Date and Time ordered: April 17, 2023 @9:15 am

Generic Name: Ceftriaxone

Brand Name: Rocephin
Classification:
Therapeutic: Anti-infectives
Pharmacologic: Third-generation cephalosporin
Dosage, Frequency, Route of Administration: 1g IV q 12 hrs
Mechanism of Action: Ceftriaxone works by inhibiting the mucopeptide synthesis in the
bacterial cell wall. The beta-lactam moiety of ceftriaxone binds to carboxypeptidases,
endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. Binding of
ceftriaxone to these enzymes causes the enzyme to lose activity; therefore, the bacteria
produce defective cell walls, causing cell death.
Desired Effect:  To stop the growth of bacteria.

NURSING RESPONSIBILITIES FOR CEFTRIAXONE

Nursing Interventions Rationale

BEFORE

1. Verify the doctor’s order ● To ensure and verify the right procedure
to the right patient.

2. Check dosage and preparation carefully ● To ensure safe, accurate, and appropriate
before administration administration of the drug.

3. Observe the 13 Rs of medication ● To prevent medication errors and ensure

administration. the patient's safety.

4. Perform hand hygiene before ● To reduce the transmission of

administration. microorganisms.

DURING
1. Administer drug intravenously by infusion ● To reduce risk of bilirubin
over a period of 30 minutes. encephalopathy.
2. Inspect injection sites for induration and ● To prevent injury to nerves, bone, and
inflammation. Rotate sites. Note IV blood vessels
injection sites for signs of phlebitis
(redness, swelling, pain).
3. Do not use diluents containing calcium, ● To prevent particulate formation and
such as Ringer’s solution or Hartmann’s possible incompatibility.
 solution, to reconstitute Rocephin vials or
to further dilute a reconstituted vial for IV
administration because a precipitate can
form.
AFTER
1. Monitor for manifestations of ● To monitor the safety of patient as an
hypersensitivity, other troublesome side early warning system from side effects of
effects such as severe or prolonged fever, the drug.
skin problems, diarrhea, or signs of
gallstones.report their appearance
promptly and discontinue the drug.
2. Advise patient and s/o to seek immediate ● To monitor the safety of patient as an
medical attention if patient experiences early warning system from adverse
cyanosis; headache, rapid heart rate, effects of the drug.
shortness of breath, lightheadedness or
fatigue.