FACULTY OF PHARMACY & Pharmaceutical Technology MESTER EXAMINATIONS ‘ebruary, 2020 Department of Pharmaceutics 2019/2020 HARMATTAN SEI Course Code: PCT305 Course Title: Forensic Pharmacy Date: SECTION 8: [ANSWER ALL QUESTIONS IN THIS SECTION (20 marks) As a young Pharmacist who has just been employed in a Government Hospital, what J etical values should guide your practice to ensure good service delivery? (10 Marks) Outline the duties of the Secretary to the Pharmacists Council of Nigeria? (5 Marks) Mcafee a native of Sagamu studied Pharmacy in Unversity of Mannitoba in Canada fin Nigeria, What are the conditions he must satisfy to be eligible CN) (5 Marks) 1 and wants to practic for registration with the Pharmacists’ Council of Nigeria (P' Q SECTION C: ANSWER ANY FOUR (4) QUESTIONS IN THIS SECTION (60 Marks) ‘Question? a. What is National Drug Formulary and Essential Drug List Act? a ~~ = What condition (s) can warrant the use of a drug not on the essenitial drug lis Sa c. List the members of the “Review committee” = d. Whatare the function(s) of the “Review Committee?” (15 Marks) =< ol = a. How does NAFDAC assist the NDLEA in the control of the abuse of Narcotics? b. What is ‘Cosmetic’ as a regulated item by NAFDAC? /- Mr Smith, a Canadian citizen who graduated with a B. Pharm Degree from the University of Manitoba, Canada applied for registration with the Pharmacists Council of Nigeria. Discuss the conditions he must satisfy to be eligible for registration to practice Pharmacy in Nigeria. [10 marks] ¥ State the Food and Drugs Act [1 mark] Gi) Youhave been appointed as an “Inspecting Oflicer’ under the Food and Drugs Act, Discuss in details your powers and limitations {3 marks/ P Gi) State the appropriate qualifications aud requirements for the officers below ‘ood and Drugs Act : eee under the provisions of TS suistiyotemts warns nalyst [3 marks] ~ (b) A ar wW/ (a) Differentiate between medical opium and prepared opium [7 marks] fa) List the drugs in Part |, Il and Ill of the dangerous drug act [3 marks] , %, (a) Recently, there isa widespread call forthe Pharmaceutical Society of Nigeria (PSN) ¢ to be disbanded because some people believe that the Society is of no use to Pharmacists. Strongly justify why PSN should not be disbanded. (5 marks] (b) The Dean, Faculty of Pharmacy OU has been invited to attend the Council meeting of Pharmaceutical Society of Nigeria xt the Sheraton Hotel, Abuja. Write a list of other Council members who will attend the meeting. [5 marks/ & (@) Inthe establishment ofthe governing council of NAFDAC, mention 5 of the members of the council. — 4 2 @ Define the following terms as relateg to NAFDAC. im Regulated products i y ow eae ron aT CO a 7. a, On what ground can a drug not listed in the es: ntial drug list be imported or ‘manufacture in Nigeria . te 4 yi b, What is the composition of the “Review Committee” of the Nationa! Drug. 7 Formulary and Essential Drug list (10. marks] Z = ‘i 1 Wa ¢FACULTY OF PHARIVIALT rmaceutical Technology tment of Pharmaceutics & Pha NATION Depar 2020/2021 HARMATTAN SEMESTER EXAMI Date: August, 2021 Course code: PCT303 ual marks SECTION B: INSTRUCTION: Answer four (4) Questions only. All Questions carry eq 1. Critically discuss the advantages of the rectal route over oral therapy for systemic drug effects (a5marks) ting drug release from ointments 2. Discuss with relevant diagrams a method for evalua! (1Smarks) neh a J. a Mention classes of oil used in emulsion formulation and give one example each: b. Discuss the different methods for identifying emulsion type (15marks) J a. Define an emulsion b. Discuss the factors that affect the rate of creaming ¢ Explain how emulsifying agents impart stability to emulsions (15marks) 5. a. Explain the osmotic pressure consideration for the formulation of parenteral preparation (5marks) b Highlight the steps involved in the manufacture of the following; i. Aqueous parenteral suspension (5marks) ii, Aqueous parenteral solution (3 marks) (2marks) iii, Oil-based parenteral solution Gee? gyanco 5, /o Blain percolation as a method of extraction b. Explain the process of drug absorption across the cornea (Smarks) ; (Smarks) : é ¢ State six (6) reasons for the extraction of active ingredient from crude materials (3marks) compared with aqueous d. State one merit and one demerit of ophthalmic ointments, ophthalmic formulation (2marks).ABISEONABANIO UNIVIERSEPY 7 onal Porn JM FACULTY OF PHARMACY sty DEPARTMENT OF PHARMACEUTICS & PHARM. TECH. £ & Pe G i ie BR & attan sementer) er 301; Physical Phi uttestT 2018/2019 sension (ar por sn: Phy Date: May, 219 “ sstions only. estions cagry eqyat mark section B: Answer FOUR (4) Question aly, All Quest y eqyal marks Section Bi eee a ae i ger’ a es oe 1. a, Discuss briefly the Applic Cons of Eutectic Mixtures in Pharmaceutical inde ns of Phase equilibrium in the industries 5 b. Mention 4 applicat [15 marks] Write a short note on Phase rules @ rhe thetlogical properties of pharmaceutical formulations should be carefully considered \ se tlr to have a product of good elegancy and adequate release profile, Discuss, [15 marks}. i 4 paste with cold water, it can be stirred slowly but ior (a) When starch powder is made into in details the flow bel tends to solidify if the stirring rate is increased. Describe [7 marks] ee Sie (1) OF SUCH Systenis imnurks) involved (6) What are ‘shead-thinning’ systein~? Discus i » practice // Smarks] oc pon sm 2h [ed socGrsts en fy SOLAS on (es. aN LA nts en gee presence of solute Can affect surface or interf {b) List the types of boundaries that may exist in pharmaceutical products with examples 4. Discuss the concept and importance of surface and interfacial phenomena to pharmacy tension /Smarks] [10marks] — \ (res- 999 Mo Tnrer Fare Gas- (owt eo oS Gey - SOY d ) wees i antago, a _ sas? Gacgeriee 9 5 ih vd Tod tt’ 9 5 zs G ~y\ UTICS & PHARM, TECHNOEOGY = DEPARTMENT OF PHARMAG! 2017/2018 HARMATTAN SEMESTER EXAMINATION — \ Date: January, 2018 Course code: PCT303 SECTION B: INSTRUCTION: Answer four (4) Questions only ; ee ‘ en [ ’ 1. (a) Wateon® emulsion was given to you for identification. Discuss how you will ify this type of emulsion. (7 marks) 1 ors Wat served; state the factors that could Wateon® emulsion, creaming was ol tl could Have been and explain how this creaming ? (b) Ind influence the rate of creamin| prevented. (8 marks) 2. Liquid Paraffin. 45 Oleic acid = 3 { Lime water 52 L (a) i. Identify-the emulsifying ager't(s) in this formulation (2 marks) ii, What class of emulsifying agent is it? (2 marks) explain the mechanismvof action of the emulsifying agent(s) (2 marks) (b). An emulsion is to be used by « patient and the prescription states: 15 ml. t.d.s What'elass of emulsifying-agentwipld have been used in the preparation of emulsion and state the reasons for “hoosing this class? (5 marks), - Tie rc se A SE (©) List the different classes of ei rs agents and give one example each. (4 { marks) 3. a. Define the term “Pyrogens of administration including the organ of the ». b. Name 6 types of parenteral ro: body in which the drug is injected. se c. Write short note on glass containers \ [15marks] 7 ‘A) a. Write short note on Extraction b. Antioxidants, included in many formulations to protect a therapeutic agent susceptible to oxidation, may function in at least two ways; Name them. [15marks] ‘ ‘ ics. of 5. (a) What aré the similarities and'differences between the characier hydrocarbon ointment bases and absorption bases (10marks) 'b) Discuss the fusi thod of oii ion using anak i a ion method o* ointment production using an absorption base (5FACULTY OF PHARMACY maceutical Technology Department of Pharmaceutics & Phar 20 session (Harmattan semester) pcr 301 2019/20: Date: February, 2020 Section B: Answer FOUR (4) Questions only. All Questions carry equal marks © Belain the relevance of Rheology in formu Discuss in details any two (2) Non Newtoniat ation of Pharmaceutical products [15 marks] n systems in Pharmacy [15 marks] aw a labelled schematic representation of the following; 3. a. Dre 1 Adrop of air formed in the bulk of a liquid showing the concave, the convex and the sides with a higher pressure. (2 marks) (2marks) 1. Anonionic surfactant in water Give examples of different interfaces encountered in dosage forms and discuss the importance of the study of interfacial phenomena to pharmaceutical formulation, (8 marks) e < i? Explain the effect of temperature on surface tension (2 marks) he formulation of charcoal as anti-poison (1marks) using each phenomenon as reference. d. How does wetting impact t Aa Briefly enumerate the importance of Eutectic mixtures in pharmaceutical industry. b. Phase equilibrium is the study of the equilibrium which exists between or within different states of matter namely solid, liquid and gas. Explain with examples. [15 marks] J With the aid of a well labelled diagram, explain the relationship between different b. Equilibrium and Metastable States are conditions that 5 very important in thermodynamics. Discuss phases 3 \ , [25 marks] ae ye re Pe es U |a OLABIS| ONABANJO UNIVERSITY FACULTY OF PHARMACY Department of Pharmaceutics & Pharmaceutical Technology PCT 301 2020/2021 session (Harmattan semester) August, 2021. Section B: Answer FOUR (4) Questions only. All Questions carry equal marks 1. Highlight the pRarmaceutical applications of adsorption from solution [415 + 2, With the aid of appropriate diagrams, distinguish between the Langmuir and Freundlich isotherms [15 marks} ve 3, (a) Discuss in details the relevance of rheological control in Pharmaceutical formulations (b) 4 plastic material was found to have yield value of 5000 dyne/cm2. At shearing stress above the yield value, stress was found to increase linearly with rate of shear. If the rate of shear was 125 s-1 when stress was 7500 dyne/cm2, calculate the plastic viscosity of the le a” [15 marks} — o Wy r om Discuss in details the different types of shear thinning flow systems most pharmaceutical apiluids exhibit [15 marks} 5.7. Phase equibrium is the study of the equilibrium which exists between or within different states of matter namely solid, liquid and gas. Explain with examples. b. Give 3 examples of eutectic mixtures [25 marks] . ‘a. Discuss in details Eutectic mixtures and their application in pharmaceutical industry. bs aula. and Metastable States are very important conditions in thermodynamics. Discuss [15 marks]OLABISI ONABANJO UNIVERSITY FACULTY OF PHARMACY \ NT OF PHARMACEUTICS & PHARM. DEPARTM! PCT 301: Physical Pharmaceutics I 2018/2019 session (Harmattan semester) Date: May, 2019 Section B: Answer FOUR (4) Questions ously. All Questions carry equal marks tures in Pharmaceutical Industry 1. a. Discuss briefly the Applications of b. Mention 4 applications of Phase equilibrium in the industries c. Write short note on Phase rite [15 marks} 2. The rheological properties of pharmaceutical formulations should be carefully considered in order to have a product of good eleyancy and adequate release profile. Discuss. [15 marks] 3. (a) When starch powder is made into a paste with cold water, it can be stirred slowly but tends to solidify if the stirring n details th t rate as increased. Describ a iol = Sate Marks, (8) What are :shear-thinning’ systems? Discuss in details any one (1) of such systems [8 marks] 4. Discuss the concept and importance of surface and interfacial phenomena to pharmacy practice (1 5marks) 5. (a) Describe how the presence of solute can affect surface or interfacial tension (Smarks] (b) List the types of boundaries that may exist in pharmaceutical products with examples [0marks] w behaviorDuell Lis [00 1! fh Olabisi Onabanjo University Department of Pharmaceutics and Pharm Tech PCT 301 INCOURSE 06/11/2019 by Uwaezuoke OJ Why does benzene float on water? adtesus* Capillary rise can be explained in terms of 2 The energy of molecules at the interface/surface is at zero. True or fats€— Why is temperature controlled during surface tension measurement? The major difference between adsorption and absorption is that one is physical while the other is chemical. True or false. Addition of surface-active agents increases the surface tension at the interface, Lea€or false One major application of adsorption 8. Fora heterogenous system to be in equilibrium (stable), the surface free energy or entropy should be i 9. One parameter that is used to quantify wetting is - Slealee i oh: . 10. Two applications of surface-active agents in FORMULATION is as 2------ and “nebse phe Unabte Qnd ey aa eg Lb Decouse th Begone was ak bd clisplace a water, og pugs? Pawn uo Bese. ol Adreswe Pe eRalStaa Vase vecast yoerease 14 WP rus. false apo Cheomateg Pry | Minimum if ature Hetetase ia suepace 1e05 | luarrn ge ! pata angle \OLABISL ONABANJO UNIVERSITY | 7 FACULTY OF PHARMACY ie DEPARTMENT OF PHARMACEUTICS AND PHA! TECHNOLOGY MESTER EXAMINATION 2021/2022 SESSION TIME 2 HOURS RMACEUTICAL HARMATTAN § ON B PCT 301: Physical Pharmaceutics IT ANSWER FOUR (4) QUESTIONS ONLY 1, A. What are shear thinning systems? (3 marks) in details, two examples of shear thinning systems. (12 marks) b. Discu: Discuss in details the relevance of rheological studies in pharmacy (15 marks) a 3. Describe with appropriate diagrams the Wilhemy Plate method of measuring surface tension. 4 Mith the aid of appropriate diagrams, distinguish between the Langmuir and Freundlich isotherms 5/ a. Phase equilibrium is the study of the equilibrium which exists between or within. different states of matter namely solid, liquid and gas. Explain with examples. b. Give three (3) examples of eutectic mixtures 6. a. Briefly enumerate the importance of Eutectic mixtures in pharmaceutical industry. b. Phase equilibrium is the study of the equilibrium which exists between or within different states of matter namely solid, liquid and gas. Explain with examples.pen ~~" OLABISI ONABANJO UNIVERSITY FACULTY OF PHARMACY DEPARTMENT OF PHARMACEUTICS AND PHARMACEUTICAL TECHNOLC SION AMINATION 2021/2022 HARMATTAN SEMESTER chnology IL SECTION B TIME 2 HOURS PCT 303: Pharmaceutical Te ANSWER FOUR (4) QUESTIONS ONLY Gy? Extensively discuss different methods of preparing ointments Discuss with relevant diagrams a method for evaluating drug release from ointments 3 /Exphain the following factors to be considered in the formulation of parenteral formulations a. Solubility of the therapeutic agent (Smarks) b. Vehicle in which medicament is dissolved (Smarks) ¢ Onsev/duration of action (Smarks) 4. Explain the following formulation consideration for ocular solution and suspension. a. Choice of drug salt (4marks) b. Viscosity modifying agent (4marks) ¢. pH of the solution (4marks) 4. Physical properties of the dispersed therapeutic agent (3marks) 4 Describe the different methods by which emulsion type can be identified (10 marks) b. List five advantages and five limitations of emulsions (Smarks) a. State the different classes of emulsityin; Ss e 9 Ying agents and give one example of eac! fe ple of each ( b, List the instabilities that can occur in emulsion and state the cause: of these instabilities (6 marks) pea ’ 2e x&Une = FACULTY OF PHARMACY aceutics & Pharmaceutical Te 2019/2020 session (Harmattan semester) Establishment, t ng, Synaral cluties Pharrrecist? Lonm ‘ (@) 4 pfesehiptign Sees any math sep etna our Pharmacy. State the 1d be an Tans i ae fares} Sea weneeae GVM Weep ree (l Bg wi I ‘oisons in of | the a ‘Schedule of Poisons and Pharmacy Act Binal PED C0EP8 er Parts af Kee, HSE Schreculg Of Prisons crcl aa. NCA marks) (© What FORMS is issued to Patent and Prpprietar oun au aPahogetetthe tae hare FORD Looks TREE = arks) te, cs) Hab-tee ord GEA diag rem) ade Unstrate hove 4 Faem 8” locks lke §. (@)What is NAFDAC? Explain 5 of her statutory functions ~ (6 marks) (b) List eight (8) composition of the NAFDAC council- ae marks) ied 6 HIACRRL Rl fase ctetel fy parcbons Co merck) sine SedabQeIR ON, en ara ahy “there is need for the saline Re Ss e Sot te ~ Essential Dt Bel ES i ETRE f ae 5) drug in the Essential Drug list= (marks) Eoplauns Crrerca For tel Eve pels im Emdoarne f the code of ethics for (b) Discuss the gen © ESscok 4) Brug Lasts Baw aa (a) What is Food and Drug Act? Boas lick 6S Free er brag Ace ) Weatastice Je gonditigns to be f Sues Bae a person can be designated as a d Gepreayenay a roche eS ~ di rst t und r this sae feels Zi M MBit fs ts na inspecting se under this Act [2 marks] —~ po fees oy eg PFCe, under NG Comat) eee ors sed passin PA Brewin mek eh shanat fe hermatibicl Geru'y & Misch: at are fl sede et Aeretanenceenet ox of Nigeria ey, (5 marks) Or Groce Baus _ Bry 7. (a) hice dameetine er bes Be Parent Agency (NDLEA) [5 marks). ~ (b) Discuss the powers of NDLEA (5 marks). 8. (a) What is the Dangerous Drug Act? (2 marks) ./ (b)In your own opinion interpret the Dangerous Drug Act (5 marks), = (c) List the drugs in part 1, part 2 and part 3 enti DDA (3 marks),_/F FACULTY OF PHARMACY CAL TECHNOLOGY DEPARTMENT OF PHARMACEUTICS & PHARMACEUTI Date: August, 2021 Course Code: PCT305 Session: 2020/2021 SECTION B: ANSWER 2 QUESTIONS (Question 1 and any other one) Grade 1 Pharmacist 1- Discuss in details the standards of conduct that should be observed by working in a G6Vernment Hospitat (25 macks} — 2. You have been appointed as the Secretary to the Council of Pharmacists Council of Nig¢ e (PCN) and the Chairman has asked you to write letters of invitation to members for the naugural meeting. List the names of those to be invited for the meeting _[ 10 marks] x S-Mr Abedi Addo, a Ghanaian who graduated with a 8. Pharm Degree from the Mapeges University, UK applied for registration with the PCN. Discuss the conditions he must satisfy to be eligible for registration to practice in Nigeria [10 marks} SECTION C: ANSWER ANY FOUR (4) QUESTIONS IN THIS SECTION Qugstion i - —2._The list that-contains the names of approved drugs inNigeriaisknown aS... b. On what condition can a drug not included in the list be imported into the country? —~ © What is the composition of the “Review committee” in charge of the list in Question 1a? (15 Marks} c 1 westion 2. “a. As.a pharmacist in a pharmacy, If Prescription is brought by a patient, what are the things you look out for? When dispensing a part 1 drug from the first schedule of the Poisons and pharmacy act, the drug is recorded in a book known as disposal of Polsons book, State all the things to be listed : To open a new retail Pharmacy, describe stepwise how this will be achieved /15 Marks]