Professional Documents
Culture Documents
Paramyxo 220912010312 4e99810a
Paramyxo 220912010312 4e99810a
PARAMYXOVIRUSES
Family Paramyxoviridae
ssRNA – single piece
Helical nucleocapsid, enveloped
Spherical, 100-300nm diameter
Classification
Five genera-
1. Respirovirus- human parainfluenza v-1,3
2. Rubulavirus- human parainfluenza V-2,4
3. mumps virus
4. Morbillivirus- measles virus
5. Pneumovirus- Human respiratory synctial virus
6. Metapneumovirus- human metapneumo virus
PROPERTIES OF ORTHOMYXOVIRUS
AND PARAMYXOVIRUS
Property orthomyxovirus paramyxovirus
viruses Influenza A,B,C Measles,mumps,
RSV,& parainfluenza
genome Segmented Non segmented
Virion RNA yes yes
polymerase
Capsid helical helical
Envelope yes yes
size Smaller(110 nm) Larger( 150 nm)
Single serotype
H- target of neutralizing Ab
1. Active immunisation
live attenuated- at 9 months
Firstly Edmonston strain- vaccination measles, then
schwartz strain- effective only after 15 months
Edmonston –Zagreb strain- passage in human diploid
cells- 1 dose, S/C route
MMR vaccine-single dose, S/C
LA vaccine- intranasal aerosol
2. Passive immunisation-pooled sera containing Ab
Prevention
1. cell culture
Specimen-saliva, spinal fluid or urine
Treatment: none
Prevention: live attenuated vaccine, used with
measles and rubella virus vaccines (MMR)
Not a part of universal immunization programme.
Respiratory Syncytical Virus
1. infants- bronchiolitis,
pneumonia
2. young children- otitis
media
3. older children and adults-
common cold
Diagnosis:
immunofluorescence
Isolation in cell culture- + CPE
serology
Treatment
Aerosolized Ribavirin
Ribavirin + hyperimmune globulins
Prevention
NO VACCINE
Virus
Rubella enters and infects the
nasopharynx and then spreads
to the lymph nodes and RE
system. The resulting viremia
spreads the virus to other
tissues and the skin. In
susceptible (seronegative)
pregnant woman, the virus
infects the placenta and then
spreads to developing fetus.
Congenital
infection
Lab Diagnosis