial. Pre, CBT + M showed greater improvement on all scales (combined 22 (good)
Iceland (TAU) + M (15, 90 min sessions, post, 3 month follow-up. scores from BL to FU) RATE-S (total)*** (d = .54) RATE-S
twice weekly for 8 weeks) symptoms*** (d = .55), RATE-S emotional control**
(d = 0.32), RATE-S antisocial scale** (d = 0.50), RATE-S
511
Table 1 (continued)
512

First author, Participant details Intervention (type, mode of delivery, Design Main findings (effect size if reported) Quality rating
year, country no. of sessions, duration)
n Attrition Female Mean
% % age

social functioning (d = .41). Overall effect of time (post v


3 month follow up) (adjusted for baseline, group, age,
emotional control scale) showing a steady improvement. CGI
also correlated with RATE-S scores at BL, PT and FU** except
antisocial scale at PT and social functioning at FU.
Young, 2015, 95 47.9 65.3 35 CBT + M v TAU + M (15, 90 min Randomized controlled trial. Pre, Ns differences between group except that TAU+M had lower 25 (excellent)
UK sessions) post, and 3 month follow up. BCS HI**. Overall effect of time: BAI* (d = 0.58), BDI*
(d = 0.52) and QOL* (d = 0.56).
Zilverstand, 13 – 53.5 36.9 fMRI neurofeedback training (4 Randomized. Single blind study. Both groups had significant activation levels between 2nd and 3rd 22 (good)
2017, weekly training sessions, 60 min) Pre and post treatment training session with levels remaining high until end of
Netherlands assessment. training*. Better ability to inhibit response* and higher
accuracy on WM tasks*, predicted improvement over sessions
in NFB group only*.
Pre and post: both groups demonstrated improvement on MSIT*.
NFB group only showed improvements on SA-DOTS* and
2-back WM*.

AAQOL , ADHD quality of life questionnaire; ADHD, attention deficit hyperactivity disorder; ADHD-RS, ADHD rating scale; AXI, angry expression; ASRS, ADHD severity; index; BAADS, Brown ADD
rating scales; BAARS, Barkley adult ADHD rating scale–IV; BAI, Beck anxiety inventory; BDI, Beck depression inventory; BHS, hopelessness; BL, baseline; BREIF-ASR, behavior rating inventory of
executive function- adult self-report version; C, controls; CAARS-INV, Conners’ adult ADHD rating scale investigator rating version; CAARS-S, Conners’ adult ADHD rating scale self-report version;
CBT , cognitive behavior therapy; CBT+ M, cognitive behavioral therapy with medication, CGI, clinical global impression; CIBIC, clinician’s interview-based impression of change; CIBIS/C, clinician’s
interview-based impression of severity/change; QLESQ CSS, adult Barkley current symptom scale; DERS, difficulties in emotion regulation scale; DS, digit span; FU, follow-up; fMRI, functional magnetic
resonance imaging; GSI, symptom checklist 90 of the global severity index; HADS, hospital anxiety and depression scale; HI, hyperactivity-impulsivity; ITT, intention to treat analysis; KIMS, mindfulness
skills; MAAS, mindful attention and awareness scale; MADRS-S, Montgomery-Asberg depression rating scale (self-report version); MSIT, multi source interference task; NFB, neurofeedback; NS, non/no
significant/significance; PANAS, positive and negative affect schedule; PSS-4, perceived stress scale-4 item version; PT, post treatment; QoL, Quality of life enjoyment and satisfaction questionnaire; RATE-
S, see https://www.psychology-services.uk.com/resources.htm#resource-9; RCT, randomized controlled trial; SA-DOTS, sustained attention dots task; SCL – 90, symptom checklist - 90; SCM, standardized
clinical management; SDS, Sheehan disability scale; STAXI, anger expression and control; T, treatment; TOVA, test of variables of attention; VAS, visual analogue scale; WM, working memory; WSAS, work
and social adjustment scale; WAIS-IV digit span, Wechsler adult intelligence scale 4th edition digit span; WRAML, wide range assessment of memory and learning; WRI, adult ADHD Wender-Reimherr
interview; WM, working memory; 2-back WM, 2-back working memory task
*p < 0.05 **p < 0.01 ***p < 0.001 d = Cohen’s effect size, g = Hedge’s effect size
J Psychopathol Behav Assess (2020) 42:500–518
J Psychopathol Behav Assess (2020) 42:500–518 513

Neurofeedback studies. This could potentially restrict the research available


to review. Secondly, many the studies included in the review
Whilst this review finds support for the effectiveness of NFB employed relatively small sample sizes, and furthermore, a
interventions, we remain tentative in our inferences as to its number were flawed with methodological weaknesses; it is
usefulness. NFB remains a controversial approach, with some proposed here that this may limit the inferences we are able
suggesting it is (as yet) too experimental to be considered a to establish. Moreover, we did not include meta-analyses; this
valid intervention for Adult ADHD (Arns et al. 2009). All was inappropriate due to the variation in study designs under
NFB studies reported positive effect however Zilverstand review. Another issue to consider is the ‘file drawer’ phenom-
et al. (2017) reported discordant results, finding positive ef- ena (Rosenthal 1979); a term coined to reference the notion
fects on cognitive functioning, but not clinical outcomes. that researchers are often less likely to publish research that
Moreover, Schönenberg et al. (2017) in one of the highest has not demonstrated a significant effect, therefore resulting in
quality rated studies included in this review, found sham feed- a publication bias (Kühberger et al. 2014). It is possible that
back produced the same improvement as true feedback. With this review would be limited in its conclusions due to this
this in mind, we suggest that before any inferences are made phenomenon; however, the level (or relevance) of this poten-
on the usefulness of NFB, more research is required to estab- tial issue is unknown here. Another point of contention relates
lish long term effectiveness of approach on core symptoms of to the idea of clinical versus statistical importance.
ADHD and generalizability beyond task. This is somewhat in Ranganathan et al. (2015) suggest that the term ‘clinical im-
line with a review by Moriyama et al. (2012) which found portance’ and ‘statistically significant’ are often used inter-
positive results for the effectiveness of NFB for ADHD, but changeably, yet they are, in fact, entirely different concepts.
the level of support decreased when higher quality studies In this sense, it should be acknowledged that the conclusions
were considered separately. Whilst support is evident, we pro- here are based on statistical significance, and relevance to
pose that we are unable to suggest NFB is a beneficial inter- clinical application is assumed.
vention in the same manner as CBT or mindfulness and that Here, we have grouped interventions based on what we
more robust research is required in this area. deemed was their main approach, however we must acknowl-
Due to the small number of studies and varying design edge the heterogeneous nature of the studies included in the
quality, we can only cautiously suggest interventions such as review, and that the overlap within interventions reported here
psychoeducation, meta-cognitive therapy, self-alert training, is large; therefore, making categorizing interventions for the
group therapy, hypnosis, etc., (see Table 1) as demonstrating purpose of evaluation a somewhat difficult task. Lee et al.
usefulness in reducing primary or secondary symptoms of (2017) also addresses this issue when suggesting that
adult ADHD. We suggest that these interventions need further mindfulness-based approaches (for example) are often very
consideration (e.g., randomization, blinded design) before ef- different and studies require a clearer protocol to enable strin-
ficacy can be justly considered. However, what is interesting gent evaluation of their usefulness. Further research that looks
here is the observation that for those studies that have com- in-depth at the efficacy of standardized approaches is
pared two interventions (e.g., intervention as control), findings warranted.
show improvement in ADHD symptoms, whether primary or
secondary, from baseline to post treatment, yet differences Concluding Remarks
between conditions are less frequent (e.g., Bachmann et al.
2018; Bueno et al. 2015; Edel et al. 2017; Hiltunen et al. This review summarizes the psychological approaches that
2014; Hoxhaj et al. 2018; Vidal et al. 2013). Therefore, it have been used in treatment of adult ADHD. It highlights that
seems there may be other variables which account for the the quality of studies is on average good, although their num-
change beyond the approach of the intervention. Future re- ber and scope could be considered limited. Also, there is het-
search should consider this. erogeneity in the design, and most were conducted in group
settings. Nevertheless, here, we find support for the use of
Strengths and Limitations psychological interventions in the treatment of ADHD in adult
populations. Collectively, 92% of studies (employing various
This review employed board nonetheless stringent inclusion non-pharmacological interventions) found a variant of signif-
criteria, alongside a consideration of a wide variety of study icant positive effect on either primary or secondary outcomes
designs. At the time of writing, we believe this to be the most associated with ADHD. Psychological interventions should
comprehensive review of the literature on psychological inter- be considered a valid and useful addition to clinical practice.
ventions for adult ADHD. However, whilst this review is con- This review calls for a continuation into the effectiveness of
fident in its inferences, it must be acknowledged that there are various psychological interventions with robust methodolog-
potential limitations in its conclusions that should be acknowl- ical approaches. If the evidence base for psychological inter-
edged. Firstly, this review included only peer-reviewed ventions continues to grow, there is a potential to improve
514 J Psychopathol Behav Assess (2020) 42:500–518

approaches to treatment and subsequently and most impor- 4. AND “social skills”.
tantly, patient experience of adult ADHD. 5. AND “behavio*r modification”.
6. AND (“cognitive behavio*r*” OR cognitive-behavio*r*).
7. AND (cognitive (treatment$ OR therapy OR training OR
Future Directions
approach OR program* OR technique OR intervention)).
8. AND “cognitive restructuring”.
This systematic review highlights important implications for
9. AND (attention training OR ATT).
future research in the area of psychological interventions in
10. AND “working memory training”.
Adult ADHD in both individual and group settings. Having
11. AND “cognitive remediation”.
reviewed a wide variety of interventions we found that the
12. AND “executive function training”.
majority demonstrated an improvement in primary ADHD
13. AND (neurofeedback OR neuro-feedback).
outcomes. At the same time, the need for a more research
14. AND (behavio*r training OR behavio*r therapy OR be-
has also come to light; the results from other interventions
havio*r treatment OR behavio*r intervention).
under review here are interesting and encouraging.
15. AND (MBCT OR MBSR OR mindfulness OR meditat*
Also, an important consideration for future research is that
OR relaxation).
many of the papers implemented approaches that take differ-
16. AND (“acceptance and commitment therapy” OR ACT).
ent elements from various manuals and psychoeducation pro-
17. AND ((“compassion focused” OR compassion-focused)
grams. These are subsequently adapted for individual research
therapy OR CFT).
objectives, but it may be useful for research purposes in the
18. AND ((“compassionate mind” OR compassionate-mind)
future, to ensure fidelity to the intervention model tested.
training CMT).
A further, key recommendation is that there are more stud-
19. AND (metacognitive OR meta-cognitive).
ies focusing on long-term outcomes rather than including pre
20. AND counsel*ing.
and post measures and short-term follow-ups only. This would
21. AND (((“dialectical behavio*r”) AND (treatment$ OR
also help with evaluating the economic impact of these inter-
therapy OR training OR approach OR program* OR tech-
ventions compared to medication.
nique OR intervention)) OR DBT).
22. AND (family AND (treatment$ OR therapy OR training
Compliance with Ethical Standards
OR approach OR program* OR technique OR intervention).
Conflict of Interest Tim Fullen, Sarah L Jones, Lisa Marie Emerson and 23. AND (systemic AND (treatment$ OR therapy OR training
Marios Adamou declare that they have no conflict of interest. OR approach OR program* OR technique OR intervention).
This research did not receive any specific grant from funding agencies 24. AND (self management OR self-management OR self-
in the public, commercial, or not-for-profit sectors. help OR self help).
Statement of Human Rights The nature of this review is retrospective.
Informed consent was not necessary, in line with our institution. This
article does not contain any studies with human participants performed
by any of the authors. References
Statement on the Welfare of Animals This article does not contain any Aadil, M., Cosme, R. M., & Chernaik, J. (2017). Mindfulness-based
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