TANTA UNIVERSITY FACULTY OF PHARMACY DEPARTMENT OF PHARMACOGNOSY ‘The exam consists of 5 questions in 11 pages (12.5 points, 30 minutes) (8 points, 20 minutes) {4.5 points, 10 minutes) (40 points, 25 mimutes) (7.5 points, 15 minutes) (11 points, 30 minutes) (9 points, 20 minutes) (question 1 ‘A- Comparison .. B- Define, mention and enumerate... Question I: MCQ: Question III: Give one example... Question TV: Complete. Question V: Match. ~ All questions must be answered in the specified places. ~In MCQs, mark the correct answer in the separate answer sheet 1 in page 6 - Use blue pen only. Answers using pencils will not be accepted. Page lof 11tion No. 1 ‘A- Cannnabinaceae and Papaveraceae are important by the items listed in the following table mention one origin, active constituents and Uses, 5 points, 30 minutes) ., compare between them drug for each with its botanical (8 points, 20 minutes) Ttems | ‘Cannnabinaceae | Papaveraceas 1- Calcium oxalate 2- Hairs - Glandular - Non-glandular 3- Secretory structures 4- Drug name 5- Botanical ori 6- Active | constituents 7- Uses Page2 of 12B- Define the stele, mention the tissues including, then enumerate the different types of it, (45 points, 10 minutes) ie Page 3 of 12,Question Hz (10 ‘Choose only one answer which you consider correct and record your choice in the corresponding place in the answer sheet 1 provided below 1- Regarding to this pietu a- Is the key element of plant called deadly night shade b- | Sweat, gastric and pancreatic secretion c= Its tonicity cause yellow vision. d- For leaf has the highest constituents in this family e- Used with diuretic 2- These leaves give +ve Mayer's test select the false: a-Catharanthus ——_b- Boldo c-Coca d+ Jaborandi 3- Regarding to this picture: pe a- T.S. of paripinnate leaf b- For leaf contains glycosides as active constituents © TS. of leaf used as iaphoretic 7 d- For leaf has anticholinergic . it e- None of the above 4- GL acetic acid + dil HNO3 —> blue — golden yellow this test is: a- Specific for menthol - Specific for Cardiac glycoside c- Called Vitali’s test d- Specific for arbutin €- Specific for peppermint oil 5- Buchu leaves have lignified pericyclic fibers: a- True b- False L 6- Regarding to these pictures: a- Picture 3 for leaf differentiated from its allied by its hair b- Picture 2 for leaf has the highest amount of active constituents in its group c- The | and 2 pictures for leaves not taken with each other d- Picture 4 for leaf used mainly as diuretic e- Picture 4 has pericyclic fibers 7- Regarding to gitoxin, select the false one: a- Is a secondary glycoside present in both D. purpurea and D. lanata be Gives +ve results with all chemical tests of cardiac glycoside ¢- Prepared by partial hydrolysis of purpurea gly. A d- Is more present in dry leaves €- Gives the same effects of purpurea glycosides Page 4 of 12 tes8- The leaf of second biennial henbane is petiolated and its base is amplexicaule. a- True b- False 9- Regarding to this picture, it is present in: a- Buchu =H. muticus &- Digilalis de Stramonium e- Leaf has crystal layer 10- Regarding to diosphenot: a- Is vol. oil present in peppermint leaves b- Is used in treatment of varicose veins ¢- Present in punctuate leaf d- Present as sphaerocrystal in epidermal layer e- With KOH — red color 11- This stomata is present in; a Buchu b- Digitalis e-Squill | Dp d-Senna e- Belladonna A 12- Regarding to this picture: a- It is the key element of Hyoscymus niger b- Present in leaves contain anomocytic stomata ©- This hair may be present in stramonium leaf d- Itis the key element of Hyoscymus muticus e- None of the above 13- These leaves are used as diuretics: a- Tea due to the presence of theophylline c+ Buchu due to diosmin e- Squill 14- Regarding to these pictures: b- Digitalis 4- Uva ursi due to arbutin res a- Picture 2 for leaf used as antispasmodic. b- Picture 1 for leaf used as expectorant c- Picture | for leaf gives positive results with all cardiac glycoside tests d- Picture 2 and 3 give red color with ruthenium red &- Picture 3 gives negative result with vanillin sulph Page Sof 11 uric acid reagent15- Henna is used as antidandruff due to the presence of Lawson. a- True b- False 16- Drowsiness, palpitations and anorexia are the toxicity symptoms of digitalis. a True b- False 17- Regarding to tea: a- Green tea contains more catechins which is used to decrease body weight b- Cured green tea contains less amount of catechins c- Contains theobromine which has smooth muscle relaxant effect 4d- Contains theophylline which has diuretic effect e- The black tea is prepared by heating the leaves to inactivate the enzymes 18- Rosemary leaves have these effects; select the false: a Antitumerogenic b- Anti-ulceroginic ¢- Hepatoprotective d- Hypoglycemic e- Antioxidant 19- KOH solution + ale. 3,5-dinitrobenzoic acid this test is: a+ Specific for buchu b- Vitali’s test c+ General test for alkaloids ives blue color e- Specific for digitalis 20- Guava leaf is used as sedative in dry cough: a. True b- False Answer Sheet 1 Yo. [a |ble|d]le [No Jajb le |d fay N 1 2 | ea 12 I 3 13 | a E 14 5 15 6 7 8 9 i | 16 | 17 I | i8 aS 0 | 120 fo Page 6 of 11Question 5 points, 15 minutes) Give one example for each of the following: | No. Statements Word 1 Leaf has isobilateral palisade and used as smooth muscle } relaxant, = 2 7 . | Constituent used to treat tropane toxicity. 3. | Leaf used in preparation for radiology or colposcopy. 1g _| Plant used to increase the activity of senna, in 5 | Leaf not taken with IV. Calcium salt therapy. 6 | Leaf gives positive result with Guignard’s test. | 7 | Leaf used to treat painful urination; and urine contains | excess uric acid, | g_| Leaf cause severe liver problems to children. 9g _| Stimulant and tonic Tea 10 | Imparipinnate leaf has emarginate apex. ee TT | Constituent gives +ve result with vanillin sulphuric acid reagent. 12 arena tee Leaf used as cholagogue. 3 Fi Tat paeonet Leaf contains vol. oil cineole and used a rubifacient, | 4 | | Leaf contains mainly mucilage. il 15. | Alkaloid used in treatment of lymphatic carcinoma, l Page 7 of 12LV: 11 points. 30 minutes) Comple' owing statements and insert your answer in table { below: = Baljet test is specific for ... (1) ... in the structure of cardiac glycoside. ~ For children ages 3-15 years, the best laxative is ... (2) = Atropine may be used to treat digitalis toxicity in case of ... (3) - Arbutin is more effective in ... (4) ~ ... (5)... is used as rubifacient due to the presence of ... (6) .. = The part used in tea is ... (7)... .. (8) ... leaf is used as antiseptic in certain skin disease. - Cherry laurel leaves contain ... (9) ... as active constituents. - Complete the following comparison: ~T Condensed Tannins | Hydrolysable Tannins | 1B ae On boiling with HCI 1}. eo | feet Yellow/brown ppt. No ppt | = The venation of this leafis....(13)..0 N - The type of lamina in this leaf - Regarding to this picture, the pericycle | (Composition) is ...(15).... is......16) T i | | | | i | | ~A single bract may enclose the whole inflorescence is called ....(17)... - The foliage leaves are yellow due to ...(18)... | - An example of modified inflated leaf with air is...(19).... In family Graminae the bract with no flower in its axil is called ...(20)... - The leaf base is rarely modified into flattened leafy structure known as.....(21).. ~ ...(22)... is a modified leaf to catch insects. . Araceae Page 8 of 11Table I No. Answer No. Answer 1 12 a 13 3 14 4 15 5 16 6 17 1 18 8 19 9 20 10 a iW 2 Page $ of 12ion V: (9 points, ‘You are provided with the following (18) sentences, please match each sentence with ONLY ONE suitable chemica} structure or words in the next page and write the number ‘corresponding to each sentence in the specified space in Table II. Table II Sentence No. | te 1 . Cardenolide cardiac glycoside. Phenolic compounds related to flavonoids with acid — oxonium salt. An alkaloidal precipitants reagent. An example of triterpenoid saponins. Bufadienolide cardiac glycoside. | A kind of plastid pigment responsible for the green color of the plant and occur in chloroplast. s An example of phenolic glycoside. | Oleogum resins may be viewed as ........ products. Cyanogenic glycosides. An example of steroidal saponins. An alkaloidal color reagents. | | An example of volatile liquid alkaloid has mice like odour is ...... | Carotene in tomato is known as nucleus. Khellin is an example of bitter principle in Ammi visnaga with a... Enzyme hydrolysis of ...... ———» Ally isothiocyanate (war gas). Volatile oil used to decongest the upper respiratory tract in case of rhinitis An example of alkaloids. | Laxative glycosides which can be identified by Birntrager's test. | L J Page 10 of 11see mo 13) Mandalin’s 15) Furanocoumarin 17) Lycopene 19) Physiopathological 21) Coniine ? \. \ 7 \ © lo: SGle H Xx. OH CH,=C—CHy“ SN.0.80,k ea ] 14) Nicotine 16) Pathological 18) Mayer’s 20) Furanochromone 22) Citronin Good Luck Page 11 of 11,