Naive lymphocytes continuously migrate mainly into secondary lymphoid organs,

whereas lymphocytes that have been previously activated by antigen (e.g., effector
lymphocytes), as well as myeloid leukocytes, preferentially home into tissues where
there is infectionor tissue injury.
Memory lymphocytes migrate into lymphoid organs, mucosal tissues, skin, and other
tissues

Selectins are plasma membrane carbohydrate-binding adhesion molecules that mediate

an initial step of lowaffinity adhesion of circulating leukocytes to endothelial
cells lining postcapillary venules .
The extracellular domains of selectins are similar to C-type lectins, so called
because they bind carbohydrate structures (the definition of lectins) in a calcium-
dependent manner.
Selectins and their ligands are expressed on leukocytes and endothelial cells.

Endothelial cells express two types of selectins, called P-selectin (CD62P) and E-
selectin (CD62E).
P-selectin, so named because it was first found in platelets, is stored in
cytoplasmic granules of endothelial cells and is rapidly redistributed to the
luminal surface in response to histamine from mast cells and thrombin generated
during blood coagulation.
E-selectin is synthesized and expressed on the endothelial cell surface within 1 to
2 hours in response to the cytokines interleukin-1 (IL-1) and tumor necrosis factor
(TNF), which are produced by tissue sentinel cells (DCs and macrophages) in
response to infection.
Microbial products such as lipopolysaccharide (LPS) also stimulate E-selectin
expression on endothelial cells.