2. Significance of HSA in drug binding 3. Apparent volume of distribution , Definition , formulae. 4. Markers for plasma volume,TBW ,ECF 5. Definitions of bioavailability,bioequivalence,therapeutic equivalence and pharmaceutical equivalence. 6. Biotransformation – DEFINITION AND SIGNIFICANCE 7. Definition of clearance and extraction ratio 8. What is Michaelis Menten Kinetics ? e.g.s of physiological processes occurring by mixed order kinetics 9. What is meant by AUC ? Methods used for determining area under the curve 10. Non- compartmental analysis 11. Diplacement interactions 12. Describe One compartment open model for IV bolus administration . Explain determination of pharmacokinetic parameters for the same. 13. Measures of bioavailability (a) Plasma concentration data (b) Urinary excretion data 14. Absolute and relative bioavailability 15. Methods of bioavailability assessment . 16. Phase 1 & phase 2 pathways comparison 17. Enlist the Physiological barriers to drug distribution . Write short note on Blood brain barrier and placental barrier 18. Name the renal and non renal routes of drug elimination 19. Describe the factors affecting renal excretion of drugs.