MYOCARDIAL INFARCTION

(COAGULATIVE NECROSIS)
 MYOCARDIAL INFARCTION
• MYOCARDIAL INFARCTION MI is
defined as a diseased condition that is
caused by reduced blood flow in a
coronary artery due to atherosclerosis
& occlusion of an artery by an
embolus or thrombus.
• MI or heart attack is the irreversible
damage of myocardial tissue caused
by prolonged ischemia & hypoxia.
 ETIOLOGY
Tobacco Stress
smoking

Hypertension Drug abuse

Obesity
Alcohol
 ETIOLOGY Family history
of Ischemic
• Age Heart Disease

• Gender

• Diabetes
Chronic
kidney disease
• Hypercholesterolemia
PATHOPHYSIOLOGY
• Histological changes take 6 to 12 Microscopic changes in
hours to develop with the first
apparent change being coagulative MI
necrosis.
• After the necrosis, the neutrophilic
influx is seen in around 12 to 24
hours.
• Loss of nuclei occurs on days 1 to
3.
• Phagocytosis by macrophages on
days 3 to 7, and granulation tissue
formation at the margins.