METABOLISM: Regulation of Transition Stage

Pyruvate (2)
• • a

2 NADH
2 NAD+
+ (Aerobic)
Alcohol Wernicke-
Korsakoff e
Syndrome 4
Thiamine
Beriberi
• • a

Thiamine deficiency 2 CO
ATP NADH
- -
Neurological Bosom •BoBB
Bo
+
-
Complications Acetyl CoA

??
Pain ☒ ⑨

+
1 TPP TPP E
J
l •
•
y •

Ca2+
Paralysis a.
PDH Phosphate
Insulin
.

:B
Death PDH 2
S
+
+
S
Edema NADH
+
Bga
KINASE BB
Pyruvate
2 CoA
Lipoate Lipoate #

E
POH
.

- *
Complex
SH E = Pyruvate Dehydrogenase
oooo oooo •

S Lipoate E = Dihydrolipoamide Acetyl Transferese

-
2
2
+ G -

E = Dihydrolipoamide Dehydrogenase
i. ATP ADP 3

•••o• BB {
CoA
3
Acetyl
CoA
SH SH i

ATP ADP 2 FAD E

2 FADH

2 NAD+ 2 NADH

Metabolism Regulation of
••••

Transition Stage
I

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