1.

Describe and compare the concepts of structure-based drug design and ligand-based drug
design in search for new drugs.
2. Describe methods used for identification of the structure of newly synthesized compounds.
3. Describe the principles of the Ames test.
4. Describe the stages of drug discovery and discuss why drug discovery is such a long and
costly business by giving example
5. Illustrate with proper examples how plants remain a potential source of new therapeutic
compounds
6. Define phase 1 studies in Drug Development and with the aid of examples discuss the
relevance of phase 1 studies
7. Discuss how drug targets and drug compounds are assessed for safety during drug discovery
8. Describe dipole-dipole interactions giving appropriate example