A © 2004 04 60S @ CONTINOUS, ASSESSMENT TEST FOR PHA2IL Section A (30 minutes): Cirele the most appropriate answer ich answer is 0.5 mark 1. When aci is 5 .™ fen acid reacts with metal carbonate the product is 7. Asan electrolyte, water is salt UW AKO, AMCLy COuetL,0 AL strong, & B. water B. neutral, 7 C. carbon dioxide ACA + Wald Co,» © weak. @) all of above \ Wall + WsO44CO, —D agood insulator. a x 2 Process in which acids (H*) and bases (OH’) react to 8. Substances that react with both acids and, ad © < form salts and water is called bases are called ef (A) neutralization (A. Jamphiproticcs, atk 6S Bea ack ik B. hydrogenation ACY E NGO ANOLE 8 coat bases C. alogenation +830 amphiterie, naprstene ; ‘D. sublimation D. conjugate acids. fom 3. Corrosive effect on skin is caused by, 9. Bronsted-Lowery. acids, ~~ Nib is bases. AL HOA, C. water. a D. mercury. 4. A specie which accepts proton maybe considered to be wan OW eccept Pa 10-Aneifeetive antacid associated with GY proton acceptor spe AA calcium carbonate, & anionic specie. JAP dowates PH” BS Siam bicarbonate: s we A ‘magnesium hydroxide. j Foasio compounal-7 D. aluminum hydroxide. 1D, amphoprotie compound. in pharmaceutical aid and antihypercalee ais A Magna 5. If pH value is greater than 7, then solutio Deen fet ews) .. Tartaric acid a eo) ZF akkalwe Phosphor soda ~ x akteetere 12, Most widely used antacid in tre disease is A, calcium carbonate. magnesium hydroxide. €. aluminum hydroxide. >) combination of aluminum by. magnesium hydroxide. 13, Amphoteric oxides react wit A, salt. B. water. C. Acids. and B. *RE EE BLOC Section B (30 minutes): Answer all in the provided space s 2001 02605~ uct Wet Myr + PCOS” HO, in hyperacidity | phint S/N Questic ed ‘Answer in space below I Total ] ‘Mark paces Marks | obtained Use an equation to show what will 4 ms a+ 1 | happen when a carbonate is given during BaCOs 7A + Crs ol & | Give one major side effect of [AI(H:0)s. (OH)3) during management of GERD. ~ Constipation wuse IW couche. wrth a Magnesuvn bb. what do you use to reduce the side effect? nydvoxrde Hyperhidrosis isa disorder caused by [jy z what? Excess at d bod Name a complex substance used inthe _(, treatment. Ee Mention two observations in the = ne Secrenos 4 | alimentary canal during achlorhydria. TE BEES 2s Pepin is made! ey ‘ T Mention four types ‘of complex = acids wake 5 | soestances 2 9 = Satks What is oxy 260? qed eat courars Ger Ss ®. oO eon, le ing Substance coutcaring what isa peroxide? Total lA UNIVERSITY OF BOTSWANA FACULTY OF HEALTH SCIENCE SCHOOL OF HEALTH AND ALLIED PRoFrS | | BACHELOR OF PHARMACY PROGRA Course Title: Pharmaceutical Chemistry Course Cod PHazit Course Level: 200 Course Credits: 3 Continuous Assessment Test Time Allowed: 2 Hours all the 25 to ark 1 @ . oy Uae ps epation ay the region lw be poser Ine PIECE 2 — m50 scar Mg + COz > MgCOs lance tlre equation and show the possible stages of this reaction ™ ase Using hs condton Reed vaca, 4iQUsing appropriate auatons where necessary lig three (3) properties ofthe le Keble les“ FOI SHES Cor +20 hincps > Keck WIE HO 19 pom i. Basicoxides © Peace Rdtse Be acid ‘ (c) Platinium is one of the useful elements in Pharmaceutical care. Name a compound of this eleme that is used in a known disease condition. Explain the basic mechanism of selectivity and action 0 this compound. (Use of equation to show mechanism of activity attracts extra marks) 2 (@) Using a defined concept explain what an acid is, (b) Discuss acids as pharmaceutical inorganic compounds under the following headings i, Types and Nomencleature fi, Classification ili, Chemical properties (The use of chemical equation is mandatory where necessary) 3 (a) What is Pharmaceutical Chemistry? — (b) What is an element? — ‘ (c) What is a compound? (@) What is a chemical bond? 3 (c) State the various ways Inorganic Pharmaceuticals can be of importance. (i) State one (1) character common to the following ¢ compounds: i) K,HPO,, Zn(NO3);, CuNOsand FeCl. i enphorOn PE wi if) Using any one of the compounds, show how this character can be seen in a cher reactor (g) State three (3) limitations to the Arrhenious Concept of an acid and base. /4 @ “ape sth i. What class of inorganic pharmaceuticals are matters with one typeof atom? ~*" 1% Ns 2% List the different groups of the class stated above... (b) i. Lithium is one of the useful elements in Pharmacy. Name a compound of this element that has found use in a known health condition. 2 ii, Explain the basic mechanism of action of this compound. 1% (©) What class and subclass of the inorganic Pharmaceuticals does the named compound (ore belong’ (@) Give five (5) general properties of the subclass the compound (above) belong. 3 * “Answer fom this page (write your registration number atthe top comer ofall the pages used) a Oo Ques wr Va eo pesence solooor “7— \” ' fey - aquest 2¢% 4 Oo 5450 i Sreget 28 ej Go 2G eg BAD OSG PO ay 4CO > nye dade otdes au cot, ater to porm acid Fay Hod He COs Poasgigteo @ Salts POk GY x xh besos to pr Sort and! I 5 F Madey 42maotay —> 300s GY y porn acéd® —Gologors__ bose Sale ond Haley, ke Pibelve TH Woker pr React th ase onde te form Gag + A0@y —s Ca COs Ga),: (1S 1, Bronsted-Lowry acid in the reaction HzO 6. What is common witl UNIVERSITY OF BOTSWANA FACULTY OF HEALTH SCIENCES PHARMACY PROGRAM PHA 211 Test (18/09/2020) ‘Time Allowed: 1.00 Hour th FeCl, CuNOs, + K28O) + NHsClis_ Zn(NOs)2 and KHPO,? oe A. They ate synthesized by complete Aa neutralization reaction Bxso, B. ‘They are synthesized from the reaction eee with weak bases. C. They are amphoteric, 4 2. In Bronsted-Lowry concept acid is nei A. an electron accepter B, a proton accepter C. an electron donor © a proton donor ~ 3. ZnO is used as A. protective ; astringent product is C. antidote salt @) amas uw & water oni . carbon dioxide A) all of above ~ 7. Amphoteric oxides include A. Kx and Ago B. CO; and AgsOs C. Op and Ago AO} and AgO a 8. When acid reacts with metal carbonate the 4, Compound which functions as antimicrobial agents through oxidative a 9. A specie which accepts proton ) — considered to be alan @ he. A. proton acceptor specie canon anionic specie C. KMnOs K oni sp D. All of the abo C. basic compound eo D. amphoprotic compound — . AgNOsis_ 10, If the pH value is greater than 7 A. aneutral compound solution is A. acidic B. basic D. a product of an amphoteric compound @© alkaline and acid D, salty SECTION B: Answer all the questions. Each carries the marks as shown in parenthesis. 1. (a) Define and give two examples of i, Simple substance Ji, Complex substance {b) Discuss the use and mechanism of action of any of the examples given above. (3 marks) _ (2) List the different classes and subclasses/subtypes of complex substances (2 marks) {b) Discuss the different subtypes of salts (examples & equations are necessary) (6 marks)