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1st mode II mode

Indications: Indications:
• MBT+ • MBT+
• extrapulmonary localizations • drug resistance (DR) to H, but sensitivity
to R
Intensive phase:
4 PTPs: HRZE or S Intensive phase:
5 PTP: mandatory R, Z, Km/Am/Cm, Lfx/
example: Mfx/Sfx further e.g. E
1. isoniazid 10 mg/kg (max. daily 900 mg)
+ vit.B6 example:
2. pyrazinamide 25mg/kg (max. daily 1. levofloxacin 10 mg/kg (max daily
2500mg) 750-1000 mg)
3. rifampicin 10mg/kg (max daily 2. pyrazinamide 25mg/kg (max. daily
600mg) + hepatoprotectors 2500mg)
4. ethambutol 15 mg/kg (max daily 3. rifampicin 10mg/kg (max daily
2000 mg) 600mg) + hepatoprotectors
4. ethambutol 15 mg/kg (max daily
duration2 months (60 days. doses) for newly 2000 mg)
diagnosed patients, 3 months (90 days. doses) in 5. kanamycin 15 mg/kg (max daily 1000
cases of repeated treatment mg)

Continuation phase: duration3 months (90doz.doz)

HR - for newly diagnosed HRE
or Z - for repeated cases Continuation phase:
4 PTP: mandatory R, Z, Lfx/Mfx/Sfx, further,
example: e.g. E
1. isoniazid 10 mg/kg (max. daily 900 mg)
+ vit.B6 example:
2. rifampicin 10mg/kg (max daily 1. levofloxacin 10 mg/kg (max daily
600mg) + hepatoprotectors 750-1000 mg)
2. pyrazinamide 25mg/kg (max. daily
duration4 months (120 days. doses) for newly 2500mg)
diagnosed cases, 5 months (150 days. doses) for 3. rifampicin 10mg/kg (max daily
repeated cases, 12 months (360 days. doses) for post- 600mg) + hepatoprotectors
articular tuberculosis and tuberculous meningitis 4. ethambutol 15 mg/kg (max daily
2000 mg)
duration6 months (180dose)
 III mode IV mode
Indications: Indications:
• MBT- • MBT+
• no LU • MDR risk (eg exposure to an MDR TB
patient)
Intensive phase: • LU to R or HR (MDR)
4 PTP: HRZE
Intensive phase:
example: 6 PTP: choose those to which you have saved
1. isoniazid 10 mg/kg (max. daily 900 mg) sensitivity
+ vit.B6
2. pyrazinamide 25mg/kg (max. daily example:
2500mg) 1. levofloxacin 10 mg/kg (max daily
3. rifampicin 10mg/kg (max daily 750-1000 mg)
600mg) + hepatoprotectors 2. pyrazinamide 25mg/kg (max. daily
4. ethambutol 15 mg/kg (max daily 2500mg) + hepatoprotectors
2000 mg) 3. protionamide 20mg/kg (max daily
750-1000mg)
duration2 months (60 days. doses) for newly 4. ethambutol 15 mg/kg (max daily
diagnosed patients, 3 months (90 days. doses) in 2000 mg)
cases of repeated treatment 5. kanamycin 15 mg/kg (max daily 1000
mg)
Continuation phase: 6. cycloserine 15mg/kg (max daily 750-1000mg)
2 PTP: HR
duration8 months (240d.dose), if only MDR
example: risk then 3 months (90d.dose)
1. isoniazid 10 mg/kg (max. daily 900 mg)
+ vit.B6 Continuation phase:
2. rifampicin 10mg/kg (max daily 4 PTP
600mg) + hepatoprotectors example:
1. levofloxacin 10 mg/kg (max daily
duration4 months (120 days. doses) for newly 750-1000 mg)
diagnosed cases, 5 months (150 days. doses) for 2. pyrazinamide 25mg/kg (max. daily
repeated cases 2500mg) + hepatoprotectors
3. protionamide 20mg/kg (max daily
750-1000mg)
4. cycloserine 15mg/kg (max daily 750-1000mg)

duration12 months (360dose)

 V mode
Indications:
• MBT+
• risk of XDR (eg exposure to a TB patient with
XDR)
• XDR

Intensive phase:
6-7 PTPs: choose those to which you have saved
sensitivity

example:
1. levofloxacin 10 mg/kg (max daily
750-1000 mg)
2. PAS 8-12g/day in 2-3 doses (max.
daily 12g)
3. linezolid 600mg/day (max daily
1200mg)
4. bedaquiline 400 mg every day for 14 days, then
200 mg 3 times a week
5. kanamycin 15 mg/kg (max daily 1000
mg)
6. cycloserine 15mg/kg (max daily 750-1000mg)

duration8 months (240dose)

Continuation phase:
4 PTP
example:
1. levofloxacin 10 mg/kg (max daily
750-1000 mg)
2. cycloserine 15mg/kg (max daily 750-1000mg)
3. PAS 8-12g/day in 2-3 doses (max.
daily 12g)
4. linezolid 600mg/day (max daily
1200mg)

durationminimum12 months (360dose)