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ADVIA® 1800 Chemistry System

Interface Specification Guide

073D0402-01 Rev. A, 2009-09


© 2009 Siemens Healthcare Diagnostics Inc. All rights reserved.
No part of this service guide or the products it describes may be reproduced by any
means or in any form without prior consent in writing from Siemens Healthcare
Diagnostics.
ADVIA, ADVIA WorkCell, LabCell, and ADVIA CentraLink are trademarks of
Siemens Healthcare Diagnostics.
Microsoft and Windows XP are trademarks of Microsoft Corporation.
Origin: US

The information in this guide was correct at the time of printing. However, Siemens
continues to improve products and reserves the right to change specifications,
equipment, and maintenance procedures at any time without notice.
If the system is used in a manner differently than specified by Siemens, the protection
provided by the equipment may be impaired. See warning and hazard statements in the
operator’s guide specific to your system
ADVIA 1800 Chemistry System Interface Specification Guide: Table of Contents 1

Table of Contents

1 Using This Guide


Intended Use . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-1
Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-1
Conventions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-2
Terminology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-2
Operation Panel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-3
Logging on . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-4
Enhancements to LIS and LAS. . . . . . . . . . . . . . . . . . . . . . . . . . 1-4

2 LIS Connectivity
Interconnecting the ADVIA Chemistry System
and the Host Computer . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-1
Communication Specifications and Parameters . . . . . . 2-2
Configuring the system for communication with the host . . . . . . 2-4
Connector Pin Assignments. . . . . . . . . . . . . . . . . . . . . . . 2-6
Message Frame Format. . . . . . . . . . . . . . . . . . . . . . . . . . . 2-7
Communication Control Codes . . . . . . . . . . . . . . . . . . . . 2-8
Communication Modes . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-9
Hardware Configuration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-9
System Customization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-10
Configuring the New Version 1
Host Protocol Format . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-11
Available Operating Modes. . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-13
Sample Identification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-15
Classification of ADVIA Chemistry Samples. . . . . . . . . . . . . . . 2-17
Test Order Operation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-18
Sample and Test Database Registration Sizing . . . . . . . . . . . . 2-19
Host Test Code Table . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-20
Communication Protocols . . . . . . . . . . . . . . . . . . . . . . . 2-21
Batch Test Registration Protocol. . . . . . . . . . . . . . . . . . . . . . . . 2-24
Automatic Test Registration Protocol . . . . . . . . . . . . . . . . . . . . 2-26
Real Test Registration Protocol . . . . . . . . . . . . . . . . . . . . . . . . 2-28
Real Data Output Protocol . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-31

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ADVIA 1800 Chemistry System Interface Specification Guide: Table of Contents 2

Error Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-33


Text Formats . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-34
Additional Online Settings . . . . . . . . . . . . . . . . . . . . . . . 2-56
Communication Error Handling. . . . . . . . . . . . . . . . . . . . . . . . . 2-57
Query Response Timeout. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2-58
Mark (Result Flag) Specifications . . . . . . . . . . . . . . . . . 2-60

3 LAS System
Operating Modes of a Chemistry System . . . . . . . . . . . . 3-2
Communication Between the System,
a LAS, and the Host Computer . . . . . . . . . . . . . . . . . . . . . 3-3
Configuring the Chemistry System for
Communication with the Host Computer . . . . . . . . . . . . . . . . . . 3-4
Using the Sample Tray in LAS Mode . . . . . . . . . . . . . . . . . . . . . 3-6
Setting Up the Chemistry System for LAS Operation . . . . . . . . . 3-6
Defining the Container Types . . . . . . . . . . . . . . . . . . . . . . . . . . 3-17
Operation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-18
Starting the System. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-19
Shutting Down the System . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-19
Running a Sample . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-19
Chemistry System Start Sequence (LAS). . . . . . . . . . . . . . . . . 3-19
Chemistry System End Sequence (LAS) . . . . . . . . . . . . . . . . . 3-20
Running Routine Analysis in LAS Mode . . . . . . . . . . . . . . . . . . 3-21
Running Interrupt Samples and re-analysis in LAS Mode . . . . 3-22
TCP/IP Communication Interface Specifications . . . . . 3-25
Connecting the TCP/IP Ethernet Cables . . . . . . . . . . . . . . . . . 3-25
TCP/IP Communications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-26
Additional Notes on TCP/IP Communication . . . . . . . . 3-29
TCP/IP Messages . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-35
Startup Sequence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-37
Communication Setup Message Types . . . . . . . . . . . . . . . . . . 3-37
System Status Message Types. . . . . . . . . . . . . . . . . . . . . . . . . 3-40
Instrument Inventory Message Types . . . . . . . . . . . . . . . . . . . . 3-43
Instrument Busyness Message Types . . . . . . . . . . . . . . . . . . . 3-52
Event Message Notification Types . . . . . . . . . . . . . . . . . . . . . . 3-52
Emergency Recovery Message Types . . . . . . . . . . . . . . . . . . . 3-53
Point in Space Sample Sharing Message Types . . . . . . . . . . . 3-55
Workstation LAS Communication Monitor . . . . . . . . . . 3-63
LAS Communication Monitor Log Print. . . . . . . . . . . . . . . . . . . 3-65

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ADVIA 1800 Chemistry System Interface Specification Guide: Table of Contents 3

Serial Communication Interface Specifications . . . . . . 3-66


Parallel Communication Interface Specifications . . . . . . . . . . . 3-67
LAS Serial Communication Signal Specifications. . . . . . . . . . . 3-68
LAS Interface Panel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-68
Test Mode . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-69
Connectors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-69
Basic Connections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-70
Signal Communications During Operation . . . . . . . . . . . . . . . . 3-71
The /HNNEXT Signal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3-77
Serial Connectivity Technical Specifications . . . . . . . . 3-83
Serial Message Text Formats . . . . . . . . . . . . . . . . . . . . . . . . . . 3-86
Sample Cycle Time Intervals . . . . . . . . . . . . . . . . . . . . . . . . . . 3-88
Methods for Calculating the
Cyclical Redundancy Check (CRC) . . . . . . . . . . . . . . . . . . . . . 3-89

Appendix A: Safety Instructions


Protecting Yourself from Biohazards . . . . . . . . . . . . . . . A-1
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .A-2
Protecting Yourself from Barcode Scanner Lasers . . . . A-3
Laser Safety Classification of the
ADVIA 1800 Chemistry System System. . . . . . . . . . . . . . . . . . .A-3
Laser Safety Classification of the Barcode Scanners. . . . . . . . .A-3
Reagent and Sample Barcode Scanners . . . . . . . . . . . . . . . . . .A-4

Appendix B: System Symbols


Warning and Caution Symbols . . . . . . . . . . . . . . . . . . . . . . . . . .B-1
System Operation Symbols . . . . . . . . . . . . . . . . . . . . . . . . . . . .B-2
System Rating Label Symbols . . . . . . . . . . . . . . . . . . . . . . . . . .B-3
Hardware Component Symbols . . . . . . . . . . . . . . . . . . . . . . . . .B-4
Ancillary Reagent Symbols . . . . . . . . . . . . . . . . . . . . . . . . . . . .B-4
Connector Symbols . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .B-5
System Packaging Label Symbols . . . . . . . . . . . . . . . . . . . . . . .B-6

Appendix C: Service, Ordering, and Warranty


Limited Instrument Warranty and Service Delivery Policy . . . . .C-1
Warranty Period . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .C-1
Contacts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C-5
Siemens Authorized Representative . . . . . . . . . . . . . . . . . . . . .C-5
Addresses. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .C-5

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ADVIA 1800 Chemistry System Interface Specification Guide: Using This Guide 1-1

1 Using This Guide

This manual provides information on connecting the ADVIA® 1800 Chemistry


system to a Laboratory Information System (LIS) or a Laboratory Automation
System (LAS).
Included in this overview is a summary of enhancements in this release to LIS and
LAS.
An LIS connects the system to a host computer. The LIS chapter describes the
communications and set up between the ADVIA 1800 Chemistry system and a
host computer (host).

An LAS is any external transport system, such as the ADVIA® LabCell® system
or the rack handler, which is connected to an ADVIA 1800 Chemistry system. The
LAS chapter provides the connectivity and set up information for the
ADVIA 1800 systems with an LAS system.

Intended Use
This system is intended for professional use in a laboratory environment only.
Tests performed using this system are intended for in vitro diagnostic use. As with
all diagnostic tests, a definitive clinical diagnosis should not be based on the
results of a single test, but should only be made by the physician after all clinical
and laboratory findings have been evaluated.

Organization
The following table describes how this operator’s guide is organized.
If you want to . . . Then refer to . . .
have a general overview of the document conventions Section 1:
and terminology, Using This Guide
learn about using the system with a Laboratory Interface Section 2:
System, LIS Connectivity
learn about using the system with a Laboratory Section 3:
Automation System, LAS System
review biohazard and laser precautions, Appendix A:
Safety Instructions
view system symbols, Appendix B:
System Symbols
view warranty, legal, and support information, view Appendix C:
contact information, Service, Ordering, and
Warranty

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1-2 ADVIA 1800 Chemistry System Interface Specification Guide: Using This Guide

Conventions
The ADVIA 1800 Chemistry System Interface Specification Guide uses the following text
and symbol conventions:
Convention Description
BIOHAZARD Biohazard statements alert you to potentially
biohazardous conditions.
LASER WARNING: Laser Warning statements alert you to the risk of
exposure to lasers.
WARNING: Warning statements alert you to conditions that
may cause personal injury.
CAUTION: Caution statements alert you to conditions that may
cause product damage or loss of data. On the
system, this symbol indicates that you should refer
to the operator’s guide for more information.
NOTE: Note statements alert you to important information
that requires your attention.
Bold Bold type indicates commands on the user
interface, keys, or the exact text that an operator
needs to type.
For example, if the word save appears as Save, it
refers to the selecting the Save button on the user
interface.
Another example is typing a specific entry into a
text box. If the word welcome appears as welcome,
it means that you should type that word into the
specified field.
Italic Italic type refers to the title of a document or a
section title in this operator’s guide. For example,
LIS Connectivity refers to Section 2 of this interface
guide.

Terminology
The following table explains some of the special terminology used in this operator’s guide
and the specific actions that you need to take when you see the terminology:
Term Description
Select To select an item, use your finger to touch the item on the touch-screen
monitor or select the item with the system pointing device. The
background of the item changes color or displays a black frame to
indicate that you selected the item.
Enter Type the specified information using the keyboard and then press
the Enter key.

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ADVIA 1800 Chemistry System Interface Specification Guide: Using This Guide 1-3

Term Description
Scan Move the hand-held barcode scanner over the specified barcode to enter
the information.

Operation Panel

1 Operating Modes
2 Load status indicator
3 Alarm message box
4 Time remaining indicator

Figure 1-1 Operating Modes

1 Request
2 Reagent
3 Calibration
4 QC
5 Maintenance
6 Setup

Figure 1-2 Menu Panel

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1-4 ADVIA 1800 Chemistry System Interface Specification Guide: Using This Guide

Logging on
There are 4 access levels to the system software:
Level Password required Comment
user No Intended for routine operation.
supervisor Yes Access to some system setup and
advanced maintenance features.
tech_manager Yes Access to most system setup and
advanced maintenance features.
You have to contact your technical
service provider or distributor in
order to change the default settings
on these windows.
service Yes Access for Siemens service
personnel.

You are automatically logged on at the user level during startup. If you log on at the
supervisor or tech_manager levels, when done, you should log on to the user level (no
password required).

Enhancements to LIS and LAS


A complete list of software changes in this release is contained in the Release Notes
accompanying the release. Listed below are only the changes that will be most important
to users of this document, the changes to LIS and to LAS.

LIS Enhancements
To use these options, the LIS must first be modified. Contact your LIS administrator for
the required modifications.
• A 10-digit QC lot number instead of a 6-digit lot number in the Comment2 field.
• The STT position information can be optionally sent as part of the “R” (result)
message. Both Sample ID (SID) and tray position are sent.
• The rack number and the rack position number fields of the “R” message are now
enabled. Rack and rack position data can be sent in the rack position field instead of
the Comment2 field.
• The patient results can be sent to the LIS as soon as they are complete. For example,
ISE results are reported when complete rather than at 10 minutes. Multiple messages
are sent to the LIS for one SID with results that are ready at different times.
• All tests listed on a workorder can be sent to the LIS even if only one test is run and
calculated. If no result is calculated, the result field is left blank.
• The patient age in weeks, months and days instead of only in years. This information
is used in the “O” (order) message as well as the “R” message. This enhancement is
not currently supported by the ADVIA CentralLink software.

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LAS Enhancements
An optional TCP/IP-based interface offers enhanced functionality and improved
workflow with your LAS. The enhancements include the following:
• a new hardware interface using TCP/IP
• resetting the LAS queue after a system error occurs
• improved communication between the system and the LAS
The following new messages have been added to improve communication and
workflow between the system and the LAS, including:
• sample status is sent to the LAS after completion of aspiration of the last test
for a sample to improve sample routing for workorder completion
• requests for samples that need rerun or reflex (if configured)
• system status messages indicate when warnings or errors occur on the
instrument
• reagent status is sent to the LAS to improve sample routing and load
balancing when multiple ADVIA 1800 Chemistry systems are connected to
the automation system
• enhanced skip tube logic without taking the system offline
• manual STAT sample notifications to the LAS

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-1

2 LIS Connectivity

This section describes the communications between the ADVIA 1800 Chemistry
system and a host computer.
The ADVIA Chemistry system and a host computer communicate in one of these
ways:
• The ADVIA Chemistry system requests a specific workorder or a batch of
workorders from the host computer.
• The host computer sends the workorders (test selections) in reply to these
requests.
• The ADVIA Chemistry system sends the sample results for patient and
control samples in real time, or in batch when initiated by the operator.
The ADVIA Chemistry system also can communicate with external samplers such
as the rack handler and laboratory automation systems (ADVIA LabCell System).
For information about these types of communications, refer to Section 3, LAS
System.

Interconnecting the ADVIA Chemistry System and the


Host Computer
As shown Figure 2-1, the ADVIA Chemistry system is connected to the host
computer via an RS-232C cable supplied by the laboratory. A 25-pin (RS-232C)
to 9-pin adapter is required.
ADVIA® Chemistry System

Host Computer Workstation Analyzer

25-pin to 9-pin adapter 9-pin connector

Scope of responsibility on Host side Scope of responsibility on System side

Figure 2-1 Simplified Interconnection Diagram

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2-2 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

Communication Specifications and Parameters


The following specifications and parameters are applicable to the interface between the
ADVIA Chemistry system and the host computer. The communication parameters are
entered in the On-Line Set window. The underlined parameter values are the default
selections.
Table 2-1 Field values for Online Settings Window, and other parameters

Transmission Specifications RS-232C


Synchronization Asynchronous
ADVIA System connector D_SUB 25-pin socket connector. (Use a plug
connector on the cable side.)
Connector signals See Table 2-2.
Transmission procedure The basic procedure is to alternately transmit a
message and to receive an acknowledgement
(ACK, or NAK or NACK).
NOTE: For a summary of NAK or NACK
messages, refer to A Note on NAK/NACK‚
page 3-1.
Communication Speed 4800 bps, 9600 bps, 14400 bps, 19200 bps.
Coding:
• Parity: None, Even, Odd
• Start bit: 1 bit
• Stop bit: 1 bit, 2 bits
• Data length 7 bits, 8 bits

Serial Port COM1


Online timeout setting: The following timeout values can be set. These
three settings can be customized if necessary in
order to improve workflow.
• Automatic test selection 60.0 seconds
(Timeout time from the
start to end of automatic
test selection.)
• Real-time test selection 3.0 seconds
(Timeout time from the
start to end of real-time test
selection.)
• Frame interval (Timeout 3.0 seconds
time between frames)
Number of retries 3
Number of error text skips 0, 1, 2, 3
When an abnormal text format causes an invalid
response, this represents the number of times that
processing of text alone can be skipped before the
system goes offline.

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-3

Table 2-1 Field values for Online Settings Window, and other parameters

Automatic transfer: An explanation of the settings are:


• Automatic test select
No indicates STT workorders requested at the
system.
Yes indicates STT workorders requested at the
host computer.
• Real test select
No indicates LAS workorders requested at the
system.
• Automatic test selection No, Yes
(STT)
• Automatic real test No, Yes
selection (Rack Handler or
LAS)
• Automatic transfer of usual No, Yes
sample results
• Automatic transfer of No, Yes
interruption sample results
• Automatic transfer of pilot No, Yes
sample results
Checksum Yes
Maximum frame size 512 bytes
Host transfer date leave blank
Host Transfer Using Select User Code number. (Selections are either
Processing Test Number or User Code Number.)
Online DATA TEXT format Select New. (Selections are either OLD (original)
or New (Version 1)).
Online test setting Determines which tests are sent in the real-time
output, batch output, and qualitative output. You
can use the ADVIA system processing test
numbers (1−326) from the Process Sequence
window, or you can define your own test codes
(host numbers) on the Test Setting dialog box of the
Online Setting window to identify the tests.

The number that is entered into the code field on


the Test Setting window must be:
• three-digit maximum
• right justified
• zero-suppressed
• unique for each test
NOTE: Press CLEAR before changing test settings.

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2-4 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

Configuring the system for communication with the host


Online Settings Screen
1. At the Menu Panel, select Setup.
2. At the Setup window, select Online Setup.
The Online Settings window displays.

Figure 2-2 Online Settings window

3. Enter the field values (see Table 2-1 on page 2-2) at the Online Settings window.

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-5

Test Setting Screen


1. At the Online Settings window, select Set Test.
The Test Settings window displays. Refer to Figure 2-3.

Figure 2-3 Test Settings window

a. Select the BATCH check box and the REAL check box for each test in use.
You can also select the Qual check box for qualitative results.
b. Verify that each number entered in each Code field matches the test
numbers entered in the host computer. The Code field can have up to 3
alphanumeric characters.
NOTE: If you enter a number in the Code field, insert spaces to the left of the
number to right justify the number in the field. If “b” is a blank, entering “b10”
will be read as a ten whereas entering “10b” will be read as a hundred. Refer to
Figure 2-4.

10 10 (Right Justify the number)

Incorrect Correct

Figure 2-4 Entering the first of the Test Settings

LIS Name information is sent automatically from the instrument to LIS at the time
of a new start or initialization. Any time the testmap changes, this information is
resent to LIS and to LAS. If an LIS test name is not defined, the test is excluded
from the Test Map.
If any tests, including slave tests such as ratio tests and serum indices, are added
or deleted on the Test Select screen or the Active Test List window, the Test Map
response message is sent to the LAS.

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2-6 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

LIS Name Setting Screen


1. You define the LIS test name on the LIS Test Name Settings screen. Open this by
clicking on the LIS Name Setting tab on the Online Settings screen.
2. You can enter the LIS Name and the LIS Test Code. (The test names are configured in
the Process Sequence screen.) The LIS test names are a maximum of 10 characters.
The information on this screen is used by the LAS Testmap function.

Figure 2-5 LIS Test Name Settings

NOTE: This entry is case-sensitive. If an existing name is accidentally entered a second


time, but with a different combination of uppercase and lowercase characters, then both
entries will be saved as if they represent two separate tests. Therefore:
• Make sure all entries observe the same “case” conventions.
• Make sure no duplicates exist.
Pressing Clear removes all the LIS Names and the fields are filled with spaces.
Pressing Exit or the Windows close button closes the screen. The changes are saved.

Connector Pin Assignments


Table 1 lists the assignments for the 9-pin female connector attached to the COM1 port of
the ADVIA system workstation.
Table 2-2 9-Pin Connector Assignments

No. I/O Signal Name Connection Information


1 IN DCD not connected
2 IN SIN ADVIA data IN

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-7

No. I/O Signal Name Connection Information


3 OUT SOUT ADVIA data OUT
4 OUT DTR Connect to pin 6 (DSR)
5 GND signal ground
6 IN DSR Connect to pin 4 (DTR)
7 OUT RTS Connect to pin 8 (CTS)
8 IN CTS Connect to pin 7 (RTS)
9 IN RI not connected
Connect pins 4 (DTR) and 6 (DSR) together, and pins 7 (RTS) and 8 (CTS)
together within the 9-pin connector because the ADVIA Chemistry system does
not control these signals.
NOTE: Use a separate shielded cable. To prevent external noise from entering
the system, connect the shield to the connector casing at each end of
the cable (if not already done).
Host Connector Omron XM2D-2501
XM2Z-0001
9-pin adapter Omron XM2A-2501 (soldered)
XM2S-2511 (screw-on case)

When connecting this cable to the COM1 port connector at the rear of the ADVIA
workstation, ensure you route it away from AC cables and any equipment that
generates noise.
Do not try to connect the 25-pin RS-232C connector on the cable directly to the
9-pin COM1 connector.
NOTE: COM1 port locations vary with different models of PC:
• PC Model SP6: COM1 is located on the top.
• PC Model SSE350: COM1 is located on the bottom.
• PC Model Seattle2: COM1 is located on the bottom.
• PC Model Arrow: COM1 is located on the bottom.

Message Frame Format


Each message frame exchanged between the ADVIA 1800 Chemistry system and
the host computer contains the following elements:

STX F# [0-7] Message Text ETX or ETB CSH CSL CR LF

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Table 2-3 Message Frame Format Feature Descriptions

Feature Description
Max frame length (selectable) 256 bytes, 512 bytes
Code used ASCII, shift JIS
STX (02H) Frame start code
F# frame number 1 (31H) to 7 (37H), “0” (30H) cyclically
After ENQ transmission, the frame number
increments beginning with 1, and when the frame
number reaches 7, it returns to 0.
Message Text to be transmitted
ETX (03H) Final-frame code
ETB (17H) Intermediate-frame code
CSH Checksum upper
CSL Checksum lower
CR (0DH) + LF (0AH) Frame end code

Communication Control Codes


The following control codes provide status information:
Table 2-4 Control Code Descriptions

Code Description
ENQ (05H) Enquire connection
ACK (06H) Affirmative acknowledge (acknowledgment)
NAK (15H) Negative acknowledge (acknowledgment)
EOT (04H) End of transmission
DC1 (11H) Sample request skip response (equipment control
character)

The communication control codes are sent independently. (They are not enclosed by STX
and ETX codes.)

Feature Description
Checksum Test No, Yes

The Checksum test, which is enabled or disabled using the Online Settings window,
checks the quality of the message. The sum of the characters, after STX, up to and
including ETX or ETB, using modulo 256, is read hexadecimally and expressed as a
2-digit ASCII character. If checksum is No, a space code (20H) transmits and a check is
not performed on the system side.

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-9

Example: <STX>1ABCDE<ETX><CSH><CSL><CR><LF>
1 (49D)
A (65D)
B (66D)
C (67D)
D (68D)
E (69D)
+ ETX (03D)
387D → 183H (hexadecimal) → modulo 256 → 83H
The checksum value 83H is sent as:
CSH = ” (38H) and CSL = 3 (33H)
If both the sending and receiving device obtain the same checksum values, the
message is considered valid.

Communication Modes
The available modes of communication are determined by the hardware
configuration and by the specific options selected by the user.

Hardware Configuration
For communication purposes, the sampling and barcode device on your
ADVIA system determine the hardware configuration. This information is in the
System Specifications Settings window. Refer to Table 2-5 for more information.
(Underlined parameter values in the table are the default settings.)
Table 2-5 System Specifications Settings Hardware Configuration

Specification Barcode Option Sample Delivery Option


Sample Tray (no barcode) Yes No Sample Tray/Rack conveyer/
External Transport
Sample Tray (with barcode) Yes No Sample Tray/Rack conveyer/
External Transport
Rack conveyer (no barcode) Yes No* Sample Tray/Rack conveyer/
External Transport
Rack conveyer (with Yes No* Sample Tray/Rack conveyer/
barcode) External Transport
Laboratory Automation Yes No† Sample Tray/Rack conveyer/
System External Transport
*This setting is not supported. The rack handler used by the ADVIA Chemistry system is managed
as laboratory automation device (LAS).
†Currently, all external sampling devices, including the rack handler, must have a barcode reader.

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2-10 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

System Customization
You can customize the system features listed in Table 2-6.
Table 2-6 System Customization

Feature Options Applicable Window


Sampler for patient samples on-board sampler System Specifications
external sampler Settings
Sample barcode reader Barcode cup posi. System Specifications
Settings
Automatic Test Select Yes No Online Setting
Results reporting Auto transfer, User Test Online Setting
Code, Data Clean

Sampler Selection for Patient Samples

If an external sampler (Rack Handler, LAS) is configured on the System Specifications


Settings window, the Start Conditions Settings determines which sampler is used for
patient samples in the next run. For example, if the external sampler is unavailable, you
can use the onboard sampler (STT) to run the patient samples.

Barcode Selection

After configuring the barcode reader in the System Specifications Settings window, the
Start Conditions Settings determines if the barcode mode or the position mode identifies
samples on the onboard sampler. This option only is valid for the onboard sampler. The
barcode mode must be used for the external sampler.
You can have workorders for the current tray download automatically from the host
computer at the start of a run. Set the Online Settings parameter, Automatic Test Select, to
Yes.
Automatic test select is only applicable for patient samples aspirated from the onboard
sampler (STT).
When the Host toggle button is set to ON and a workorder is found, the system downloads
a workorder from the host. If a workorder is not found at the host, the system searches its
internal database. If a workorder is not found in the internal database, the sample is not
aspirated.
The host workorder contains information that tells the system how to manage the
workorder that was downloaded. The system can receive 4 different instructions as shown
in Table 2-7.
Table 2-7 System Instructions for Workorders

Instruction System Action


0 Create a new workorder in the system database. If a workorder with
the same ID exists, it is overwritten.

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-11

Instruction System Action


1 Create an additional test for the existing workorder. If a workorder
with the same ID does not exist, a new one is created.
2 The system does not create a workorder for this ID.
3 An ID currently in the system database will be deleted.
Select No for the Automatic Test Select parameter if work orders will be created
using the ADVIA Order Entry window.
Select Yes for the Real Test Select to download work orders when using an
external sampler.

Data Output

In the Online Settings Window, you can verify that sample results are sent to the
host computer in real time:
• Automatic transfer: automatic test select (STT)
• Automatic transfer of interruption sample result (Rack Handler, LAS)
• Automatic transfer of pilot sample results (Controls)

Configuring the New Version 1 Host Protocol Format


You can choose several protocol text formats from the Online Settings windows:
• OLD - Original
• New - Version 1
The New (Version 1) host protocols sends rack and position numbers (URH), an E
flag, a 3-character user code, and aspiration time. The TDworkstation software
V.8.22.1 does not support the new protocol format. Host computers must be
modified to support the new format. The ADVIA CentraLink™ software supports
both new and old formats.

Configuring the New Host Protocol


1. Log on to the ADVIA software as supervisor.
2. Set the data text form:
a. Select Setup on the Menu Panel, then select On-Line Settings.
b. At the On Line settings window, choose the Online DATA TEXT format
for the software version you are using:
• select OLD for the Original version software
• select NEW Version 1 for Version 1 software
c. Select Save, then Yes.

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2-12 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

New Version 1 Configuration


1. Set communication with the PC:
a. Select Setup on the Menu Panel, then select System Parameter Settings.
b. At the System Parameter Settings window, select LIS from the drop down list.
c. Select Next Page, to locate parameter 213.
d. In the Value field for 213: Sample Log Communication with PC, type 2.
e. Select Next Page, to locate parameter 224.
f. In the Value field for 224: LAS Sample Log Communication, type 2.
g. Select Save, then Yes.
2. Set communication with the Rack Handler:
a. At the Windows Desktop, double-select the ARHOperator icon.
b. At the Universal Rack Handling System Operation Panel, select the
Administration menu, then select LAS Configuration.
c. At the LAS Configuration window, select Yes from the drop down list, then select
OK.
d. At the Universal Rack Handling System Operation Panel, select the Exit, then
select Yes.
3. Restart the ADVIA 1800 Chemistry system software.

New Version 1 Configuration

Once you change and save the values of the LIS system parameters in the LIS view, these
values are saved in the corresponding System Parameter Settings list items including
Controller, DP, Operation Console, and Controller 2.
The ADVIA system is set to transmit the new LIS format.
Refer to Measurement Data Text‚ page 2-46, for a description of the new data text record
format. When you change the Data Test format, a notification displays warning that the
protocol format was modified. To continue and save the changes, select Save. The new
settings take effect when a New Start is performed. To cancel the changes, select Cancel.

Turning off the New LIS format (reset to Original)


1. Log on to the ADVIA software as supervisor.
2. Set the data text form:
a. Select Setup on the Menu Panel, then select On-Line Settings.
b. At the On-Line settings window, select OLD for Online DATA TEXT format.
c. Select Save, then Yes.
The ADVIA 1800 Chemistry system is set to transmit the old LIS format.

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-13

Available Operating Modes


The operator modes are described in the Table 2-8 on page 13.
Table 2-8 Operating Modes

Order
System Sample Sample regis-
Mode Configuration Case ID Feed tration Main Purpose
1 Onboard <1> TT-CUP Sample Auto. Operation in
sampler only Tray which a
(no barcode TT-CUP
reader) numbers
worksheet is
drawn up by the
host.
2 <2> TT-CUP Sample Batch When automatic
Tray test registration*
is not possible.
3 Onboard <3> Barcode Sample Auto. Sample
sampler only Tray numbers are
(with barcode used as
reader) barcodes.
4 <4> Barcode Sample Batch When automatic
Tray test registration
is not possible.
5 <1> TT-CUP Sample Auto. Processing of a
Tray sample that
does not permit
barcode
operation.
6 <2> TT-CUP Sample Batch Processing of a
Tray sample that
does not permit
barcode
operation.
7 Rack Handler <5> Barcode Rack Real Sample
(with barcode) option numbers are
used as
barcodes.
8 <6> Barcode Rack Batch When real test
Option registration* is
not possible.

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2-14 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

Order
System Sample Sample regis-
Mode Configuration Case ID Feed tration Main Purpose
9 Modes 9 & 10 <7> Rack Rack Real When barcode
are not number option operation is not
supported at this possible.
10 time. Instead, <8> Rack Rack Batch When barcode
the rack handler Number option operation is not
is managed as possible.
an LAS device
as described in
modes 17 to 24.
11 <9> SEQ† Rack Batch Sample
number option numbers
automatically
occurred are
used.
12 <9> SEQ Rack Real Sample
number option numbers
automatically
occurred are
used.
13 <3> Barcode Sample Auto. Interruption
Tray sample
processing.
14 <4> Barcode Sample Batch Interruption
Tray sample
processing
15 <1> TT_CUP Sample Auto. Processing of a
Tray sample that
does not permit
barcode
operation
16 <2> TT_CUP Sample Batch Processing of a
Tray sample that
does not permit
barcode
operation
17 LAS device <5> Barcode LAS Real Sample
available numbers are
including the used as
rack handler barcodes.
18 <6> Barcode LAS Batch When real test
registration is
not possible.

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-15

Order
System Sample Sample regis-
Mode Configuration Case ID Feed tration Main Purpose
19 <7> Rack LAS Real When barcode
number‡ operation is not
possible.
20 <8> Rack LAS Batch When barcode
number operation is not
possible.
21 <3> Barcode Sample Auto. Interruption
Tray sample
processing
22 <4> Barcode Sample Batch Interruption
Tray sample
processing
23 <1> TT_CUP Sample Auto. Processing of a
Tray sample that
does not permit
barcode
operation.
24 <2> TT-CUP Sample Batch Processing of a
Tray sample that
does not permit
barcode
operation.
*
Refer to Communication Protocols‚ page 2-21 for explanations of the communica-
tion protocols.

Sequential number analysis.

This setting is not presently supported.

In modes 1 and 7, prepare the loadlist using the host, and also to set the data
concerning the position number in the test selection instruction text.
In modes 2 and 8, you can draw up a loadlist using the ADVIA 1800 Chemistry
system as well as the host.
In mode 9, draw up a worksheet using the host, and also set the data concerning
the sample number in the test selection instruction text.

Sample Identification
The ADVIA Chemistry system can identify samples internally within its database,
during sampling, and during the transfer of data between the system and the host
computer, or an external sampler (rack handler or other LAS device). This
identification is made using a registration number, position number, sample
number, or sample information, the ADVIA 1800 Chemistry system identifies
samples.

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2-16 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

Registration Number

The registration number is a sequence number between 1 and 10,000. This number is
employed in various workstation software windows, but it cannot be used to identify
samples in the communications between the ADVIA Chemistry system and the host
computer or an external sampler.

Position Number

When not using barcodes, the sample position number identifies patient samples aspirated
from the onboard sampler (STT). You also can use the position number as a data inquiry
key in various ADVIA workstation windows.
The STT position number format is:
01-01 TT-CC (TT = tray number, 1 to 97; CC = sample position, 1 to 84)
Online communications messages use position numbers. The numbers are left-justified,
not zero-suppressed, and terminated with an ASCII space character (20H). When using
position numbers, you must enter a sample number. Position numbers cannot be used to
identify samples aspirated from an external sampler, such as, the rack handler.

Sample Number

The sample number consists of up to 13 alphanumeric characters. When barcode labels are
used, the sample number becomes the barcode ID that identifies patient samples aspirated
from the onboard sampler (STT) or an external sampler. You can also use the sample
number as a data enquiry key in various ADVIA workstation windows.
A sample number is required for all workorders. This includes the position mode as
described in the previous paragraph. The ADVIA Chemistry system does not accept a
workorder that is missing a sample number.
Three sample number formats are available:
• General samples and interruption samples
You can use IDs consisting of up to 13 arbitrary characters.
In the Samp No. field, you can enter A-Z, 0-9, and special characters - (minus), +
(plus), period (.), $ (dollar), / (slash), % (percent), * (asterisk), and ; (semi-colon).
• STAT samples
A sample number from E01 to E84 (3 characters, fixed length) is automatically
assigned when the operator uses the STAT button on the Operation Panel to run a
STAT sample.
• Control samples
A sample number from PA001 to PZ200 (5 characters, fixed length) is automatically
assigned when a control sample is run.
Pxnnn (P = pilot [control], x = control letter assigned on QC Sample Definition window,
nnn = sequence number)

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-17

Sample numbers are used in online communications messages. When transmitted,


these sample numbers are left-justified, not zero-suppressed, and terminated with
an ASCII Space character (20H). For example: 001 and 1 are recognized as
different sample numbers.

Sample Information

The sample information consists of comment 1, comment 2, sex, age, and so on.
Comments 1 and 2 each consist of a maximum of 16 arbitrary characters. You can
use them as patient numbers or patient names. You can use them as search keys
for making data inquiries. No check for duplicate entries exists.
In online communications messages, the sample data is treated as character data.

Classification of ADVIA Chemistry Samples


Table 2-9 Sample Types

Sample Setting*
Data
Test Output
Registration to the Sample External
Sample Sample ID by the Host Host Tray Sample
General 13 digits yes‡ yes yes§ yes#
Sample†
Interruption 13 digits yes yes yes no
Sample**
STAT E01–E84 no yes yes no
sample††
Control PA001–PZ200 no yes yes no
Sample‡‡
Calibration C0101–C0110 no no yes no
§§ M980101–M980110
*Run all samples except general samples on the Sample Tray (onboard sampler).
General samples are run on the Sample Tray or an external sampler such as the rack
handler or an LAS, if available. When the run starts, the operator uses the Start Con-
ditions window to select which sampler is used for general samples. If, for any rea-
son, multiple samplers are selected, the analysis priority is to use the Sample Tray
first and then use the rack handler or LAS.
†The ADVIA Chemistry system manages a maximum of 10,000 general samples.
‡The host computer can create workorders (test registration) for general samples
and interruption samples.
§The position number for a sample on the Sample Tray (STT) consists of a tray
number and a cup number. The tray number (TT) range is 01 to 97. The cup number
range is 01 to 84.

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2-18 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

#
Currently, rack position numbers are not used for external samplers. Barcode la-
bels are required for the LAS devices including the rack handler. However, for ref-
erence purposes, the rack position number consists of a rack number and a sample
number. The rack number range is 0001 to 9999. The sample number range is 01 to
10.
**
Interruption samples are treated as general samples; however, these samples are
set at the CUP positions preset on the Sample Tray. These are analyzed first.
††
STAT samples are also set at predetermined positions on the Sample Tray, and are
analyzed preferentially. However, STAT est selection cannot be downloaded from
the host computer. STAT test selectivity is determined using the STAT Order Setup
window. The sample IDs E01 to E84 are reserved for STAT examples.
‡‡
Quality control samples are aspirated from positions on the Sample Tray (CTT).
The listed sample IDs are reserved for controls only. Controls cannot be requested
from the host computer. Instead, controls are usually requested from the Start Con-
ditions window.
§§
Calibration samples are not handled online. Samples are orderable by LIS but not
sent to LIS.
Single-point calibration: Cxxyy xx: Cup No. (01–61) yy:request counter(01–10)
Multi standard: Mxxyyzz xx:TT No. (98,99) yy:Cup No. (01–84) zz:request coun-
ter (01–10)

Test Order Operation


When the host computer is online (HOST ON), all of the sample workorders, regardless of
analysis results of the sample, are requested by the host computer. Next, workorders from
the host computer and the ADVIA Chemistry system are combined, and the ADVIA
Chemistry system selects the analysis orders.
The following table explains how the system manages workorders from the host computer.
Table 2-10 Managing Workorders from the Host Computer

Host Order System Order System Response


New workorder No The system registers the sample and runs
the tests requested by the host computer as
a new workorder.
New workorder Yes The sample is registered in the system, and
the tests requested by the host computer are
run as a new workorder.
Addition No The sample is registered in the system, and
Re-analysis the tests requested by the host computer are
run as a new workorder.

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-19

Host Order System Order System Response


Addition Yes If tests requested by the host computer
Re-analysis have not been run, they are run as originals
under first-analysis conditions.
If tests requested by the host computer
have already been run, they are repeated
using the re-analysis conditions. In this
case, check the parameter mdu priority
host to confirm that the desired dilution
has been performed.
No workorder No This sample is not analyzed.
No workorder Yes The tests in the system-created workorder
are run.
Sample deletion No This sample is not analyzed.
Sample deletion Yes System order information of this sample is
deleted. No analysis.

Sample and Test Database Registration Sizing


• The system allows registration of routine samples. The system can register up
to 10,000 routine samples
• A single database block can store 10 tests
• 30,000 blocks are available
• If 11 tests are run, 2 blocks are required
Table 2-11 Registered Samples by Number of Tests

Number of
# Tests Registered Samples
10 10,000
20 10,000
30 10,000
40 7,500
50 6,000
60 5,000
70 4,285
80 3,750
90 3,333
100 3,000

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Host Test Code Table


The ADVIA Chemistry system manages up to 626 tests:
• 200 tests, each with two additional sub-parameters
• 20 computed results (ratios)
• 3 serum indices (lipemia, hemolysis, and icterus)
• 3 electrolyte tests (NA+, K+, and CI-)
The ADVIA Chemistry system transmits a unique numeric code for each test (e.g.,
Glucose = test code 123) to the LIS. The ADVIA Chemistry system software provides two
options when defining test codes:
• Using the processing item number
• Creating user-defined codes that meet your laboratory’s numbering scheme
The selection of the processing item number or user-defined code is typically made during
the initial set up of your system and remains the same for the life of the system. A
processing item number is automatically assigned by the system, using the slot number
with which the user configured the test in the Process Sequence window. User-defined
codes are entered manually.
NOTE: If the software selection is changed from processing item number to
user-defined code, remember to confirm that all test codes are unique.
After setting the user code numbers, you can use the host test codes when ordering tests or
managing results at the host computer.
To create the user-defined test codes:
1. In Online Settings>Host Transfer Using field, select User Code Number.
2. Select Set Test.
3. Enter the required numbers in the Code boxes of the Test Setting window.
The Serum indices area in the System Specification Settings window determines if the
serum indices are automatically run for each sample or if they must be requested each time
using the Order Entry window.
When any electrolyte test is ordered, the other two tests run automatically.
The number of decimals in a test result can be specified, by test, in the Chemistry
Parameter window.
Table 2-12 Host Test Codes

Host Number of To right of


Processing Test Test Digits decimal
Test No. Codes Name (Indication) point Classification
xx1 xx1* (AST) 8 digits test specific photometric test
xx2 xx2 (AST) 8 digits test specific photometric test

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-21

Host Number of To right of


Processing Test Test Digits decimal
Test No. Codes Name (Indication) point Classification
xxx xx3 (AST) 8 digits test specific photometric test
xxx xxx (AST) 8 digits test specific photometric test
xxx xxx (AST) 8 digits test specific photometric test
xxx xxx (AST) 8 digits test specific photometric test
xxx xxx (A/G) 8 digits test specific ratio
xxx xxx (A/G) 8 digits test specific ratio
xxx xxx (A/G) 8 digits test specific ratio
xxx xxx (A/G) 8 digits test specific ratio
xxx xxx (A/G) 8 digits test specific ratio
xxx xxx Lipemia Qualitative test specific Blood serum
display data
possible
xxx xxx Hemolysis Qualitative test specific Blood serum
display data
possible
xxx xxx Icterus Qualitative test specific Blood serum
display data
possible
xxx xxx NA 8 digits test specific Electrolyte test
xxx xxx K 8 digits test specific Electrolyte test
xxx xxx CI 8 digits test specific Electrolyte test
*
Normal test code is zero-suppressed, right-justified.

Communication Protocols
The following communication protocols are available:
• Batch test registration
Communication starts after the operator uses the Host Request dialog box of
the Order Entry window to identify a group (batch) of workorders to
download from the host computer.
• Automatic test select (Host Query Mode)
When this feature is selected on the Online Select window, the host computer
downloads available workorders for STT patient samples upon request at the
start of the run.

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2-22 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

• Real test select


This communications protocol supports external samplers, such as the rack handler or
a laboratory automation system. The host computer downloads an available workorder
for each sample identification number supplied by the external sampler.
• Batch data output
Communication starts after the operator uses the Host Transfer dialog box of the
Review / Edit window to identify a group (batch) of sample results to send to the host
computer.
• Real data output
Whenever each sample’s assay is completed, the results are sent to the host computer.
The following information is applicable to each of the communication protocols.
• Time outs
NOTE: The Data Transmit window can also be used to re-send results to the host.

The system-side timer value is the maximum time that the ADVIA Chemistry system
waits for a correct response from the host. Similarly, the host-side timer is the maximum
time allowed for the ADVIA Chemistry System to respond.
NOTE: The ADVIA Chemistry system can analyze individual tests at 3-second intervals.
If the sum of the system-side and host-side values exceeds the analysis time interval, the
system sampling time is increased resulting in decreased throughput. To avoid a
significant decrease in throughput, the host-side timer value should be less than that of the
analyzer, and the host computer should respond as quickly as possible.
If one sample has n requested tests, the sample analysis interval is
3.0 seconds x n. Consequently, the greater the value of n, the smaller the possibility of
decreased throughput during the communication waiting period.
The 3-second cycle time of the ADVIA Chemistry system imposes some restrictions on
the response time of the host computer program. If you want to continuously process
samples with a single photometric test requested on the workorder (single-test
registration), then the host computer response time must be less than 3.0 seconds. A
response time greater than 3.0 seconds reduces system throughput. The ADVIA Chemistry
system must wait for a Host response before sampling can continue.
In addition the ADVIA Chemistry system gives priority to the communication of
workorders (test registration) over result transfer (data communication). If the test
registration does not complete within 3.0 seconds, then data accumulates in the ADVIA
PC.
NOTE: This accumulation of data can cause performance problems on the system.

The need for a 3.0 second response is reduced if two or more photometric tests are
requested per workorder. The Host response time should be less than 3.0 seconds times the
number of tests requested (3.0 sec x n tests). ISE analysis (Ion-selective electrodes) by the
ADVIA Chemistry system requires 24 seconds.

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-23

Table 2-13 Example of Response Time to Meet 3.0 Second Limitation

Host
ADVIA Estimate
Commun- Commun- Typical Response
Test ication ication Response Time
Registration Byte time (sec) time (sec) (sec)
ADVIA → Host ENQ 1 0.00104
ADVIA ← Host ACK 1 0.00104 0.25
ADVIA → Host Test 30 0.03125 0.13
request
ADVIA ← Host ACK 1 0.00104 0.25
ADVIA → Host EOT 1 0.00104 0.13
ADVIA ← Host ENQ 1 0.00104 0.25
ADVIA → Host ACK 1 0.00104 0.13
ADVIA ← Host Test 93 0.09687 0.25
regist.
ADVIA → Host ACK 1 0.00104 0.13
ADVIA ← Host EOT 1 0.00104 0.25
Data Online
ADVIA → Host ENQ 1 0.00104
ADVIA ← Host ACK 0.00104 0.25
ADVIA → Host Data 112 0.11667 0.13
online
ADVIA ← Host ACK 1 0.00104 0.25
ADVIA → Host EOT 1 0.00104 0.13
247 0.25729 0.78 1.75
Total Online Time
(sum of three right-hand columns): 2.79
• Required host response to communication initialization
The ADVIA Chemistry system initiates communications regardless of the
receiving condition of the host computer. The first line request (ENQ) of the
communication procedure is communicated to identify whether the host
computer can receive or not. Regardless of the host process conditions, the
host must receive the line request (ENQ) and reply for confirmation.

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2-24 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

If the host computer is temporarily unable to respond, the ADVIA Chemistry system
retransmits a line request (ENQ) repeatedly up to the maximum number of times1, if a
negative response (NAK) is returned to the ADVIA Chemistry system line request
within an analyzer-side time-out. This retransmission can expand the host reception
starting time. Note that these processes reduce system performance.
• Host means of identifying samples
The position-mode method (TT-CUP No.) is available for patient samples aspirated
from the on-board sampler (STT). For example, a user who operates the
ADVIA Chemistry system in the barcode mode can request a suitable ID that is
different from the barcode ID during analysis, and process interruption samples using
the TT-CUP numbers. If the barcode sample is still being analyzed, the ADVIA
Chemistry system cannot be offline. In this case, the automatic test registration by
TT-CUP No. message transmits to the host. The ID that the host does not handle is
transmitted, and the host must respond as follows:

To test inquiries No order response


To measurement data text Confirmation response

If the response is not transmitted, a time-out error occurs on the analyzer side.

Batch Test Registration Protocol


Communication is started from the Order Entry window.
The request conditions (sample identification, range, and related data) entered by the
operator are inserted into the batch test inquiry text, which is then transferred to the host
computer as a workorder inquiry.
The host sends the test-selection instruction text, under specified conditions, for the
samples with tests to be analyzed by the ADVIA Chemistry system.
If these communications are interrupted by the operator, the ADVIA Chemistry system
sends an EOT signal to the host, and the transmission is ended.
The event numbers in the following dialog, for example <1>, are explained in Table 2-15.
Table 2-14 Batch Test Registration Dialog

System ENQ → Host


<1>
System ← Acknowledgment Host
<2>
System Batch Test inquiry → Host
<3>
System ← Acknowledgment Host
1Refer to the error processing information on Error Processing Example‚ page 2-33.

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<4>
System EOT → Host
<5>
System ← ENQ Host
<6>
System Acknowledgment → Host
<7>
System ← Test-selection Host
instruction*
<8>
System Acknowledgment → Host
...(Repetition)
System ← Test-selection Host
instruction
<8>
System Acknowledgment → Host
<7>
← EOT Host
*
Only samples that have test-selection instructions are registered. If the line finish-
es on their first timing, no registration is done.
Table 2-15 Batch Test Registration Events

Timer Monitoring Interval


Timer
Timer Start End Interval Action
<1> ENQ ENQ sent Receipt of 5 seconds EOT is sent
acknowledgment and
processing
stops.
<2> System-side Acknowledgment Inquiry sent (2 seconds)
processing received
period
<3> Inquiry Inquiry sent Acknowledge- 3 seconds EOT is sent
acknowl- ment received and
edgement processing
stops
<4> System-side Acknowledgment EOT sent (2 seconds)
processing
period

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Timer Monitoring Interval


Timer
Timer Start End Interval Action
<5> Response EOT sent ENQ received 5 seconds The system
after EOT + a* sends EOT
changeable and test
selection
processing
stops.
<6> System-side ENQ received Acknowledgment (2 seconds)
processing sent
period
<7> Response Acknowledgment Next-frame 5 seconds The system
after an sent message received +a sends EOT
acknowledg changeable and test
ment selection
process is
interrupted.
The received
part is valid.
<8> System-side Test selection Acknowledgment 2 seconds
processing received sent
period
<9> Entire System ENQ sent Host EOT sent Not
procedure observed
processing
time
*
a is the time-out value between frames.

Automatic Test Registration Protocol


If the Automatic test select option is selected on the Online Settings window, the system
requests workorders for the current tray (samples loaded onto the STT). When the Sample
Tray-analysis mode starts, communications take place and analysis starts automatically
after the workorders are downloaded and registered.
The event numbers in the following dialog, for example <1>, are explained in Table 2-17.
Table 2-16 Automatic Test Registration Dialog

System ENQ → Host


<1>
System ← Acknowledgment Host
<2>
System Test inquiry → Host
<3>

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System ← Acknowledgment Host


<4>
System EOT → Host
<5>
System ← ENQ Host
<6>
System Acknowledgment → Host
<7>
System ← Test-selection Host
instruction*
<8>
System Acknowledgment → Host
...(Repetition)
System ← Test-selection Host
instruction
<8>
System Acknowledgment → Host
<7>
System ← EOT Host
*Only samples that have test-selection instructions are registered. If the line finish-
es on this first timing, registration is done.
Table 2-17 Automatic Test Registration Events

Timer Monitoring Interval


Timer
Timer Start End Interval Action
<1> ENQ ENQ sent Receipt of 5 seconds EOT is sent
acknowledgment and
processing
stops.
<2> System-side Acknowledgment Inquiry sent (2 seconds)
processing received
period
<3> Inquiry Inquiry sent Acknowledg- 3 seconds EOT is sent
acknowl- ment received and
edgement processing
stops
<4> System-side Acknowledgment EOT sent (2 seconds)
processing
period

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Timer Monitoring Interval


Timer
Timer Start End Interval Action
<5> Response EOT sent ENQ received 5 seconds EOT is sent
after EOT + a* and
changeable processing
stops.
<6> System-side ENQ received Acknowledgment (2 seconds)
processing sent
period
<7> Response Acknowledgment Next-frame 5 seconds EOT is sent
after an sent message received +a and
acknowledg changeable processing
ment stops.
<8> System-side Test selection Acknowledgment 2 seconds
processing received sent
period
<9> Entire System ENQ sent Host EOT sent 42 seconds EOT is sent
procedure + b† and
processing changeable processing
time stops.
*
a is the time-out value between frames.

Automatic test-selection time-out value.

Real Test Registration Protocol


During analysis in which patient samples are aspirated from an external sampler such as
the rack handler or LAS device, the external sampler reads the barcode ID for each sample
and sends it to the ADVIA Chemistry system. If the required workorder is not available, the
system queries the host computer.
The event numbers in Table 2-18, for example <1>, are explained in Table 2-19.

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Table 2-18 Real Test Registration Dialog

System ENQ → Host


<1>
System ← Acknowledgment Host
<2>
System Test inquiry → Host
<3>
System ← Acknowledgment Host
<4>
System EOT → Host
<5>
System ← ENQ Host
<6>
System Acknowledgment → Host
<7>
System ← Test-selection Host
instruction*
<8>
System Acknowledgment → Host
...(Repetition)
System ← Test-selection Host
instruction
<8>
System Acknowledgment → Host
<7>
← EOT Host
*
Only samples that have test-selection instructions are registered. If the line finish-
es on this first timing, registration is done.

Table 2-19 Real Test Registration Events

Timer Monitoring Interval


Timer Timer
Start End Interval Action
<1> ENQ ENQ sent Receipt of 5 seconds EOT is sent
acknowledgment and
processing
stops.

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Timer Monitoring Interval


Timer Timer
Start End Interval Action
<2> System-side Acknowledgment Inquiry sent (2 seconds)
processing received
period
<3> Inquiry Inquiry sent Acknowledg- 3 seconds EOT is sent
acknowl- ment received and
edgement processing
stops
<4> System-side Acknowledgment EOT sent (2 seconds)
processing
period
<5> Response EOT sent ENQ received 5 seconds EOT is sent
after EOT + a* and
changeable processing
stops.
<6> System-side ENQ received Acknowledgment (2 seconds)
processing sent
period
<7> Response Acknowledgment Next-frame 5 seconds EOT is sent
after an sent message received +a and
acknowledg changeable processing
ment stops.
<8> System-side Test selection Acknowledgment 3 seconds
processing received sent
period
<9> Entire System ENQ sent Host EOT sent 52 seconds EOT is sent
procedure + b† and
processing changeable processing
time stops.
*a is the time-out value between frames.
†Automatic test-selection time-out value.

Batch Data Output Protocol


Communication is started from the Review/Edit window, where the operator identifies the
group of sample results to send to the host computer.
You can use the Data Clean Set feature of the Online Settings window to validate the
sample results before they are transmitted. Results that fail are not sent. Use the Test
Results List dialog box of the Review / Edit window to determine which samples failed
the data clean check.
If you interrupt this communication, the ADVIA Chemistry system sends an EOT signal to
the host and the transmission is ended.

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The event numbers in Table 2-20 are explained in Table .


Table 2-20 Batch Data Output Dialog

System ENQ → Host


<1>
System ← Acknowledgment Host
<2>
System Sample Results → Host
<3>
System ← Acknowledgment Host
...(Repetition)
System Sample Results → Host
<3>
System ← Acknowledgment Host
<2>
System EOT → Host

Table 2-21 Batch Data Output Events

Timer Monitoring Interval


Timer
Timer Start End Interval Action
<1> ENQ ENQ sent Receipt of 5 seconds EOT is
acknowledgment sent and
processing
stops.
<2> System-side Acknowledgment Sample results (3 seconds)
processing received sent
period
<3> Data Sample results sent Acknowledg- 3 seconds EOT is
acknowl- ment received sent and
edgement processing
stops
<4> All not
processing observed
period

Real Data Output Protocol


The results for each sample are automatically sent to the host computer when they
are available.

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Use the Automatic transfer area on the Online Settings window to designate which kinds
of sample results are sent. Use the Data Clean Set feature to validate the sample results
before they are transmitted. Results that fail are not sent. Use the Test Results List dialog
box of the Review / Edit window to determine which samples failed the data clean check.
The event numbers in Table 2-22 are explained in Table .
Table 2-22 Real Data Output Dialog

System ENQ → Host


<1>
System ← Acknowledgment Host
<2>
System Sample Results → Host
<3>
System ← Acknowledgment Host
<2>
System EOT → Host

Table 2-23 Real Data Output Events

Timer Monitoring Interval


Timer Timer
Start End Interval Action
<1> ENQ ENQ sent Receipt of 5 seconds EOT is
acknowledgment sent and
processing
stops.
<2> System-side Acknowledgment Sample results (3 seconds)
processing received sent
period
<3> Data Sample results sent Acknowledg- 3 seconds EOT is
acknowl- ment received sent and
edgement processing
stops
<4> All not
processing observed
period

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Error Processing
Abnormal Text Format
If the system receives text that is abnormally formatted, the ADVIA Chemistry
system sends a NAK (or NACK) signal. The abnormal text-NAK cycle can repeat
up to 3 times.
For a summary of NAK or NACK messages, refer to A Note on NAK/NACK‚
page 3-1.
When the system receives text that is abnormally formatted again, the error-skip
counts (by the internal counter) increase, and the number of counts is compared to
the Set Error-sample Skip number. One of the following processes takes place
(refer to example below).
• If the number of error-skip counts is less than or equal to the number of text
error-skip counts:

System The system transmits a request-skip response (DC1).


Host The host transmits test-selection an instruction for the next sample or
EOT.
• If the number of error-skip counts exceeds the number of text error-skip
counts:

System The system transmits EOT. Test-selection is terminated. Valid


workorders are implemented.
Host The host transmission of an test-selection instruction is terminated.
• If the ADVIA Chemistry system does not respond:

System The system does not transmit.


Host The host timeouts after 20 seconds. After the timeout, the host transmits
ENQ, waits for ACK from the system, and resends the last attempted
sample ID.

Error Processing Example


Responses from the ADVIA Chemistry system (when text that has an abnormal
format is received while executing an test-selection instruction).

System ← Test selection-instruction Host


System Acknowledgment (ACK) Host
System Text format abnormal ← Test selection-instruction Host
System Negative acknowledge (NAK) Host
System Text format abnormal ← Test selection-instruction Host
System Negative acknowledge (NAK) Host
System Text format abnormal ← Test selection-instruction Host

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System Negative acknowledge (NAK) Host


System Text format abnormal ← Test selection-instruction Host
(The number of error-skip counts does not exceed the number of text error-skip counts.)
System Sample request skip response (DC1) Host
System ← Next sample test Host
selection-instruction
...
System ← Test selection-instruction Host
System Acknowledgment (ACK) ® Host
System Text format abnormal ← Test selection-instruction Host
System Negative acknowledge (NAK) ® Host
System Text format abnormal ← Test selection-instruction Host
System Negative acknowledge (NAK) ® Host
System Text format abnormal ← Test selection-instruction Host
System Negative acknowledge (NAK) ® Host
System Text format abnormal ← Test selection-instruction Host
(The number of error-skip counts exceeds the number of text error-skip counts.)
System Circuit interruption (EOT) ® Host

Receipt Of Resend Request


If the ADVIA Chemistry system receives a negative acknowledgment (NAK) from the
host, it resends the same frame 3 times. At the fourth negative acknowledgment (NAK),
the ADVIA Chemistry system sends EOT and terminates the processing.

Text Formats
The following text formats specify how workorder and result information are transmitted.
• batch-test query text
• test-query text
• test-selection instruction text (previous time No/previous time Yes)
• measurement-data text
Typically, this information requires more than one frame:
• termination code for intermediate frame = ETB (17H) + checksum + CR + LF
• termination code for last frame = ETX (03H) + checksum + CR + LF

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Batch-Test Query Text


The Batch-Test Query text is from the ADVIA system Order Entry Window.

Applicable communications Batch test registration


function
Communication direction ADVIA Chemistry system → Host Computer

Table 2-24 Batch Test Query Text (fixed length 41 bytes)

Data Test Bytes Code


Starting Code 1 STX
Frame number 1 1–7, 0
Text Classification 1 q (71H)
Equipment 1 Not used, space (20H)
identification
number
Total number of 2 01 (no zero suppression)
block
Block Number 2 01 (no zero suppression)
ID classification 1 0 (30H) Arbitrary sample ID, Barcode ID, Sequential ID
1 (31H) Sample Tray TT No. and cup position no.
2 (32H) Rack No. and number indicating position in rack
3 (33H) Independent hold No.
Initial Sample ID 13 The response to the ID classification (previous test) is:
Arbitrary-sample ID: Up to 13 alphanumeric characters,
no zero suppression, left-justified, 20H at the end
Barcode ID: Up to 13 alphanumeric characters, no zero
suppression, left-justified, 20H at the end and additonal
formatting described in Sample Number‚ page 2-16.
Sequential ID: Up to 9 digits, no zero suppression,
left-justified, 20H at the end
Sample Tray: Fixed-length, 5 digits, no zero
suppression, left-justified, 20H at the end
Rack No.: Fixed-length, 7 digits, no zero suppression,
left-justified, 20H at the end
Independent holder No.: Fixed-length, 4 digits, no zero
suppression, left-justified, 20H at the end

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Data Test Bytes Code


Final Sample ID 13 The response to the ID classification (previous test) is:
Arbitrary-sample ID: Up to 13 alphanumeric characters,
no zero suppression, left-justified, 20H at the end
Barcode ID: Up to 13 alphanumeric characters, no zero
suppression, left-justified, 20H at the end and additonal
formatting described in Sample Number‚ page 2-16.
Sequential ID: Up to 9 digits, no zero suppression,
left-justified, 20H at the end
Sample Tray: Fixed-length, 5 digits, no zero
suppression, left-justified, 20H at the end
Rack number: Fixed-length, 7 digits, no zero
suppression, left-justified, 20H at the end
Independent holder No.: Fixed-length, 4 digits, no zero
suppression, left-justified, 20H at the end
Spare 1 Not used (20H)
Termination code 5 (ETX or ETB) + checksum + CR + LF
Before communication is initiated, the following information is provided by the operator
using the Host request dialog box of the Order Entry window:
• The ID classification test indicates the method used to identify the starting sample ID
and the final sample.
• The starting sample ID and the final sample ID determine the range of workorders
being requested.
The ADVIA Chemistry system does not check for the order ID and the number of received
samples, relative to the test-selection instruction text of the host. In the case of
transmission without range designation, the ID positions for the initial and final samples
are blank spaces. When inspection without range designation is performed, both the blank
spaces and zeros should be taken into account.

Test Request Text


Test Request text comes from the ADVIA Chemistry system.
Table 2-25 Test Request Text

Applicable communication function Automatic test registration (Refer to


Automatic Test Registration Protocol‚
page 2-26)
Real test registration. (Refer to Real Test
Registration Protocol‚ page 2-28)
Communication direction ADVIA Chemistry system→ Host Computer

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Table 2-26 Test Request Text – Frame Size, Block Count


Maximum frame size Maximum number of blocks
256 bytes 5 blocks
512 bytes 3 blocks
Table 2-27 Test Request Text (first block to last block, variable length

Data Test Bytes Code


Starting code 1 STX
Frame number 1 1–7, 0
Text classification 1 Q (51H)
Equipment identification 1 Not used, space (20H)
number
Total number of blocks 2 01–05 (no zero suppression)
Block number 2 01–05 (no zero suppression)
Number of inquiry 2 01–99 (no zero suppression)
samples in a block
ID classification 1 0 (30H) Arbitrary sample ID, Barcode ID,
Sequential ID
1 (31H) Sample Tray TT No. and cup position
No.
2 (32H) Rack No. and number indicating
position in rack
3 (33H) Independent holder No.
Sample ID 13 byte The response to the ID classification (previous
xn * test) is:
Arbitrary-sample ID: Up to 13 alphanumeric
characters, no zero suppression, left-justified,
20H at the end
Barcode ID: Up to 13 alphanumeric characters,
no zero suppression, left-justified, 20H at the
end and additonal formatting described in
Sample Number‚ page 2-16.
Sequential ID: Up to 9 digits, no zero
suppression, left-justified, 20H at the end.
Sample Tray: Fixed-length, 5 digits, no zero
suppression, left-justified, 20H at the end
Rack No.: Fixed-length, 7 digits, no zero
suppression, left-justified, 20H at the end
Independent holder No.: Fixed-length, 4 digits,
no zero suppression, left-justified, 20H at the
end.
Spare 1 Not used (20H)
Termination code 5 (ETX or ETB) + checksum + CR + LF

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*
When the maximum frame size is 256 bytes, the maximum number of test is
n=18. The maximum number of samples inquired with one text is 84 samples
(Sample Tray) and 5 or 10 samples (rack).
When the maximum frame size is 512 bytes, the maximum number of tests is
n = 38. Quality control samples have no test inquiry.

Test-Selection Instruction Text


Two test-selection instruction texts are used, one with previous data and the other without
previous data. The number of tests for which a request can be made for one sample is 326.

Table 2-28 Test-selection Instruction Text – No Previous Value

Applicable communication function Batch test registration (Refer to Batch Test


Registration Protocol‚ page 2-24)
Automatic test registration (Refer to
Automatic Test Registration Protocol‚
page 2-26)
Real test registration. (Refer to Real Test
Registration Protocol‚ page 2-28)
Communication direction ADVIA Chemistry system← Host Computer

Table 2-29 Test-selection Instruction Text – No Previous Value – Frame Size, Block
Count
Maximum Frame size Maximum number blocks
256 bytes 7 blocks
512 bytes 3 blocks

Table 2-30 Test-selection Text – No Previous Value (first block, variable length)

Data Test Bytes Code


Starting code 1 STX
Frame number 1 1–7, 0
Text classification 1 O (4FH)
Equipment identification 1 Not used, space (20H)
number
Total number of blocks 2 01–07 (no zero suppression)
Block number 2 01 (no zero suppression)
Number of test in a block 2 001–099 (no zero suppression)
Sample classification 1 N (4EH) General Sample
I (49H) Interruption Sample

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Data Test Bytes Code


Registration data 1 0 (30H) New request. If a registered sample
workorder exists, it is overwritten.
1 (31H) Test addition, re-run. In case of an
unregistered sample, same as a new request.
2 (32H) No request. The system does not
perform registration.
3 (33H) Sample deletion.(Deletion of a
previously registered sample
Sample ID 13 Arbitrary-sample ID: Up to 13 alphanumeric
characters, no zero suppression, left-justified,
20H at the end.
Barcode ID: Up to 13 alphanumeric characters,
no zero suppression, left-justified, 20H at the
end and additonal formatting described in
Sample Number‚ page 2-16.
Sequential ID: Up to 9 digits, no zero
suppression, left-justified, 20H at the end.
Be sure to set unique sample numbers, even for
an order of position number designation.
Position Number 7 Filled with blank spaces when not used (20H).
Sample Tray: Fixed-length, 5 digits, no zero
suppression, left-justified, 20H at the end
Rack No.: Fixed-length, 7 digits, no zero
suppression, left-justified
Independent holder No.: Fixed-length, 4 digits,
no zero suppression, left-justified, 20H at the
end
Comment 1 16 ASCII or shift JIS. Filled with blank spaces
(20H) when not used
Comment 2 16 ASCII or shift JIS. Filled with blank spaces
(20H) when not used
Sex 1 M (4DH) Male or F (46H) Female. If not used,
set to M.
Age 3 Year=999 (right-justified). When not used, age is
always 0. Month=M99 (right-justified).
Week=W99 (right-justified). Date=D99
(right-justified).
Blood sampling data 8 YYYYMMDD Example: 19990229 Filled with
blank spaces (20H) when not used
Dilution coefficient 4 Format: 99.9 (right-justified): When not used, be
sure to insert Format: ^1.0 (^0.1–99.9). ^: blank
space
Sample classification 1 1 (31H) blood serum
2 (32H) urine
When not used, enter 1.

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Data Test Bytes Code


Container classification 1 1–9 When not used, enter 1.
Request Test (3+1) Test number 3 bytes, Format: 999
xn * (right-justified), 0 suppression
Sample volume and dilution determined via the
Analytical Parameters (Chemistry) window. One
byte M or D or U. Normally set to M.
M = Analytical conditions values.
D or U = Reanalysis condition values.
Spare 1 Not used (20H)
Termination code 5 (ETX or ETB) + checksum + CR + LF
*
When the maximum frame size is 256 bytes, the maximum number of tests is
n=41. When the maximum frame size is 512 bytes, the maximum number of test
is n=105.
Table 2-31 Test-selection Text – No Previous Value (2nd to last block, variable
length)

Data Test Bytes Code


Starting code 1 STX
Frame number 1 1–7, 0
Text classification 1 O (4FH)
Equipment identification 1 Not used, space (20H)
number
Total number of blocks 2 02–07 (no zero suppression)
Block number 2 02–07 (no zero suppression)
Number of test in a block 2 001–099 (no zero suppression)
Spare 2 Not used, space (20H)
Sample ID 13 Arbitrary-sample ID: Up to 13 alphanumeric
characters, no zero suppression, left-justified,
20H at the end.
NOTE: Although technically the system can
accept more than 13 characters, do not use more
than 13 because the system may misinterpret a
higher number of characters.
Barcode ID: Up to 13 alphanumeric characters,
no zero suppression, left-justified, 20H at the
end and additonal formatting described in
Sample Number‚ page 2-16.
Sequential ID: Up to 9 digits, no zero
suppression, left-justified, 20H at the end.
Be sure to set unique sample numbers, even for
an order of position number designation.

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Data Test Bytes Code


Position Number 7 Filled with blank spaces when not used (20H).
Sample Tray: Fixed-length, 5 digits, no zero
suppression, left-justified, 20H at the end
Rack No.: Fixed-length, 7 digits, no zero
suppression, left-justified
Independent holder No.: Fixed-length, 4 digits,
no zero suppression, left-justified, 20H at the
end
Request Test (3+1) x Test number 3 bytes, Format: 999
n* (right-justified), 0 suppression
Sample volume and dilution determined via the
Analytical Parameters (Chemistry) window. One
byte M or D or U. Normally set to M.
M = Analytical conditions values.
D or U = Reanalysis condition values.
Spare 1 Not used (20H)
Termination code 5 (ETX or ETB) + checksum + CR + LF
*
When the maximum frame size is 256 bytes, the maximum number of test is
n=54. When the maximum frame size is 512 bytes, the maximum number of tests
is n = 118.

Operational Notes
• If the ID is classified as a sample ID for a batch-test inquiry or a test inquiry,
set the sample ID in the test-selection instruction text, and leave the position
number unused (barcode operation or creation of worksheets using the
ADVIA Chemistry system).
• If the ID is classified as a Sample Tray ID or rack-number ID for a batch-test
inquiry or an test inquiry, set the position number to which the inquiry was
addressed, and also set the sample number to be controlled by the host in the
sample ID test (creation of worksheet using the host).
At the start of Sample Tray analysis, the sample classified as an interruption
sample (I) is analyzed first. The ADVIA Chemistry system also has a built-in
function to give priority to interruption samples for Sample Tray analysis.
When the samples are analyzed on the rack option or conveyor-belt system,
analysis begins sequentially as ordered regardless of that function. Any
interruption samples for these systems should be set on the Sample Tray.
• Registration data box
• 0 New Request
A new request is unconditionally registered as a new test selection. In case of
an already registered sample, its information is deleted and overwritten,
thereby erasing the analysis-result data. If you cannot judge whether it is a
new request or registered test on the host side, specify all of the tests in the
next box as 1 test addition, rerun.

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• 1 Test addition and rerun


If the sample is an unregistered sample, it is registered as a new request. If the sample
is a registered test, the information of the registered test and test selection order from
the host are subjected to the OR condition and then analyzed. If there is an order for an
analyzed test, the test is analyzed again under rerun conditions. If an order is an
un-inspected test, the test is analyzed under initial-inspection conditions.
• 2 No request
Applicable when there is no sample information is on the host side or no new order for
analysis exists. In this case, the request test box is omitted.
• 3 Sample deletion
Sample registration is normally deleted from the system. Use this box when deleting
orders by batch test registration from the host.
Table 2-32 Test-selection Instruction Text – Previous Value Exists

Applicable communication function Batch test registration (Refer to Batch Test


Registration Protocol‚ page 2-24)
Automatic test registration (Refer to
Automatic Test Registration Protocol‚
page 2-26)
Real test registration. (Refer to Real Test
Registration Protocol‚ page 2-28)
Communication direction ADVIA Chemistry system← Host Computer

Table 2-33 Test-selection Instruction – Previous Value Exists – Frame Size, Block
Count
Maximum Frame size Maximum number blocks
256 bytes 24 blocks
512 bytes 11 blocks

Table 2-34 Test-selection Text – Previous Value Exists (first block, variable length)

Data Test Bytes Code


Starting code 1 STX
Frame number 1 1–7, 0
Text classification 1 o (6FH), lowercase alphabetic o character
Equipment identification 1 Not used, space (20H)
number
Total number of blocks 2 01–24 (no zero suppression)
Block number 2 01 (no zero suppression)
Number of test in a block 3 001–099 (no zero suppression)

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Data Test Bytes Code


Sample classification 1 N (4EH) General Sample
I (49H) Interruption Sample
Registration data 1 0 (30H) New request. If a registered sample
workorder exists, it is overwritten.
1 (31H) Test addition, re-run. In case of an
unregistered sample, same as a new request.
2 (32H) No request. The system does not
perform registration.
3 (33H) Sample deletion. Deletion of a
previously registered sample.
Sample ID 13 Arbitrary-sample ID: Up to 13 alphanumeric
characters, no zero suppression, left-justified,
20H at the end.
Barcode ID: Up to 13 alphanumeric characters,
no zero suppression, left-justified, 20H at the
end and additonal formatting described in
Sample Number‚ page 2-16.
Sequential ID: Up to 9 digits, no zero
suppression, left-justified, 20H at the end.
Be sure to set unique sample numbers, even for
an order of position number designation.
Position Number 7 Filled with blank spaces when not used (20H).
Sample Tray: Fixed-length, 5 digits, no zero
suppression, left-justified, 20H at the end
Rack No.: Fixed-length, 7 digits, no zero
suppression, left-justified
Independent holder No.: Fixed-length, 4 digits,
no zero suppression, left-justified, 20H at the
end
Comment 1 16 ASCII or shift JIS. Filled with blank spaces
(20H) when not used
Comment 2 16 ASCII or shift JIS. Filled with blank spaces
(20H) when not used
Sex 1 M (4DH) Male or F (46H) Female. If not used,
set to M.
Age 3 Year=999 (right-justified). When not used, age is
always 0. Month=M99 (right-justified).
Week=W99 (right-justified). Date=D99
(right-justified).
Blood sampling data 8 YYYYMMDD Example: 20090229. Filled with
blank spaces (20H) when not used
Dilution coefficient 4 Format: 99.9 (right-justified): When not used, be
sure to insert Format: ^1.0 (^0.1–99.9). ^: blank
space

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Data Test Bytes Code


Sample classification 1 1 (31H) blood serum
2 (32H) urine
When not used, enter 1.
Container classification 1 1–9 When not used, enter 1.
Request Test (3+1+8 Test number 3 bytes, Format: 999
+3) (right-justified), 0 suppression
x n* Sample volume and dilution determined via the
Analytical Parameters (Chemistry) window. One
byte M or D or U. Normally set to M.
M = Analytical conditions values.
D or U = Reanalysis condition values.
Previous value: 8 bytes for 8-digits number
(including “-” sign) and floating decimal point,
right-justified†. Filled with blank spaces when
not in use.
Mark: 3 bytes. Refer to Mark (Result Flag)
Specifications‚ page 2-60
Spare 1 Not used (20H)
Termination code 5 (ETX or ETB) + checksum + CR + LF
*
When the maximum frame size is 256 bytes, the maximum number of tests is
n=41. When the maximum frame size is 512 bytes, the maximum number of test
is n=105.

Previous values are:
123.45 ® ^^123.45
-6.7 ® ^^^^-6.7
^: Blank space (20H)
Table 2-35 Test-selection Text – Previous Value Exists (2nd to last block, variable
length)

Data Test Bytes Code


Starting code 1 STX
Frame number 1 1–7, 0
Text classification 1 o (6FH), lowercase alphabetic o character
Equipment identification 1 Not used, space (20H)
number
Total number of blocks 2 02–24 (no zero suppression)
Block number 2 02–24 (no zero suppression)
Number of test in a block 2 001–099 (no zero suppression)
Spare 2 Not used, space (20H)

073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-45

Data Test Bytes Code


Sample ID 13 Arbitrary-sample ID: Up to 13 alphanumeric
characters, no zero suppression, left-justified,
20H at the end.
Barcode ID: Up to 13 alphanumeric characters,
no zero suppression, left-justified, 20H at the
end and additonal formatting described in
Sample Number‚ page 2-16.
Sequential ID: Up to 9 digits, no zero
suppression, left-justified, 20H at the end.
Be sure to set unique sample numbers, even for
an order of position number designation.
Position Number 7 Filled with blank spaces when not used (20H).
Sample Tray: Fixed-length, 5 digits, no zero
suppression, left-justified, 20H at the end
Rack No.: Fixed-length, 7 digits, no zero
suppression, left-justified
Independent holder No.: Fixed-length, 4 digits,
no zero suppression, left-justified, 20H at the
end
Request Test (3+1+8 Test number 3 bytes, Format: 999
+3) x (right-justified), 0 suppression
n* Sample volume and dilution determined via the
Analytical Parameters (Chemistry) window. One
byte M or D or U. Normally set to M.
M = Analytical conditions values.
D or U = Reanalysis condition values.
Previous value: 8 bytes for 8-digit number
(including “-” sign) and floating decimal point,
right-justified†. Filled with blank spaces when
not in use.
Mark: 3 bytes. Refer to Mark (Result Flag)
Specifications‚ page 2-60.
Spare 1 Not used (20H)
Termination code 5 (ETX or ETB) + checksum + CR + LF
*When the maximum frame size is 256 bytes, the maximum number of test is
n=11. When the maximum frame size is 512 bytes, the maximum number of tests
is n=28.
†Previous values are:
123.45 ® ^^123.45
-6.7 ® ^^^^-6.7
^: Blank space (20H)

Refer to Operational Notes‚ page 2-41 for information.

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Measurement Data Text


The Measurement Data text sends data such as Sample ID, Sample Classification,
comments to the host computer.
Table 2-36 Measurement Data Text (first block, variable length)

Applicable communication function Batch test registration (Refer to Batch Test


Registration Protocol‚ page 2-24)
Real test registration. (Refer to Real Test
Registration Protocol‚ page 2-28)
Communication direction ADVIA Chemistry system→ Host Computer

Table 2-37 Measurement Data Text – Frame Size, Block Count


Maximum Frame size Maximum number blocks
256 bytes 25 blocks
512 bytes 11 blocks

Table 2-38 Measurement Data Text (first block, variable length)

Data Test Bytes Code


Starting code 1 STX
Frame number 1 1–7, 0
Text classification 1 R (52H)
Equipment identification 1 Not used, space (20H)
number
Total number of blocks 2 01–25 (no zero suppression)
Block number 2 01 (no zero suppression)
Number of test in a block 3 001–099 (no zero suppression)
Inspection Date 8 YYYYMMDD Example: 20090229
Inspection Time 6 HHMMSS Example: (18:55:33) 185533
Sample classification 1 N (4EH) General Sample
C (43H) Control Sample*
I (49H) Interruption Sample
ID specification 1 0 (30H) New request. If a registered sample
(workorder) exists, it is overwritten.
1 (31H) Test addition, re-run. In case of an
unregistered sample, same as a new request.
2 (32H) Rack number. Not used.
3 (33H) Sample deletion. Deletion of a
previously registered sample.

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-47

Data Test Bytes Code


Sample ID 13 Arbitrary-sample ID: Up to 13 alphanumeric
characters, no zero suppression, left-justified,
20H at the end.
Barcode ID: Up to 13 alphanumeric characters,
no zero suppression, left-justified, 20H at the
end and additonal formatting described in
Sample Number‚ page 2-16.
Sequential ID: Up to 9 digits, no zero
suppression, left-justified, 20H at the end.
Be sure to set unique sample numbers, even for
an order of position number designation.
Position Number 7 Filled with blank spaces when not used (20H).
Sample Tray: Fixed-length, 5 digits, no zero
suppression, left-justified, 20H at the end†
Rack No.: Fixed-length, 7 digits, no zero
suppression, left-justified‡
Independent holder No.: Fixed-length, 4 digits,
no zero suppression, left-justified, 20H at the
end
Comment 1 16 ASCII or shift JIS. Filled with blank spaces
(20H) when not used
Comment 2§ 16 ASCII or shift JIS. Filled with blank spaces
(20H) when not used
Patient:
Rack No.: Fixed-length, 7 digits, no zero
suppression, left-justified#
Control: Fixed-length, 15 digits, control lot no.
information, left-justified, 20H at the end
Sex 1 M (4DH) Male or F (46H) Female. If not used,
set to M.
Age 3 Year=999 (right-justified). When not used, age is
always 0. Month=M99 (right-justified).
Week=W99 (right-justified). Date=D99
(right-justified).
Blood sampling data 8 YYYYMMDD Example: 20090229. Filled with
blank spaces (20H) when not used
Dilution coefficient 4 Format: 99.9 (right-justified): When not used,
insert Format: ^1.0 (^0.1–99.9). ^ : blank space
Sample classification 1 1 (31H) blood serum
2 (32H) urine
When not used, enter 1.
Container classification 1 1–9 When not used, enter 1.

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Data Test Bytes Code


Request Test (3+1+8 Test number 3 bytes, Format: 999
+3) (right-justified), 0 suppression
x n** Analysis condition: 1 byte M or D or U.
Normally set to M.
Previous value: 8 bytes for 8-digits number
(including “-” sign) and floating decimal point,
right-justified. Filled with blank spaces when not
in use.
Mark: 3 bytes. Refer to Mark (Result Flag)
Specifications‚ page 2-60
Spare 1 Not used (20H)
Termination code 5 (ETX or ETB) + checksum + CR + LF
*
Control Samples are sent with the sample classification and a unique alphanu-
meric ID assigned by the ADVIA Chemistry system. Control ID is 4 characters
(PA001 to PZ200), no zero suppression, left justified, 20H at end.

STT Position is stored here when [LIS-STT Position Transmit] is set to “1”.

RACK No. is stored here when [LIS-RACK Position Transmit] is set to “1”.
§
The Comment 2 field transmits quality control information to the
ADVIA CentraLink system. Refer to customer bulletin, Uploading Control Lot
Numbers and Expiration Dates to a Host Computer, PN 073D0270-01. In addition
to lot number and expiration date, there is an option to also include rack number
and position number.
#
RACK No. is stored here when [LIS-RACK Position Transmit] is set to “0”.
**
When the maximum frame size is 256 bytes, the maximum number of tests is
n=8. When the maximum frame size is 512 bytes, the maximum number of test is
n=21.

Table 2-39 Measurement Data Text (2nd to last block, variable length)

Data Test Bytes Code


Starting code 1 STX
Frame number 1 1–7, 0
Text classification 1 R (52H)
Equipment identification 1 Not used, space (20H)
number
Total number of blocks 2 02–25 (no zero suppression)
Block number 2 02–25 (no zero suppression)
Number of test in a block 3 001–099 (no zero suppression)
Inspection Date 8 YYYYMMDD Example: 20090229
Inspection Time 6 HHMMSS Example: (18:55:33) 185533
Sample classification 1 N (4EH) General Sample
C (43H) Control Sample
I (49H) Interruption Sample

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-49

Data Test Bytes Code


ID specification 1 0 (30H) New request. If a registered sample
workorder exists, it is overwritten.)
1 (31H) Test addition, re-run. In case of an
unregistered sample, same as a new request.
2 (32H) Rack number. Not used.
3 (33H) Sample deletion. Deletion of a
previously registered sample.
Sample ID 13 Arbitrary-sample ID: Up to 13 alphanumeric
characters, no zero suppression, left-justified,
20H at the end.
Barcode ID: Up to 13 alphanumeric characters,
no zero suppression, left-justified, 20H at the
end and additonal formatting described in
Sample Number‚ page 2-16.
Sequential ID: Up to 9 digits, no zero
suppression, left-justified, 20H at the end.
Set unique sample numbers, even for an order of
position number designation.
Position Number 7 Filled with blank spaces when not used (20H).
Sample Tray: Fixed-length, 5 digits, no zero
suppression, left-justified, 20H at the end*
Rack No.: Fixed-length, 7 digits, no zero
suppression, left-justified†
Independent holder No.: Fixed-length, 4 digits,
no zero suppression, left-justified, 20H at the
end.
Request Test (3+1+8 Test number 3 bytes, Format: 999
+3) (right-justified), 0 suppression
x n‡ Analysis condition: 1 byte M or D or U.
Normally set to M.
Previous value: 8 bytes for 8-digits number
(including “-” sign) and floating decimal point,
right-justified§. Filled with blank spaces when
not in use.
Mark: 3 bytes. Refer to Mark (Result Flag)
Specifications‚ page 2-60
Spare 1 Not used (20H)
Termination code 5 (ETX or ETB) + checksum + CR + LF
*STT Position is stored here when [LIS-STT Position Transmit] is set to “1”.
†RACK No. is stored here when [LIS-RACK Position Transmit] is set to “1”.
‡When the maximum frame size is 256 bytes, the maximum number of tests is
n=8. When the maximum frame size is 512 bytes, the maximum number of tests
is n=21.

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§
Results formats are:
123.45→ ^^123.45
-6.7 → ^^^^-6.7
Overflow→ ////////
^: Blank space (20H)

Tests that are set to output qualitative measurement data are:


• Each of the tests is fixed at 8 characters in length. Up to 6 characters are used for
analysis-condition settings and they are right-justified. The first 2 characters are used
for spaces. Setting 3 two-byte characters is possible, and in this case, SHIFT JIS codes
are output.
• The position-number box of the sample that was subjected to barcode analysis using a
sample ID is invalid.

Table 2-40 Measurement Data Text – New Format Version 1

Applicable communication function Batch test registration (Refer to Batch Test


Registration Protocol‚ page 2-24)
Real test registration. (Refer to Real Test
Registration Protocol‚ page 2-28)
Communication direction ADVIA Chemistry system→ Host Computer

Table 2-41 Measurement Data Text – New Format Version 1 – Frame Size, Block
Count
Maximum Frame size Maximum number blocks
256 bytes 8 blocks
512 bytes 21 blocks

Table 2-42 Measurement Data Text New Format Version 1 (first block, variable
length)

Data Test Bytes Code


Starting code 1 STX
Frame number 1 1–7, 0
Text classification 1 R (52H)
Equipment identification 1 Not used, space (20H)
number
Total number of blocks 2 01–25
Block number 2 01 (no zero suppression)
Number of test in a block 3 001–099 (no zero suppression)
Inspection Date 8 YYYYMMDD Example: 20090229
Inspection Time 6 HHMMSS Example: (18:55:33) 185533

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Data Test Bytes Code


Sample classification 1 N (4EH) General Sample
C (43H) Control Sample*
I (49H) Interruption Sample
ID specification 1 0 (30H) If a registered sample workorder exists,
it is overwritten.
1 (31H) Test addition, re-run. In case of an
unregistered sample, same as a new request.
2 (32H) Rack number. Not used.
3 (33H) Sample deletion. Deletion of a
previously registered sample.
Sample ID 13 Arbitrary-sample ID: Up to 13 alphanumeric
characters, no zero suppression, left-justified,
20H at the end.
Barcode ID: Up to 13 alphanumeric characters,
no zero suppression, left-justified, 20H at the
end and additonal formatting described in
Sample Number‚ page 2-16.
Sequential ID: Up to 9 digits, no zero
suppression, left-justified, 20H at the end.
Set unique sample numbers, even for an order of
position number designation.
Position Number 7 Filled with blank spaces when not used (20H).
Sample Tray (STT): Fixed-length, 5 digits, no
zero suppression, left-justified, 20H at the end†
Rack No.: Fixed-length, 7 digits, no zero
suppression, left-justified‡
Independent holder No.: Fixed-length, 4 digits,
no zero suppression, left-justified, 20H at the
end.
Comment 1 16 ASCII or shift JIS. Filled with blank spaces
(20H) when not used
Comment 2§ 16 ASCII or shift JIS. Filled with blank spaces
(20H) when not used
Patient:
Rack No.: Fixed-length, 7 digits, no zero
suppression, left-justified#
Control: Fixed-length, 15 digits, control lot no.
information, left-justified, 20H at the end
Sex 1 M (4DH) Male or F (46H) Female. If not used, set
to M.
Age 3 Year=999 (right-justified). When not used, age is
always 0. Month=M99 (right-justified).
Week=W99 (right-justified). Date=D99
(right-justified).

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Data Test Bytes Code


Blood sampling data 8 YYYYMMDD Example: 20090229. Filled with
blank spaces (20H) when not used
Dilution coefficient 4 Format: 99.9 (right-justified): When not used,
insert Format: ^1.0 (^0.1–99.9). ^ : blank space
Sample classification 1 1 (31H) blood serum
2 (32H) urine
When not used, enter 1.
Container classification 1 1–9 When not used, enter 1.
Request Test ((3+1+ Test number 3 bytes, Format: 999
8+3)+ (right-justified), 0 suppression
(1+3)) Analysis condition: 1 byte M or D or U.
x n** Normally set to M.
Previous value: 8 bytes for 8-digits number
(including “-” sign) and floating decimal point,
right-justified. Filled with blank spaces when not
in use.
Mark: 3 bytes. Refer to Mark (Result Flag)
Specifications‚ page 2-60
Mark: 1 byte. When the user manually enters the
measurement, an E sends in this position.
User code: 3 bytes. This code is sent for each
measurement value.
Spare 1 Not used (20H)
Termination code 5 (ETX or ETB) + checksum + CR + LF
*
Control Samples are sent with the sample classification and a unique alphanu-
meric ID assigned by the ADVIA chemistry system. Control ID: 4 characters
(PA001 to PZ200), no zero suppression, left justified, 20H at end.

STT Position is stored here when [LIS-STT Position Transmit] is set to “1”.

RACK No. is stored here when [LIS-RACK Position Transmit] is set to “1”.
§
The Comment 2 field transmits quality control information to the
ADVIA CentraLink system. Refer to customer bulletin, Uploading Control Lot
Numbers and Expiration Dates to a Host Computer, PN 073D0270-01. In addition
to lot number and expiration date, there is an option to also include rack number
and position number.
#
RACK No. is stored here when [LIS-RACK Position Transmit] is set to “0”.
**
When the maximum frame size is 256 bytes, the maximum number of tests is
n=8. When the maximum frame size is 512 bytes, the maximum number of test is
n=21.
Table 2-43 Measurement Data Text New Format Version 1 (2nd to last block,
variable length)

Data Test Bytes Code


Starting code 1 STX
Frame number 1 1–7, 0

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-53

Data Test Bytes Code


Text classification 1 R (52H)
Equipment identification 1 Not used, space (20H)
number
Total number of blocks 2 02–25 (no zero suppression)
Block number 2 02–25 (no zero suppression)
Number of test in a block 3 001–099 (no zero suppression)
Inspection Date 8 YYYYMMDD Example: 20090229
Inspection Time 6 HHMMSS Example: (18:55:33) 185533
Sample classification 1 N (4EH) General Sample
C (43H) Control Sample
I (49H) Interruption Sample
ID specification 1 0 (30H) New request. If a registered sample
workorder exists, it is overwritten.
1 (31H) Test addition, re-run. In case of an
unregistered sample, same as a new request.
2 (32H) Rack number. Not used.
3 (33H) Sample deletion. Deletion of a
previously registered sample.
Sample ID 13 Arbitrary-sample ID: Up to 13 alphanumeric
characters, no zero suppression, left-justified,
20H at the end.
Barcode ID: Up to 13 alphanumeric characters,
no zero suppression, left-justified, 20H at the
end and additonal formatting described in
Sample Number‚ page 2-16.
Sequential ID: Up to 9 digits, no zero
suppression, left-justified, 20H at the end.
Set unique sample numbers, even for an order of
position number designation.
Position Number 7 Filled with blank spaces when not used (20H).
Sample Tray (STT): Fixed-length, 5 digits, no
zero suppression, left-justified, 20H at the end*
Rack No.: Fixed-length, 7 digits, no zero
suppression, left-justified†
Independent holder No.: Fixed-length, 4 digits,
no zero suppression, left-justified, 20H at the
end.

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Data Test Bytes Code


Request Test ((3+1+ Test number 3 bytes, Format: 999
8+3)+ (right-justified), 0 suppression
(1+3)) Analysis condition: 1 byte M or D or U.
x n‡ Normally set to M.
Previous value: 8 bytes for 8-digits number
(including “-” sign) and floating decimal point,
right-justified§. Filled with blank spaces when
not in use.
Mark: 3 bytes. Refer to Mark (Result Flag)
Specifications‚ page 2-60
Mark: 1 byte. When the user manually enters the
measurement, an E sends in this position.
User code: 3 bytes. This code is sent for each
measurement value.
Spare 1 Not used (20H)
Termination code 5 (ETX or ETB) + checksum + CR + LF
*
STT Position is stored here when [LIS-STT Position Transmit] is set to “1”.

RACK No. is stored here when [LIS-RACK Position Transmit] is set to “1”.

When the maximum frame size is 256 bytes, the maximum number of tests is
n=8. When the maximum frame size is 512 bytes, the maximum number of test is
n=21.
§
Results formats are:
123.45→ ^^123.45
-6.7 → ^^^^-6.7
Overflow→ ////////
^: Blank space (20H)

Tests that are set to output qualitative measurement data are as follows:
• Each of the tests is fixed at 8 characters in length. Up to 6 characters are used for
analysis-condition settings and they are right-justified. The first 2 characters are used
for spaces. Setting 3 two-byte characters is possible, and in this case, SHIFT JIS codes
are output.
• The position-number box of the sample that was subjected to barcode analysis using a
sample ID is invalid.

Measurement Data Text Comment (LIS Result-Format Control Parameter)

If you select New: Version 1 in the Online Settings window, the system parameter, LIS
Result-Format-Control, enables you to choose the format of the Measurement Data Text
Comment 2 field. The settings are:

0 Full Lot Number (LLLLLLLLLL/yymm)


1 Six-digit Lot (LLLLLL/yyyymmdd)

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The lot number is alphanumeric. The date is independent of locale settings. The
year (yy) and month (mm) in the Full Lot Number Format is the control expiration
date. It indicates that the control expires on the last day of the month. (The 2-digit
year field considers the value 00 as the year 2000.)
The lot number transmission size is 10 characters. This is equivalent to the
maximum number of input characters available to the operator in the Ctrl/Cal Set
screen.
NOTE: If the system parameter is set to a value of 1, limited control lot number
information transmits, creating a potential safety hazard.
The 6-digit Lot is the default setting. It indicates the existing ADVIA Chemistry
software six-digit lot number transmission format.

Measurement Data Text – Comment 2 Format

The following table indicates the expected field transmission of Comment 2 field
of Measurement Data Text for Lot Number and Expiration Date information
extracted from the analyzer Ctrl/Cal Setup screen for the two defined formats.
The Comment 2 field is a maximum of 16-characters. The ^ character indicates
that the operator pressed the space-bar on the keyboard to create a space character
(20H). The ^ character in the LIS Transmission column below indicates a space
character in the transmission field.
A No-entry indicates that the operator did not input a value into the field.
Table 2-44 Measurement Data Text Comment 2 Field

Lot # Expiration Date Format 0 Format 1


1234567890 Sept 1, 2007 1234567890/0709^ 567890/20070901^
123 Oct 12, 2009 123^^^^^^^/0910^ 123/20091012^^^^
891 No entry 891^^^^^^^/^^^^^ 891/^^^^^^^^^^^^
2^48 Aug 05, 2009 2^48^^^^^^/0908^ 2^48/20090805^^^
^^9 Aug 05, 2009 ^^9^^^^^^^/0908^ ^^9/20090805^^^^
^^^^^^^016 Aug 05, 2009 ^^^^^^^016/0908^ ^^^016/20090805^
No entry Aug 05, 2009 ^^^^^^^^^^/0908^ /20090805^^^^^^^
No entry No entry ^^^^^^^^^^/^^^^^ /^^^^^^^^^^^^^^^

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Additional Online Settings


This section describes new settings and system parameters. Selecting New Version 1 in the
Online Settings window, provides additional features and settings.

Online Monitor
The ADVIA system Online Monitor screen includes a listing of the online data
transmissions between the analyzer and the LIS. Each transmission entry begins as a
separate line in the log. Each line of the log includes:
• A date and time stamp displays the time the message is sent or received by the
instrument (The format is the short date format: mmddyy hhmmss. The format can be
a 12-hour clock or 24-hour clock.)
• An S to indicate a transmission sent from the analyzer or an R to indicate a
transmission received by the analyzer.
The Online Monitor screen automatically updates with new LIS Transmission data during
Host On conditions.
Pressing the Refresh button refreshes the contents of the online monitor screen.
If the transmission data includes a space character (20H), it displays in the Online Monitor
screen as the ASCII character ^ (5E H).
Table 2-45 Display of Space Character Data

05/25/2008 09:59:00 AM S:<ENQ>


05/25/2008 10:00:02 AM R:<ACK>
05/25/2008 10:00:04 AM S:<STX>1R010101120080515B9S91^^^^^^^^^^^^^^^^^^^^^^
^^^^^^M^^020070516^1.011^44 M////////C^^^53M ^^^^^^44H
^^^56M^^^^^^76^^^^40M^^^^^3.4^^^^20M113L^^^36M^^^^
^^15^^^^97M////////C^^ 101M^^^3.579^^^121M^^^281.1 ^^^
122M ^^^^-5.2^^^123M
05/25/2008 12:01:06 PM <ACK>

Online Monitor Data automatically saves to a file. Each time you open the software and
perform a New Start, a file is created reflecting the Online Monitor transmission data. It
begins at the time in which the previous New start was performed and ending at the time in
which the New Start was just executed. The file also sent to RTS in order to complete the
RTS requirement. The parameter, LIS: Keep Online Monitor File (days), can be 7 to 30
days. The default is 7 days.
A new folder is in the existing C:\A002 directory called Log\LIS. This folder contains up
to 7 files reflecting the 7 most recent Online Monitor transmission data files. There is not a
restriction on the size of each file and files are handled FIFO.
The filename format is sys#-MMDDYY-XXZZ.txt. MMDDYY indicates the current
system date; XX indicates a value, enabling the file name to be unique.

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The first file saved for a given day uses 01 as an identifier. The second file saved
on that same day uses 02 as an identifier, and so on. ZZ specifies the internal
sequence of the log files.

Printing the LIS monitor Log

To print the entire log file:


1. Select Print.
2. Select Print again.
NOTE: The entire contents of the log are printed to the printer connected to your
system. Printing the LIS monitor log may require a large amount of paper.
To print a subset of the log:
1. Select the section of the data you want to capture using the mouse.
2. Right click and select print.

Opening an LIS log file

Use this procedure to open an existing LIS log file. The file default name is
formatted as sys*yymmdd-xxxx.txt.
1. Select File>Open
2. Select the log file, then select Open.

Clearing the LIS monitor log

Use this procedure to clear the log. The log is archived for future inspection.
1. Select All Clear.
NOTE: All Clear archives, without erasing, existing data.

Refreshing the LIS monitor log

Use this procedure to update the log display. The log is not real-time, so you must
perform a Refresh to display any new data.
1. Select Refresh.
The latest data is updated to the window.

Communication Error Handling


A system parameter, xxx, enables handling of error conditions: enable or disable.
When the error condition occurs, analyzer communication either:
• Remain enabled, in the Host On status condition;
• Set to disabled, in the Host Off status condition.

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2-58 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

When an error condition occurs, a message posts in the alarm log and an event notification
sends to the LIS.
The error messages are listed in the message file called: SFYONLIN.msg. The behavior of
the system when each of these errors occurs can be customized by setting the appropriate
settings in the file sfyerr.txt. These files are located in the C:\A002\ETC folder. Once the
file sfyerr.txt has been located, it can be modified by the following procedure:
1. Create a backup of the file by copying it to a temporary folder and renaming it
sftyerr_bak.txt.
2. Open the file in Notepad or WordPad.
3. Find the error number causing the system to stop or that turns off the host.
4. Change the L that follows the error number to a 0 (zero) and remove the # symbol, to
avoid stopping the system.
5. Select File, then Save.
6. Close Notepad or WordPad.
7. Close Explorer, then shut down and restart the computer.

Invalid Test Code Processing


The ADVIA Chemistry software processes all valid test codes for a workorder. If an order
transmits from the LIS with an invalid test code, then an entry is added to the Alarm log.
The balance of the requested tests with valid test codes will complete processing.

Query Response Timeout


If you select New: Version 1 in the Online Settings window, you can set these values:
• Time-out: Automatic Test Selection
• Time-out Real Test Selection
• Time-out: Between Frames
• Error Sample Skip Number (Request)
• Error Sample Skip (Result Trs)

Time-out: Automatic Test Selection

The Time-out: Automatic Test Selection field is a variable in calculating the total amount
of time allocated for execution of workorder query for a sample located on the onboard
sample tray. The field input range is 0.0–1800.0 seconds. If you attempt to input a value
outside the allowable range, the system prompts you to enter a value between 0.0 and
1800.0. After you move from this field, the input value is displays as a real number with at
least one integer digit, and one decimal digit.

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-59

Time-out: Real Test Selection

The Time-out: Real Test Selection field is a variable in calculating the total
amount of time allocated for execution of workorder query for a sample located
on an external device. The field input range is 0.0–1800.0 seconds. If you attempt
to input a value outside the allowable range, the system prompts you to enter a
value between 0.0 and 1800.0. After you move from this field, the input value is
displays as a real number with at least one integer digit, and one decimal digit.

Time-out: Between Frames

The Time-out: Between Frames field is a range of 0.0–5.0 seconds. If you attempt
to input a value outside the allowable range, the system prompts you to enter a
value between 0.0 and 5.0. After you move from this field, the input value
displays as a real number with at least one integer digit, and one decimal digit.

Error Sample Skip Number (Request)

The Error Sample Skip Number (Request) field is a range of 0–3. The input value
displays as an integer. If you attempt to input a value outside the allowable range,
the system prompts you to enter a value between 0 and 3.

Error Sample Skip Number (Result Trs.)

The Error Sample Skip Number (Result Trs.) is a range of 0–3. The input value
displays as an integer. If you attempt to input a value outside the allowable range,
the system prompts you to enter a value between 0 and 3.

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2-60 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

Mark (Result Flag) Specifications


A mark or result flag is 3 bytes consisting of: judgment, status, and rerun. Each mark or
result flag is 1 byte.
Table 2-46 ADVIA 1800 System Mark (Result Flag) Specifications

Status (second byte)


Judgment Rerun
(first byte) Photometric Flag Electrolyte Flag (third byte)
Original
Receive
Send Orig Rcv Snd Orig Rcv Snd

C Calibration S Safety error s Insufficient R Rerun value


not possible Sample
L, H Abnormal s Insufficient S Safety error Space first run
value limit sample value
l, h Normal r Insufficient u Selectivity
value limit reagent abnormal
Space No mark t Insufficient * CAL
(flag) diluted allowable
liquid value
A S Clot error B Liquid
remaining in
dilution cup
M S Mix error r Insufficient
reagent
Q S Liquid T Abnormal
sensor error thermistor
G S Crash I ID error
F S Reaction d Dilution
bath times error
temper-
ature limit
K Maximum
absorbance
limit—
check
flagging
j Calibration
range (H)
k Calibration
range (L)
c S Calibration A S Clot error
mismatch

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-61

Status (second byte)


Judgment Rerun
(first byte) Photometric Flag Electrolyte Flag (third byte)
Original
Receive
Send Orig Rcv Snd Orig Rcv Snd

u Light Q S Liquid Level


absorption abnormal
limit
d Light G S Probe crash
absorption
limit
U Light No mark
absorption (flag)
limit
D Light
absorption
limit
P Prozone
* Dispersion
abnorm-
ality
n Abnormal
number of
effective
points
N Cell-blank
abnorm-
ality
SP No mark
(flag)
In Table 2-47, the higher the position in the mark or result flag, the higher degree
of priority.
Table 2-47 Mark (Result Flag) Specifications for ADVIA 1800 Version 1

Status (second byte)


Judgment Rerun
(first byte) Photometric Flag Electrolyte Flag (third byte)
C Calibration s Insufficient s Insufficient R Rerun
not possible sample Sample value
L, H Abnormal t Insufficient S Safety error Space first run
value limit dilutent value
liquid

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2-62 ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity

Status (second byte)


Judgment Rerun
(first byte) Photometric Flag Electrolyte Flag (third byte)
l, h Normal S Safety error B Liquid
value limit remaining in
dilution cup
Space No mark r Insufficient T Abnormal
(flag) reagent Thermistor
u, d Light r Insufficient
absorption reagent
limit
P Prozone u Selectivity
limit abnormal
* Dispersion * CAL
abnorm- allowable
ality value
n Abnormal Space No mark
number of (flag)
effective
points
N Cell-blank
abnorm-
ality
U, D Light
absorption
limit
Space No mark
(flag)

Current Test Current Test Type


4th byte Status (5th byte) (6th byte) ReXmit (7th byte)
E Manually 1 1 Initial 0 No Xmit
enter Request
measurement Initial Reflex
value Request
SP No mark 2 2 Rerun of 1 ReXmit
initial Result flag
Rerun of
Initial Reflex
Request
3 SP
4
5

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ADVIA 1800 Chemistry System Interface Specification Guide: LIS Connectivity 2-63

Current Test Current Test Type


4th byte Status (5th byte) (6th byte) ReXmit (7th byte)
6
Space No mark
(flag)

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073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-1

3 LAS System

The Laboratory Automation System (LAS) is any external transport system, such
as the ADVIA LabCell system or the rack handler, which is connected to an
ADVIA 1800 Chemistry system. In this documentation, external transport
systems will be referred to using the generic term LAS.
The chemistry system must meet the following to operate with an LAS:
• The system is configured to run in LAS mode (Refer to Setting Up the
Chemistry System for LAS Operation‚ page 3-6). In the LAS mode, the system
expects the LAS to supply samples.
• You can interrupt an LAS run for interrupt analysis, re-analysis, calibration, or
quality control from the sample tube tray/control tube tray (STT/CTT). You
return to the LAS mode after the interrupt samples are processed.
• As with a normal run, you must enter in the system all relevant information
pertaining to an LAS run, including methods, workorders, container types,
and other settings. Refer to the Operator’s Guide for your analyzer for further
instructions.
The system must have the correct hardware and software components installed,
including the LAS signal interface box (PN 073-0344-02). The ADVIA 1800
Chemistry system uses either a serial/parallel connection or TCP/IP connection.
For more information on connecting the system using a serial connection, refer to
Serial Communication Interface Specifications‚ page 3-66. For more information
on connecting the system using a TCP/IP connection, refer to TCP/IP
Communication Interface Specifications‚ page 3-25.

A Note on NAK/NACK

The terms NAK and NACK both mean “negative ACK” and are used
interchangeably in this document. There are four parameters associated with this
message. The table below lists its use in different scenarios.
Table 3-1 Chemistry System Operation Modes

LAS sends to instrument Instrument response


NAK (1) Sends Reset Communication and closes the sockets
NAK (2) resend Resends message for the number of times set in
“Retry Count,” then resets communication.

If this is during Startup sequence, sends Reset


Communication immediately and resets the
communication.
NAK (3) unsupported message Sends Reset Communication and closes the sockets

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-2

LAS sends to instrument Instrument response


NAK (4) busy Resends the message after the time specified in
“NACK (busy) retry timeout” elapses.

If this is during Startup sequence, sends Reset


Communication immediately and resets the
communication.
Message with unsupported Sends Reset Communication and closes the sockets
message type field
Corrupt message or message Please refer to “NACK Send Case” sheet in this file
with bad Seq ID for Corrupt Message.

If Seq ID in ACK is a bad one, sends Reset


Communication and closes the sockets
LAS does not send the ACK or Waits for ACK until the time specified in “Response
NACK message Timeout” elapses. Then sends Reset Communication
and resets the communication

Operating Modes of a Chemistry System


The sections below and Table 3-2 describe the system setup configuration. The
LAS configuration includes connectivity to a host computer.
• Host Computer: At the Operation Panel, select HOST ON to establish or
HOST OFF to end communications with a host computer.
To establish host connectivity you must also enter settings in the following
windows: System Specifications Settings, System Monitor, and Online
Settings. (See Communication Between the System, a LAS, and the Host
Computer‚ page 3-3 for a typical setup.)
• Host Query: You can configure the system to query the host computer for
workorders using the following steps:
a. At the Menu Panel, select Setup.
b. At the Setup window, select Online Settings.
The Online Settings window displays.
c. For Real Test Select, select Yes.

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-3

Real Test Select indicates samples that are introduced to the system via
Automation (track) system or URH. When Real Test Select is Yes, and
the system cannot find workorders locally, the system queries the host
computer for workorders. Whether or not the system queries the host
computer, it does not analyze samples that do not have workorders.
• Host Transfer Method: You can configure the system to transfer result data
automatically as it becomes available, or you can manually transfer data in
batch at the Review/Edit window.
• Sampling Source: The system aspirates a sample either from the sample tray
(STT/CTT) or from the aspiration position of the LAS. This depends on the
Sample delivery setting at the System Specifications Settings window.
• As shown in Table 3-2, not all host transfer methods are available for a given
sampling source.
• Sample Container Identifier: If the sampling source is the STT, the system
identifies samples by tray position number or by barcode, depending on
settings in the Order Entry or Start Conditions window. LAS samples are
always identified by a barcode.
Table 3-2 Chemistry System Operation Modes

Host Sample
Host Transfer Sampling Container
Computer Host Query Method Source Identifier
ON YES Real LAS Barcode
Auto STT Barcode
Tray position
NO Batch LAS Barcode
STT Barcode
Tray position
OFF --- --- LAS Barcode
STT Barcode
Tray position

Communication Between the System, a LAS, and the


Host Computer
This section describes how information is exchanged between the system, the
LAS, and the host computer.
The test code (TP for total protein, for example) in the host computer must match
the test code in the system.

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-4

Although the sequence of events below involves the LAS, communications


between the system and the host computer do not change if an LAS is not
connected.
• At startup, the LAS communications protocol, which enables communication
between the system and the LAS, acknowledges that the system and the LAS
are ready to communicate with each other.
For detailed information on communications specifications, see LAS Interface
Panel‚ page 3-68 and Signal Communications During Operation‚ page 3-71.
• The LAS reads the barcode on the sample and sends the sample’s barcode
number, which is known as the pre-read sample ID, to the system. The sample
has not yet arrived at the aspiration position.
• The system sends a request to the host computer for the workorder associated
with the sample. The system also checks itself for an existing workorder
associated with the sample. The host sends the workorder to the system. If the
system already has a workorder associated with the sample, this will be
overwritten by a new workorder coming from the host. This process occurs
only if the system is configured for host query mode at the Online Settings
window.
• After the sample arrives at the aspiration position, the LAS transmits a request
to the system to aspirate the sample.
• The system responds by sending a request to the LAS for the barcode number
of the sample currently at the aspiration position.
• The LAS responds by sending the barcode number, which is known as the
Sampling Sample ID Number.
• When the system confirms that the barcode number is valid and a workorder
exists for it, it aspirates the sample.
• After aspiration, the system transmits a signal to the LAS that aspiration is
complete.
• The system begins analyzing the sample. The LAS moves the next sample to
the aspirate position.
• After the system analyzes the sample, it sends the result data to the host
computer.

Configuring the Chemistry System for


Communication with the Host Computer
This section describes how to configure the system to exchange data with the host
computer.
Configure the ADVIA 1800 Chemistry system for communication with the host:
1. At the Menu Panel, select Setup.
2. At the Setup window, select Online Setup.
The Online Settings window displays.

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-5

Figure 3-1 Online Settings window

3. Enter the test settings at the Online Settings window:


a. At the Online Settings window, select Set Test.
Refer to Figure 3-1.
b. Select the BATCH check box and the REAL check box for each test in use.
You can also select the Qual check box for qualitative results.
c. Verify that each number entered in each Test field matches the test
numbers entered in the host computer. The Test field can have up to 3
alphanumeric characters.
NOTE: If you enter a number in the Test field, insert spaces to the left of the
number to right justify the number in the field. If “b” is a blank, entering “b10”
will be read as a ten whereas entering “10b” will be read as a hundred. For an
example, see Figure 2-4, Page 2-5.

4. Reset the system:


NOTE: In this step you also verify On-Line settings.
a. At the Menu Panel, select Setup.
b. At the Setup window, select System Specification Settings.
The System Specification Settings window displays.
c. Under System Basic Configuration, verify that On-Line is set to Avail.
d. Select System(s) in the upper left corner of the window to reset the
system PC.
e. At the Startup window, select New Start.

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-6

f. Wait for the reset to complete.


g. At the Operation Panel, select HOST ON.

Using the Sample Tray in LAS Mode


While the system is in LAS mode, an operator can use the tube tray (STT/CTT) to
process the following types of interrupt samples:
• Interrupt samples
• Reruns
• Calibrators
• Controls
• Samples that the LAS is unable to handle. (For example, samples the LAS
barcode reader cannot identify.)
Table 3-3 illustrates where each sample type is placed for each analysis mode.
Table 3-3 Sample Placement for Sample Types

Sample Type LAS Mode Normal Mode


General LAS STT
Interrupt STT STT
Calibrator STT or CTT, depending upon STT or CTT, depending
the calibration upon the calibration
Control CTT CTT
Interrupt STT STT
Rerun STT STT
Undefined STT Not applicable

Setting Up the Chemistry System for LAS Operation


NOTE: Only authorized Siemens service personnel should change the system
settings. Contact your authorized technical support provider before changing the
settings.

Enter the Basic System Specification Settings


1. At the Menu Panel, select Setup.

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-7

2. At the Setup window, select System Specification Settings.


The System Specification Settings window displays.

Figure 3-2 System Basic Configuration Setup for LAS Mode

3. Under System Basic Configuration, make the following selections:


a. For Sample delivery, select External transport.
b. For Number of rack, select 1.
c. For Sample bar code, select Avail.
When you have finished, the System Basic Configuration area should display
as shown in Figure 3-2.
NOTE: To retain the rerun function, under Basic System Operation Mode, select
DTT retest for Auto retest.
4. Select Save.
The System Specification Settings dialog box displays.
5. Select Yes.

Re-start the System


1. At the system, set the Operate/Standby switch to STANDBY.
2. Shut down the system software and power off the PC.
3. Turn on the PC, then turn on the system, and set the Operate/Standby switch
to OPERATE.
4. At the Start window, select New Start.
5. Select OK.
6. At the Menu, select System(s).
7. Select Password.

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-8

8. Log on with manager level user ID.

Enter the Pre-Operation Setting


1. At the Menu panel, select Maint.
2. At the Maintenance Window, select System Monitor.
The System Monitor window displays.
3. Select External Transport in Sample delivery.
4. Under Pre-operation set, for Labo. Auto-Sys. / Rack Handler, select Operate.
5. Select Save.

Figure 3-3 Pre-operation Set Area of the System Monitor Window

Enter the System Parameter Settings for TCP/IP


If you are using serial connectivity refer to Enter the System Parameter Settings
for Serial Connectivity‚ page 3-14.
1. At the Menu Panel, select Setup.
2. At the Setup window, select System Parameter Settings.
The System Parameter Settings window displays. Refer to Figure 3-4.

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-9

3. From the drop-down list at the top of the System Parameter Settings window,
select LAS.

Figure 3-4 System Parameters Settings

4. For each parameter listed in the table, the Value field should already be
populated with the parameter’s default value. Confirm that the value is
correct, or enter an alternative value based on the parameter’s Description
field shown in Table 3-4.
The system parameter settings must appear in the System Parameter Settings
window before you run the system in the Rack Handler/LAS mode. Ensure
you select Controller from the list.
NOTE: To navigate to the parameter numbers listed in Table 3-4, use the
navigation buttons at the bottom of the System Parameter Settings window.
NOTE: The following Parameter Numbers are general parameters that are
common to both Table 3-4 on page 10 and Table 3-5 on page 15. Default
values and descriptions for these parameters should be common to both
tables:
119
169
510
546

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-10

Table 3-4 TCP System Parameter Settings for LAS

Parameter Default
Number Parameter value Description
119 HNREADY signal 1 Displays the system action when the
OFF processing LAS READY signal turns OFF during
an LAS sample run on the system
when the system has no workorders
associated with that sample. In all
cases, sample is not aspirated.
0–Ignore
1–Warning (default setting)
2–Warning and STOP
3–Warning and WAIT
510 DPP limit point in 143 The total distance from the conveyor
Rack position belt to the bottom of the probe tip.
Enter 143 as the default value. After
you have completed Procedure D,
enter the correct value.
546 DPP no diluent 1.0000 Coefficient for calculating DPP
aspiration aspiration volume. For Japanese
adjustment value market only. Leave at 1.0000.
281 Communication 1 0: Old (Parallel/Serial)
Protocol 1: New (TCP-IP)
155 LAS←→WS 20003 Socket Port number
Socket Port No
282 CPU →LAS 20004 Socket Port Number
Socket Port No
283 LAS → CPU 20005 Socket Port Number
Socket Port No
284 Response Time 2000 Range is 1–3000 msec
Out
285 Network Character 3000 Range is 1–3000 msec
Timeout
286 Conversation 30 1–3600 seconds
Timeout
287 NACK retry count 3 0–3
288 NACK (busy) retry 2000 50–3000 msec
timeout
156 Handshake 260 NOTE: The default value of 260 is
Protocol Version converted to the hex value of 10004
and this is the value that LAS
receives.
157 Handshake 1 The numeric value of the system.
Instrument Type 1: ADVIA Chemistry

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-11

Parameter Default
Number Parameter value Description
158 Handshake 10000 Version number. If version number is
Capability Version V1.00.00, enter numerics only without
decimals and commas.
159 Handshake Version number. If version number is
Software Version V1.00.00, enter numerics only without
decimals and commas.
160 Handshake 255 Set by LAS system.
Instrument ID
291 Checksum use 1 0: Do not Use
1: Use
292 Checksum 1 0: small character
Alphabet Type 1: large character
294 LAS-KP Message 30 1–3600 seconds
Send Rate
295 LAS-KP Message 1 0: KP Log Off
Log 1: KP Log On
296 LAS-KP Send 1 0: Do not use
Option 1: Use
297 LAS-STT Sample 0 0: Do not use
Interaction 1: Use
Complete send
167 LAS Request 1 0: On
Sample 1: Off
168 Request Sample 300 1–3600 seconds
retry time
170 LAS Alarm 1 0: Disable
Message Send 1: Warning and Fatal
2: Fatal only
171 The Preservation 7 0–60 days
days of the Log
224 LAS Sample Log 1 0: No (Old LAS format)
Communications 1: Yes (New LAS format)
123 LAS First sample 30 0–999 seconds
waiting time In LAS mode, the waiting time
between the start of the system and the
arrival of the first sample from the
LAS. If the sample does not arrive at
the end of the set time, the system
changes to WATCH mode.

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-12

Parameter Default
Number Parameter value Description
124 LAS Next sample 30 0–999 seconds
waiting time In LAS mode, the waiting time
between the aspiration of a sample and
the arrival of the next sample from the
LAS. If the sample does not arrive at
the end of the set time, the system
changes to WATCH mode.
132 LAS Max dummy 300 1–9999 cycles. 1 cycle equals 3
cycle seconds.
The waiting cycles the system remains
in HOLD SHIFT after conveyor 4 is
filled and sampling is suspended.
System goes to STOP state when the
cycle count is exceeded. LC = 9999.
135 LAS Signal 2 LAS communication protocols:
Specification 0–V1.40 (6-second cycle)
1–V2.02 (No CRC check, 3-second
cycle)
2–V2.02 (Yes CRC check, 3-second
cycle)
136 LAS E Message 0 (Yes) 0: Yes (Sending error messages)
sending 1: No (No error messages sent)
Indicates whether the LAS can receive
error messages (E) from the
ADVIA 1800 system in the
LAS-to-chemistry system.
137 LAS No Order 1 or 2 The action taken if a sample arrives
Item Processing from the LAS to the system and the
system has no workorders associated
with that sample. In all cases, sample
is not aspirated.
0–Ignore (default setting)
1–Log (record logged in error report)
2–Warning (record logged and
warning generated)
3–Warning and STOP (record logged,
warning generated, and system
changes to the STOP mode)
(Options 1, 2 or 3 generate a 6200
E002 alarm)
140 LAS Receive 3 System action on receiving a 6200
Message error error with an E006–E008 reason.

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-13

Parameter Default
Number Parameter value Description
300 Processing: 1 0: Ignore
AddTube recv 1: Warning
when ADVIA is
not ready.
301 Processing mode: 0 0: Ignore
AddTube when 1: Warning
LAS is OFFLINE
302 Processing mode: 0 0: Ignore
Index Queue 1: Warning
Response (0x2) 2: Fatal
received
303 Processing mode: 0 0: Ignore
Index Queue 1: Warning
Response (0x3) 2: Fatal
received
304 Processing mode: 0 0: Ignore
Index Queue 1: Warning
Response (0x4) 2: Fatal
received
305 Processing mode: 0 0: Ignore
Index Queue 1: Warning
Response (0x5) 2: Fatal
received
306 Processing mode: 1 0: Ignore
SMPINT 1: Warning
CompleteRes 2: Fatal
(0x2) received
307 Processing 1 0: Ignore
SkipTube param 1: Warning
(SampleID) 2: Fatal
doesn’t exist
308 Processing 1 0: Ignore
SkipTube param 1: Warning
(SampleID) is 2: Fatal
NULL
309 Processing Mode: 0 0: Ignore
NACK (0x01) 1: Warning
received 2: Fatal
310 Processing Mode: 0 0: Ignore
NACK (0x02) 1: Warning
received 2: Fatal
311 Processing Mode: 0 0: Ignore
NACK (0x03) 1: Warning
received 2: Fatal

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-14

Parameter Default
Number Parameter value Description
312 Processing Mode: 0 0: Ignore
NACK (0x04) 1: Warning
received 2: Fatal
83 Reagent Low 10 10% is typical. The range is 1–99 per
Warning Level cent.
135 LAS Signal 2 LAS communication protocols:
Specification 0–V1.40 (6-second cycle)
1–V2.02 (No CRC check, 3-second
cycle)
2–V2.02 (Yes CRC check, 3-second
cycle)
136 LAS E Message 0 (Yes) Indicates whether the LAS can receive
sending error messages (E) from the
ADVIA 1800 system in the
LAS-to-chemistry system serial
communication.
169 LAS E message 0 0 is typical (no delay time). The range
delay time is 1–999 msec.
227 LAS R test Alarm 3 3 is typical entry for this field. Ranges
are:
0: Ignore
1: Log
2: Warning
3: Warning and Stop
4: Warning and Wait

Enter the System Parameter Settings for Serial Connectivity


1. At the Menu Panel, select Setup.
2. At the Setup window, select System Parameter Settings.
The System Parameter Settings window displays. Refer to Figure 3-4.
3. From the list at the top of the System Parameter Settings window, select
Controller.

4. Enter the value shown in Table 3-5 for each parameter number listed.
Table 3-5 contains the descriptions of the system parameter settings that you
must enter before you run the system in the Rack Handler/LAS mode. Ensure
you select Controller from the list.
NOTE: To navigate to the parameter numbers listed in Table 3-5, use the
navigation buttons at the bottom of the System Parameter Settings window.

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Table 3-5 LAS Controller Settings on the System Parameter Settings


Window

Parameter Default
Number Parameter value Description
119 HNREADY signal 1 Displays the system action when the
OFF processing LAS READY signal turns OFF during
an LAS sample run on the system
when the system has no workorders
associated with that sample. In all
cases, sample is not aspirated.
0–Ignore
1–Warning (default setting)
2–Warning and STOP
3–Warning and WAIT
123 LAS first sample 30 (sec.) In LAS mode, the waiting time
waiting time between the start of the system and the
arrival of the first sample from the
LAS. If the sample does not arrive at
the end of the set time, the system
changes to WATCH mode.
124 LAS next sample 30 (sec.) In LAS mode, the waiting time
waiting time between the aspiration of a sample and
the arrival of the next sample from the
LAS. If the sample does not arrive at
the end of the set time, the system
changes to WATCH mode.
132 LAS max dummy 300 The waiting cycles the system remains
cycle (cycles in HOLD SHIFT after conveyor 4 is
where filled and sampling is suspended.
1cyl = System goes to STOP state when the
3s) cycle count is exceeded. LC = 9999.
135 LAS Signal 2 LAS communication protocols:
Specification 0–V1.40 (6-second cycle)
1–V2.02 (No CRC check, 3-second
cycle)
2–V2.02 (Yes CRC check, 3-second
cycle)
136 LAS E Message 0 (Yes) Indicates whether the LAS can receive
sending error messages (E) from the ADVIA
1800 system in the LAS-to-chemistry
system serial communication. Refer to
the LAS signal specifications for
details.

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Parameter Default
Number Parameter value Description
137 LAS No Order 1 or 2 The action taken if a sample arrives
Item Processing from the LAS to the system and the
system has no workorders associated
with that sample. In all cases, sample
is not aspirated.
0–Ignore (default setting)
1–Log (record logged in error report)
2–Warning (record logged and
warning generated)
3–Warning and STOP (record logged,
warning generated, and system
changes to the STOP mode)
(Options 1, 2, or 3 generate a 6200
E002 alarm)
140 LAS Receive 3 System action on receiving a 6200
Message error error with an E006 - E008 reason.
510 DPP limit point in 143 The total distance from the conveyor
Rack position belt to the bottom of the probe tip.
Enter 143 as the default value. After
you have completed Procedure D,
enter the correct value.
546 DPP no diluent 1.0000 Coefficient for calculating DPP
aspiration aspiration volume. For Japanese
adjustment value market only. Leave at 1.0000.
5. At the System Parameter Settings window, select Controller2 from the list.
6. Enter the settings as shown in Table 3-6.
Table 3-6 LAS Controller2 Settings on the System Parameter Settings
Window

Parameter Default
Number Parameter value Description
169 LAS E message 0 0: Typical (no delay time)
delay time 1 <-> 999 (msec)
173 DPP LLS Check 7 This value includes the LLS bias value
Sensitivity Setting (at the wash station) added to the LLS
Reference value (LLS value in air).
This value must be exceeded to trip
the level sensing circuit while the
probe level sense is checked at the
wash station (lower the value to
increase sensitivity).
174 RPP1 LIS check 7 The same as the description for
Sensitivity Setting Parameter Number 173.

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Parameter Default
Number Parameter value Description
175 RPP2 LIS check 7 The same as the description for
Sensitivity Setting Parameter Number 173.

Defining the Container Types


The following procedure explains how to set up the container types for rack
handler sample tubes. Defining container types allows the system to lower the
DPP into a sample tube without damaging the probe.
NOTE: Because the aspiration positions for the rack handler and the sample tray
may be at different heights, you must define each container type separately in each
sampling mode, LAS, or STT. That is, if the same container is used on the rack
handler and the sample tray, you must define it as two different container types,
one for LAS and one for STT. Also, if a container is not specified with the host
workorder, the system defaults to container set #1.
Figure 3-5 shows two possible container types: a vial and a tube with an insert
cup.
1. Refer to the Working with the Software, Setup Menu, System Specification Set
window, and the Sample containers sections of the Operator's Guide.
NOTE: If multiple container types are used and the host is not capable of
downloading all the container types to the system, you must define a
composite sample container in container type 1 using the smallest diameter
(D1) container and the largest h1 and the smallest h3 height dimensions.
Please make sure that the operator understands that this is now the default
definition for container set #1.
2. To obtain the container heights, h1, h2, and h3, measure each height as
follows.
• h1 is the height from the conveyor belt to the top of the container (D1).
• h2 is the height from the conveyor belt to the point where the container
shape changes (D2).
• h3 is the height from the conveyor belt to the bottom of the sample
container (D3).
NOTE: If you are using a sample tube without an insert cup, h3 is 26 mm.

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Figure 3-5 Height measurements to set up container types

3. At the Menu Panel, select Setup.


4. At the Setup window, select System Specification Settings.
The System Specification Settings window displays.
5. Under Sample Container Specifications, enter the appropriate container
settings based on the container heights determined during step 2.
6. Select Save.
7. Select Exit.
8. At the Menu Panel, select System(S).
9. Select Version Info(A).
The Version Information window appears.
10. In the System Version text box, the System Version must be 3.30e or higher.

Operation
This section describes the basic operating procedures for an ADVIA 1800
Chemistry system equipped with an LAS. These procedures assume that you have
configured the system to run in LAS mode.

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Starting the System


Use this procedure to start the system, after it is configured for LAS mode.
1. Start the host computer, if needed.
2. Start the LAS.
3. Start the Chemistry System.
See Chemistry System Start Sequence (LAS)‚ page 3-19.

Shutting Down the System


1. Shut down the Chemistry System.
See Chemistry System End Sequence (LAS)‚ page 3-20.
2. Shut down the LAS.
3. Shut down the host computer, if needed.

Running a Sample
To run a sample, refer to the ADVIA 1800 Chemistry System Operator’s Guide.

Chemistry System Start Sequence (LAS)


1. Start the system workstation.
In a few seconds, the Startup window displays.
2. On the system, set the Operate/Standby switch to OPERATE.
3. In the Startup window, select New Start or Re-start.
4. Select OK.
5. When the Operating Mode becomes WAIT, select INITIALIZE.
When the system is initialized, the operating mode is READY.
6. If a host computer is used, confirm that HOST ON displays in the Operating
Mode window.
Select HOST ON if needed.
This indicates the system is communicating with the host computer.
Be sure the host computer is started before you start the system. If the system
is started first, select HOST OFF, start the host, then select HOST ON.
7. Select PRINT ON.
NOTE: This option is only available in older versions of the software.
8. Make sure the printer is online.
9. At the System Monitor window, verify that:
a. Labo.Auto-Sys is set to Operate.

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See Figure 3-3.


If not, change the setting and restart the system.
b. Verify that no abnormalities exist (all operating conditions display with an
OK status).
c. If you observe any alarms, check the Error Report for further instructions.
At the Operation Panel, select ALARM to display the Error Report.
10. Perform the normal startup tasks, including PRIME, WASH, calibration, and
control.
Seethe ADVIA 1800 Operator’s Guide for more information on the daily
startup routine.
11. To start a run:
a. Select START.
b. Place a check mark on Analyze, for outside analyze.
The system is now ready to run in LAS mode.

Chemistry System End Sequence (LAS)


When you have completed running samples in LAS mode (including all interrupt
samples processed from the STT while the system is paused), use the following
procedure to end the sequence. (The Operation Panel displays WATCH. This is the
normal operating mode while LAS samples are processing.)
1. At the Operation Panel, select STOP.
The operating mode becomes STOP, indicating that communications with the
LAS are being stopped. In a few seconds, the operating mode becomes
READY.
2. After the system displays READY mode, perform the normal shutdown tasks,
such as a WASH2.
See the ADVIA 1800 Operator’s Guide for more information on the daily
shutdown routine.
3. At the Menu Panel, make the following selections:
a. Select System.
b. Select Exit.
The confirmation dialog box displays.
c. Select Yes to confirm that you want to exit.
d. When prompted again, select Yes.
4. At the Startup window, select Shutdown.
NOTE: Wait until you are prompted before shutting down the system PC.
5. On the system power panel, set the Operate/Standby switch to STANDBY.
6. Shut down the system PC.

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Running Routine Analysis in LAS Mode


Running samples from the LAS is similar to running samples from the STT. The
major differences are as follows:
• You load LAS samples after starting a run. While in normal mode, you load
the STT before starting the run.
• You only run patient samples from the LAS (calibrators and controls are run
from the sample tray).
• The DPP aspirates the sample from the aspiration position of the LAS, rather
than that of the STT.
• The 1 mL sample cups cannot be used on the LAS. The 1 mL cups can shift
during transfer to the aspiration position and possibly damage the DPP.

CAUTION
Do not use the 1 mL cups on the LAS. The cups can shift
during transfer to the aspiration position and possibly
damage the DPP.

After you start the LAS, run the samples as described in this procedure:
1. At the Operation Panel, select Start.
NOTE: The General smp. Analyze option is only available if the System
Specifications Settings window is set correctly.
2. At the Start Conditions window, select General smp. Analyze.
3. Select Start.
If needed, you can run calibrators, controls, and patient samples from the STT
at the same time.
After you select Start, the operating mode changes to START.
Cuvette washes are run and the reagent probes aspirate reagent. The operating
mode changes from START to HOLD.
If the system cannot communicate with the LAS, the operating mode returns
to READY. Correct the problem and restart the run. Any error messages
display in the ALARM message box in the Operation Panel.
4. Place the sample tubes in the appropriate position in the LAS.
Ensure each tube has its barcode label positioned so that the barcode reader
can read it.
The chemistry system performs the following actions:
• The barcode reader reads the labels on each sample, then sends the
barcode numbers to the system. The system locates the workorder
associated with the barcode.

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• The system waits for the sample to arrive from the LAS. If a sample with
a barcode number received by the system does not arrive within time
settings specified in the System Parameter Settings window (see
parameter #123 on Page 3-15), the system goes into WATCH mode.
• After the LAS transports the sample to the aspiration position, the DPP
aspirates the sample. The diluted sample is dispensed into the DTT for
analysis. The barcode number displays in the Operation Panel.
• The liquid level sensor in the DPP uses the sample container settings
selected for this run to instruct the DPP how far into the container it must
go to aspirate the sample.
• If any abnormalities occur while an LAS sample is processing, the run
stops and the operating mode changes to STOP. Rerun the sample being
analyzed (as an interrupt sample), then restart the run (after the operating
mode returns to READY) to reconnect to the LAS and resume sampling.
Any error messages display in the ALARM message box in the Operation
Panel.
5. When all LAS samples are processed, at the Operation Panel, select Stop.
The operating mode changes to STOP, and then to READY.

Running Interrupt Samples and re-analysis in LAS


Mode
You run Interrupt and re-analysis samples (STT) from the sample tray, not the
LAS. You also use the STT to run samples whose barcodes could not be read by
the LAS barcode reader.
Normally you run with DTT re-analysis, which uses the sample already dispensed
into a DTT cuvette. You set up a DTT re-analysis at the System Specification
Settings window. You can also run an STT re-analysis, in which new sample is
aspirated from the STT.
1. If a workorder for the interrupt sample does not exist in the host computer,
create one at the Order Entry window (as you would for samples run in
normal mode).
Be sure to perform the following actions:
a. Include the barcode number or (for a sample without a barcode) a unique
sample number.
b. Specify the container type, if you do not use the type specified in the Cup/
Tube Assign window.

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You can also specify the container type in the Temp Cup/Tube Assign
window.

Figure 3-6 Order Entry window

2. At the Operation Panel, select Pause.


The LAS run stops temporarily, as indicated by the operating mode changing
from either WATCH or START to PAUSE, and the load status indicator
changing to SMP LOAD OK.
NOTE: Make sure the Operation Panel displays PAUSE before you proceed.
3. Confirm that the LAS run is paused.
4. Process the interrupt samples.
You should resume the LAS run after processing the interrupt samples.
5. If Auto.restest at the System Specification Settings window is not set to DTT,
retest the sample and then place the samples on the STT.
6. If you are running the interrupt samples in cup position mode, be sure to place
them in the tray positions assigned to them in the workorder.
7. In the Operation Panel, select Start.

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8. At the Start Conditions window, in the Ordinary sample section, select the
Routine smp. Analyze check box, and then select the appropriate options
(barcode or tray position mode).

Figure 3-7 Start Conditions Window (interrupt samples)

NOTE: Use the Temp Cup/Tube Assign window to select a container type, if
needed.
9. Select Start to begin the interrupt analysis.
10. Confirm barcode information in the Sample Confirmation window (if the
workorder comes from the host, for example, you may have to type the
barcode for that sample), then select OK to begin the run.

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TCP/IP Communication Interface Specifications


This section provides the specifications for connecting the instrument and the
LAS via TCP/IP interface.
The communication is through a client-server setup.

Connecting the TCP/IP Ethernet Cables


Figure 3-8 shows an example of connecting the system using hubs and ethernet
cables. Your site configuration may vary.

Figure 3-8 LAS Ethernet Connections

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TCP/IP Communications
The TCP/IP (socket) communications uses 100BASE-T. The TCP/IP ports for the
LAS and Instrument communications are:
LAS to ADVIA system 2 Ports (Transmit and Receive)
LAS to PC 1 Port (Full Duplex Transmit and Receive)
(instrument workstation)
ADVIA to PC 3 Ports (1 Transmit and 2 Receive)

The system automatically recovers lost TCP/IP connections and enables the
external interface. If the connection to the LAS is lost, the system waits for Reset
Queue command to clear the queue of any pending samples.
LAS must monitor all three socket connections. If any one of them disconnect, the
connections on all sockets must be closed and a reconnect and handshake
attempted.
If all three socket connections are lost, a safety error is recorded in the Alarm Log.
The message indicates an auto recovery in process. At the end of the recovery
process, another safety error is logged with a message describing the success or
failure of the recovery attempt.
Each ADVIA system has a fixed (static) IP address. This IP address is assigned by
Siemens. You do not need to configure software on the hub (or switch). The IP
addresses are:
LAS 128.1.91.25
Workstation PC 128.1.91.26 assigned to port 20003
Line 1/2 128.1.91.27 assigned to ports 20004 (send) and 20005
(receive)

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An illustration of a system setup is shown in Figure 3-9.

Figure 3-9 LAS Communications Settings

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ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-28

Figure 3-10 TCP/IP Communication Relationships Between the


Chemistry System, LAS, and Host Computer

Connection (Refer to
Figure 3-10) Signal Direction Data exchanged
1 Host → LAS Sample Information
2 Host → System Sample Information
System → Host Analysis Results
3 LAS ←→ System Sample ID, sampling
(bidirectional) communications

The responsibility of the LAS-to-system connections is that of the LAS. An


example of the responsibility is shown in Figure 3-11.

Figure 3-11 LAS Responsibility with TCP/IP Connectivity

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Setting the Workstation Parameters


NOTE: The PC image should already have the correct settings, in which case this
section may be skipped.
1. Start Network settings on the workstation PC.
2. Scroll to Internet Protocol TCP/IP connections.
3. Select Properties. The Properties window displays.
4. Select Use the Following IP address.
5. Enter the IP address for this workstation.
Enter the DNS address:
1. Select Use the following DNS server address:
2. Type your preferred DNS IP address.

Testing the Connectivity

Line Master PC to Computer Interface

Ping both LAS and the analyzer from the workstation.


1. At the Start > Run menu, type CMD and press Enter.
2. Type ping and then the IP address of the analyzer, and press Enter.
3. ping the LAS name, and press Enter.
In each case, the response should return a reply from each IP address. If the ping
command times out, check that you have entered the correct name and computer
interface information.

Additional Notes on TCP/IP Communication


The tables and figures in this section provide additional information about support
messages and communication flows essential to the LAS.

ADVIA Support Messages


The following table lists all message types and shows which are supported in this
release of the ADVIA 1800 system.
Table 3-7 ADVIA Support Messages

Message WS WS Instr. Instr.


Type Message from LAS Receive Send Receive Send
NOTE: Y means supported; N means unsupported
0x0001 Handshake Y Y Y Y
0x0003 Reset Communication Y Y Y Y

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Message WS WS Instr. Instr.


Type Message from LAS Receive Send Receive Send
0x0005 Keep Alive Y Y Y Y
0x0007 Shutdown Y Y N N
0x0201 System Status request Y N N N
NOTE: When establishing communication with the instrument, ensure
that the instrument is not performing any actions (e.g., barcode scanning,
initializing, transitioning from READY to START mode). It is
recommended that the instrument be in a WAIT or a READY state. See
“System Status response” for explanation.
0x0202 System Status response N Y N N
NOTE: If the system is performing an action, it cannot respond to a
System Status request until it has completed performing the task.
Instead, it will send the last known status as soon as possible.
0x0301 Consumable Inventory Y N N N
request
0x0302 Consumable Composition N Y N N
Request
0x0303 Test Inventory request Y N N N
0x0304 Test Inventory response N Y N N
0x0305 Test Map request Y N N N
0x0306 Test Map response N Y N N
0x0307 Consumable Composition Y N N N
request
0x0308 Consumble Composition N Y N N
response
0x0501 Emergency Stop N N Y Y
Notification
0x0502 Emergency Stop response N N Y Y
0x0601 Sample queue request N N Y N
0x0602 Sample queue response N N N Y
0x0603 Reset sample queue request N N Y N
0x0604 Reset sample queue N N N Y
response
0x0605 Add tube request N N Y N
0x0606 Add tube response N N N Y
0x0607 Skip tube request N N Y N
0x0608 Skip tube response N N N Y
0x060A Index queue request N N N Y
0x060B Index queue response N N Y N

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Message WS WS Instr. Instr.


Type Message from LAS Receive Send Receive Send
0x060E Sample interaction N N N Y
complete response
0x060F Sample interaction N N Y N
complete response
0x0611 Request sample N Y N N
0x0612 Request sample response Y N N N
0x0801 Event notification N N N N
0x0A01 Message channel N N N N
registration request
0x0A02 Message channel N N N N
registration response
0x0A03 Message channel mode N N N Y
control

Communication Flow
The diagram on the following page, which is annotated in Table 3-8, shows the
LAS communication flows.

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Figure 3-12 LAS TCP/IP Communication Flows (callout numbers refer


to the table that follows)

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Table 3-8 Notes on LAS TCP/IP Communication Flow Diagram (above)


Callout
No. Description
1 Handshake can be initiated by both sides. Handshake will be done to WS
and CPU (Line 1) lines. All responses and ACKs for messages sent to Line
1 will be from CPU (Line 2).
2 At initialization, all startup messages will be exchanged from the
instrument to LAS.
3 Keep alive is sent by instrument when no message has been received or sent
for x time--x being defined by System Parameter 294. The keep alive
message is sent from WS and CPU.
4 Skip Tube Request will be sent with Sample ID of tube to be skipped. In
this case, the instrument should send the Skip Tube Response instead of an
Index Queue Request.
NOTE: For ADVIA WorkCell™/LabCell system, skip tubes will use the
#2 option, above.
5 The mode control is used during sampling time—an estimated 1100 ms per
aspiration for ADVIA 1800. ACK for Mode Control Blocked will be sent
from LAS to CPU (Line 2) and then no other communication is allowed to
the CPU until the Mode Control Active message.
EXCEPTION: Emergency Stop Notification can be sent by both sides
during blocking and will be ACK’d. It is also possible that the Reset Queue
Response may be sent by the instrument after the Mode Control Blocked
message has been sent.
6 NAK (Busy) will be used by the instrument until an Index Queue Request
has been issued by the instrument. There is a ceiling of up to 150 ms
between Mode Control Active messages and the Index Queue Request
message.
NOTE: The NAK (Busy) response is not supported when it is sent from
the LAS to the instrument.
7 LAS must not send any Add Tube commands from the time the Mode
Control Blocked message is sent until the Index Queue Request message is
sent by the instrument. Tubes can be diverted and Add Tube messages can
be buffered during this time. After the Index Queue Request message is
received, if many Add Tube messages need to be sent, then LAS must send
them in groups of up to 10 messages and then wait for 100 ms before
sending more. This is done to ensure that system performance is not
negatively affected by a big burst of messages.
NOTE: The same logic applies to any request type message from LAS
(e.g., System Status Request or Reagent Inventory Request).
NOTE: E-Stop is allowed to be sent at any time, regardless of Mode
Control status.

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NOTE: It is possible to receive a System Status message while the instrument is


sampling (i.e., between Mode Control Blocked and Mode Control Active
messages). The LAS must not move the sample under aspiration until the Index
Queue Request is sent by the instrument to indicate that the tube can be moved.
(See NOTE regarding Probe Status on Page 3-42.)
In the case of an E-Stop message from the LAS to the instrument, if LAS wants to
move the tube, it must request the System Status in order to determine the probe
position before moving the tube at that time.

Universal Router Analyzer Protocol Interactions


The following figure illustrates hardware interactions in the Siemens Universal
Router Analyzer Protocol (uRAP).

Figure 3-13 uRAP Interaction Diagram

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TCP/IP Messages
The Siemens Universal Router Analyzer Protocol (uRAP) protocol is the
communication link between sample tube transportation system and sample
analyzers. This protocol lays out a common message format, arrays of standard
messages, and the means to expand the basic set to meet specific needs. The
protocol can be implemented in part or entirety. For more information about the
uRAP protocol, contact your authorized Siemens support provider.
The following sections provide information about the specific messages used by
an ADVIA Chemistry system.
The communications between the LAS and the system are arranged in these
message type categories:
• Communication Setup Messages
• System Status Messages
• Instrument Inventory Messages
• Instrument Busyness Messages
• Event Notification Messages
• Emergency Recovery Messages
• Point in Space Sample Sharing Messages
• Sample Tube Sharing Messages
The general message format is header, message, and footer. Refer to Table 3-9 for
the format details.
A message acknowledgement is sent upon each message received. The header
includes a Return Sequence ID that matches the acknowledgement to the original
message.
If the check sum code is not correct, a negative acknowledgement (NAK) returns
to the requestor. If the requestor receives a NAK three times in a series, it is Reset.
(LAS ADVIA line and LAS-PC line separately count the Reset.)

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Table 3-9 General Message Format

Data Size
Parameter Type (Byte) Description
Header Start Signature Binary 1 <STX> 02h
Message Length Binary 2 Number of bytes of the entire
message including the header
and footer. It does not include
the transport header and footer,
although Signature bytes are
included.
Sequence ID Binary 2 0x0001–0xFFFF and return to
0x0001
Return Sequence ID 0x0000 is
reserved.
Return Sequence Binary 2 0x0001–0xFFFF on a response
ID message. Response Message
value is the sequence ID of
requested message.
0x000 is an unsolicited message.
Message Type Binary 2 Unique identifier of the type of
the type of communications
between the LAS and the
system. There are eight
categories, listed on Page 3-35
and defined in Table 3-9. The
value range is 0x0001–0x0901.
Time Stamp Binary 8 This is a custom format:
Year (3 digits) 000–255
(000=2000)
Month 01–12
Day 00–31
Hour 00 –24
Minute 00–59
Second 00–59
Millisecond 000–999
Instrument ID Binary 1 ID is determined after
handshake.
Message Message Type determines this content
Footer Checksum ASCII 2 The algorithm is a binary sum. It
is formatted as the ASCII
representation of its
hexadecimal value (modulo
256) in two digits.
End Signature Binary 1 <ETX> 03h

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Startup Sequence
These messages are sent to the LAS at system startup or anytime communications
are interrupted and reestablished:
NOTE: Reset communication may not be sent every time, but all the other
messages will always be sent or exchanged.
• Reset communication
• Handshake
• Test map
• Consumable Composition
• Consumable Inventory
• Test Inventory
• Reset Sample Queue
NOTE:Reset Sample Queue is the only message in this sequence that has a
request as well as a response.
• Instrument Status
Descriptions of these messages are in their respective message sections.

Communication Setup Message Types


The communication setup message type range is 0x0001 – 0x00FF.
These messages include:
• Handshake
• Reset Communication
• Keep Alive
• Shutdown

Handshake
The Handshake message is sent at the initial startup and any time the
communication is interrupted between the LAS and the instrument. This message
indicates that a successful connection is established between the system and the
LAS.
Heading Protocol Instrument Capability Software Instrument F Instrument Footer
Version Type Version Version ID L Serial
(2 bytes) (2 Bytes) (2 Bytes) (2 Bytes) (1 Byte) Number
(n Bytes)

Table 3-10 Handshake Parameters

Message Number
Information of Bytes Message Details
Message Direction – Bidirectional

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Message Number
Information of Bytes Message Details
Message type – 0x0001
Protocol Version 2 “Default value” field is pre-populated with a
two-byte hex representation of the correct
version number.
Instrument Type 2 The number corresponding to the instrument
type. For example, 01=ADVIA Chemistry.
Capability Version 2 Describes the subset of the message types in
the protocol. Uses the same format as the
protocol version. Numbering begins at 1 and
increments by 1.
Software Version 2 Same version as the instrument software.
During handshake, this information is filled
in by the instrument handshake message and
reflected back by the sample transportation
system. If the sample transportation system
initiates the handshake, the data is 0xFF. For
example, V04.01.01 => in handshake =
04101
Instrument ID 1 ID is 0xFF at start up and setup by LAS to a
new number used by all future messages
(variable number of bytes).
FL 1 Length of next field.
Instrument Serial variable Defined in System Parameter Settings. It is
Number used for instrument verification.
NOTE: The display and format of the instrument software version number is
aa.bb.cc. The values of the fields are:
aa is 0−60
bb is 0−9
cc is 0−99

Reset Communication Message


Header Footer

Message Direction Bidirectional


Message Type 0x0003

The instrument sends a Reset message in the event of a communications error. A


header and footer are sent to verify. Fields are not sent.
NOTE: A Reset command may not be sent in cases where the system disconnects
the communication socket because it has detected a problem in communication
(e.g., the NACK count has been exceeded).

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Keep Alive Message


Header Footer

Message Direction Bidirectional


Message Type 0x0005

A keep alive message transmits from the LAS to the system to maintain an active
connection during periods of idleness and to prevent the circuit from timing out
and terminating the connection. After a signal is sent, if no reply is received the
link is assumed to be down. If LAS sends a keep alive message to the instrument,
the instrument returns an ACK to the LAS. (A header and footer are sent to verify.
Fields are not sent.)
The keep alive message does not interrupt the constant communication flow
between the instrument and the LAS. If you disable external sampling, the keep
alive message continues to be sent to the LAS system.
NOTE: This does not apply to “Point in Space Sample Sharing” messages, but
does apply to all other types of messages.
A keep alive signal is sent at predefined intervals. The time interval is set in the
LAS system settings in the LAS-KP Message Send Rate parameter. The send rate
can be 5 to 60 seconds. The system default is 10 seconds.
The keep alive messages sent from the LAS and from the instrument are recorded
in the LAS monitor.
You can track keep alive messages by using the LAS-KP Message Log parameter
in the LAS system settings. The default value is 0, which disables the tracking
capability. To track the keep alive message history, change the LAS-KP Message
Log parameter to 1.
In addition to the interval parameter, and the logging parameter, there is a third
keep alive parameter which turns keep alive messaging on or off. You must have a
manager or supervisor security level to modify any of these system settings.

Shutdown Message
Header Footer

Message Direction Bidirectional


Message Type 0x0007

This shutdown message is sent to the LAS when the software is shut down on the
workstation PC. (A header and footer are sent to verify. Fields are not sent.) This
shutdown message can be received from the LAS at any time.

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System Status Message Types


The System Status Message type range is 0x0201–0x02FF.
The system status message provides a general or detailed status of the system to
the LAS. The System Status messages are:
• System Status Request Message
• System Status Response Message

Determining “Ready for Sampling”: A Note on General and Detailed Status

LAS should not stop adding tubes when LIS is offline in the system status
message.
The instrument software will send an event notification to tell LAS that LIS is
offline: this will allow a message to be displayed to users so they can respond
appropriately.
Therefore, Ready for Sampling is determined by:
General status = 01x01
This status is set based on one of the following being true:
Status Code = 01x01 - consumables ok
01x02 - consumables low (this usually means that tests
will run until consumables run out)
02x01 - LAS online (indicating that LAS is set up
correctly on the instrument)
04x01 - ready to sample external (meaning the user has
started the instrument for external sampling and
is ready to aspirate)

System Status Request

The LAS queries the instrument regarding status to accept or process a sample. A
header and footer are sent to verify. Fields are not sent.
NOTE: When establishing communication with the instrument, ensure that the
instrument is not performing any actions (e.g., barcode scanning, initializing,
transitioning from READY to START mode). It is recommended that the
instrument be in a WAIT or a READY state. See “System Status Response
Message” for explanation.
Header Footer

Message Direction LAS to Instrument


Message Type 0x0201

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System Status Response Message

This message is sent from the instrument to the LAS on request, after a successful
handshake, or upon a status change.
NOTE: If the system is performing an action, it cannot respond to a System Status
request until it has completed performing the task. Instead, it will send the last
known status as soon as possible.
Header General Status Detailed Status Probe Status Recovery Time
(1 Byte) (1 Byte) (2 Bytes) (2 Bytes)

Status Code count First of Status Codes Last of Status Codes Footer
(2 Bytes) (2 Bytes) ..... (2 Bytes)

Message Number
Information of Bytes Message Details
Message Direction – Instrument to LAS
Message Type – 0x0202
General Status Code 1 Describes the system’s capability to accept or
process a sample. The levels are:
• 0x01 Run. Can accept and process a
sample.
• 0x02 Pause. Temporarily unable to
accept or process a sample.
• 0x03 Stop. Instrument cannot accept or
process a sample.
Detail Status Code 1 The Detailed Status Code provides more
instrument specific status. The Detailed
Status Code maps to the General Status Code.
0x01 If Run is the General Status Code, then
the Detailed Status Code for Run is Run.
If Pause is the General Status Code, then
Detailed Status Codes for Pause are:
• 0x01 Error Pause
• 0x02 Sample Pause
• 0x03 Reagent Pause
If Stop is the General Status Code, then
Detailed Status Codes for Stop are:
• 0x01 Error Stop
• 0x02 User Stop
• 0x03 Not Initialized (Need Initialization)
• 0x04 Initializing

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Message Number
Information of Bytes Message Details
Probe Status 1 The Probe Status indicates where the probe is
located:
• 0x01 – Probe in Instrument Area
• 0x02 – Probe in Track Area
NOTE: For System Status messages sent between Mode
Control Blocked and Mode Control Active, the System
Status message will only be sent when the probe is in the
instrument area.
Recovery Time 2 When the instrument general status is in
Pause mode (0x02) and is recoverable. When
the system recovery time is not known, it
returns 0xFFFF. The recovery time is in
seconds from message time.
Status Code Count 2 Number of returned status codes in the
message. (Yellow or Red level.) This is an
optional field. The Status Code is a 2-byte
field with the first byte providing information
about the hardware and the 2nd byte provide
status of the item.
Status Code 2 The Status Code (2nd Byte) is a series of
status codes in the Status Code Count. This
series is optional. There are four statuses in
the series, with values of green, yellow or red
(described below in Table 3-11). The entire
series is sent, regardless of how many
statuses change.
Table 3-11 Status Items and Status Item Select code

Status Status Item


Item Area Status Item Code (2nd Status Item Select Code
(1st Byte) Definition Byte) Definition
0x01 Instrument/Hardware 0x01 Ready and Functional.
System Status 0x02 Warning Condition. The
instrument is functional, but a
reagent or consumable is low,
or a warning condition exists.
0x03 Instrument is not functional.
0x02 LAS Online/Offline 0x01 Online (configured) and Ready.
0x02 Not used.
0x03 Offline. Not configured for
external sampling.
0x03 LIS Online/Offline 0x01 Instrument software is set to
HOST ON.

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Status Status Item


Item Area Status Item Code (2nd Status Item Select Code
(1st Byte) Definition Byte) Definition
0x02 Not used.
0x03 Instrument software is set to
HOST OFF.
0x04 Ready to Process 0x01 Instrument ready to receive
Samples samples or LAS ready to send
samples to the instrument.
0x02 Instrument configured for
external sampling but a sample
run needs to be initiated.
0x03 Instrument is prevented—by a
system or software state—from
processing external samples.

Instrument Inventory Message Types


The Instrument Inventory Message type range is 0x0301–0x03FF.
Instrument Inventory Messages include:
• Consumable Composition Request
• Consumable Composition Response
• Consumable Inventory Request
• Consumable Inventory Response
• Test Map Request
• Test Map Response
• Test Inventory Request
• Test Inventory Response

Consumable Composition Request


Header Footer

Message Direction LAS to Instrument


Message Type 0x0307

Consumable Composition Response


ADVIA Chemistry systems have 19 consumables. Consumables 1–16 are
required by the instrument. Consumables 17–19 are used for cleaning.
First Last
Consumable ID Conumable ID

Header Consumable Consumable ID Requirement (1 Consumable ID Requirement Footer


ID Count (1 Byte) Byte) ..... (1 Byte) (1 Byte)
(1 Byte)

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Message Number
Information of Bytes Message Details
Message Direction – Instrument to LAS
Message Type – 0x0308
Consumable ID Count 1 The number of consumables supported by the
instrument.
Consumable ID 1 Indicates a specific consumable by the
numeric value.
Consumable 1 A binary field indicates if the proceeding
Requirement consumable described by the Consumable ID
is required to launch a test. The values for this
field reflect:
0x00 False. Not required for launch.
0x01 True. Required for launch.

Consumable IDs
The IDs that identify consumables are in Table 3-12.
Table 3-12 Consumable Inventory and Conditions

Consumable Condition Condition Condition


Inventory ID Description 1 (Green) 2 (Yellow) 3 (Red)
0x01 Saline Not empty n/a Empty
0x02 Cuvette Wash Not empty n/a Empty
0x03 Incubation Bath Oil Not empty n/a Empty
0x04 Cuvette Conditioner Not empty n/a Empty
0x05 ISE Buffer Not Empty n/a Empty
0x06 ISE Reference Buffer Not Empty n/a Empty
0x07 Pure Water Not Empty n/a Empty
0x08 Spare Oil Level Not Empty n/a Empty
0x09 RTT1 Probe Wash 1 More than Less than Empty
10% of the 10% of the
full volume full volume
of container of container
0x10 RTT1 Probe Wash 2 More than Less than Empty
10% of the 10% of the
full volume full volume
of container of container
0x11 RTT1 10% Cuvette Wash More than Less than Empty
10% of the 10% of the
full volume full volume
of container of container

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Consumable Condition Condition Condition


Inventory ID Description 1 (Green) 2 (Yellow) 3 (Red)
0x12 RTT1 DI Water More than Less than Empty
10% of the 10% of the
full volume full volume
of container of container
0x13 RTT2 Probe Wash 1 More than Less than Empty
10% of the 10% of the
full volume full volume
of container of container
0x14 RTT2 Probe Wash 2 More than Less than Empty
10% of the 10% of the
full volume full volume
of container of container
0x15 RTT2 10% Cuvette Wash More than Less than Empty
10% of the 10% of the
full volume full volume
of container of container
0x16 RTT2 DI Water More than Less than Empty
10% of the 10% of the
full volume full volume
of container of container
0x17 CTT 10% Cuvette Wash n/a
0x18 CTT DI Water 50 n/a
0x19 CTT DI Water 51 n/a

Consumable Inventory Request


Header Consumable Item First Consumable ID ...... Last Consumable ID Footer
Count (1 Bytes) (2 Bytes)
(1 Byte)

Message Number
Information of Bytes Message Details
Message Direction – LAS to Instrument
Message Type – 0x0301
Consumable Item Count 1 Provides the number of consumable being
queried. If the value is 0x00, then it is
querying for all consumables.
Consumable ID 1 The number of the consumable ID. Refer to
Table 3-12.

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Consumable Inventory Response Message

The instrument sends this response message at start up or when a change in status
occurs. At start up, or when you press start, a full message is sent—all fields for
all consumables. If a change in status happens, such as the consumable is low, a
single message is sent with only the fields pertinent to the change.

First Consumable ID ...

Header Consumable Item Consumable ID Severity Code Consumable


Count (1 Byte) (1 Byte) (1 Byte) Count (2 bytes)

... Last Consumable ID

Consumable ID Severity Code Consumable Footer


(1 Byte) (1 Byte) Count (2 bytes)

Message Number
Information of Bytes Message Details
Message Direction – Instrument to LAS
Message Type – 0x0302
Consumable Item Count 1 Provides the number of consumable in this
response message.
Consumable ID 1 The number of the consumable ID. Refer to
Table 3-12.
Severity Code 1 Thresholds are green, yellow, red, or
unknown.
0x01 Green: consumables are above
threshold quantity.
0x02 Yellow: consumables are below the
threshold level quantity.
0x03 Red: instrument consumables are
empty.
0xFF Unknown: state of consumables is not
known.
Consumable Count 2 Provides the actual inventory count. If this
quantity is unknown or out of range, the field
is indicated by 0xFFFF.

The Consumable ID identifies the consumables by code. See Consumable


Inventory and Conditions on page 3-44.
NOTE: Test Inventory Response is updated whenever this is sent to reflect Test
availability for processing.

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Test Map
A response message is sent at startup or upon request. If a change in the supported
test map occurs, a message is sent. If the new map sent from the instrument does
not match the map on the LAS, then the test map sent should overwrite the map on
the LAS. The test map is not automatically overwritten. Any LAS that interfaces
with the ADVIA Chemistry platform must update its status based on this message.
When any change is made on the instrument test selections (tests available to run),
a Test Map message will be sent followed by a Test Inventory status message
indicating the status of all available tests.

Test Map Request

A header and footer are sent to verify (fields are not sent).
Header Footer

Message Direction LAS to Instrument


Message Type 0x0305

Test Map Response

The test map response sends all tests available. If an LIS test name is not defined,
then the test is excluded from the Test Map.
First Test ID Last Test ID

Header Test ID F Test ID F Test ID F Test ID F Test ID Footer


Count L (LAS) L (LIS) ...... L (LAS) L (LIS)
(2 bytes) (n Bytes) (2 Bytes) (n Bytes) (n Bytes)

Message Number
Information of Bytes Message Details
Message Direction – LAS to Instrument
Message Type – 0x0306
Test ID Count 2 Number of Test IDs in this message.
FL 1 Length of next Field.
Test ID (LAS) variable Test code used by the Track system. (ASCII
string of 3 bytes with a format of 999 (right
justified) and zero suppression).
FL 1 Length of next Field.
Test ID (LIS) variable Test code used by the LIS system.

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Test Inventory
Test Inventory allows the instrument to update LAS on the tests available to run
on a system; it can be sent unsolicited or in response to an LAS request. The Test
Inventory message includes a Test ID Count and a Test ID. The Test ID Count is
the number of the Test ID with the request message. The value of 0x0000 means a
request for all tests in the instrument. If all tests are requested (0x0000), Test ID
fields are not used.
When any change is made on the instrument test selections (tests available to run),
a Test Map message will be sent followed by a Test Inventory status message
indicating the status of all available tests.

Test Inventory Request


Heading Test ID Count F Test ID F Test ID Footer
(2 Bytes) L (n Bytes) ..... L (n Bytes)

Message
Information Message Details
Message Direction LAS to Instrument
Message Type 0x0303
Test ID Count The number of Test IDs within the request message. The
value of 0x0000 indicates that the request is for all tests in
the instrument.
Test ID • ASCII string
• alphanumerical value
• optional field, depending on Test ID count
• 3 bytes, with no space suppression and no zero
suppression
NOTE: Because there is no space- or zero-suppression, it is
important to designate where spaces and zeroes are in 2-digit
entries; otherwise a 2-digit entry may be recorded as a
3-digit value. If you enter “12,” the system will add a space
at the end and record the number as “12b.”

If information for a particular test is requested, the Test ID field is set to the test
identifier requested. Multiple information can be requested. The test identifier is
defined in the Test Map generated by the instrument.

Test Inventory Response

The Test Inventory Response message is sent during a barcode scan, reagent
pause, change in threshold, and ready→start state transition (when start is
pressed), and after a consumable inventory response message. If changes occur to
the status of a test’s Active/Inactive status, the message is sent.

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The instrument can send one or all tests in a message. At Startup, all tests are
reported. During Processing, only updates may be reported.
NOTE: The instrument generally sends full inventory, but in some special cases it
can send an incremental inventory. Since there is no way to distinguish from the
protocol whether a message is full or incremental, LAS must treat the 1st one after
handshake, and the first one after Start has been pressed, as full and all others as
incremental.
The exception cases are:
1) Anytime a testmap is received, the test inventory after receipt must be treated
as a “full” inventory message.
The Test Inventory status for ISE tests is indicated as enabled or disabled. All
other fields can be null for ISE tests.
First Test ID

Header Test ID F Test ID Quantity Severity Test Count Enabled Reason Lot
Count L (n Bytes) Type (1 Byte) (2 Bytes) (1 Byte) (1 Byte) Count
(2 bytes) (1 Byte) (1 Byte)

Optional fields for Detailed Test Inventory

F Lot Number Availability F Lot Number Availability


L (n Bytes) (2 Bytes) ..... L (n Bytes) (2 Bytes)

Lastt Test ID

F Test ID Quantity Severity Test Count Enabled Reason Lot


L (n Bytes) Type (1 Byte) (2 Bytes) (1 Byte) (1 Byte) Count
(1 Byte) (1 Byte)

F Lot Number Availability F Lot Number Availability Footer


L (n Bytes) (2 Bytes) ..... L (n Bytes) (2 Bytes)

Message Number
Information of Bytes Message Details
Message Direction – Instrument to LAS
Message Type – 0x0304
Test ID Count 2 The number of Test IDs in this message.
FL 1 Length of next field
Test ID variable The Test ID in the ASCII string
Quantity Type 1 This field always has a value of 1 for ADVIA
Chemistry.
The values for this field reflect:
0x00 Test count is the remaining test count
after currently allocated tests
0x01 Test count is the raw test count on the
instrument

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Message Number
Information of Bytes Message Details
Severity 1 The Severity levels are Green, Yellow, and
Red.
Green (01) indicates that the instrument s
ready to run a Sample.
Yellow (02) indicates that one or more of the
components of the test (R1 and R2) are below
the threshold. This means that: for Serum
indices, at least one of the tests configured as
the master is either yellow or red; for Ratios,
at least one of the master tests is yellow.
NOTE: For ISE test, Yellow means one of
the calibrations has a problem. See Table
3-10 for possible cases for ISE calibrations.
Red (03) indicates that a test cannot be run.
This means that: for Serum indices, all of the
master tests are red; for Ratios, at least one of
the tests is red.
This field is set to Red when:
• there are no valid matched pair for a test,
e.g., missing R1 or R2
• the test is not enabled on the Active Test
List screen
• the test is not enabled on the Test Select
screen
• consumables are empty
• the test cannot be run for any other
reason (e.g., hardware)
• the QC Status becomes Inactive
• the reagent quantity for either R1 or R2
is 0
• the test is not calibrated (has a C flag)
and cannot be run
NOTE: If a test is not calibrated, its status
will be “disabled” in the Test Inventory Status
message. However, if the tube shows up to be
processed, the tube will be processed and the
Sample Interaction Complete message will
show a status of “successful.” The final result
for the test will be flagged with a “C” flag
(calibration needed).

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Message Number
Information of Bytes Message Details
Test Count 2 The Test Count field reports the minimum
number of tests that can be run based on
quantity of the R1 and R2 volumes available.
If there are multiple lots of a test installed and
runnable (Green status), then the test count
returns the total test count of all lots.
ISE, Serum indices and Ratio tests have
either the maximum value of 65535 or 0.
Enabled 1 The Enabled field indicates if the instrument
is ready to run a test. The value 0x01
indicates the system is ready. The value 0x00
indicates the system in not ready. If the test is
not ready, an additional code is added to the
Response:
• 0x00 disabled
• 0x01 ready
NOTE: If a test is not calibrated, its status will be
“disabled” in the Test Inventory Status message. However, if
the tube shows up to be processed, the tube will be
processed and the Sample Interaction Complete message
will show a status of “successful.” The final result for the
test will be flagged with a “C” flag (calibration needed).
Response Code / 1 The value 0x00 indicates the system in not
Reason Code ready. If the test is not ready, an additional
code is added to the Response:
• 0x01 consumable missing/reagent
deselect/Active Test List OFF/Test
Select OFF
• 0x02 instrument failure
• 0x04 calibration error/ISE serum
calibration error/QC status
INACTIVE
• 0x08 ISE urine calibration error
NOTE:The status of ISE tests is communicated based on the
calibration status of ISE tests for Serum and Urine. For
example:
If ISE is calibrated for Serum but not for Urine, then the
reason code will be 0x08.
If ISE is calibrated for Urine but not for Serum, then the
reason code sent will be 0x04.
Lot Count 1 The number of Lots for the current Test ID.
The Lot count provides the number of valid
reagent pairs on the system that are can be
run.

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Message Number
Information of Bytes Message Details
FL 1 Length of next field.
Lot Number variable The lot number format is RTT1 lot number,
RTT2 lot number. (A comma separates the
RTT1 and RTT2 entry.) This is in ASCII
format.
Availability 2 This field indicates the minimum of R1 and
R2 volume test counts.

Instrument Busyness Message Types


The Instrument Busyness Message Type Range is 0x0401–0x04FF.
The ADVIA Chemistry LAS does not support the Instrument Busyness Message
types.

Event Message Notification Types


The Event Message Type Range is 0x0801–0x08FF.
NOTE: The Event Range is bidirectional but the instrument is not set up to
receive this message.

Event Notifications

Message Direction Bidirectional


Message Type 0x0801

The Event Notification is a bidirectional message that notifies the LAS and the
instrument of current events. It is dynamic in nature to provide usage flexibility. It
can be used with a declared structure at implementation of the system or it can
send a series of ASCII messages. Primarily, the Event Notification notification
communicates safety alarm codes that are Warning level or Fatal level. The
default event codes (for warning level uses) are in this file:
C:\A002\etc\warning.tbl

If you delete this file, all events are sent. This file can be modified to add
additional warnings.
If the Event Messages notification is disabled, no events are sent to LAS. The
input values are:
• 0: No values are sent
• 1: Warning and Fatal
• 2: Fatal only

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Event notification gathers the following information from the Error Report
window (this information conforms to the local PC language and settings):
Heading Total Data Fields F First Data Field F Last Data Field Footer
(1 Byte) L (n Bytes) ..... L (n Bytes)

Message Number
Information of Bytes Message Details
Message Direction – Bidirectional
Message Type – 0x0801
Total Data Fields 1 Counts of data fields expected in current
event notification message. Always 7.
FL 1 Length of the next field
Date Field variable MM/DD format
FL 1 Length of the next field.
Time Field variable HH:MM format
FL 1 Length of the next field.
Alarm Code variable 4-digit numeric character, no 0 suppression.
(0001–19999)
FL 1 Length of the next field.
Alarm Level variable Warning, Emergency Stop, Stop + R,
FL 1 Length of the next field.
Sample ID variable Sample ID information.
FL 1 Length of the next field.
Test Name variable Name of the test.
FL 1 Length of the next field.
Summary Test Message variable Includes any wildcard modified information.
NOTE: This message will be sent in the
same language that the system software is
written in.

Emergency Recovery Message Types


Emergency stop messages are different from status messages in that they focus on
recovery from hardware collision. The message originator waits for a response. If
both sides cannot recover from the condition, you must correct the hardware error.
The Message Type Range is 0x0501–0x05FF.
The Emergency message types are:
• Emergency Stop Notification
• Emergency Stop Response

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Emergency Stop Notification

The Emergency Stop Notification sends a status code detailing the type of stop.

Heading Status Code Footer


(1 Byte)

Message Number
Information of Bytes Message Details
Message Direction – Bidirectional
Message Type – 0x0501
Status Code 1 The status codes indicate:
• Originator stopped and receiver may
move
• Originator stopped and receiver may not
move
• Originator requests to clear out of the
interaction area

Emergency Stop Response


Heading Return Code Footer
(1 Byte)

Message Number
Information of Bytes Message Details
Message Direction – Bidirectional
Message Type – 0x0502
Status Code 1 The status codes indicate:
• 0x01 Receiver is not in the Interaction
Area. The originator can attempt
recovery action.
• 0x02 Receiver is in the Interaction Area.
The originator cannot attempt
recovery action.
NOTE: The system will send a Sample
Status code 0x02 when DPP Probe is on the
LAS side (external position) and already
moved down for sampling, because it does
not want LAS to execute a recovery
operation. In other cases, status 0x01 will be
sent to LAS. If the instrument sends 0x02,
LAS should not perform recovery process
until ADVIA has been initialized. LAS will
be informed of this by the System Status
message.

NOTE: This message is sent when the red Emergency Stop on the instrument is
pressed.

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NOTE: If the instrument is the originator of the emergency stop, all data in
process is lost and the samples need to be rerun.

Point in Space Sample Sharing Message Types


The Message Type Range is 0x601–0x06FF.
The Point in Space sample Sharing Message types are:
• Sample Queue
• Reset Sample Queue
• Add Tube
• Insert Tube (not supported)
• Skip Tube
• Index Tube
• Sample Access (not supported)
• Sample Interaction Complete
• Request Sample

Sample Queue
The Sample Queue Request and Response messages provides the instrument with
a snapshot of the current sample queue. This information is helpful when
recovering from sample queue data loss or a connection reset.

Sample Queue Request Message


Header Footer

Message Number
Information of Bytes Message Details
Message Direction – Bidirectional—although functionally the
instrument can only receive, and cannot
originate, this message.
Message Type – 0x0601

A header and footer are sent to verify (fields are not sent).

Sample Queue Response Message

Sample Queue Response Message is sent (a) upon request and (b) unsolicitied
upon success handshake by LAS.
Tube at Sample Last Tube in Queue
Access Postion

Header Tube Count F Sample ID F Sample ID Footer


(1 Byte) L (n Byte) ..... L (n Byte)

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Message Number
Information of Bytes Message Details
Message Direction – Instrument to LAS
Message Type – 0x0602
Tube Count 1 Number of tubes in queue (max. 255)
FL 1 Length of next field
Sample ID n A series of Sample ID in queue from sample
access position to last sample in the queue
(ASCII string/numerical value). The first
Sample ID is the first tube in queue. Each
Sample ID is preceded by a FL.
FL 1 Length of next field

Reset Sample Queue


These messages are sent and responded if a mismatch in the sample queue occurs.

Reset Sample Queue Request Message

The LAS sends the Reset sample queue message if there is a mismatch in the
sample queue or if the sample queue needs to be cleared. A header and footer are
sent to verify (fields are not sent).
Header Footer

Message Direction LAS to Instrument


Message Type 0x0603

Reset Sample Queue Response Message

This message is sent in response to the request from LAS.


NOTE: If an error condition causes a shutdown and the system needs to be
initialized using the “initialize button,” then the instrument does an internal “reset
queue.” No messages are sent to LAS when an internal reset queue is done, until it
is completed. If multiple “Reset Queue” requests are sent while one is already in
process, the instrument will send a NAK (04)—busy response.
Heading Completion Code Footer
(1 Byte)

Message Number
Information of Bytes Message Details
Message Direction – Instrument to LAS
Message Type – 0x0604

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Message Number
Information of Bytes Message Details
Completion Code 1 The completion codes are:
• 0x01 reset complete
• 0x02 reset in progress
• 0x03 unable to reset
NOTE: Only the code 0x01 is used for
ADVIA Chemistry.

Add Tube

Add Tube Request

LAS sends this message to the instrument when a tube needs to be added to the
instrument’s queue.
Heading F Sampe ID Tube Type Footer
L (n Bytes) (1 Byte)

Message Number
Information of Bytes Message Details
Message Direction – LAS to Instrument
Message Type – 0x0605
FL 1 Length of next field
Sample ID variable Sample ID to be added to queue (ASCII
string/numerical value)
Tube Type 1 Describes the tube size:
• Reserved. The tube type can be specified
in the work order.
• 10-mL tube
• 7-mL tube

Additional identifiers can be added to accommodate user-defined containers,


although not on the instrument side; the instrument is limited to seven container
types.

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Add Tube Response


Heading Completion Code Footer
(n Bytes)

Message Number
Information of Bytes Message Details
Message Direction – LAS to Instrument
Message Type – 0x060B
Completion Code 1 The codes are:
• 0x01 Tube added
• 0x02 Invalid parameter
• 0x05 Not ready for sampling
• 0x07 Sample ID is too long

Skip Tube
The LAS sends this message when an unexpected tube is present while the
instrument is trying to access a current sample at the sample access position or if
the trying to index the queue.

Skip Tube Request Message


Header F Sample ID Footer
L (n Byte)

Message Number
Information of Bytes Message Details
Message Direction – LAS to Instrument
Message Type – 0x0607
FL 1 Length of next field
Sample ID variable Sample ID to skip (ASCII String/Numerical
value)

Skip Tube Response Message


Header Completion F Sample ID Footer
Code L (n Byte)
(n Bytes)

This message is sent upon request.


Message Number
Information of Bytes Message Details
Message Direction – Instrument to LAS
Message Type – 0x0608

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Message Number
Information of Bytes Message Details
Completion Code 1 The completion codes provide this status:
• 0x01 Sample skipped
• 0x02 LAS is offline
• 0x03 Tube not found in spur
• 0x95 Invalid parameter
NOTE: If the SampleID is more than 13, the
system will send a NACK (0x02).
FL 1 Length of next field
Sample ID variable Sample ID skipped (ASCII string/numerical
value)

Index Queue
Index queue is a command from the instrument to the LAS to advance the current
sample queue by releasing the current sample located at the sample access
position. The request is used by the instrument to tell LAS that it is done with the
sample and LAS is free to move the tube out. Once the sample is released, the
sample ID of the new sample (located at the sample access position) is verified.
The Index Queue Response may be used by LAS to tell the instrument that there is
a tube ready for aspiration.

Index Queue Request Message


Header F Sample ID Footer
L (n Byte)

Message Number
Information of Bytes Message Details
Message Direction – Instrument to LAS
Message Type – 0x060A
FL 1 Length of next field
Sample ID variable Current sample tube at sample access
position

Index Queue Response Message


Tube at Sample Access Last Tube in Queue
Postion

Header Completion Tube Count F Sample ID TubeType F Sample ID Tube Footer


Code (1 Byte) L (n Bytes) (1 Byte) ..... L (n Bytes) Type
(2 bytes) (1 Byte)

Message Number
Information of Bytes Message Details
Message Direction – LAS to Instrument

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Message Number
Information of Bytes Message Details
Message Type – 0x060B
Completion Code 1 The completion codes provide this status:
• 0x01 Index complete. Tube present at
sample access position.
• 0x02 Index complete. No tube present at
sample access position.
• 0x03 Index complete. Tube present but
Sample ID read failed.
• 0x04 Index failed.
• 0x05 Index complete. Tube present but
Sample ID too long.
• 0x06 Skip next tube.
• Any other code indicates severe error.
Take LAS offline and check the log.
Tube Count 1 The number of tube information sent in
sequence. Value must be greater than 0.
FL 1 Length of next field
Sample ID variable Sample tube at sample access position and
any extra tubes in queue up to the Tube
Count.
Tube Type 1 Tube type describes tube geometry. The
enumerated tube type value is platform
specific. The value 0x00 is reserved and
specifies that the tube may can be specified in
the work order.

Request Sample
NOTE: ADVIA WorkCell/LabCell Automation System does not support this
feature.

Sample Interaction Complete Messages

Sample Interaction Complete Notification

This message is sent from the instrument to the LAS to provide the sample
process status. This message also indicates manual Interrupt sample notification
for samples that are run on the STT.
NOTE: Serum indices and ratios are never reported in the Sample Interaction
Complete message, because they are “calculated” tests and the system does not
have any status to report on them at aspiration time.
Header F Sample ID F Tube Postion Tube Status
L (2 bytes) L (n Bytes) Code
(1 Byte)

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F Lot Number Availability F Lot Number Availability


L (n Bytes) (2 Bytes) ..... L (n Bytes) (2 Bytes)

Message Number
Information of Bytes Message Details
Message Direction – Instrument to LAS
Message Type – 0x060E
FL 1 Length of next field.
Sample ID variable This is the ID of the sample at the sample
access position.
FL 1 Length of next field.
Tube Position variable The tube position.
Tube Status Code 1 Conveys status of the tube:
• 0x01 tube processing successful
• 0x02 tube processing not successful or
aborted
• 0x03 tube processing skipped
• 0x04 error processing tube
• 0x05 instrument error – LAS Offline
Total Test Count 1 Number of tests for the sample.
Success Test Count 1 Number of successful test launches.
FL 1 Length of next field.
Success Test ID variable This value follows the Success Test Count to
indicate the successful tests by Test ID
number.
Test Completion Time 2 This is the delta time, in seconds, to complete
proceeding Success Test IDs.
Failed Test Count 1 Number of failed test launches.
FL 1 Length of next field.
Failed Test ID variable Test ID numbers of any failed tests.

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Message Number
Information of Bytes Message Details
Test Failed Code 1 This code follows the Failed Test ID field
providing the failure reason for each failed
test:
• 0x01 Test select/Active test list off/QC
inactive
• 0x02 Reagent/ Consumable empty
• 0x03 Short or empty sample
• 0x04 Dilution shortage
• 0x05 Clot error
• 0x06 Hardware error processing (“S”
mark)
• 0x07 Test not calibrated
NOTE: Tests that are not calibrated are
always reported as “successful.”

A system parameter, LAS-STT Sample interaction Complete message send,


enables the use of this message to be sent for samples being processed from the
STT. This parameter is accessible at the supervisor or manager level.
The default setting is 0, which is a disabled state. A setting (0) disables the
sending of a Sample Interaction Complete message for samples processed from
the STT.
A setting of 1 enables the sending of a Sample Interaction Complete message for
all samples processed from the STT.
A setting of 2 enables the sending of a Sample Interaction Complete message for
Interrupt samples processed from the STT.

Sample Interaction Complete Response


Header Completion Code Footer
(1 Byte)

Message Number
Information of Bytes Message Details
Message Direction – LAS to Instrument
Message Type – 0x060F
Completion Code 1 The new mode of current Channel Index:
(Example Codes) • 0x01 Interaction Complete is accepted
• 0x02 Invalid Message parameter

Message Control
NOTE: ADVIA Chemistry does not use message registration.

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Message Channel Mode Control Notification

This message contols message channel modes. It indicates that the instrument is
aspirating samples from the LAS and not accepting any messages.
Header Channel Index Channel Mode Footer
(1 Byte) (1 Byte)

Message Number
Information of Bytes Message Details
Message Direction – Bidirectional
Message Type – 0x0A03
Channel Index 1 This field is used for verification. It is a
numerical value (0x00–0xFE). 0x00 is the
primary channel. The channel index must
match the channel it is originating from.
Channel Mode 1 The new mode of current Channel Index:
• 0x01 Active
• 0x02 Blocked. Messages are not
accepted until reset to Active (0x01)
Once the channel is blocked by one side, the
other side cannot block the channel and must
wait for Active mode.
ESTOP is allowed during Block mode but no
other messages.
NOTE: If LAS sends messages during Active
mode, the instrument will send a NACK
(0x04 Busy).

Sample Tube Sharing Message Types


The Message Type range is 0x0701–0x07FF.
These messages are not supported in this version. These messages are for carrier
(rack) based interfaces and do not apply. The system responds with an ACK for
these message types with a return code of 03 Message Type Unsupported.

Workstation LAS Communication Monitor


The system software includes a monitoring function for monitoring and
troubleshooting the LAS interface. This function is a log displaying the
communications of the TCP/IP between the instrument, workstation, and LAS.
This log includes timestamp, messages, message type, sequence and resequence.
To view the monitor:
1. At the Menu Panel, select Maint.

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2. Select LAS monitor


Each line in the log is a separate transmission. Received messages for Line 1
(LAS to Instrument) appear as R. Send messages for Line 2 appear as S.
Message for Line 3, Workstation, appear as WS. Messages for Line 4,
Workstation receive, appear as WR. The log includes:
• Timestamp, which displays the date and time of the transmission.
• S/R displays the status of the message (Send or Receive).
• Message type displays the type of message transmitted or received.
• Seq displays the sequence of the transmission
• ReSeq displays the return sequence of the transmission.
To indicate the direction of the message:
• Line 1 (Receive) displays LAS to Instrument (ADVIA Chemistry system)
• Line 2 (Send) displays instrument to LAS
• Line 3 (Workstation Send) displays PC to LAS
• Line 4 (Workstation Receive) displays LAS to PC

Figure 3-14 LAS Communication Monitor Log

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LAS Communication Monitor Log Print


Using the Print button, you can output the log to your printer or a file. You can
filter the results by selecting ALL, CPU or WS at the LAS Monitor Window.
To filter the messages that you want to print or print to file:
1. Select File.
2. Select Messages.
The Message Type Select windows displays. You can add or remove fields to
include in the printed report or file.
3. Select Save.
When you leave the session, the system returns to default (no messages filtered).

Printing the LAS monitor Log

1. Select Print.
2. Select Print again.
NOTE: The log is printed to the printer connected to your system. Printing the
LAS monitor log requires a large amount of paper.

Printing selected messages

You can highlight specific messages to print or save, rather than printing the entire
log.
1. In the left column, highlight the messages in the Message type field, that you
want to print.
2. With the messages highlighted, right click the mouse.
3. A print button displays, select Print.

Printing One Detailed message

To print one message with all details displaying in the right:


1. In the left column, highlight the message you want to print or save.
2. With the message highlighted, right click the mouse in the detailed screen
(right side of display).
3. A print button displays, select Print.

Saving an LAS monitor log to a file


1. Select Print.
2. Select Save to File.
The Save As dialog box displays.

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3. Do one of the following:


• To save the file with the default name to C:A002>Report, select Save.
• To save the file to another location, browse and choose the location.

Opening an LAS log file

Use this procedure to open an existing LAS log file or save your current LAS log
file. The file default name is formatted as LAS-CA-yymmdd-##.txt.
1. Select File>Open.
2. Select the log file, then select Open.

Clearing the LAS monitor log

Use this procedure to clear the log. The log is archived for future inspection.
1. Select All Clear.
This increments the sequence and creates a log file.

Refreshing the LAS monitor log

Use this procedure to update the log display. The log is not real-time, so you must
perform a Refresh to display any new data.
1. Select Refresh.
The latest data is updated to the window.

Serial Communication Interface Specifications


The ADVIA 1800 Chemistry system uses either a serial/parallel or a TCP/IP
connection. This section describes serial connectivity:
• Standard: RS-232C
• Communication method: Asynchronous (start-stop synchronization) half
duplex
• Baud (the rate of data transmission): 9600 bits per second (bps)
• Data length: 8 bits
• Parity: Even
• Stop bit: 1 bit
• Connector: D-SUB 25 pin female connector (use male connector on the cable
side)
Table 3-13 lists the pin assignments for the RS-232C connector.

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Table 3-13 Serial Connector Pin Assignments

Pin Pin
number Signal Type number Signal Type
1 FG (Frame ground) 14 Not connected to system
2 SD (send data from system to LAS) 15 Not connected to system
3 RD (receive data from LAS) 16 Not connected to system
4 Not connected to system 17 Not connected to system
5 Not connected to system 18 Not connected to system
6 Not connected to system 19 Not connected to system
7 SG (signal ground) 20 Not connected to system
8 Not connected to system 21 Not connected to system
9 Not connected to system 22 Not connected to system
10 Not connected to system 23 Not connected to system
11 Not connected to system 24 Not connected to system
12 Not connected to system 25 Not connected to system
13 Not connected to system

Parallel Communication Interface Specifications


Connector: Amphenol 36-pin female connector (use a male connector on the cable
side). Table 3-14 lists the pin assignments for the parallel connector.
Table 3-14 Parallel Connector Pin Assignments

Pin Pin
number Signal Type IO number Signal Type IO
1 +24V (for 19) ° 19 /BMREADY °
2 +24V (for 20) ° 20 /BMONL °
3 +24V (for 21) ° 21 /BMINIT (unused in °
v1.40)
4 +24V (for 22) ° 22 /BMTRBL °
5 +24V (for 23) ° 23 Not used °
6 +24V (for 24) ° 24 /BMSMP °
7 +24V (for 25) ° 25 Not connected to -
system
8 +24V (for 26) ° 26 /IDREQ °
9 Not connected to - 27 Not connected to -
system system
10 /HNREADY | 28 Ground (10-return) |
11 Not connected to - 29 Ground (11-return) |
system

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Pin Pin
number Signal Type IO number Signal Type IO
12 /SMPREQ | 30 Ground (12-return) |
13 Not used | 31 Ground (13-return) |
14 /HNNEXT (unused | 32 Ground (14-return) |
in v1.40)
15 Not connected to - 33 Ground (15-return) |
system
16 Not connected to - 34 Ground (16-return) |
system
17 Not connected to - 35 Ground (17-return) |
system
18 Not connected to - 36 Ground (18-return) |
system

LAS Serial Communication Signal Specifications


This section describes the signals used by the chemistry systems and the LAS to
communicate with each other. One system sends a signal to the other system to
indicate its readiness to receive data, or to report its status.
The LAS signals transmits via parallel connector so that more than one signal can
be transmitted at once. The actual data transmissions (such as sample ID numbers)
transmit via serial connection.

LAS Interface Panel


The LAS interface panel (PN 073-0344-02) contains several LED displays that
indicate the signals sent between the system and the LAS (see Table 3-15 on
page 69). Figure 3-15 illustrates the serial connection for the LAS interface panel,
which must be installed on the back of the chemistry system before you can run
samples in LAS mode. Table 3-15 explains the signals represented by the panel
indicators.

Figure 3-15 LAS Interface Panel with Serial and Parallel Cables

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Table 3-15 LAS Signal Display References

Signal Name Signal Direction Explanation


24V Not applicable. Power indicator
/HNREADY LAS-to-system The LAS is connected (ready to send samples
to the system).
/SMPREQ LAS-to-system The LAS sample has arrived at the aspiration
position.
/BMREADY System-to-LAS The system is ready to receive the next
sample from the LAS.
/BMONL System-to-LAS The system has been started in LAS mode.
/BMTRBL System-to-LAS This LED indicates the LAS and the system
are not communicating (the system cannot
receive LAS samples at this time).
/BMSMP System-to-LAS This LED indicates the LAS and system are
not communicating (system cannot receive
LAS samples at this time).
/IDREQ System-to-LAS The system is requesting the sample ID from
the LAS. (This also may mean that a sample
with an unknown barcode number has arrived
at the aspiration position.) If the ID received
is correct, the system begins sampling.
/HNNEXT System-to-LAS This LED indicates that the next LAS sample
has arrived at the aspiration position. Not used
in v1.40.
/BMINIT System-to-LAS The system is in INITIALIZE mode; it has
not yet been initialized, and is not ready to
receive LAS samples. Not used in v1.40.

Test Mode
When the system is in test mode, SW1 and SW2 (inside the LAS interface panel)
are normally set to OFF. When the switches are ON, they function as described
below:
Table 3-16 Switch Function in Test Mode

Switch Description
SW1 Test switch that generates the /HNREADY signal and turns the
HNREADY light on. This indicates a state of connection with the LAS.
SW2 Test switch that generates the /SMPREQ signal and turns the SMPREQ
light on. This indicates a state where an LAS sample has arrived at the
aspiration position.

Connectors
The connectors function as described below:

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Table 3-17 Connectors

Connector Explanation
CN1 For parallel signal interface.
CN2 For serial signal interface.

Basic Connections
This section describes the basic LAS signal operations used in an LAS
connection. Refer to the LAS interface panel in the back of the system for LED
status. See LAS Interface Panel‚ page 3-68 for more information.

Turning the /BMONL Signal On


The following steps turn the /BMONL signal on. The /BMONL signal indicates
that the LAS is communicating with the system.
1. Set up the system to run in LAS mode.
See Operation‚ page 3-18.
2. When starting the run at the Start Conditions window, select
General smp. Analyze.
See Running Routine Analysis in LAS Mode‚ page 3-21.

Turning the /BMREADY Signal On


These conditions must be met to turn the /BMREADY signal on, indicating the
system’s readiness to receive samples.
• The run must complete 28 cycles (84 seconds). Then the system may accept
incoming I messages. See Pre-read Sample ID (I message)‚ page 3-86.
• The system operating mode must be START, HOLD, or WATCH.

Sending the Pre-read Sample ID (I Message)


1. The LAS confirms that the /BMONL and the /BMREADY signals are on, and
that the /IDREQ signal is off.
2. The LAS sends the pre-read sample ID to the system.
3. The system sends an acknowledgment (ACK) to the LAS upon receipt.
See Communication Control Codes‚ page 3-85. An error occurs if sampling
does not take place after I message is sent.

Sending the Sampling Sample ID (R Message)


1. The LAS confirms that the /BMONL signal is on and that the /BMSMP signal
is off.
2. The LAS turns the /SMPREQ signal on.

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3. The system turns the /BMSMP and /IDREQ signals on.


4. The LAS turns /SMPREQ signal off.
5. The LAS sends the R message. See Sampling Sample ID (R Message)‚
page 3-86.
6. The system sends an ACK to the LAS upon receipt, then turns the /IDREQ
signal off. This indicates that the LAS is communicating with the system
correctly.
7. Sampling takes place.
8. After sampling has ended, the /BMSMP signal turns off, indicating that the
next sample can be transported.

Control Signals When Stopping or Pausing a Run


1. At the Operation Panel, select STOP or PAUSE.
2. The system turns the /BMREADY signal off.
The system can no longer receive a pre-read sample ID (I message).
The /BMSMP signal remains on so that the current aspiration request remains
intact, but it cannot receive additional requests.
3. Upon restart (or releasing the system from PAUSE mode), the /BMREADY
signal turns on.
4. Sampling resumes for the sample currently at the aspiration position.

Signal Communications During Operation


This section describes the communications between the system and the LAS that
are involved in processing LAS samples and the signals used in the various
processing stages.

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Initialization and Starting Analysis


Figure 3-16 illustrates LAS signal communications during normal system
operation, which is described in the procedure below.

/HNREADY

VERIFY /HNREADY
/BMINIT

/BMONL

/BMREADY

OPERATING
MODE WAIT INITIALIZE READY START HOLD STOP READY

Figure 3-16 Communications During Various System Operating Modes

1. When the LAS detects the system, it sends an /HNREADY signal to the
system, indicating that it is ready to send samples to the system.
This occurs after the system is powered up.
As long as the /HNREADY signal is on, the LAS is communicating with the
system and sampling can take place.
2. The system begins in WAIT mode.
As it is being initialized, it is in INITIALIZE mode.
3. The system sends a /BMINIT signal to the LAS, informing the LAS that
initialization is taking place (and that it cannot receive samples).
4. After initialization, the /BMINIT signal stops.
The /BMINIT signal is sent during every initialization, even if the system and
LAS are not communicating.
5. After it has been initialized, the system is in READY mode.
6. After washes and other startup tasks are completed, the system returns to
READY mode.
Analysis can now begin.
7. When an analysis is started (after about 90 seconds), the system sends a
/BMONL signal to the LAS indicating that it is ready to receive samples.
The /BMONL signal remains on (just like the /HNREADY signal), unless one
of the following conditions occurs:
• The system shuts down or the system becomes unable to analyze samples.
• A system error occurs (if this occurs, the system also sends a /BMTRBL
signal).
• The system is taken out of LAS mode.

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At this time, the system also confirms that the /HNREADY signal is still on
(see Figure 3-17). If it is on, the next sample can be analyzed. If it is off (it can
go off for the same reasons as /BMONL signal), the analysis stops. The
system goes into STOP mode, and you must restart the run.

/HNREADY
(LAS → System)
verify /HNREADY
System
Request for next
pre-read sample ID
LAS
/BMREADY
(System → LAS )

Figure 3-17 Verification of the /HNREADY Signal

8. When the system is ready for the next sample, it requests the LAS to send the
next pre-read sample ID with a /BMREADY signal.
The /BMONL signal must still be on for this to happen.
If the system cannot receive any more pre-read sample ID numbers,
/BMREADY goes off. The LAS cannot send any more sample IDs until
/BMREADY goes back on (the system needs to process the existing sample
IDs for the signal to start again).

Transmission of Pre-read Sample ID


1. The LAS verifies that the /BMREADY and /BMONL signals are on, then
sends the pre-read sample ID.
Also, the /IDREQ signal must be off for pre-read sample ID transmission to
take place.
2. The system sends an acknowledgment (ACK) to the LAS.
A serial communications error occurs, and the LAS stops attempting to send
the sample ID, if either of the following occurs:
• The system does not respond to a sent sample ID with an ACK or a NAK
(negative acknowledgment) for 3 seconds.
• The system returns a NAK for three successive attempts by the LAS to
send the ID.
3. The system stores the pre-read sample ID in memory; it can hold up to 80
sample IDs.
If the number of sample IDs in memory reaches 80, the /BMREADY signal is
off; the LAS cannot send any more pre-read sample IDs.
An LAS error occurs, breaking the connection between the LAS and the
system
(the /HNREADY, /BMREADY, and /BMONL signals turn off) if either of the
following occurs:

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• A sample arrives at the aspiration position and a pre-read sample ID for it


was not already received by the system.
• The order in which pre-read sample IDs and sampling sample IDs are
received by the system differs.
In these instances, the system goes into STOP mode and the analysis must be
restarted. The sample IDs stored in memory are erased; the LAS must re-send
the pre-read sample IDs.
Figure 3-18 illustrates the normal transmission sequence.

LAS ID(1) ID(2)


BARCODE
READER

/BMREADY

LAS VERIFY /BMREADY ON

ACK ACK
PREREAD (1) PREREAD (2)
SYSTEM SAMPLE ID SAMPLE ID
(1) (2)

WORK WORK
ORDER ORDER
HOST SAMPLE ID (1) SAMPLE ID (2)
(1) (2)

Figure 3-18 Transmission of pre-read sample ID

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Sampling Sequence
Figure 3-19 illustrates LAS communications during sampling.

0.0 sec 3.0 sec


sample (1) sample (2)
Sample Transport transport transport
0.25 sec. 2.05sec. 0.25 sec. 2.05sec.

Sampling movement Verify /BMONL sample (1) Verify /BMONL sample (2)
sampling sampling

Verify sample (2) Verify sample (3)


/HNNEXT
(LAS→ System)

/SMPREQ
(LAS→ System)

System
Send pre-read sample ID (6 sec.)+
(LAS→ System)
host (6 sec.)
/IDREQ
(System→ LAS )

/BMSMP
(System→ LAS )

Verify next sample 2.5 sec. 2.5 sec.


(System)
Sample ID (1) Sample ID (2)
Send sending sample ID
(LAS→ System)

ACK ACK ACK


(System→ LAS )

Figure 3-19 LAS signals During 3-second Sampling Sequence

1. When the sample arrives at the aspiration position (the pre-read sample ID has
already arrived), the LAS verifies that the /BMONL signal is on, then sends
an /SMPREQ signal to the system.
The /BMONL signal must be on so the system can respond to /SMPREQ; by
detecting this signal, the system can aspirate the sample.
2. The system turns on /BMSMP to acknowledge the /SMPREQ sent by the
LAS, thereby informing the LAS that it is ready for sampling.
The /BMSMP signal stays on until sampling completes.
The system also turns on the /IDREQ signal to request the sampling Sample
ID of the sample now at the aspiration position.
The LAS turns off the /HNNEXT signal, indicating that what was previously
the next sample is now the current sample to be processed.

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3. The LAS sends the sampling sample ID to the system; the system sends back
an acknowledgment (ACK) when it has confirmed the validity of the ID.
The system also turns off /IDREQ. (The LAS can send pre-read sample IDs to
the system when /IDREQ is off.)
If the ID does not arrive in five seconds, the system issues an LAS error,
thereby stopping communications with the LAS.
If the system sends a negative acknowledgment (NAK) in response to the ID,
the LAS attempts to send the ID up to two more times. If the system returns a
NAK a total of three times, the LAS stops sending the ID and judges that a
serial communications error has occurred.
If the system has no workorders for the sampling sample ID it has received, it
does not aspirate the sample.
4. The system begins sampling 2.05 seconds into the three-second sampling
cycle (time managed by the system).
5. After 2.5 seconds, the system verifies that /HNNEXT is on; if it is, the
sampling process for the next sample can begin.
The /HNNEXT verification takes place while sampling of the current sample
is taking place; the actual sampling process for the next sample does not begin
until the current sample is processed.
6. After sampling for the current sample has completed, the system turns off
/BMSMP.
7. After verifying that /BMSMP is off, the LAS begins to transport the next
sample to the aspiration position.
If /SMPREQ is still on when /BMSMP goes off, the system issues an LAS
error, thereby stopping communications with the LAS.
If the LAS detects /IDREQ signal after /BMSMP goes off, it judges that an
error has occurred in the system.

Error Communication
1. If the system detects an abnormality during sampling, it sends an error
message to the LAS.
See Error message (E message)‚ page 3-87. The LAS then acknowledges the
error message.
2. If the LAS does not send an acknowledgment (ACK) within three seconds,
the system attempts to resend the E message up to two more times.
If the LAS does not acknowledge the error message after three attempts by the
system, the system issues an LAS error and turns off the /BMREADY,
/BMONL, /BMSMP, and /IDREQ signals, thereby stopping communications
with the LAS.

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3. If the system receives the sampling sample IDs in a different order than it
received the pre-read sampling IDs, it sends an E message (with error code
005) to the LAS, and turns off /BMONL (stops communication with the
LAS).
Figure 3-20 depicts the LAS signals used for error message communications.

Figure 3-20 Error Message Signals in an LAS

The /HNNEXT Signal


1. The /HNNEXT signal (sent by the LAS to the system) determines whether the
next sample can be aspirated by identifying the next sample ID as being
consecutive from the previous sample ID.
2. Before the sample is aspirated, a 3-second cycle, controlled by /HNNEXT,
occurs on the system.
3. The preparation cycle sets up subsequent 3-second sampling cycles.
4. If the /SMPREQ signal (LAS command to the system to aspirate the sample)
is on when the /HNNEXT signal goes off, a preparation cycle is required.
In these cases, aspirating the next sample takes 2 cycles (preparation and
aspirating cycles), requiring 6 seconds.
5. When the /SMPREQ signal is on, the current state of the /HNNEXT signal
from the LAS (on or off) remains.
The /HNNEXT signal is assumed to be that of the sample identified by the
/SMPREQ signal as ready for aspiration.
The /HNNEXT signal on during the 2.5 seconds of the current aspiration
cycle is assumed to be that of the next sample ID.

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6. If the /SMPREQ signal is sent for all samples, the /HNNEXT signal is always
on, except for the first and last samples of the run.
Since the LAS controls /SMPREQ by the current sample, the /HNNEXT
signal can be held (while on) to correspond to the sample that turned on
/SMPREQ.
7. When a sample arrives at the aspiration position, the LAS usually controls the
/HNNEXT signal.
After turning off /SMPREQ, /HNNEXT is kept for the next sample (see
Figure 3-27 on page 3-89).
8. The /BMSMP signal synchronizes a valid sample with the system. Because
/BMSMP is off during sample transport, an invalid sample can be transported
asynchronously.

Summary of /HNNEXT Control Methods


Methods of controlling the /HNNEXT signal vary, according to the current state
of the LAS. Table 3-18, and the sections that follow, provide the details.
• A sample (that has a valid sample ID and workorder) that causes /SMPREQ to
turn on is a valid sample.
• A sample (that has an invalid sample ID or does not have a workorder) that
does not cause /SMPREQ to turn on is an invalid sample.
NOTE: The system recognizes valid samples only.
• The table headings are defined below:
• Transportation ability: Maximum transport ability of LAS corresponds to
3-second sampling cycle.
• Invalid sample ID: LAS identifies invalid samples (aspiration request
controlled).
• Sample arrival: Synchronous if the sample interval is not blocked by
transport, asynchronous if the sample interval is blocked by transport.
Method:
• SR: When /SMPREQ is turned off, next valid sample is processed
(/HNNEXT remains on).
• TR: When sample transport begins, next valid sample is processed
(/HNNEXT remains on).
• SB: When /SMPREQ is turned off, /HNNEXT also turns off. The next valid
sample is detected when /SMPREQ, then BMPSMP, turn off. (/HNNEXT
turns on afterward.)

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Table 3-18 /HNNEXT Control Methods

Invalid
Transport sample Sample
ability ID arrival Method Description
Yes Yes Sync. or SR + TR LAS identifies an invalid sample,
Async. but does not turn on /SMPREQ.
When a valid sample ID following
an invalid sample ID is
consecutive, /HNNEXT remains
on. The LAS can transport the
invalid sample by its maximum
transport ability, but does not
know its sample ID (cannot
transmit information to the host
computer). Administration occurs
using the system’s maximum
processing ability.
Sync. SR The LAS identifies an invalid
sample, but does not turn on /
Async. SB
SMPREQ. When a valid sample
ID following the invalid sample
ID is consecutive, /HNNEXT
turns off. The LAS can transport
an invalid sample with its
maximum transport ability, but
does not know its sample ID
(cannot transmit information to
the host computer).
Administration of a valid sample
following an invalid sample
requires two 3-second cycles.
No Sync. SR The LAS turns on /SMPREQ in all
Async. SB samples regardless of ID validity.
For all samples, /HNNEXT is on.
The LAS can transport an invalid
sample with its maximum
transport ability. Aspiration
depends on validity of pre-read
sample ID. The system
communicates information about
the valid sample to the host
computer. Administration occurs
using the system’s maximum
processing ability.
Yes or No Sync. or Always /HNNEXT signal is not
Async. off controlled. Administration always
requires 2 cycles (6 seconds).

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Synchronous Sampling Sequence


Figure 3-21 depicts an LAS system where a sample arrives synchronously (the
sample and rack intervals are not interrupted). Sample transport corresponds with
the 3-second sampling cycle. An invalid sample is transported asynchronously
(sample or rack interval is blocked asynchronously by transport).

System sampling position Valid sample

/HNNEXT position Invalid sample

A B C D E F G H I J K L
Figure 3-21 Synchronous Sampling Sequence

The /HNNEXT signal is controlled at the aspiration position as follows:


1. If no sample exists (which starts the LAS), the /HNNEXT signal is turned off.
2. When aspiration is needed (A), the LAS keeps the /HNNEXT signal after
/SMPREQ is turned off and on.
3. When sample transport begins, the /HNNEXT signal is on (B).
If an invalid sample is transported, this sequence does not occur.
Administration of the sample following an invalid sample requires two
3-second cycles.
4. If the rack interval becomes empty, the /HNNEXT signal of the last sample on
the first rack (J) goes off.

Asynchronous Sampling Sequence


Figure 3-22 depicts the asynchronous arrival of a sample (the sample interval or
rack interval is interrupted). The next sample arrives asynchronously while
aspirating; sample transport corresponds with a 3-second cycle.

System sampling position Valid sample

/HNNEXT position Invalid sample

A B C D
Figure 3-22 Asynchronous Sampling Sequence

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This sequence describes the /HNNEXT signal (at the aspiration position) during
transport of a valid sample:
1. If no sample is available upon starting of the LAS, the /HNNEXT signal is
initialized by being turned off then on.
2. When a sample (A) is ready for aspiration, /HNNEXT remains on.
3. Subsequent valid samples are processed until /BMSMP turns off after
/SMPREQ turns off.
If the following sample ID (B) is valid and consecutive from the previous
sample, /HNNEXT remains on.
If the next consecutive valid sample ID arrives asynchronously, /HNNEXT
remains on (C).

/HNNEXT On During Sample Transport


Figure 3-23 depicts /HNNEXT being on during sample transport. The /HNNEXT
signal is on when sample transport begins, and when /SMPREQ is turned off at
the time the sample is aspirated by the system.

/HNNEXT

/SMPREQ
A C F G H
/BMSMP

Sample
transport
A B C D E F G

Figure 3-23 /HNNEXT on During Sample Transport

Aspiration of the first sample (A) requires two 3-second cycles.


A valid sample following an invalid sample requires one cycle for aspiration if the
sample arrives at the aspiration position in time for the system’s timing cycle (C).
Otherwise, two cycles are required (F).
Valid sample IDs numbered consecutively from previous sample IDs (G,H) are
aspirated in 1 cycle.

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/HNNEXT Off During Sample Transport


Figure 3-24 depicts /HNNEXT being off during sample transport. The /HNNEXT
signal turns on when /SMPREQ is turned off (when the sample is aspirated by the
system).

/HNNEXT

/SMPREQ
A C F G H
/BMSMP

Sample
transport
A B C D E F G

Figure 3-24 /HNNEXT Off During Sample Transport

Aspiration of the first sample (A) requires two 3-second cycles.


A valid sample following an invalid sample (C,F) requires two cycles for
aspiration. Valid sample IDs (H) numbered consecutively from previous sample
IDs (G) are aspirated in one cycle.
The /HNNEXT signal may or may not be on during transport of an invalid
sample, depending on the generation frequency of the invalid sample.

Nonconsecutive Sample IDs


Figure 3-25 depicts an instance where the next valid sample ID is not consecutive
with the previous sample ID. In this case, 2 cycles are required for aspiration
(even if a sample with a consecutive sample ID has already arrived at the
aspiration position).

/HNNEXT

/SMPREQ
A B C D
/BMSMP

Sample transport
A B C D
HNNEXT position AB C D

Figure 3-25 /HNNEXT for nonconsecutive valid sample IDs

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The first sample (A) requires 2 cycles for aspiration. A valid sample with a
consecutive sample ID (B) is aspirated in one cycle.
If the next valid sample (C) arrived at the aspiration position during aspiration of
the previous valid sample ID, it will be aspirated in 1 cycle. A valid sample ID
arriving after aspiration ends (D) requires 2 cycles for aspiration.

Serial Connectivity Technical Specifications


Figure 3-26 and Table 3-19 depict the connections and data exchanged between
the Chemistry System, the LAS, and the host computer. This section (and LAS
Serial Communication Signal Specifications‚ page 3-68) addresses the
connections between the system and the LAS.
Figure 3-26 Serial Communication Relationships Between the

Chemistry System, the LAS, and the Host Computer

Table 3-19 Information Exchanged Between the System, LAS and Host
Computer

Connection
(see above) Signal direction Data exchanged
1 Host → LAS Sample information
2 Host → system Sample information
System → host Analysis results
3 LAS ←→ system (bidirectional) Sample ID, sampling
communications.

The responsibility of the LAS-to-system connections is that of the LAS.

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Message Structure (v2.02 with Cyclical Redundancy Check)


Each data packet contains the information pictured below:
STX Message Message Message Message CPC ETX CR LF
(02H) type number length (variable (4 (03H) (0DH) (0AH)
(1 byte) (1 byte) (2 bytes) length) bytes)

Message Structure (v2.02 without Cyclical Redundancy Check)


Each data packet contains the information pictured below:
STX Message Message Message Message ETX CR LF
(02H) type number length (variable (03H) (0DH) (0AH)
(1 byte) (1 byte) (2 bytes) length)

Serial Message Structure (v1.4)


Each data packet contains the information pictured below:
STX Message Message ETX (03H) CR (0DH) LF (0AH)
(02H) type (variable
(1 byte) length)

Table 3-20 explains the data found in each packet. Unless otherwise indicated, the
data is in ASCII format.
Table 3-20 Serial Message Specifications

Data type Description


STX (02H) Start transmission (code to start message).
Message type Possible values:
I: Pre-read sample ID.
R: Sampling sample ID.
E: Error message.
See Serial Message Text Formats on page 3-86.
Message number (not in v1.4) Incremented from A through Z with each new
transmission. After Z, the number starts over at A. If
the number contains 0, the next transmission begins
with A. If NAK is received, sender resends packet
using original number (even if that number contains a
0). If the message number sequence fails, the receiver
sends a NAK to the sender.
Message length (not in v1.4) Length of the message after message number and up to
but not including the CRC. Possible values: 01 - 99.
Message Variable length message text.
CRC (cyclical redundancy STX through message 16-bit cyclic redundancy check.
check) - only in v2.02 with Uses binary format. If CRC is all space code (20h),
CRC CRC is not calculated and therefore is not checked. If
CRC fails, an error message is generated

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Data type Description


ETX (03H) End transmission (final message code).
CR (0DH) + LF (0AH) Carriage return and line feed (message end codes).

Communication Control Codes


These codes are transmitted as single data items (not part of a packet enclosed by
STX/ETX codes):
• ACK (06H): Affirmative acknowledgment by the receiver of a request from
the sender.
• NAK (15H): Negative acknowledgment by the receiver of a request from the
sender.

Exclusivity in Serial Communications


In serial communications, only one message can be sent (SD) or received (RD) at
a time. This means that at any time, no more than one of the following types of
data packets will be transmitting via the serial connection between the system and
the LAS:
• I message: Only takes place when the /IDREQ signal is off.
• R message: Only takes place when the /IDREQ signal is on.
• E message: Can take place any time and will interrupt a sample ID
transmission.
• ACK or NAK.

Timeout Values
Table 3-21 describes the timeout values (the maximum permissible delay of an
ACK or NAK response) for each message type sent between the system and the
LAS.
Table 3-21 Timeout Values

Response Time out Maximum number


Message type description interval of resends
I (pre-read sample ID) System response time 3 seconds 3
after LAS sends
pre-read sample ID.
R (sampling sample System response time 3 seconds 3
ID) after LAS sends
sampling sample ID.
LAS response time (to 5 seconds 0
send sampling sample (LAS-system
ID) after system sends communications stop;
/IDREQ signal. restart system)

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Response Time out Maximum number


Message type description interval of resends
E (error message) LAS response time 3 seconds 3
after system sends
error message.

Serial Message Text Formats


Pre-read Sample ID (I message)
The pre-read sample ID is sent to the system after the LAS barcode reader
identifies the sample.
Transmission direction: LAS-to-system (response: system-to-LAS)
Table 3-22 “I” Message Format

Number
Data type of bytes Code
Starting code 1 STX (02H)
Message type 1 I (49H)
Message number 1 0, A-Z
Message length 2 14
Sample ID 13 ASCII, maximum 13 alphanumeric
characters, no zero suppression,
left-justified, space (20H) at back, and
additonal formatting described in Sample
Number‚ page 2-16. .
Container classification 1 0 (container specified in workorder)
1-9 (container type number to use for each
LAS sample).
CRC - only in v2.02 with 4 STX through message 16-bit cyclic
CRC redundancy check.
Termination code 3 ETX + CR + LF (03H + 0DH + 0AH)

Sampling Sample ID (R Message)


The sampling sample ID is sent to the system to confirm the sample currently at
the aspiration position.
Transmission direction: system-to-LAS (response: LAS-to-system)
Table 3-23 R Message Format

Number
Data type of bytes Code
Starting code 1 STX (02H)
Message type 1 R (52H)

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Number
Data type of bytes Code
Message number 1 0, A-Z
Message length 2 14
Sample ID 13 ASCII, maximum 13 alphanumeric
characters, no zero suppression, left-justified,
space (20H) at back, and additonal formatting
described in Sample Number‚ page 2-16. For
more information, see the next section.
Container classification 1 0 (container specified in workorder)
1-9 (container type number to use for each
LAS sample).
CRC - only in v2.02 4 STX through message 16-bit cyclic
with CRC redundancy check.
Termination code 3 ETX + CR + LF (03H + 0DH + 0AH)

Default Sample ID
When the LAS uses two barcode readers, the R message is sent after the second
barcode reader scans the sample. If the R message and the I message sent earlier
do not match, the LAS software assigns a default sampling sample ID to the R
message. This ID allows the system to continue operating. (If the default ID is not
created, the non-matching sample IDs cause the system to stop operation.)
In accordance with the three-second sampling cycle, the system aspirates a sample
with the default sampling sample ID, because it had previously received a valid
“I” message from the LAS. However, it does not analyze the sample, because the
“R” message contains the default ID added by the LAS. Neither results nor flags
are produced. The next sample is analyzed according to normal protocols.
When the “R” message is sent with the default ID, all other data types must be
correct and the normal parallel signal communications must be used.

Error message (E message)


Transmission direction: system-to-LAS (response: LAS-to-system)
Table 3-24 E Message Format

Number
Data type of bytes Code
Starting code 1 STX (02H)
Message type 1 E (45H)
Message number 1 0, A-Z
Message length 2 14

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Number
Data type of bytes Code
Sample ID 13 ID of sample involved in the error.
ASCII, 13 alphanumeric characters, no zero
suppression, left-justified, space (20H) at
back.
Error code 3 ASCII fixed 13 numeric characters, no
suppression.
• 001: Lack of sample volume. Analysis
continues.
• 002: No workorder. Analysis continues
(sample skipped).
• 003: Mechanical error on system; sample
transport possible. Cannot stop and
restart.
• 004: Mechanical error on system; sample
transport not possible. Cannot stop/
restart.
• 005: Sequence error involving pre-read
sample ID and sampling sample ID.
Cannot stop/restart.
• 006: Message number error. Cannot stop/
restart.
• 007: Message length error. Cannot stop/
restart.
• 008: Message CRC error; sample
transport not possible. Cannot stop/
restart.
CRC - only in v2.02 4 STX through message 16-bit cyclic
with CRC redundancy check with expanded ASCII.
Termination code 3 ETX + CR + LF (03H + 0DH + 0AH)

Sample Cycle Time Intervals


Operation in 3-second Sampling Cycles
In the Chemistry System, sampling of each item takes place in a 3-second cycle.
In each 3-second sampling cycle, the system provides the following time
allotments:
• 0.1 seconds: for sampling to start, once the /SMPREQ signal is on.
• 1.2 seconds: for sampling.
• 1.3 seconds: for sample transport time.
• 0.4 seconds (total): for sample transport to start, when the /BMSMP signal is
off, and for turning on the /SMPREQ signal after completing sample
transport).

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Figure 3-27 illustrates the interaction of the LAS signals during the 3-second
sampling cycle.

/HNNEXT

/SMPREQ

AFTER /SMPREQ TURNS ON, SAMPLING


OPERATION STARTS WITHIN MAXIMUM 0.1 sec.

/BMSMP
SAMPLING (MAX 1.2 sec.)

SAMPLE TRANSPORTATION

Figure 3-27 LAS Signals (Serial) During 3-second Sampling Cycle

Transmission Time of Pre-read Sample ID


When the system receives a pre-read sample ID from the LAS, the system
prepares for sampling, including locating the workorders for that sample. If the
sample has reached the aspiration position and /SMPREQ is turned on before the
preparations have completed, sampling cannot take place.
The required preparation time (T) is calculated with this formula:
T = t1 + t2, where:
t1 = System internal processing time (maximum: 6 seconds) and
t2 = Communication time between the system and the host computer
(maximum 6 seconds). Without a host connection, t2 = 0.
System processing performance declines with the increase of T. This decline in
performance can be avoided if the time interval between barcode reading and
arrival at the aspiration position is greater than T.
Normally, no more than 5 cycles (15 seconds) are needed for communication of
each pre-read Sample ID.

Methods for Calculating the Cyclical Redundancy


Check (CRC)
Method of Calculating Transmission CRC Code
The total bit length of the entire transmitted content = n bits.

The message bit length = k bits, or m ( x )

The CRC bit length = n-k bits, or r ( x )

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The polynomial to make the bit code and the polynomial correspond one-to-one is
called the code polynomial.
Example:
3 2
1101 = X + X + 1 (MSB is made to correspond to the coefficient of
higher-order degree).
k–1 2 1
Message part: m ( x ) = m k – 1 X + … + m2 X + m1 X + m0

n–k–1 2 1
CRC part: r ( x ) = r n – k – 1 X + … + r2 X + r1 X + r0

1
It is equal to the left shift of one bit of the bit expression to multiple X to the code
polynomial. The code polynomial when the message part is shifted to the left of
the r bit and the n bit is assumed is as follows:
r
X m(x) =
n–k n–1 n–k+1 n–k
X m ( x ) = mk – 1 X + … + m1 X + m0 X

Example:
3 2
m ( x ) = X + X + 1 (1101)
3 6 5 3
X m(x) = X + X + X (1101000)

n–k
The expression in which X m ( x ) is divided by another polynomial g ( x ) is
shown below:
n–k
X m ( x ) = q ( x )g ( x ) + r ( x ) , where

g ( x ) is the generating polynomial (it is assumed to be a polynomial of the n-k


degree).

q ( x ) is a quotient.

r ( x ) is the remainder.
n–k
Because X m ( x ) is n degrees, r ( x ) becomes below the n-k-1 degree.
n–k
The one that r ( x ) was added to X m ( x ) can be divided by g ( x ) . That is:
n–k
X m ( x ) + r ( x ) = q ( x )g ( x )

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The left side of the equation is interpreted as the whole transmission code.
Therefore, the transmission CRC code becomes r ( x ) .

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Example:
3 2
Transmission message: m=(1101), that is m ( x ) = X + X + 1

3 1
Generating polynomial: g=(1011), that is g ( x ) = X + X + 1

In this case, the transmission CRC code is the remainder r ( x ) of


3 6 5 3
X m ( x ) = X + X + X divided by g ( x ) . The calculations can be represented
in either of the following manners:

3 2
X +X +X +1 1111
3 6 5 3
X +X+1 X +X +X 1011 1101000
6 4 3
X +X + X 1011
5 4
X +X 1100
5 3 2
X +X + X 1011
4 3 2
X +X +X 1110
4 2
X + X +X 1011
3
X +X 1010
3
X + X+1 1011
1 (remainder) 0 0 1 (remainder)

2 1
r ( x ) = 0X + 0X + 1. That is, r(x) = (001), which is used as the
transmission CRC code.
The whole transmission message is represented as follows:
3 6 5 3
V ( x ) = X m ( x ) + rx = X + X + X + 1 (1101001)

In this calculation, the rule is: A + B = A – B = A ⊕ B

EX OR using the carry over is ignored.

Method of Calculating Received Code

The total received code including the CRC code r ( x ) is assumed to be R ( x ) ,


where:
n–k
R(x) = X m(x) + r(x)

R ( x ) can be divided by the generating polynomial g ( x ) .

Therefore, when the received code R ( x ) is divided by g ( x ) , then the remainder


is 0 (no error). If the remainder is not 0, an error exists.

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The same g ( x ) must be used between the system and the LAS.

Selection of Generating Polynomial

The system’s error detection varies, depending on the g ( x ) . The following are the
normal generating polynomials:

16 12 5
g( x) = X +X + X + 1 , or 10001000000100001(X.25 standard)
16 bits 16 15 2
g( x) = X +X + X + 1 , or 11000000000000101(CRC-16).
Used in this signal specification.

Relation Between Digits in CRC and Digits in Generating


Polynomial
The received code polynomial of CRC is shown below:
n–k–1 2 1
r ( x ) = rn – k – 1 X + … + r2 X + r1 X + r0

r = CRC. Bit length: n-k bits.


n–k
The expression into which X m ( x ) is divided by g ( x ) is as follows:
n–k
X m ( x ) = q ( x )g ( x ) + r ( x )

Because g ( x ) is the n-k degree of this polynomial, the highest order degree of the
generating polynomial equals the CRC bit length.
Example:
3
For g ( x ) = X + X + 1 : CRC is 3 bits.

16 12 5
For g ( x ) = X +X + X + 1 : CRC is 16 bits.

073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: LAS System 3-94

Converting the CRC Code into Printable ASCII Code


In the 16-bit signal specifications, the CRC code is converted into printable ASCII
characters using the process shown below. There are 4 bytes; they do not conflict
with ASCII standard control codes.
Table 3-25 CRC Conversion

CRC Conversion process


023E 16 bit CRC hexadecimal code (2 bytes).
‘0,’ ‘2,’ ‘3,’ ‘E’ Each byte is converted to printable ASCII code (4 bytes).

073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: Safety Instructions A-1

Appendix A: Safety Instructions

This information summarizes the established guidelines for handling laboratory


biohazards. This summary is based on the guidelines developed by the Centers for
Disease Control, the Clinical and Laboratory Standards Institute Document
M29-A3, Protection of Laboratory Workers from Occupationally Acquired
Infections, and the Occupational Safety and Health Administration’s Bloodborne
Pathogens Standard.1–3

Protecting Yourself from Biohazards


Use this summary for general information only. It is not intended to replace or
supplement your laboratory or hospital biohazard control procedures.
By definition, a biohazardous condition is a situation involving infectious agents
biological in nature, such as the hepatitis B virus, the human immunodeficiency
virus, and the tuberculosis bacterium. These infectious agents may be present in
human blood and blood products and in other body fluids.
The following are the major sources of contamination when handling potentially
infectious agents:
• needlesticks
• hand-to-mouth contact
• hand-to-eye contact
• direct contact with superficial cuts, open wounds, and other skin conditions
that may permit absorption into subcutaneous skin layers
• splashes or aerosol contact with skin and eyes

073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: Safety Instructions A-2

To prevent accidental contamination in a clinical laboratory, strictly adhere to the


following procedures:
• Wear gloves while servicing parts of the instrument that have contact with
body fluids such as serum, plasma, urine, or whole blood.
• Wash your hands before going from a contaminated area to a
noncontaminated area, or when you remove or change gloves.
• Perform procedures carefully to minimize aerosol formation.
• Wear facial protection when splatter or aerosol formation are possible.
• Wear personal protective equipment such as safety glasses, gloves, lab coats
or aprons when working with possible biohazard contaminants.
• Keep your hands away from your face.
• Cover all superficial cuts and wounds before starting any work.
• Dispose of contaminated materials according to your laboratory’s biohazard
control procedures.
• Keep your work area disinfected.
• Disinfect tools and other items that have been near any part of the instrument
sample path or waste area with 10% v/v bleach.
• Do not eat, drink, smoke, or apply cosmetics or contact lenses while in the
laboratory.
• Do not mouth pipet any liquid, including water.
• Do not place tools or any other items in your mouth.
• Do not use the biohazard sink for personal cleaning such as rinsing coffee
cups or washing hands.
To prevent needlestick injuries, needles should not be recapped, purposely bent,
cut, broken, removed from disposable syringes, or otherwise manipulated by
hand.

References
1. Centers for Disease Control. 1988. Update: Universal precautions for
prevention of transmission of human immunodeficiency virus, hepatitis B
virus and other bloodborne pathogens in healthcare settings. MMWR,
37:377–382, 387, 388.
2. Clinical and Laboratory Standards Institute (formerly NCCLS). Protection of
Laboratory Workers from Occupationally Acquired Infections; Approved
Guideline - Third Edition. CLSI Document M29-A3.[ISBN 1-56238-567-4].
Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite
1400, Wayne, Pennsylvania 19087-1898 USA, 2005).
3. Federal Occupational Safety and Health Administration. Bloodborne
Pathogens Standard. 29 CFR 1910.1030.

073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: Safety Instructions A-3

Protecting Yourself from Barcode Scanner Lasers


To avoid damage to the eyes, never look directly at the laser beam or at its
reflection from a shiny surface. Never point a hand-held barcode scanner at
anyone.

Laser Safety Classification of the ADVIA 1800


Chemistry System System
During normal operation with all of the protective housings in place, the ADVIA
1800 Chemistry System system is classified as CDRH Class I and EN 60825-1
Class 1. No direct exposure to laser hazard exists for persons in the immediate
area.

Figure A-1 CDRH Class 1 Label

Some field service procedures require the removal of the protective housings that
prevent human access to the laser radiation. The removal of the protective
housings may change the classification of the system to CDRH Class 2 and
EN60825-1 Class 2. All field service procedures must be followed precisely. Only
Siemens-trained field service personnel should perform procedures related to laser
assemblies.

Figure A-2 CDRH Class 2 Label

The laser labels are positioned on the instrument as shown below.

Laser Safety Classification of the Barcode Scanners


The laser safety classification of the reagent and sample barcode scanners when
they are unprotected by the system housings is CDRH Class 2 and EN 60825-1
Class 2. The laser safety classification of the hand-held barcode scanner used with
the system is CDRH Class 2 and EN 60825-1 Class 2.

073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: Safety Instructions A-4

Reagent and Sample Barcode Scanners


ADVIA 1800 Chemistry System Operator’s Guide procedures for testing the
reagent or sample barcode scanners contain the following laser warning:

LASER WARNING
Never look directly at the laser beam or at its reflection from a shiny surface.
Looking directly at the laser beam or its reflection could cause damage to the
eyes. Only trained field service personnel should perform procedures related to
laser assemblies. Refer to Appendix A, Protecting Yourself from Barcode Scanner
Lasers, for more information.

The specifications for the laser optical assemblies in the ADVIA 1800 Chemistry
System ancillary reagent, primary reagent, and sample barcode scanners are
summarized in the following table:
Characteristic Specification
Maximum Power Output 1.0 mW
Wavelength 670 nm
Pulse Duration Continuous Wave (cw)
Units of Beam Divergence 0.7 mr

The locations of the reagent and sample barcode scanners and their associated
laser safety labels are shown below. The laser apertures for the sample and
ancillary reagent barcode scanners are directed into the system away from the
operator.
During normal operation, reflections from the sample barcode scanner laser beam
may be visible to persons in the immediate area, but no laser safety hazard is
associated with this exposure. The laser aperture for the primary reagent barcode
scanner is directed toward the barcode labels at the end of the reagent packs inside
the primary reagent compartment.
During normal operation, the barcode scanner does not scan the reagent packs
until the primary reagent compartment door is closed. When the primary reagent
compartment door is closed, no operator exposure to the laser exists.

073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: System Symbols B1

Appendix B: System Symbols

This section describes the symbols that can display on the exterior of the ADVIA
1800 Chemistry system or on the system packaging. The symbols on the system
identify the location of certain components and, where necessary, display
warnings for proper operation. The symbols on the system packaging provide you
with other important information.

Warning and Caution Symbols

These symbols are used for both caution and warning.


WARNING indicates the risk of personal injury or
loss of life.
CAUTION indicates the possibility of damage to or
destruction of equipment.
When this symbol appears on the system without
CAUTION additional information, you must consult the
instructions for use.
This symbol indicates a moving component that can
cause injury.
This symbol alerts you to a potential electrical hazard.

This symbol alerts you to the risk of exposure to


lasers.
The onboard sampler is equipped with a laser barcode
reader. When covers are opened, there is a risk of
radiation exposure. Do not stare into the beam.
This symbol alerts you to a potential biohazard.
Biohazard labels are also placed on the sample and
dilution probes, which are exposed to the sample
during the analysis.
This symbol indicates the presence of a part emitting
high temperature.
Caution -
Laser radiation when open and interlocks defeated. Do not stare into beam

073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: System Symbols B2

System Operation Symbols

Start symbol

Standby symbol

Some parts of the system are on

Some parts of the system are off

Alarm symbol

Stop button

Reset button

Prime button

Error log

Indicates consult online instructions

Operator's guide

Wash button

I indicates closed circuit or On.


O indicates open circuit or Off.

073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: System Symbols B3

System Rating Label Symbols

Date of manufacture of the product

Name and location of the product manufacturer.

Manufacturer's authorized representative within the European


community
Product complies with the applicable directives of the European
Union
On the Universal Rack Handler this symbol indicates that the
product is UL approved for safety in the United States and
Canada.
On the analyzer, this symbol indicates that the product is UL
approved for safety in the United States.

Revision letter of a part or product

Serial number of part or product

Number used for ordering a part or product

An in vitro diagnostic device

Product is a Class 1 laser product under the provisions of 21


CFR 1040.10.

The WEEE symbol indicates that this equipment is classified as


Waste Electrical and Electronic Equipment under the European
WEEE Directive. It must be recycled or disposed of in
accordance with applicable local requirements.
This system contains toxic or hazardous substances or elements.
The environmental protection use period for this system is 50
years. The system can be used safely during its environmental
protection use period, after which it should be recycled
immediately.

073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: System Symbols B4

Hardware Component Symbols


Indicates the location of the lamp.

Universal Rack Handling System

Analyzer

Computer monitor

Computer workstation

Vacuum pump pressure gage

Reagent tray 1

Reagent tray 2

Controls and calibrators tray

Sample tray

Use these arrow symbols to align the tray covers.

Ancillary Reagent Symbols


Deionized water symbol on the reagent and sample trays

10% cuvette wash

Probe wash 1

Probe wash 2

ISE Det ISE detergent

073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: System Symbols B5

Connector Symbols

Isotonic saline diluent connector

Incubation bath oil connector

Cuvette wash connector

Cuvette conditioner connector

ISE buffer connector

Strong concentrated drain bottle sensor connector

Concentrated drain bottle sensor connector

073D0402-01 Rev. A
ADVIA 1800 Chemistry System Interface Specification Guide: System Symbols B6

System Packaging Label Symbols

Contents of the package are fragile.

Packaging is recyclable.

Expiration date for the package

Lot number of the package.


10 Minimum and maximum storage temperature for the package
2
The specified range may vary.

Contents of the package should be protected from heat and light.

Product or container should be oriented in the direction of the


arrows.

Package is printed with soy ink.

Contents of the package must not be frozen.

Number of tests available from the contents of this package

Packaging materials can be or are recovered and recycled.

073D0402-01 Rev. A
ADVIA 1800 Chemistry SystemInterface Specification Guide: Service, Ordering, and Warranty C-1

Appendix C: Service, Ordering, and Warranty

This section provides the following information:


• address of the Siemens authorized representative, which is the Siemens
contact within the European community
• addresses for obtaining service and technical information and for ordering
supplies
• system warranty and service delivery policy information

Limited Instrument Warranty and Service Delivery


Policy
Siemens Healthcare Diagnostics and its authorized distributors may provide
customers who acquire new Siemens instruments with a limited warranty either in
a specific agreement or in standard language on their invoices. This limited
warranty is designed to protect customers from the cost associated with repairing
instruments that exhibit malfunctions due to defects in materials and/or
workmanship during the warranty period.
Siemens Healthcare Diagnostics, at its election, provides warranty service either
by providing repair service of the instrument on site, or by exchanging the
defective instrument or component, subject to the limitations and exclusions set
forth in Replacement of Parts and Warranty and Service Exclusions below.
Repairs, replacements or exchanges of instruments or components provided
during the warranty or any additional service period, does not extend the warranty
or service period beyond the initially agreed upon period.
When the customer calls for service, the Siemens representative or authorized
distributor informs the customer of the type of service available for the customer’s
instrument, and instructs the customer as to how to obtain that service.

Warranty Period
The limited warranty period generally commences upon installation of the
original instrument at the customer’s location and extends for a period of 1 year
thereafter, unless otherwise specifically agreed to by and between
Siemens Healthcare Diagnostics (or its authorized distributors) and customer in a
writing signed by duly authorized representatives of both parties (sales
representatives are generally not authorized representatives of Siemens for these
purposes).

073D0402-01 Rev. A
ADVIA 1800 Chemistry SystemInterface Specification Guide: Service, Ordering, and Warranty C-2

Additional Service Period


The customers, with some exceptions, may purchase additional service coverage
beyond any initial warranty period as part of the original instrument acquisition
for second or subsequent years beyond the original installation date. The
customer’s original Purchase Invoice or appropriate Agreement Addendum must
indicate the term in months for additional service coverage.

Service During Normal Hours


The customer may obtain service for instruments during normal business hours by
contacting the nearest Siemens Healthcare Diagnostics location or authorized
distributor. Refer to the list of Siemens locations in this section.

Extent of a Service Call


Warranty or service calls generally include onsite repair or exchange of
instruments or components, travel to the location of the instrument, and onsite
labor during normal business hours. A warranty or service call is initiated by the
customer by following the instructions on how to obtain service for the customer’s
instrument. The service call is considered complete when any defects in material
or workmanship have been corrected by repair or replacement and the instrument
conforms to the applicable specifications. When service is complete, the customer
receives a copy of the documentation detailing all work performed by the
Siemens Healthcare Diagnostics representative or authorized distributor.

Service Outside Normal Hours


Customers, with some exceptions, may also request service to be delivered or an
exchange to be initiated outside normal business hours, including evenings,
weekend days, or nationally observed holidays, by contacting the nearest
Siemens Healthcare Diagnostics location or authorized distributor. Service
performed outside normal hours is subject to a surcharge unless the customer has
in place a service product option that provides service at the time requested.

Replacement of Parts
In performing service, Siemens Healthcare Diagnostics or its authorized
distributors provide appropriate parts to repair the instrument, or arranges for the
exchange of the instrument or affected parts, at no charge with the exception of
certain parts or subassemblies that are considered Customer Maintenance Items.
Customer Maintenance Items include, but are not limited to, the following items:
lamps, electrodes or sensors (which are covered by a separate warranty), reagents,
calibrators, controls, paper, and pens. Consult the appropriate system operator’s
manuals for a complete list of Customer Maintenance Items for any specific
model of instrument.

073D0402-01 Rev. A
ADVIA 1800 Chemistry SystemInterface Specification Guide: Service, Ordering, and Warranty C-3

Design Changes and Retrofitting of Instruments


Siemens Healthcare Diagnostics reserves the right to change the design or
construction of specific models of instruments at any time without incurring any
obligation to make such changes available to individual customers or instruments.
If Siemens notifies customers of a change that improves the performance or
reliability of their instrument, and requests to retrofit that instrument, the customer
must agree to allow Siemens or an authorized distributor, at Siemens’ expense, to
retrofit components or make design changes, which does not adversely affect the
instrument’s performance characteristics.

Key Operator Designation


Each customer designates a key operator who is available to Siemens
representatives to describe instrument malfunctions by telephone and/or to
perform simple adjustments and corrections as requested. If a key operator is not
designated or is unavailable when the customer requests service, the delivery of
service may be delayed.

OSHA Requirements (US only)


When service is required at a customer location, the customer must provide the
Siemens representative with adequate facilities that comply with the regulations
of the Secretary of Labor under the Occupational Safety and Health Act (OSHA)
of 1970, as amended.

Warranty and Service Exclusions


The following exclusions are in addition to any exclusions provided for in any
written warranty or service agreement.
IF ANY OF THE FOLLOWING EVENTS OCCUR, THE WARRANTY OR
SERVICE PROVISIONS DO NOT APPLY:
1. Repairs or modifications have been made to the instrument by someone other
than an authorized Siemens Healthcare Diagnostics representative.
2. The instrument has been operated using accessories and supplies other than
Siemens brand accessories, or consumable supplies and/or reagents not
having the same grade, quality, and composition as defined in the system
operator’s manuals.
3. Siemens Healthcare Diagnostics has notified customers of a change that
improves the performance or reliability of their instrument and customer has
not agreed to retrofit or make design changes to the instrument.
4. Customer did not purchase the instrument from
Siemens Healthcare Diagnostics or one of its authorized distributors.
5. The instrument has not been installed within 90 days of shipment to the
customer’s facility unless otherwise specified.

073D0402-01 Rev. A
ADVIA 1800 Chemistry SystemInterface Specification Guide: Service, Ordering, and Warranty C-4

6. The customer has not performed appropriate customer maintenance


procedures, as outlined in the system operator’s manuals.
7. The instrument has been misused or used for a purpose for which it was not
intended.
8. The instrument has been damaged in transit to the customer or damaged by
the customer while moving or relocating it without supervision by a Siemens
representative.
9. Damage was caused by floods, earthquakes, tornados, hurricanes, or other
natural or man-made disasters.
10. Damage was caused by Acts of War, vandalism, sabotage, arson, or civil
commotion.
11. Damage was caused by electrical surges or voltages exceeding the tolerances
outlined in the system operator’s manuals.
12. Damage was caused by water from any source external to the instrument.
13. The customer has purchased an alternative agreement whose terms of
warranty or service supersede these provisions.
Siemens Healthcare Diagnostics or its authorized distributors can invoice
customers, at current standard labor and parts rates, for instruments repaired to
correct damage or malfunctions due to any of the reasons listed above.
OTHER THAN AS STATED ABOVE, THERE ARE NO OTHER
WARRANTIES, EXPRESS OR IMPLIED, WITH RESPECT TO THE
INSTRUMENT, ITS SALE TO THE CUSTOMER, ITS LEASE TO THE
CUSTOMER, OR THE SALE OF THE INSTRUMENT TO THE CUSTOMER
AT THE EXPIRATION OR TERMINATION OF THE LEASE AGREEMENT.
SIEMENS SPECIFICALLY DISCLAIMS ANY AND ALL IMPLIED
WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A
PARTICULAR USE OR PURPOSE. SIEMENS’ LIABILITY FOR BREACH OF
ANY WARRANTY OR SERVICE AGREEMENT SHALL BE LIMITED ONLY
TO THE REPAIR OR REPLACEMENT OF DEFECTIVE EQUIPMENT AND
SHALL NOT INCLUDE ANY DAMAGES OF ANY KIND, WHETHER
DIRECT, INDIRECT, INCIDENTAL, CONTINGENT, OR CONSEQUENTIAL.
SIEMENS SHALL NOT BE LIABLE FOR DELAY FROM ANY CAUSE IN
PROVIDING REPAIR OR EXCHANGE SERVICE.
ANY LIMITATIONS OR OTHER PROVISIONS NOT CONSISTENT WITH
APPLICABLE LAW IN PARTICULAR JURISDICTIONS OR A SPECIFIC
WRITTEN AGREEMENT DO NOT APPLY TO CUSTOMERS IN THOSE
JURISDICTIONS OR SUBJECT TO THOSE AGREEMENTS.

073D0402-01 Rev. A
ADVIA 1800 Chemistry SystemInterface Specification Guide: Service, Ordering, and Warranty C-5

Contacts
This section provides the following information:
• the address of the Siemens authorized representative, which is the Siemens
contact within the European community
• the Siemens addresses for obtaining service and technical information and for
ordering supplies

Siemens Authorized Representative

Addresses
For technical assistance contact your local technical support provider. For
customer service or additional information contact your local technical support
distributor.
www.siemens.com/diagnostics

073D0402-01 Rev. A

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