DEPARTMENT OF PHARMACEUTICAL SCIENCES. ‘GURU NANAK DEV UNIVERSITY (AMRITSAR) SUBJECT-PHARMACEUTICAL PROCESSING AND TECHNOLOGY(CYL-485) SECTION-A(ALL QUESTIONS CARRY TWO MARKS) (MAX MARKS-—~20 ‘L.DEFINE MIXING 5 job 30" aie 2. DEFINE REYNOLD NUMBER t eenMID TERM EXAM (Sept, 2018) MSc. App. Chem (Pharm.) Sem-I ‘Time: 1 hr CYL-472 : Physical Chemistry Note: Do all the questions. <7 igaids A and B fom an ideal solution obeying Raoul’ Taw. At50°G, | 2.5) at epeur pressure ofa solution containing 1 mole of A and 2 moles to Te 00 thee, When 1 more mole of A is added to the solution, tts) Sapour pressure increases to 400 torr. Determine the vapour Pressures of pure components. Discuss the variation of mutual solubility of (phenol + water) system @ \with variation of temperature. 5. Draw and explain vapour pressure-composition curves and boiling | (2.5) temperature-composition curves for type II binary solutions. | Define partition fmction. What are its characteristics? ey 5. Define ensemble. , @ © | Derive relation between Cy and partion funtion. 7 [® | 5 [are taion farmer enslave! partion funtion. | 636,27, 845.93 and 1054.38 em" above zero 845.9 8 point energy level. Determine vibrational partition function at 298 K. a6 CYL -478 M. Sc. Applied Chemistry(September 2018) Note: Do all the questions Time Allowed: 1 Hr. Max. Marks: 20 {1._| Draw the dipeptide Asp-His at pH 7. 1 | 2. | How many Penta-peptides are possible with one each of the following amino acids: 4 | Ala, Gly, His, Lys and Val. Draw structure of at-least three. Describe Edman degradation. wT x 5 Write short note on i) Gel filtration hremaeee rap Explain Primary and Secondary k ets = cs ete bys Ka a“ M, Se. Applied Chernistry (Pharmaceuticals) Mid Term Exam (18.09.2018) MM: 20 Time: Ih Note: Attempt all question Q. 1. Write three factors which influence the cher compounds. ical shift of protons in simple organic 4 Q. 2. If chemical shift ofa proton is 1.5 kHz on a 300 MHz. spectrometer, Calculate its chemical shift (both in ppm and Hz) be at S00 MHz spectrometer? 4 > (Q. 3) Predict the structure using following 'H NMR data, (CsHyCD ee ‘Chemical Shift | J-Splitiing | Integration Ratio Y 237 Singlet 9 7.10. Doubiet 6 730 Double 6 4 Q. 4. Write down chemical shifts, J-spitting pattern, and Integration ratio of expected NMR. spectrum for the following molecule. AA en between Transverse and Longitudinal relaxation times.M.Se(Appl. Chem) ist sem Midterm Fxamination September 2018 Atiempt all questions Max Marks 20 Time 1Hour 1) How will you proceed to determine the me 44 2) What are carbenes? How are carbenes generated and can be tra hanism of a reaction? pped. 3) What are kinetic and thermodynamic requi of a reaction? 3 4) Show that Hammet equation represents a linear free energy relationship. 5) What is primary kinetic isotope effect? Explain with one example. 1 24 6) How C-C single bond act as neighbouring group. explain with suitable examples. 7) Complete the following reaction: AN SbFs802 UO ee “(0 78°C cH,ch,cr 8) What are the intermediate in the following reactions: CH.CHBr Preoron ’ . os zs MialecaeyM.Se. Applied Chemistry (Pharma.) ‘Subject + Inorganic Chemistry-| Marks 320 Subject Code: CYLA73 Max Time :Thour Note: > All the questions are compulsory > Bight questions on one page in the question paper > Marks are written in front of questions in square brackets. 1 Platinum(Il) complexes serve as suitable substrates for investigating substitution [2] reactions of square planar complexes. Justify this statement. 2 Suggest suitable mechanisms for the following reactions: (4) (a) W(CO)« + PPhy —————+ W(CO).(PPh;) +CO (b) [Co(en),(NH3)CIP* | + OH ———+ [Cofen),(NH,)OH}” + CI 3 Following the 18e rule as a guide, determine x in the following complexes. pl a) [(1)’-CsHs)Os(CO)]2 (Os-Os single bond) b) [Co(CO),]* ©) [€Ni(CO);(NO)}* (consider NO as linear) _d) [(n°-CsH1s)(CO),Fe(PhC=CH))]* Although, tris(ethylenediamine)zine(I1), [Zn(en);}”* violates 18 electron rule but it is [2] stil stable complex. Why? (3) complete the following reactions: el CoH;OH/iZ0 (a) RbCl + CoH, ———? co (6) HCo(CO)« + 1,3-butadiene ———+ ?. 6 Write down two methods of preparations of bis(n’-arene)Metal complexes, 2 7 What is the reason of stabilization of a-carbonium ion during the ring substitution [2] reaction in ferrocene? Discuss structure and bonding of monoolefin metal complexes in detail. (4). Novew i= 301% M.Se. Applied Chemistry (Pharmaceuticals) Semester 1 CYL 475: Biological Chemistry Time Allowed: 3 Hrs. Max. Marks: 80 Note: Do five questions in all. Select at least one question from each of the four sections. Section 1 1. a) What is azwitterion? What does an isoelectric point mean? Give relationship “* 5 between isoelectric point and solubility. b)Lilustrate classification of proteins giving one example cach. 6 Jeseribe colour reactions of proteins and amino acids 5 Az Describe various methods use inthe puritication of peptides 16 Section 2 <1 a) What are enzymes? Give their classification, 4 ') Explain Kinetis of enzymatic reactions using Michaelis Menton model. What are 12 its limitations? Explain Significance of Ky and Voun What is enzyme inhibition? Explain the following types of enzyme inhibitions and 16 theie applications: 4) Reversible inhibition . iii) AMlostesi inhibition - Section 3 5. 4) Explain the terms; Coenzyme, Apoenzyme and Holoenzyme. 2 ~_») Give the structure and functions ofthe following: NAD, NADP, FMN and FAD. 4 Name end give structure and functions of various coenzymes derived from Vitamins 16 B,,Bs, Be and Vitamin H Ee Section 4 Describe different methods for the immobilization of enzymes, 16 ‘An explanation of various applications of immobilized enzymes, 16DEPARTMENT OF APPLIED CHEMISTRY , GURU NANAK DEY UNIVERSITY (AMRITSAR) (MS.C.APPLIED CHEMISTRY) PHARMACEUTICAL PROCESSING AND TECHNOLOGY (CYL-476) Marks: 80 ‘Time: 3Hrs Note: Attempt Five questions. Each question carries 16 marks. Candidates are required to attempt five questions, selecting at least one question from each Section. The fifth question may be attempted from any Se Section-A 1. Write a note on methods of determining the particle size and pharmaceutical applications of milling 2 Discuss the fluid mixing mechanism and write a complete note on Reynolds number, power number and roller mill, Section-B 1 Discus the analytical methods for characterization of drugs 2. Discuss the types of tablets and write a complete note on compression and granulation ‘method Seetion-C Discuss about microencapsulation and wr about various techniques and equipment for roencapsulation 2 Discuss about sustained release medication and write a note on measurement of drug availability vvivo and in-vitro Section-D about floceulated and non-flocculated suspension and write a note on preparation ‘of suspension and preparation of ointment creams and supposi- v yy c End Semester Examination M.Se. Applied Chemistry (Pharmaceuticals), Semester-1 Subject + Inorganic Chemisity-1 Max Marks +80 Subject Code cyLa73 Max Time +3 hour Note: > Four sections (A-D) in the question paper comaining 8 questions, > Attempt any five questions, selecting at least one question may be attempted from any section > Marks are writien in front of questions in square brackets, from each section. D ih question Section A Q1 _ {@) Some metal complexes undergo ligand exchange reactions via eleetron exchange, [4] Explain giving suitable example, (©) Give suitable mechanism forthe following reaction: is] trans-{Pi(en).CP* + “cr __y. rrans.gPa(en)sct'cny* + ct (©) Give mechanism for the substitution reactions of square planar complexes, Also [8] cuss the factors governing these reactions. Q2 (@ Briefly discuss the main features of Marcus theory of electron transfer reactions [4] ‘with one example ; (b) Briefly discuss stereochemical nomtigidity in trigonal bipyramidal co wy (©) Give mechanism for the following reaction isi ) [CetH.OY™ + [COONH).C1}™” —ACHHLO)SCIF{CodtO)s) + SNH i) Mg(CO)p+2PPiiy —eax, ax- (PPhi)(CO).Mn-Mn(CO)APPs) + 2CO Section B Q.3 8) Which ofthe following obey 18 electron rules? a i) Fe(CO)s i) Mas(CO)i0 . fi) [Rh(bipy),Cl]" iv) [(n’-CsH;)Mo(CO)>|” b) Write down the four common synthetic methods for the preparation of [4] bis(arene)metal complexes. ©) The metal cluster (Rux(CO)(PPhs)] is very stable. Which among the following [4] will be the actual structure ofthe molecule? Justify your answer. op me 0 ps aR mee NAL. oe t Ie Bee YY. < " Cf ‘nt? ‘ . e |do you mean by f-climination and what are important conditions required for, [4] 2 ‘he bonding in meta ally complexes in dal fal) Which of the following molecules do not undergo P-hydtride elimination and why? [4] i) WMeg ii) PH(C=CH)L2 iii) Cr(CHMe2)s iv) LaP(CH)s Where L= Generalized ligand, in particular a 2e ligand. «© Discuss the following reactions of ferrocene (8) (i) Friedal craft acetylation (ii) Vilsmeier reaction (ii) Atkylation (i) Sulphonation Section C QS (@Iilustrate the structure of vitamin Bra. Deseribe the important role played by itin [8] biological systems (&) What is Mercurie ion reductase? Discuss its structure, function, mechanism and [8] applications. Q.6 2) Write a short note on Technetium Radiopharmaceuticals i) >) Draw the structure of all approved platinum-based anticancer drugs. Discuss the [4] mechanism of action of cis-platin in detail +c) What is Auranofin?: Draw its structures and writes down its side effects. [41 +d) What is Iron overload? Discuss is symptoms, toxic does, diagnosis and treatment. [4] Section D Q7 a) By taking examples of CO and CHs=CHy diseuss 1,1- and 1.2-migratory insertion [4] reactions in detail b) Discuss the factors affecting the reductive elimination reactions 4) ©) What is oxidative coupling reaction? Explain it with suitable example fal &) What do you mean by c-c coupling resction? Write down its two types with [A] examples QA +a) What is Sonogashira coupling reaction? Explain the mechanism along with (8) catalysicaleyele in detail ~b) Discuss Nepishi coupling reaction slong with its catalytic eycle. Complore the (8) following reaction ¢ eo ee | Meme meme 5) ee Papas. PP Pha THF en, 4 leach We Too“ enatM.Sc. Applied Chemistry (Pharmaceuticals) - Semester-T 4 Organic Spectroscopy (CYL-474) Time: 3h MM: 80 ‘Note: Attempt five questions, selecting at least one question from each Section. ‘The fifth question may be attempted from any Section. Section A. Q. 1. (a) Explain three factors which influence the chemical shit of hydrogen nucle -{b) A proton possesses a chemical shift of 6 ppm at a magnetic field corresponding to proton Larmor frequency of 300 MHz. What will its chemical shift in Hz and ppm at a field of 800 MHz. <(©) Write a note on the limitations of Continuous Wave NMR spectroscopy in comparison to Fourier Transform NMR spectroscopy. (44616) 2. (a) Provide two reasons for the usage of Deuterated solvents in 1H NMR spectroscopy. (b) Write a short note on various steps involved in analysis of a 'H NMR spectrum for structure characterization purpose. (©) Deseribe the conditions under which first or second order NMR spectra are observed (4616) Section B Q. 3. (@) Drow and assign the 1H, SC, PC DEPT-90, and YC DEPT-135 spectra of the following compound: (b) Give a brief account of all the tran influence of UY radiations. possible in 4-methylbenzoic acid under the (848) 2. 4. (a) Write short note on: (9) auxochrome (i) blue shift (iv) hyperchromic effect (8) What is the derence (in term of ouput) between poten coupled ad pron decoupled °C NMR spectroscopy. Write one advantage and one disadvantage of 1 aes is a fr spread over & much lenge ppm range as standard ‘molecules. (6614)Section C Q.5. Give detailed account of MALDI and ESI modes of ionization in mass spectrometry ‘What are the advantages of these ionization modes over El and FAB modes? (16) Q 6 (A) How intramolecular and intermolecular H-bonding affect the IR spectrum of the ‘compound. Discuss by taking suitable examples. (B) Starting with the formation of molecular ion, depict all the fragmentations that are possible in the mass spectrum of 2-hexanone. (2x8) Section D 7, Draw the structure of the compound which contains C, H and O and has the following spectral data IR: strong absorption at 1730 ent’, broad and strong absorption between 3500 and 2500 em". 'INMR: 5 091 GH, t,J= 7 Ha), 145 (sextet, 2H), 1.62 CH, quintet), 265 2H, 0,725 (2H, d, 1= 7H), 8.05 (2H, dJ=7 Hz), 12.0011 5) NMR=6 13,89, 22.34, 33.23, 38:80 126.60, 128.61, 130.28, 149.49, 172.62, ‘rom High resolution mass spect, Wim 1G 04 a6) 8. Predict and assign the molecular structure of eompourd (CsH1.0sN) using following ‘Ht NMR data ‘Chemical Shift | J-Splitting (peaks) | Integral ratio 137 Z 3 Ts i 3 i 1 3 7 as 82 2 1 12.56 7 I 5)Section € 5. a) The oxidation of tis(1,10-phenanthrotine}iron(l) by periodate in aqueous solution is a feaction that shows autocatalytic behaviour, The rate constants at a variety of concentrations of Na;S0, far in excess of reactant concentrations is reported in the following data: TNaSOuy (mole) [02 [eat mor 5) | OAD What can be inferred about the charge of the activated complex of the rate determi step? Explain briefly }) Describe the formulation of Erying Equation. Also explain briefly the pre-exponential term in Erying equation for a bimolecular gas phase reaction 10,6 Ba consi long torent cn scheme: AsI—P ‘Assuming that only reactant A is present at t=0, what is the expected time dependence of [P] using the steady-state approximation? }) Consider the collision-induced dissociation of N2Os(g) via the following mechanism: NaOs(g) + N2Os(g) = Nz0x(g)* +NzOs(2) N204(g)*+(g) + NOxig) ‘The asterisk in the first reaction indicates that the reactant is activated through collision, Experimentally it is found that the reaction can be either first or second order in NxOx(e) depending on the concentration of this species. Derive a rate law expression for this reaction consistent with this observation. 88 Section D 4) Discuss briefly Langmuir’s unimolecular theory of adsorption. Derive an expression for Langmuir’s adsorption isotherm. Derive thermodynamically the Gibbs adsorption isotherm for the adsorption of a solute surface of a liquid 8,8 BET theory of mulilayer adsorption and derive an expression for BET discuss the types of adsorption isotherms, a6)‘MSc. Applied Chemistry (Pharmaceuticals)(CBCEGS) Sem | Physical Chemistry-1 CYL-472 ME: 3 Hrs MMB) ce: Attempt any five questions selecting atleast one ftom each section. Graph paper may be juested. Section A 4) Deseribe the Debye-Huckel theory of mean ionie activity coefficients, }) Determine the AH; AVwins AGnig and Sn of an ideal solution made at 25°C by mixing 1 mole of benzene and 2 moles of toluene. ©} What is meant by chemical potential? Derive the Gibbs-Duhem equation ) Discuss the various methods for determination of partial molar properties. 44.4.4 ‘a) Draw and discuss the phase diagram for two component systems in which the two ‘components form a stable compound with congruent melting compound. Also, give an example. b) For each of the following systems, find the number of components, phases and degrees of freedom: Fey + HO) SAFeOp) + How. CaCh 6120 (9, CA" CHa), HOU, 20 c) Discuss the application of temary liquid diagram in crystallization of pure components, only. 6.4.6 Section B & Describe Lagrange method of undetermined multipliers. b) Derive expression for evaluating molecular rotational and vibration partition funetion. ¢) Calculate translational, rotational and vibrational partition function of HI molecule in the gaseous state 0=9.38 K, moment of inertia=2.586 amu A”, temperature-SO0K, pressure=I atm Hil bond distance=0.1608 nm and vibrational frequency is 2309 cm". 45,7 8) Compare the three distribution laws. for the relation between equilibrium constant and partition function using Law ion tor the following reaction. . 583MSc. Applied Chemistry (Pharmaceuticals)-Ist Sem. ‘Organic Synthesis-l Paper: CYLA71 Attempt five questions selecting at least one from each section, All questions carry equal marks TIME: 3 Hours Maximum Marks 80 Section A Ql. (a) Explain the generation, structure, stability and reactivity of free radicals + 4 ()_ Wht are hard and soft acids and bases? How does the structure and medium affect the strength of aids and bases? 4 (©) What are the various types of organic reactions? Explain with one example each. 5 (@) How intermediates of a reaction help in determining the mechanism of a reaction, 3 Q2. (wFExplain the Hammett equation and linear free energy relationship. Also give the * significance of the constants used in the equation and how these constants are affected by the substituents? 6 {b) Explain the resonance and field effect, steric effect on reactivity of substrate with suitable examples. i ‘© Explain Hammond’s postulate and Curtin-Hammet principle. 4 Section B Q3. (a) Explain tetrahedral mechanism in detail with suitable examples. 5 {@) Complete the following reactions 6 i on _ te ondon ea COs — on Recsc-¢e; ——“" > x Explain phase transfer estalysis with suitable examples. 5 Q4 G@Explain SNi mechanism (substitution nucleophilic intemal in detail 3 How branching ata, f postion effect SNI and SN2 mechanism 3 ()Give nucleophilic substitution at vinylic cazbon with suitable examples. 3 {Gy Explain the neighbouring group participation by m and sigma bonds with suitable ‘example. 3 Section © els and trans isomers of 1,2-dibromocyclohexane are treated separately with “in aqucous ethanol, leading predominantly to elimination products. The els ‘only I-bromocyclohexene while the trans isomer is converted {0 3- which - further elimination to 1,3-cyclohexadiene. 1 Pte.{b) Menthyl chloride reacts with sodium ethoxide in ethyl alcohol to give a single \ preduet as shown while ncomenthyl chloride treated in same way gives an additional Drodust which is major. Moreover menthyl chloride reacts much more slowly than ‘neomenihyl chloride. Explain with mechanism why this is so? 3 ps pane Heo by oy et Chore HH HCH a C.tu0Ne, . . GaMOH cy Cn Neomenthyl Choro 24 HCH je oH 15% (© Explain in detail SyAr mechanism giving evidences + Q6. {p¥How do structure of the substrate and the nature ofthe attacking nucleophile affect the reactivity in the case of aromatic nucleophilic substitution? 5 J) How will you prepare m-bromobenzoie acid from p-bromonitrobenzene. Name the ction and write the mechanism ofthe reaction. 6 Benzylic quatemary ammonium salts undergo rearrangement when treated with alkali metal amides. What is the name of this rearrangement? Write the mechanism of this rearrangement, 5 Section D OPN od cape the mechanism of ie follwing rertion ‘ é + oe Oh Discuss Houben-Hoesch reaction with its mechanism 4 ‘Why aniline is more reactive than acetanilide in electrophilic substitution? 4 42 Explain why the bromination of toluene is five times faster than that of butylbenzene? 3 8 _fa'Discuss $2 and Sri mechanism and also the effect of solvent and leaving group. § {6) Diseuss the stereochemistry of product in non-polar, polar protic and polar aprotic solvents in case of Sel mechanism. 3 (©) Complete the following reactions, é ; “i rao WH HA Br 1 All the questions are compulsory Seven questions on one page in the question paper Marks are written in front of questions square brackets. BI (a) Give suitable mechanism for the following reaction {Co(en),NEACIP* + OFT > [Co(en;NHOH]" + Cl Suggest suitable mechanism for substitution reactions of square planar complexes. [5] ‘Also discuss various factors in{luencing the rate of such reactions. Following the 18e rule as a guide, determine x in the following complexes. RI a) [(n'-CsH;)03(CO),]p (Os-Os single bond) _ b) [Co(CO)s]" ©) [(Ni(CO);(NO)F* (consider NO as linear) A) [(1°-CsH15(CO)sFe(PHC=CH))]" Although, tris(ethylenediamine)zine(I1), [Zn(en);}°* violates 18 electron rule but it is (2) still stable complex. Why? Write down two general methods of preparations of bis(n'-arene)Metal complexes. [2] Prepare the following products starting from the ferrocene: ira} ogc ow Gr ‘CHO Gr Nov AD Fe B) Fe cc) Fe D) Fe structure and bonding of monoolefin metal complexes in detail, or7 MSe. Applied Chemistry (Pharmaceuticals) ~ Semester-1 Organic Spectroscopy (CYL-A74) Ti MM: 20 Note: Attempt five questions. Q. 1. What are the nuclear spin values for the following atoms: @H @"C @"B @)"B Q) Q. 2. What is the origin of Chemical shift in NMR spectroscopy? Explain by taking a suitable example. a) Q.3. How the magnetic field affects the sensitivity of the NMR spectrometer? “) Q. 4, Give a brief account of relaxation times (TI and T2) in NMR spectroscopy. 4 Q. 5. Predict the splitting pattem of the Hs’ marked ‘a’, ‘b’, “e’ and ‘din the following molecule 2 Hie cH Hs" =e CH ©. 6. Why do we need more number of seans for recording "C NMR spectrum in comparison to the 'HNMR spectrum of the same sample? @ 0. 7. 3C NMR spectrum of ethyl alcohol is recorded in CDCI. What will be the chemical ‘shift and splitting patter of C* of CDCh? Give appropriate justification in support of ’ ‘your answer. @Mid Semester Exam. Sept.2019 ‘M.Sc. Applied Chemistry (Pharma), Semester-t ‘CYL -472 : Physical Chemistry Time: 1 hr |. What are partial molar quantities? Drive the Gibbs-Duhem equation. 2. (a) For the Ammonia synthesis AG (in eal. mot") is given as a function of temperature as AG =~ 9190 + 7.127 InT- 3,182 « 10° T? +132 «1071 21.61T Calculate AS and AH at 1000 K. (b) Drive the Gibbs Phase rule. 3.(a)_ What is Gibbs free energy? Prove that AG =~ (Wn ~ PAV). (b) What are excess thermodynamic functions? Derive the expression for excess. Gibbs free energy . ‘M.M=20 6) Q 3 @ @“M.Sc. Applied Chemistry Sem I Organic Chemistry Mieter--2019 Max. Marks 20 1. Discuss the benzyne mechanism with evidences? . 4Sr.No. 9062 "M.Sc. Applied Chemistry (Pharmaceuticals) - 1st Sem. (CBEGS) (2119) Paper : CYL-473 Inorganic Chemistry-1 Time allowed : 3 hrs. Max. Marks : 80 Note: Candidates are required to atiempt any five questions, selecting at least one question from each section. The fifth question may be attempted from any section Section A 7 * Explain the acid and base hydrolysis mechanism? With the help of examples, explain Why base hydrolysis is faster than acd hydrolysis? Go (@) Distinguish between outer sphere and inner sphere reactions with the help of ‘examples. _p3) Balan asocintive mshiom inthe taeda cmpex reaction (3) Section B 1. Discuss the following 2. a) Classification of organ transition metal compousls b) 18 electron rule. 3) 2. Write short notes on preparatior, properties and nature of bondi 8) Meta ally and dienyl complexes. 1) Ferrocene 6s) Section € What re anicancer ups Write down detaled mechanism ofc plain Sl wh pier i TC in By. ¢ 46) What are metaloenzymes? Discuss the structure of Vit PTOSr.No.9062 (a) Section D Discuss the detailed mechanism for any two coupling reaction based on 46) tapenade ( 2 (@)_ Discuss the following organometallic reactions: (Reductive elimination (ii) B— elimination {b) With the help of suitable chemical reactions diseuss the insertion reaction of alkenes and carbon monoxide in transition metal complexes, (4A).8) 9062(2119)100MsSe. Appticd Chemistry (Pharmaceuticals) Semester 1 CYL 475: iological Chemistry Time AMlowed: 3 Hrs Max. Marks: 80 Note: Do five questions in all, Select atleast ome question from each of the four sections. ‘ection 1 1. a) Give chemical equations and uses of the following rexetions ofa i) Reaction of Amino Acids with Ninhydin, axa ) Sanger’s reaction Fadman’s Reaction \ iy) Dansyl Chloride reaction. 4) The following peptide chain was hydrolyzed separately by chemotrypsin and 6 pepsin. Give the fragments produced by each enzyme: val-ala-lys-gly eluephe-val-met-tyrcysrglutrp-met-ply-es-phe +b) What are the findings of Ramachandran plot? How are P-shecis formed? 10 Section 2 4 Bi pe his comet ve ela by Explain Kinetics of enzymatic reetions «its fimitations? Expl 4 What is enzyme ini + their applications: » ip Reversible inhibition + fi) Irreversible inhibition ‘iy Allosteric inhibition Jaactis Mentani mes, What a significance of Ky, ona V sn? Explain the following types oFenzyne inhibitions nd 16 Section 1 the terms: Coenzyme, Apocnzyme and HMoloenzy me the structure und finetions uf the cvemzsnves that pti i Hydro reactions. u ive structure and fimetions coenzymes that puticipate in the transfer of 16 ally grup axl ulyoxal group. Also give stable examples fr reactions in the presence ofthese enenzymes Section # lo alent euipling mets fi the 16 targets for dg design,DEPARTMENT OF APPLIED CHEMISTRY GURU NANAK DEV UNIVERSITY AMRITSAR. SUBJECT: PHARMACEUTICAL PROCESSING AND TECHNOLOGY(CYL-476) Endl Ses. Nout 2019 Time! 2 bws. a Max marks—-80 EIGHT QUESTIONS OF EQUAL MARKS ARE TO BE SET,TWO IN EACH OF FOUR SECTIONS QUESTIONS MAYBE SUBDIVIDED INTO PARTS.CANDIDATES ARE REQUIRED TO ATTEMPT FIVE QUESTIONS, SELECTING AT LERST ONE QUESTION FROM EACH SECTION.THE FIFTH QUESTION MAY BE ATTEMPTED FROM ANY SECTION. SECTION-A _EWRITE A COMPLETE NOTE ON MICROSCOPY,SIEVING AND SEDIMENTATIONAND APPLICATIONS OF MILUNG 2.WRIE A COMPLETE NOTE ON REYNOLD NUMBER, POWER NUMBER,GRANULATION PROPERTIES AND STRENGTH OF GRANULES. SECTION-B ANOTE ON ANALYTICAL METHODS FOR THE CHARACTERIZATION OF ORUG AND [DETERMINATION OF PH SOLUBILITY PROFILE 2.WRITE A COMPLETE NOTE ON FILM COATING EVALUATIGN OF COATED TABLETS AND DEFECTS OF FMS. SECTION. WRITE A COMPLETE NOTE ON MICROENCAPSULATION,VARIOUS TECHNIQUES AND EQUIPMENT EMPLOYED FOR MICRO-ENCAPSULATION. tn & COUPEE NOTE ON HARD GEA CAPSLNESVALUATIONPISKCAL STABLITY AND “PACKING secTION.© ITE A COMPLETE NOTE ON STABILITY TESTING PREPARATION AND EVALUATION OF SUSPENSIONS ‘A COMPLETE NOTE ON PHARMACEUTICAL AEROSOLS,FORMULATION AND THERE