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  • Differences Between Albumins and Globulins

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    Albumins and globulins are plasma proteins that differ in molecular weight, amino acid composition, isoelectric point, salting out properties, plasma concentration, and role. Albumins have a lower molecular weight than globulins, contain more glycine and acidic amino acids, are precipitated at full ammonium sulfate saturation, and function in nonspecific transport and maintaining blood pressure. Globulins have higher molecular weight, less glycine but more acidic amino acids, are precipitated at half ammonium sulfate saturation, and serve specific transport, blood clotting, and immune response roles.

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    Albumins and globulins are plasma proteins that differ in molecular weight, amino acid composition, isoelectric point, salting out properties, plasma concentration, and role. Albumins have a lower molecular weight than globulins, contain more glycine and acidic amino acids, are precipitated at full ammonium sulfate saturation, and function in nonspecific transport and maintaining blood pressure. Globulins have higher molecular weight, less glycine but more acidic amino acids, are precipitated at half ammonium sulfate saturation, and serve specific transport, blood clotting, and immune response roles.

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    7 views1 page

    Differences Between Albumins and Globulins

    Uploaded by

    baba
    Albumins and globulins are plasma proteins that differ in molecular weight, amino acid composition, isoelectric point, salting out properties, plasma concentration, and role. Albumins have a lower molecular weight than globulins, contain more glycine and acidic amino acids, are precipitated at full ammonium sulfate saturation, and function in nonspecific transport and maintaining blood pressure. Globulins have higher molecular weight, less glycine but more acidic amino acids, are precipitated at half ammonium sulfate saturation, and serve specific transport, blood clotting, and immune response roles.

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    Differences between albumins and globulins

    Parameter Albumin Globulins

    Mr 70 kDa > 100 kDa

    Amino acid 1% glycine, 3,5% glycine


    composition 18% asp + glu 12 % asp + glu

    рI 4,7 6,5-6,8

    Salting out are precipitated by are precipitated by


    full saturation with half saturation with
    ammonium sulfate ammonium sulfate
    Plasma 40-50 g / l 20-30 g / l
    concentration

    Role 1. Nonspecific 1. Specific transport


    transport of (Transferrin)
    hydrophobic 2. Blood clotting factors
    substances: bilirubin, (Thrombin)
    fatty acids, medicinal
    substances 3. Protect against
    2. Create oncotic antigens
    pressure of blood (Immunoglobulins)
    plasma
    3. Reserve proteins

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